77 completed. 77 Phase 2, 17 Phase 1, 9 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 77 | Completed 77 |
| Phase 1 | 17 | Completed 17 |
| Phase 3 | 9 | Completed 9 |
Follow Foot Ulcer: new trials by email Literature Review of Foot Ulcer trials Research Report on Foot Ulcer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU) PEP (Purified Exosome Product) / TISSEEL - Diabetic Foot Ulcer | Phase 2 | Completed | Rion Inc. | 59 | 2024-02-27 | 2026-07-20 |
| Evaluation of AUP12602-C as New Topical Treatment for DFUs (DIAMEND STUDY) AUP1602-C, Placebo - Diabetic Foot Ulcer | Phase 2 | Completed | Aurealis Oy | 64 | 2023-07-21 | 2026-02-12 |
| Restoring Tissue and Evaluating Novel Treatments for Efficacy in Wounds Lavior Diabetic Wound Gel, Smith & Nephew Solosite Gel Hydrogel Wound Dressing - Diabetic Foot Ulcer | Phase 2 / Phase 3 | Completed | Lavior Pharma Inc. | 75 | 2022-12-15 | 2024-10-08 |
| Assessment of the Clinical, Cellular and Molecular Effects of Royalactin-Royal Jelly on the Healing of Wagner Grad II Diabetic Foot Ulcers. Royalactina, Placebo - Diabetic Foot Ulcer | Phase 2 | Completed | Universidad Autonoma de Nuevo Leon | 10 | 2022-09-09 | 2026-04-03 |
| Multi-center Study to Assess Safety, Tolerability and Efficacy of Topical Pravibismane in Moderate DFI Patients Topical Pravibismane, Standard of Care - Diabetic Foot Infection, Diabetic Foot | Phase 2 | Completed | Microbion Corporation | 47 | 2022-06-13 | 2024-11-04 |
| Evaluation of a Folic Acid Wound Treatment (FAWT) for Chronic, Early-Stage Diabetic Foot Ulcer (DFU) Healing Folinic acid calcium salt - Diabetic Foot Ulcer | Phase 2 | Completed | Joseph Boykin, MD | 15 | 2021-12-01 | 2024-10-04 |
| Bioactive Smart Dressings for Diabetic Foot Ulcers: Randomized Controlled Trial PRP gel and SOC-treatment, EPO/ISDN/UFH cryogel dressing, Standard of Care - Diabetic Foot Ulcer | Phase 2 | Completed | Mansoura University | 30 | 2021-07-15 | 2023-01-04 |
| A Study to Evaluate the Clinical Performance, Safety and Pharmacology Effect of EscharEx in Patients With Lower Leg Ulcers EscharEx (EX-02 formulation) - Venous Leg Ulcer, Diabetic Foot Ulcer | Phase 2 | Completed | MediWound Ltd | 12 | 2021-04-21 | 2022-07-26 |
| Bacteriophage Therapy TP-102 in Diabetic Foot Ulcers TP-102 - Diabetic Foot Ulcer, Pseudomonas Aeruginosa Infection | Phase 1 / Phase 2 | Completed | Technophage, SA | 20 | 2021-03-22 | 2022-10-04 |
| Allogeneic Platelet Rich Plasma (PRP) to Treat Diabetic Foot Ulcers PRP+HA, HA - Diabetic Foot Ulcer, Skin Lesions | Phase 1 / Phase 2 | Completed | Ospedale Policlinico San Martino | 72 | 2021-02-23 | 2024-11-08 |
| Nitric Oxide Footbath for Treatment of Diabetic Foot Ulcers Nitric Oxide-Releasing Solution, Saline solution, hypotonic - Diabetic Foot Ulcer | Phase 1 / Phase 2 | Completed | Sanotize Research and Development corp. | 40 | 2021-02-23 | 2023-05-31 |
| Safety and Efficacy of Allogeneic Adipose Tissue Mesenchymal Stem Cells in Diabetic Patients With Critical Limb Ischemia High dose allogeneic mesenchymal stromal cells, Low dose allogeneic mesenchymal stromal cells, Placebos - Limb Ischemia, Diabetic Foot | Phase 2 | Completed | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | 90 | 2021-01-11 | 2025-04-27 |
| A Study to Evaluate Safety and Efficacy of APO-2 at Three Different Doses in Patients With Diabetic Foot Ulcer APO-2, Placebo - Diabetic Foot Ulcer (DFU) | Phase 1 / Phase 2 | Completed | Aposcience AG | 159 | 2020-10-09 | 2024-01-31 |
| Treatment of Diabetic Foot Ulcers With AUP1602-C AUP1602-C - Diabetic Foot Ulcer | Phase 1 / Phase 2 | Completed | Aurealis Oy | 26 | 2020-01-28 | 2023-09-28 |
| TWB-103 for Treating Lower Limb Ulcers on Patients With DM TWB-103 - Diabetic Foot Ulcer | Phase 1 / Phase 2 | Completed | Transwell Biotech Co., Ltd. | 10 | 2019-12-19 | 2023-07-12 |
