32 completed, 11 unknown, 8 terminated, 6 recruiting. 63 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 63 | Completed 32, Unknown 11, Terminated 8, Recruiting 6, Withdrawn 4, Active not recruiting 1, Not yet recruiting 1 |
Follow Foot Ulcer: new trials by email Literature Review of Foot Ulcer trials Research Report on Foot Ulcer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Seltoplasmid Plus Revascularization for Diabetic Infrapopliteal Chronic Limb-Threatening Ischemia Lower-Extremity Revascularization, Donaperminogene Seltoplasmid - Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer | Phase 4 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 180 | 2026-10-20 | 2026-09-18 |
| A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL DermaBind TL - Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU) | Phase 4 | Completed | HealthTech Wound Care | 150 | 2025-12-10 | 2026-10-30 |
| Efficacy of Plasma Rich in Growth Factors (PRGF) in the Treatment of Foot Ulcers in Diabetic Patients With Peripheral Arterial Disease Topical application of Plasma Rich in Growth Factors (PRGF), Conventional treatment (conventional treatment with adequate offloading and metabolic control, +/- antibiotic). - Foot Ulcers, Diabetic | Phase 4 | Recruiting | Biotechnology Institute IMASD | 38 | 2025-11-01 | 2025-09-11 |
| A Multicenter, Prospective, Controlled Clinical Trial Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers XWRAP - Diabetic Foot, Foot Ulcer | Phase 4 | Recruiting | Applied Biologics, LLC | 60 | 2025-08-26 | 2026-02-11 |
| Effect of Amnio-Maxx on the Healing Rate of Chronic Diabetic Foot Ulcers. Amnio-Maxx® Dual Layer Amnion Patch, Standard of Care (Investigator Choice) - Diabetic Foot Ulcer (DFU), Amnio-Maxx | Phase 4 | Recruiting | Royal Biologics | 248 | 2025-08-14 | 2025-10-07 |
| Intraosseous Versus Intravenous Vancomycin in Below-Knee Amputation for Ischemic Diabetic Foot Intraosseous Vancomycin, Intravenous Vancomycin - Diabetic Foot Disease, Diabetic Foot Infection | Phase 4 | Completed | Başakşehir Çam & Sakura City Hospital | 40 | 2025-08-06 | 2026-07-10 |
| Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers Standard of Care DFU, Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU - Diabetic Foot, DFU | Phase 4 | Recruiting | BioLab Holdings | 650 | 2025-07-15 | 2025-07-28 |
| Randomized Evaluation of Nonhealing Diabetic Foot Ulcers With Exclusive Wound Therapy Activate™ Matrix, AmnioDefend™ FT Matrix, Palisade™ DM Matrix - Diabetic Foot Ulcer, DFU | Phase 4 | Recruiting | Sequence LifeScience, Inc. | 350 | 2025-07-11 | 2026-05-19 |
| Nonhealing Diabetic Foot Ulcers Treated With Standard of Care (SOC) Alone or Standard of Care and Amnion-Intermediate-Chorion (AIC) Amnion-Intermediate-Chorion, Standard of Care (SOC) - Diabetic Foot Ulcer | Phase 4 | Completed | Cellution Biologics | 84 | 2025-07-03 | 2026-08-20 |
| Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers. ACApatch™, caregraFT™, Standard of Care - Venous Leg Ulcer, Venous Leg | Phase 4 | Recruiting | Tiger Biosciences, LLC. | 340 | 2024-12-06 | 2026-09-22 |
| Study Evaluating Several CAMPs in Nonhealing Diabetic Foot and Venous Leg Ulcers Amnion-Intermediate-Chorion, Amnion-Chorion-Amnion, Standard of Care - Diabetic Foot Ulcer, Venous Leg Ulcer | Phase 4 | Completed | Cellution Biologics | 292 | 2024-10-14 | 2026-04-13 |
| Clinical Observation and Mechanism Study of Yunnan Baiyao in Different Stages of Diabetic Foot Yunnan Baiyao - Diabetic Foot, Therapeutics | Phase 4 | Unknown | Peking University Third Hospital | 100 | 2023-12-01 | 2024-06-25 |
| Study on Regeneration of Skin Defects in Diabetic Ulcers Treated With New Electrospun Material PLCL/Fg PLCL/Fg group, control group - Diabetic Foot | Phase 4 | Unknown | Guili Wang | 52 | 2023-03-01 | 2023-08-28 |
