131 completed, 82 unknown, 19 recruiting, 18 terminated. 276 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 276 | Completed 131, Unknown 82, Recruiting 19, Terminated 18, Not yet recruiting 10, Active not recruiting 8, Withdrawn 6, Enrolling by invitation 1, Suspended 1 |
Follow Fibrosis: new trials by email Literature Review of Fibrosis trials Research Report on Fibrosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase IV, Two-part, Open-label Study Assessing the Pharmacokinetics, Safety and Pharmacodynamics of Spironolactone Oral Suspension in Pediatric Patients Spironolactone Oral Suspension - Edema Due to Heart Failure or Cirrhosis | Phase 4 | Not yet recruiting | CMP Development, LLC | 96 | 2027-06-01 | 2026-10-22 |
| Reducing Wound Complications in Breast Surgery Using hACM Dehydrated Human Amnion Chorion Membrane - Surgical Wound Healing, Scar Tissue | Phase 4 | Not yet recruiting | Rutgers, The State University of New Jersey | 200 | 2026-11-01 | 2026-11-09 |
| Gabapentin vs. Benzonatate vs. Standard of Care for Cough in ILD Gabapentin, Benzonatate 200 mg, Standard of care treatment for ILD - Interstitial Lung Disease | Phase 4 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 177 | 2026-10-07 | 2026-10-08 |
| Mechanistic Evaluation of Atrasentan in Patients With IgA Nephropathy (IgAN) atrasentan - IgA Nephropathy (IgAN), Immunoglobulin A Nephropathy (IgAN) | Phase 4 | Not yet recruiting | University of Illinois at Chicago | 20 | 2026-09-29 | 2026-09-21 |
| Daridorexant for Sleep Disturbance in Adults With Liver Cirrhosis Daridorexant, Placebo - Liver Cirrhosis, Sleep Disturbance | Phase 4 | Not yet recruiting | Wang Fengmei | 180 | 2026-09-01 | 2026-10-16 |
| This is a Trial Designed to Evaluate the Combination of Nerandomilast With Mycophenolate Across a Wide Variety of Pulmonary Fibrosis Subtypes, With the Aim of Providing Clinicians With Assurance That This is an Appropriate Therapeutic Combination. Nerandomilast 18 mg - adult formulation - Pulmonary Fibrosis, Interstitial Lung Disease (ILD) | Phase 4 | Not yet recruiting | University of British Columbia | 120 | 2026-06-01 | 2026-05-11 |
| DICE Study- Diastolic Improvement With Carvedilol & Empagliflozin in Patients With Cirrhosis Empagliflozin + Carvedilol, Carvedilol - Cirrhotic Cardiomyopathy, Empagliflozin | Phase 4 | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 400 | 2026-04-01 | 2026-05-14 |
| Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis Apixaban, Carvedilol, Placebo - Cirrhosis, Esophageal and Gastric Varices | Phase 4 | Recruiting | Asian Institute Of Medical Sciences | 220 | 2026-04-01 | 2026-04-09 |
| Effect of Pirfenidone on TA Fibrosis Pirfenidone Capsules, Placebo - Takayasu Arteritis | Phase 4 | Not yet recruiting | Shanghai Zhongshan Hospital | 92 | 2025-12-20 | 2026-01-08 |
| Remimazolam vs Propofol in Laser Burn Cases Remimazolam besylate, Propofol - Burn Scar, Hypertrophic Scarring | Phase 4 | Recruiting | Medical University of South Carolina | 136 | 2025-11-12 | 2025-11-20 |
| Vericiguat and Reverse Remodeling Indices in Heart Failure Vericiguat, Guideline Directed Medical Therapy for Heart Failure (GDMT) - Heart Failure With Reduced Ejection Fraction (HFrEF), Chronic Heart Failure | Phase 4 | Recruiting | University Medical Centre Ljubljana | 70 | 2025-11-01 | 2026-09-29 |
| Role of Allopurinol in Prevention of Complications Related to Decompensated Cirrhosis of Liver Allopurinol Tablet, Placebo - Cirrhoses, Liver, Decompensated Cirrhosis of Liver | Phase 4 | Recruiting | Bangladesh Medical University | 54 | 2025-09-10 | 2026-09-02 |
| Effect of an Early Time Restricted Eating Mediterranean Diet Compared to Naltrexone/Bupropion on Liver Fibrosis in People With Cardiometabolic Risk Factors in a Hospital Outpatient Clinic (MEDFAST-study) early time restricted Mediterranean diet, Mysimba - Diabetes Mellitus, Type 2, Liver Fibrosis | Phase 4 | Enrolling by invitation | Carmen Dietvorst | 70 | 2025-04-14 | 2026-04-21 |
| Comparison of Intralesional Triamcinolone Versus Verapamil for Keloid Treatment Triamcinolone Acetonide 1 ml of 40 mg/mL suspension, Verapamil Injection - Keloid Scars | Phase 4 | Not yet recruiting | Nishtar Medical University | 60 | 2025-04-01 | 2025-04-01 |
| Evaluation of the Effectiveness of a Topical Medical Device in Wound Healing and Symptom Relief in the Postoperative Period of Open Excisional Hemorrhoidectomy (The Emor Study) Gel containing a Propionibacterium extract, Hyaluronic acid and silver sulfadiazine - Anus Diseases, Gastrointestinal Diseases | Phase 4 | Completed | University of Cagliari | 114 | 2025-03-04 | 2025-07-02 |
