12 completed, 2 recruiting, 1 enrolling by invitation, 1 not yet recruiting. 5 Not applicable, 2 Phase 2, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 4, Unknown 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Validation of the French Version of the SERQoL Questionnaire Smile, Smile Esthetics | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 120 | 2026-01-01 | 2026-01-28 | |
| 5 Year Follow up of SMILE® Procedure for the Correction of Hyperopia Hyperopia | Enrolling by invitation | Gemini Eye Clinic | 100 | 2025-01-01 | 2025-08-21 | |
| Analysis of Influencing Factors of High-Order Aberrations of SMILE With Lenticule Retained Small-incision Lenticule Extraction (SMILE) Surgery, Corneal Higher-order Wavefront Aberrations | Recruiting | Second Affiliated Hospital of Nanchang University | 33 | 2024-10-31 | 2026-04-22 | |
| Potential Risk Factors and Predictive Model Construction of OBL During SMILE Small incision lenticule extraction - Myopia, Small-incision Lenticule Extraction (SMILE) Surgery | Completed | Second Affiliated Hospital of Nanchang University | 4678 | 2024-05-01 | 2024-08-29 | |
| Combined Treatment With Pulsed Light and Photobiomodulation Before Laser Refractive Surgery IPL+LLLT - Dry Eye, Dry Eye After LASIK-Laser in Situ Keratomileusis | Not applicable | Completed | University Hospital, Brest | 62 | 2023-06-06 | 2026-01-05 |
| The Effect of Periodontal Health on Smile Periodontal health and gingivitis - Smiling, Gingival Diseases | Completed | Abant Izzet Baysal University | 108 | 2023-05-15 | 2025-02-04 | |
| First Impressions and Attractiveness Levels of Smiling Individuals With and Without a Mask First Impressions, Attractiveness | Completed | DeNova Research | 808 | 2022-03-04 | 2022-04-25 | |
| Diagnostic Efficacy of CNN in Predicting Intraoperative Complications and Postoperative Outcomes in SMILE AI diagnostic algorithm - Deep Convolutional Neural Network, Small-incision Lenticule Extraction (SMILE) Surgery | Recruiting | Second Affiliated Hospital of Nanchang University | 1250 | 2021-06-15 | 2026-04-24 | |
| Factor Analysis of Unintended Initial Dissection of the Posterior Plane Small incision lenticule extraction - Myopia, Small-incision Lenticule Extraction (SMILE) Surgery | Completed | Yifeng Yu | 3003 | 2021-04-01 | 2022-05-10 | |
| Analysis of the Results of Intense Pulsed Light Treatment Previously to Laser Refractive Surgery Study group, Control group - Meibomian Gland Dysfunction, Blepharitis | Not applicable | Unknown | Vissum, Instituto Oftalmológico de Alicante | 60 | 2021-02-15 | 2022-10-18 |
| Application of Botulinum Toxin at the Yonsei Point for the Treatment of Gummy Smile the injection of onabotulinumtoxinA at different point - Smiling, Botulinum Toxins, Type A | Not applicable | Completed | Peking University | 48 | 2020-10-17 | 2021-11-16 |
| Higher Doses of Botulinum Toxin in the Treatment of Gummy Smile injection of Botulinum type A - Smiling, Botulinum Toxins, Type A | Phase 1 / Phase 2 | Completed | Peking University | 33 | 2019-11-20 | 2023-04-26 |
| Effects of Dose and Injection Site for Gummy Smile Treatment With Botulinum Type A injection of Botulinum type A - Smiling, Botulinum Toxins, Type A | Phase 4 | Completed | Peking University | 55 | 2019-02-20 | 2021-04-01 |
| Botulinum Toxin in the Treatment of Gingival Smile Botulinum toxin type A - Smiling | Phase 2 | Completed | Universidade Ibirapuera | 20 | 2018-08-01 | 2019-06-05 |
| Evaluation of Social ABCs With Attention Training Intervention for Toddlers With Suspected Autism Attention Training Program, Social ABCs, Treatment As Usual - Autism Spectrum Disorder | Not applicable | Completed | Holland Bloorview Kids Rehabilitation Hospital | 150 | 2017-04-01 | 2021-01-27 |
| An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia Propofol - Anesthesia, Propofol | Completed | Osijek University Hospital | 124 | 2016-09-07 | 2020-01-22 | |
| Social ABCs for Toddlers With Signs of Autism Spectrum Disorder: Trial of a Parent-Mediated Intervention Social ABCs parent-mediated intervention program - Autism Spectrum Disorder | Not applicable | Completed | Jessica Brian | 63 | 2011-05-01 | 2017-07-13 |
Autism Spectrum Disorder (2) · Autistic Disorder (2) · Communication (2) · Myopia (2) · Blepharitis (1) · Dry Eye Syndromes (1) · Facial Expression (1) · Gingival Diseases (1) · Gingivitis (1) · Hyperopia (1) · Intraoperative Complications (1) · Meibomian Gland Dysfunction (1)
Behavior (17) · Nonverbal Communication (17) · Facial Expression (16) · Communication (15) · Eye Diseases (5) · Refractive Errors (3) · Child Development Disorders, Pervasive (2) · Mental Disorders (2) · Neurodevelopmental Disorders (2) · Eyelid Diseases (1) · Infections (1) · Lacrimal Apparatus Diseases (1) · Mouth Diseases (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1)
Botulinum Toxins, Type A (1) · Control Groups (1) · Intense Pulsed Light Therapy (1) · Propofol (1) · Therapeutics (1)
Peking University (3) · Second Affiliated Hospital of Nanchang University (3) · Abant Izzet Baysal University (1) · Assistance Publique - Hôpitaux de Paris (1) · DeNova Research (1) · Gemini Eye Clinic (1) · Holland Bloorview Kids Rehabilitation Hospital (1) · Jessica Brian (1) · Osijek University Hospital (1) · Universidade Ibirapuera (1) · University Hospital, Brest (1) · Vissum, Instituto Oftalmológico de Alicante (1) · Yifeng Yu (1)
China (7) · Canada (2) · France (2) · Brazil (1) · Czechia (1) · Germany (1) · Spain (1) · Turkey (Türkiye) (1) · United Kingdom (1) · United States (1)
Alejandra Rodriguez, MSc, PhD (1) · Aline B Costa, DDS (1) · Anke Messerschmidt-Roth, Dr. rer. medic. (1) · Dinete Romansina, MSc (1) · Helena Matus, MD (1) · Jessica Brian, PhD (1) · Juliana Ramalho, DDS (1) · Karen M Ramalho, PhD (1) · Maria A Amesty, MD, PhD (1) · Maria Martinez Hergueta, MD (1) · Pavel Stodulka, Dr. Ph.D, FEBOS-CR (1)
PMID 11097583, PMID 11311627, PMID 17216074, PMID 20712970, PMID 26989003, PMID 28574669, PMID 29688838, PMID 30481814, PMID 32182637, PMID 32188437, PMID 35056370, PMID 41748188