| Treatment of Chronic Wounds in Diabetic Foot Syndrome With Allogeneic Adipose Derived Mesenchymal Stem Cells Application of allogeneic ADSC stem cells in fibrin gel, Standard care in diabetic foot ulcer - Diabetic Foot Ulcer | Phase 1 / Phase 2 | Completed | Medical University of Warsaw | 46 | 2019-07-01 | 2021-10-14 |
| Effect of WF10 (TCDO) on HbA1c Values in Diabetic Foot Ulcer Patients WF10 - Diabetic Foot Ulcer (DFU), Uncontrolled Diabetes With Foot Ulcer | Phase 2 | Completed | Srinakharinwirot University | 40 | 2019-06-19 | 2020-10-22 |
| Clinical Study of ALLO-ASC-SHEET in Subjects with Diabetic Foot Ulcers ALLO-ASC-DFU, Hydrogel SHEET(Vehicle control) - Diabetic Foot Ulcer | Phase 2 | Completed | Anterogen Co., Ltd. | 66 | 2019-01-02 | 2025-01-23 |
| Preventing Diabetic Foot Ulcers Through Cleaner Feet Chlorhexidine, Placebo - Diabetic Foot Ulcer | Phase 2 | Completed | VA Office of Research and Development | 175 | 2019-01-02 | 2024-08-09 |
| CHF6467 SAD and MAD in Patients With Diabetic Foot Ulcer CHF6467 active - Diabetic Neuropathic Foot Ulcers | Phase 1 / Phase 2 | Completed | Chiesi Farmaceutici S.p.A. | 93 | 2018-10-17 | 2022-02-23 |
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Diabetic Foot (74) · Diabetes Mellitus (20) · Ulcer (11) · Wounds and Injuries (9) · Infections (5) · Diabetic Neuropathies (3) · Pressure Ulcer (3) · Varicose Ulcer (3) · Bronchiolitis Obliterans Syndrome (2) · Chronic Limb-Threatening Ischemia (2) · Diabetes Complications (2) · Diabetes Mellitus, Type 2 (2) · Peripheral Vascular Diseases (2) · Acinetobacter Infections (1)
Skin Diseases (77) · Skin and Connective Tissue Diseases (77) · Leg Ulcer (76) · Skin Ulcer (76) · Endocrine System Diseases (75) · Cardiovascular Diseases (74) · Diabetic Angiopathies (74) · Vascular Diseases (74) · Diabetes Complications (72) · Diabetic Neuropathies (71) · Diabetes Mellitus (55) · Glucose Metabolism Disorders (21) · Metabolic Diseases (21) · Nutritional and Metabolic Diseases (21)
Standard of Care (9) · Levofloxacin (3) · Dalteparin (2) · Metformin (2) · Saline Solution (2) · 2-(2-(4-chlorophenyl)ethoxy)adenosine (1) · Atorvastatin (1) · Bandages (1) · Becaplermin (1) · Chlorhexidine (1) · Congresses as Topic (1) · Doxycycline (1) · Fibrin Tissue Adhesive (1) · Foot Orthoses (1) · Huang Qi (1)
Baylor College of Medicine (3) · GlaxoSmithKline (3) · Pfizer (3) · Anterogen Co., Ltd. (2) · Aurealis Oy (2) · Chinese University of Hong Kong (2) · Innocoll (2) · PluroGen Therapeutics, Inc (2) · Skingenix, Inc. (2) · US Department of Veterans Affairs (2) · Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud (1) · Andalusian Network for Design and Translation of Advanced Therapies (1) · Aposcience AG (1) · Asker & Baerum Hospital (1) · Bayer (1)
United States (32) · Germany (9) · Poland (6) · Russia (5) · United Kingdom (5) · Czechia (4) · Italy (4) · Spain (4) · Taiwan (4) · Austria (3) · Canada (3) · China (3) · Israel (3) · Norway (3) · Ukraine (3)
David Prior (2) · Robert S Kirsner, MD, PhD (2) · Alexander M. Reyzelman, DPM (1) · Alireza Goodarzi, MSc (1) · Amira Motawea (1) · Andreas Kerstan, Dr. (1) · Andres Gutierrez, M.D., Ph.D. (1) · Antonio Chacon, MD, PhD (1) · Antonio de la Cuesta, MD (1) · Arthur Tucker, PhD (1) · Beata Mrozikiewicz-Rakowska, . Assoc.Prof. (1) · Behnam Molavi, MD (1)
PMID 15504999, PMID 20923537, PMID 22284892, PMID 22289660, PMID 22463944, PMID 22659765, PMID 22672145, PMID 23216959, PMID 24330156, PMID 24760263, PMID 25411598, PMID 26696670, PMID 29564750, PMID 30679183, PMID 30943782, PMID 33011075, PMID 33407796, PMID 33504262, PMID 33735146, PMID 34488845, PMID 35507774, PMID 35844773, PMID 36064604, PMID 37740111, PMID 38216296, PMID 39313976, PMID 39740667, PMID 39838970, PMID 39964684
2018 (2), 2008 (1), 2015 (1), 2016 (1), R44DK059074 (1)