95 completed, 30 recruiting, 30 unknown, 22 terminated. 63 Phase 2, 44 Phase 3, 26 Phase 1, 20 Not applicable, 14 Phase 4.
Follow Liver Cirrhosis, Biliary: new trials by email Literature Review of Liver Cirrhosis, Biliary trials Research Report on Liver Cirrhosis, Biliary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus Nemolizumab-ilto - Chronic Hepatic Pruritus, Cholestatic Liver Disease | Phase 2 | Not yet recruiting | Mayo Clinic | 15 | 2026-11-01 | 2026-09-28 |
| J-LINX: Japan LINerixibat eXtension Study Linerixibat - Pruritus | Phase 3 | Not yet recruiting | GlaxoSmithKline | 40 | 2026-10-09 | 2026-10-06 |
| Study of Seladelpar and Cilofexor in Participants With Primary Biliary Cholangitis Seladelpar, PTM Seladelpar, Cilofexor Dose B - Primary Biliary Cholangitis | Phase 2 | Not yet recruiting | Gilead Sciences | 132 | 2026-10-01 | 2026-09-25 |
| Phase I/II Trial of Human Umbilical Cord Mesenchymal Stromal Cells for UDCA-Refractory Primary Biliary Cholangitis Standard background therapy, Placebo, hUC-MSC Dose Level 1 - Primary Biliary Cholangitis | Phase 1 / Phase 2 | Not yet recruiting | Beijing 302 Hospital | 68 | 2026-08-31 | 2026-08-31 |
| Study of Saroglitazar Magnesium for PBC Patients With Incomplete Response or Intolerant to UDCA Therapy Saroglitazar Magnesium 1 mg, Placebo - Primary Biliary Cholangitis | Phase 3 | Recruiting | Zydus Therapeutics Inc. | 90 | 2026-08-11 | 2026-09-15 |
| Study on Clinical and Pathological Features of Primary Biliary Cholangitis and Risk Factors Related to Disease Progression PBC | Not yet recruiting | Beijing Municipal Administration of Hospitals | 300 | 2026-08-01 | 2026-08-04 | |
| Elafibranor Pregnancy Surveillance Program: A Study to Evaluate the Safety of Elafibranor During Pregnancy Elafibranor - Pregnancy Related | Recruiting | Ipsen | 3 | 2026-07-29 | 2026-10-06 | |
| LEOPARD Prospective Validation Cohort 1 Standardized assessments, guided tumor biopsy and biobanking, Standardized assessments and biobanking - Decompensated Liver Cirrhosis, Primary Biliary Cholangitis | Recruiting | Assistance Publique - Hôpitaux de Paris | 630 | 2026-07-07 | 2026-07-29 | |
| Using Digital Health Technology to Monitor Patients With Primary Biliary Cholangitis (PBC) Primary Biliary Cholangitis (PBC) | Enrolling by invitation | Stanford University | 30 | 2026-07-01 | 2026-06-11 | |
| The Value of Spleen Stiffness Measurement in Patients With PBC Spleen stiffness measurement - Primary Biliary Cholangitis, Spleen Stiffness | Not applicable | Not yet recruiting | Universitair Ziekenhuis Brussel | 125 | 2026-07-01 | 2026-05-01 |
| TH104 for the Treatment of Pruritus in Primary Biliary Cholangitis Nalmefene, Placebo - Pruritus, Primary Biliary Cholangitis | Phase 2 | Not yet recruiting | Tharimmune Inc | 40 | 2026-06-01 | 2025-09-09 |
| The Safety and Efficacy of Upadacitinib in Refractory Autoimmune Related Cholangitis and Atopic Dermatitis With Moderate to Severe Itching Upadacitinib 15 MG - Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | RenJi Hospital | 44 | 2026-06-01 | 2026-07-01 |
| Patients With Primary Biliary Cholangitis(PBC) Primary Biliary Cholangitis, Liver Fibrosis | Active not recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 30 | 2026-05-18 | 2026-06-05 | |
| Patients With Primary Biliary Cholangitis Reflex AMA and ANA testing - Primary Biliary Cholangitis, Intrahepatic Bile Duct Cancer | Not applicable | Active not recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 2000 | 2026-04-23 | 2026-05-07 |
| Long-Term Study to Evaluate the Safety and Efficacy in Participants With Primary Biliary Cholangitis of Saroglitazar Magnesium-V on Clinical Outcomes Saroglitazar magnesium 1 mg, Placebo - Primary Biliary Cholangitis | Phase 3 | Recruiting | Zydus Therapeutics Inc. | 386 | 2026-03-24 | 2026-08-04 |
| Austrian PBC Registry Primary Biliary Cholangitis, Liver Cirrhosis | Recruiting | Medical University of Vienna | 500 | 2026-03-18 | 2026-05-20 | |
| Epidemiology of PrImary Biliary Cholangitis in Spain PBC, Primary Biliary Cholangitis (PBC) | Active not recruiting | Fundacio Privada Mon Clinic Barcelona | 3000 | 2026-02-11 | 2026-09-15 | |