| Exploring the Effect of Fespixon Cream for the Treatment of Diabetic Foot Ulcers (TEXAS 3A, 3B) Fespixon Cream - Diabetic Foot Ulcer (DFU) | Phase 4 | Terminated | Oneness Biotech Co., Ltd. | 3 | 2022-08-04 | 2024-05-16 |
| Nocardia Cell Wall Skeleton for the Treatment of Diabetic Foot Ulcer Wounds Nocardia rubra Cell Wall Skeleton, Silver ions dressing - Diabetic Foot Ulcer, Therapy, Directly Observed | Phase 4 | Unknown | The Affiliated Hospital of Xuzhou Medical University | 116 | 2022-05-20 | 2022-05-10 |
| Does Increasing Oxygen Nurture Your Symptomatic Ischemic Ulcer Sufficiently? Hyperbaric oxygen - Peripheral Vascular Disease, Diabetic Foot Ulcer | Phase 4 | Active not recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 30 | 2021-10-08 | 2024-11-08 |
| Intensive Glycemic Control For Diabetic Foot Ulcer Healing Insulin Glargine, Diabetic DM - Diabetic Foot Ulcer | Phase 4 | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 326 | 2021-10-01 | 2021-11-02 |
| Fitostimoline® Hydrogel Versus Saline Gauze Dressing in Diabetic Foot Ulcers Fitostimoline ® hydrogel group, Saline gauze group - Diabetic Foot | Phase 4 | Completed | Federico II University | 40 | 2021-02-01 | 2022-12-22 |
| Fluorescence Image-Guided Healing Trial Moleculight i:X - Diabetic Foot Ulcer | Phase 4 | Unknown | University Health Network, Toronto | 294 | 2021-01-01 | 2020-11-03 |
| The Effect of Treatment With Umbilical Cord Blood Platelet Lysate on Diabetic Foot Ulcers Umbilical cord blood platelel lysate gel - Diabetic Foot | Phase 4 | Completed | Attikon Hospital | 120 | 2019-06-10 | 2023-12-05 |
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Diabetic Foot (55) · Diabetes Mellitus (13) · Varicose Ulcer (7) · Ulcer (6) · Diabetes Mellitus, Type 2 (4) · Diabetes Mellitus, Type 1 (3) · Leg Ulcer (3) · Ischemia (2) · Pressure Ulcer (2) · Abscess (1) · Cellulitis (1) · Chronic Limb-Threatening Ischemia (1) · Diabetic Neuropathies (1) · Directly Observed Therapy (1)
Skin Diseases (63) · Skin Ulcer (63) · Skin and Connective Tissue Diseases (63) · Endocrine System Diseases (60) · Leg Ulcer (60) · Cardiovascular Diseases (55) · Diabetes Complications (55) · Diabetic Angiopathies (55) · Vascular Diseases (55) · Diabetic Neuropathies (54) · Diabetes Mellitus (47) · Glucose Metabolism Disorders (15) · Metabolic Diseases (15) · Nutritional and Metabolic Diseases (15)
Standard of Care (8) · Collagenases (6) · Anti-Bacterial Agents (2) · Control Groups (2) · Daptomycin (2) · Histocompatibility Testing (2) · Ascorbic Acid (1) · Bacitracin (1) · Bandages (1) · Collagen (1) · Hydrogels (1) · Hyperbaric Oxygenation (1) · Insulin Glargine (1) · Intercellular Signaling Peptides and Proteins (1) · Maggot Debridement Therapy (1)
Healthpoint (8) · Osiris Therapeutics (4) · Smith & Nephew, Inc. (3) · Cellution Biologics (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Applied Biologics, LLC (1) · Assistance Publique - Hôpitaux de Paris (1) · Attikon Hospital (1) · Avita Medical (1) · Başakşehir Çam & Sakura City Hospital (1) · BioLab Holdings (1) · Biotec Pharmacon ASA (1) · Biotechnology Institute IMASD (1) · Celleration, Inc. (1) · Clinical Alliance for Research & Education - Infectious Diseases, LLC. (1)
United States (32) · China (5) · Italy (4) · Sweden (4) · Canada (3) · United Kingdom (3) · Denmark (2) · Germany (2) · Greece (1) · India (1) · Mexico (1) · Netherlands (1) · Spain (1) · Switzerland (1) · Taiwan (1)
Herbert B Slade, MD (6) · Alejandro E Macias, MD (1) · Art J Tallis, DPM (1) · Carl Van Gils, DPM, CWS (1) · David Armstrong, DPM (1) · Davin Haraway, DO (1) · Donald Poretz, MD (1) · Fany Guadalupe Pat Espadas, MCs (1) · Frances Game, FRCP (1) · Giulia Cattarini (1) · Hebert B Slade, MD (1) · Hongting Zheng, Ph.D (1)
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