| A Study to Evaluate Role of Inhaled Amikacin to Prevent Ventilator Associated Pneumonia in Patients With Cirrhosis Inhaled amikacin, Placebo - Hepatic Encephalopathy, Cirrhosis | Phase 4 | Recruiting | Asian Institute of Gastroenterology, India | 162 | 2025-02-12 | 2025-04-04 |
| Carvedilol Plus EVL or Not for the Primary Prevention of Esophageal Variceal Bleeding in Carvedilol Non-responders Carvedilol plus endoscopic variceal ligation, Carvedilol alone - Cirrhosis, Esophageal Varices | Phase 4 | Recruiting | Taipei Veterans General Hospital, Taiwan | 80 | 2025-01-06 | 2025-02-11 |
| Henagliflozin on Liver Fibrosis in Patients with MASLD and T2DM Henagliflozin 10 mg daily, Metformin 1700 mg daily, Placebo of Henagliflozin - Metabolic Dysfunction-associated Steatotic Liver Disease, Type 2 Diabetes Mellitus | Phase 4 | Not yet recruiting | Xiqiao Zhou | 190 | 2024-12-31 | 2025-01-07 |
| Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients Tranexamic Acid and vitamin K, Placebo - Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding | Phase 4 | Recruiting | Tanta University | 194 | 2024-12-02 | 2025-03-18 |
| A Trial for Comparing Rifaximin, Probiotic and L-ornithine- L Aspartate With Lactulose in Overt Hepatic Encephalopathy. Probiotic plus lactulose, Rifaximin plus lactulose, L-ornithine-L-aspartate plus latulose - Overt Hepatic Encephalopathy | Phase 4 | Completed | Qurratul Ain Jamil | 252 | 2024-12-02 | 2025-06-25 |
Showing 20 of 276. Sign in to see all of them.
Liver Cirrhosis (88) · Hypertension, Portal (25) · Hepatic Encephalopathy (20) · Cicatrix (18) · Keloid (17) · Liver Cirrhosis, Biliary (15) · Ascites (14) · Hepatitis C (12) · Pulmonary Fibrosis (12) · Hepatitis B (10) · Hepatitis B, Chronic (10) · Cicatrix, Hypertrophic (9) · Esophageal and Gastric Varices (9) · Tissue Adhesions (9)
Pathological Conditions, Signs and Symptoms (276) · Pathologic Processes (275) · Digestive System Diseases (166) · Liver Diseases (147) · Infections (48) · Virus Diseases (40) · Hepatitis (37) · Blood-Borne Infections (35) · Communicable Diseases (35) · Hepatitis, Viral, Human (34) · Nutritional and Metabolic Diseases (34) · Metabolic Diseases (33) · Cicatrix (30) · Nervous System Diseases (26)
Rifaximin (12) · Carvedilol (10) · Albumins (9) · Ribavirin (8) · Propranolol (7) · Spironolactone (7) · Warfarin (7) · entecavir (7) · Lactulose (6) · Nadroparin (6) · Saline Solution (6) · Sodium Chloride (6) · ornithylaspartate (6) · Terlipressin (5) · Amino Acids, Branched-Chain (4)
Hospital Clinic of Barcelona (6) · Shanghai Zhongshan Hospital (6) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (5) · Kafrelsheikh University (5) · Korea University (5) · Medical University of Vienna (5) · Taipei Veterans General Hospital, Taiwan (5) · West China Hospital (5) · Beijing Friendship Hospital (4) · Mahidol University (4) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (4) · Shanghai Changzheng Hospital (4) · Cairo University (3) · Hospital Universitari Vall d'Hebron Research Institute (3) · Peking Union Medical College Hospital (3)
United States (55) · China (44) · Spain (24) · South Korea (18) · Egypt (17) · Italy (12) · Taiwan (12) · India (10) · United Kingdom (10) · Austria (9) · Germany (9) · Mexico (9) · Belgium (7) · Brazil (7) · Canada (7)
Shiyao Chen, Professor (5) · Arnulf Ferlitsch, MD (4) · Hong You, Doctor (3) · Ming-Chih Hou, MD (3) · Soon Ho Um, Prof (3) · Aya Emad Fouda, MSc in Clinical Pharmacy (2) · Candido Villanueva, MD (2) · Dimitrios G Goulis, MD, PhD (2) · Dou-Sheng Bai, MD (2) · German Soriano (2) · Guo-Qing Jiang, MS (2) · Herbert B Slade, MD (2) · Juan Cordoba, MD (2)
PMID 37467180, PMID 19208350, PMID 19570764, PMID 33460002, PMID 34843068, PMID 39373164, PMID 10221490, PMID 10347109, PMID 10403745, PMID 10613747, PMID 10798738, PMID 11208726, PMID 11588440, PMID 11772973, PMID 11855555, PMID 11876689, PMID 12438948, PMID 12500513, PMID 12699951, PMID 12761269, PMID 12806613, PMID 12873814, PMID 12924658, PMID 12963433, PMID 14988829, PMID 15140214, PMID 15222044, PMID 15365369, PMID 15470215, PMID 15985009, PMID 16134766, PMID 16206505, PMID 16306522, PMID 16460491, PMID 16708058, PMID 17234504, PMID 17241381, PMID 17327353, PMID 17387740, PMID 17484872, PMID 17644502, PMID 18251131, PMID 18410283, PMID 18492024, PMID 18547224, PMID 19344721, PMID 19628656, PMID 20109575, PMID 20163377, PMID 20927486
2008 (4), 2014 (2), 2016 (2), 2004 (1), 2018 (1), 2019 (1), 2023 (1), R01DK087913 (1), U01AI115714 (1), U24CA086368 (1)