| Biochemical Response and Clinical Outcomes in Patients With PBC Only observation - Primary Biliary Cholangitis (PBC), Primary Biliary Cholangitis | Recruiting | RenJi Hospital | 3000 | 2026-02-01 | 2026-03-04 | |
| FIREFLY Trial: Fenofibrate Intervention---Randomized Evaluation in First-Line PBC Therapy Fenofibrate, UDCA (Ursodeoxycholic acid) - Primary Biliary Cholangitis (PBC) | Phase 3 | Recruiting | Xijing Hospital of Digestive Diseases | 132 | 2025-12-15 | 2025-12-29 |
| A Study of CS0159 in Patients With PBC With Inadequate Response or Intolerance to UDCA 2mg CS0159, Placebo - Primary Biliary Cholangitis | Phase 3 | Recruiting | Cascade Pharmaceuticals, Inc | 135 | 2025-12-01 | 2026-07-08 |
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Cholangitis, Sclerosing (19) · Pruritus (15) · Hepatitis, Autoimmune (14) · Cholestasis (13) · Fibrosis (13) · Cholangitis (9) · Fatigue (9) · Liver Cirrhosis (9) · Liver Diseases (7) · Digestive System Diseases (5) · Non-alcoholic Fatty Liver Disease (5) · Rare Diseases (5) · Alagille Syndrome (4) · Biliary Atresia (4)
Pathologic Processes (212) · Pathological Conditions, Signs and Symptoms (212) · Cholestasis, Intrahepatic (211) · Bile Duct Diseases (209) · Biliary Tract Diseases (209) · Digestive System Diseases (207) · Liver Diseases (205) · Liver Cirrhosis (203) · Cholestasis (199) · Fibrosis (199) · Signs and Symptoms (27) · Immune System Diseases (19) · Skin and Connective Tissue Diseases (19) · Cholangitis (18) · Skin Diseases (18)
Ursodeoxycholic Acid (24) · obeticholic acid (13) · Fenofibrate (12) · seladelpar (8) · 2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid (6) · saroglitazar (6) · Bezafibrate (5) · Blood Specimen Collection (4) · (2-methyl-4-(5-methyl-2-(4-trifluoromethyl-phenyl)-2H-(1,2,3)triazol-4-ylmethylsulfanyl)phenoxy)acetic acid (3) · 3-((((3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl)methyl)amino)pentanedioic acid (3) · Budesonide (3) · Methotrexate (3) · Surveys and Questionnaires (3) · (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid (2) · Emtricitabine (2)
Xijing Hospital of Digestive Diseases (12) · Intercept Pharmaceuticals (11) · Gilead Sciences (10) · GlaxoSmithKline (8) · Ipsen (7) · Mayo Clinic (7) · University of Alberta (7) · University of Aarhus (6) · Zydus Therapeutics Inc. (6) · Cascade Pharmaceuticals, Inc (5) · West China Hospital (5) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (4) · Assistance Publique - Hôpitaux de Paris (3) · Beijing 302 Hospital (3) · Han Ying (3)
United States (82) · China (52) · United Kingdom (41) · Canada (39) · Germany (32) · Spain (32) · France (26) · Italy (25) · Australia (19) · Belgium (19) · Austria (15) · Netherlands (15) · Poland (15) · Argentina (14) · Israel (13)
Li Yang, MD (5) · Christopher L Bowlus, MD (3) · Christian Weyer, MD (2) · Cynthia Levy, MD (2) · Deven Parmar (2) · Francesca Romana Ponziani (2) · Keith D Lindor, MD (2) · Liem Nguyen (2) · Lynda Szczech, MD (2) · M. Eric Gershwin, MD (2) · Puneeta Tandon (2)
PMID 25543678, PMID 28249726, PMID 37953500, PMID 38780109, PMID 40439725, PMID 10051462, PMID 10102814, PMID 10343514, PMID 10347106, PMID 10655252, PMID 12360466, PMID 15017671, PMID 15128074, PMID 15468571, PMID 16299032, PMID 16530513, PMID 16848809, PMID 16863557, PMID 17399846, PMID 17680647, PMID 18041714, PMID 18752324, PMID 18778710, PMID 19458352, PMID 19491853, PMID 19554543, PMID 19782361, PMID 20578265, PMID 21083674, PMID 21810549, PMID 22245904, PMID 22259000, PMID 22271046, PMID 22454486, PMID 22911624, PMID 23141888, PMID 23490343, PMID 24317935, PMID 24440215, PMID 24561556, PMID 24625898, PMID 24671010, PMID 24835895, PMID 25329189, PMID 25500425, PMID 26966160, PMID 27121784, PMID 27148676, PMID 27431238, PMID 27532829
2016 (5), 2014 (2), 2015 (2), 2019 (2), 2023 (1), R01DK046602 (1), R03DK052344 (1), U01DK130113 (1), U01DK130134 (1), U01DK130168 (1), U01DK130177 (1), U01DK130180 (1), U01DK130181 (1), U01DK130185 (1), U01DK130190 (1)