193 completed, 40 unknown, 29 recruiting, 10 not yet recruiting. 70 Phase 1, 67 Phase 2, 39 Not applicable, 28 Phase 4, 25 Phase 3.
Follow Enterobacteriaceae Infections: new trials by email Literature Review of Enterobacteriaceae Infections trials Research Report on Enterobacteriaceae Infections
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing of a New Rapid Antigen Test for Plague in Ituri, Democratic Republic of the Congo. Plague, Bubonic; Plague, Skin | Not yet recruiting | Institute of Tropical Medicine, Belgium | 300 | 2026-12-01 | 2026-09-29 | |
| Curcumin Extract Added to Ciprofloxacin for Typhoid Carriers Among Food Handlers of the Free Nutritious Meal Program Curcumin extract, Ciprofloxacin, Placebo - Typhoid Carrier, Typhoid Fever | Phase 2 | Not yet recruiting | Universitas Sebelas Maret | 100 | 2026-11-02 | 2026-10-30 |
| Aztreonam-Avibactam in Immunocompromised Hosts Aztreonam-Avibactam, Ceftazidime-Avibactam Plus Aztreonam - Enterobacteriaceae Infections, Carbapenem-Resistant Enterobacteriaceae Infection | Recruiting | Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno | 814 | 2026-10-14 | 2026-10-27 | |
| Comparative Study of the Genomic Characteristics of Uropathogenic Escherichia Coli According to the Severity of Community-Acquired Urinary Tract Infections in Guadeloupe (COLIGENURI) Whole-genome sequencing (WGS) of E. coli isolates (applies to all 3 groups) - Urinary Tract Infections | Not yet recruiting | Centre Hospitalier Universitaire de la Guadeloupe | 210 | 2026-10-01 | 2026-10-29 | |
| Genomic and Phenotypic Diversity of Carbapenemase-producing Escherichia Coli Strains Circulating in Southern France MultiLocus Sequence Typing - Antibiotic Resistance, Enterobacteriaceae Infections | Not yet recruiting | Centre Hospitalier Universitaire de Nīmes | 163 | 2026-08-01 | 2026-07-08 | |
| COMPARISON OF SINGLE VERSUS COMBINATION DRUG THERAPY IN EXTENSIVELY DRUG RESISTANT SALMONELLA TYPHI IN TERMS OF TIME TO DEFERVESCENCE meropenem, Meropenem and azithromycin combination - Typhoid Fever | Not applicable | Not yet recruiting | Iqra Asghar Ali | 94 | 2026-07-01 | 2026-06-11 |
| Safety and Immunogenicity Study of IP-QSV Vaccine in Healthy Adults/Adolescents, Children and Infants 30μg IP-QSV, Placebo, 10μg IP-QSV - Shigella Infection | Phase 1 / Phase 2 | Not yet recruiting | International Vaccine Institute | 370 | 2026-07-01 | 2026-06-24 |
| Cefotetan Therapy for Escherichia Coli Infections Cefotetan, Carbapenems, Beta Lactam Antibiotics - E Coli Infection, ESBL Producing E.Coli | Phase 2 | Recruiting | Oregon Health and Science University | 50 | 2026-06-26 | 2026-10-16 |
| A Study to Evaluate the Safety, Reactogenicity, and Immune Response of the GSK Vaccines Institute for Global Health (GVGH) Quadrivalent Pan-Salmonella Vaccine With and Without Alum in Healthy Young Adults Pan-Salmonella-with-Alum (Low dose) vaccine, Pan-Salmonella-with-Alum (Full dose) vaccine, Pan-Salmonella-without-Alum (Low dose) vaccine - Salmonella Infections | Phase 1 | Recruiting | GlaxoSmithKline | 196 | 2026-06-24 | 2026-07-28 |
| A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella Disease and Typhoid Fever in Infants Low dose of iNTS-TCV, Full dose of iNTS-TCV, TYPHIBEV - Salmonella Infections | Phase 2 | Recruiting | GlaxoSmithKline | 537 | 2026-04-01 | 2026-04-20 |
| The Impact of Shigellosis and Recommended Treatment in Children Azithromycin, Placebo - Diarrhea Infectious, Shigella | Phase 2 | Recruiting | Johns Hopkins Bloomberg School of Public Health | 700 | 2026-03-18 | 2026-03-30 |
| Study of Probiotic Adjunctive Therapy for Decolonization of Carbapenem-Resistant Enterobacterales Probiotic Preparation, Conventional Antibiotic - Enterobacteriaceae Infections, Carrier State | Not applicable | Active not recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 20 | 2026-03-01 | 2026-07-16 |
| Impact of Implementing a Rapid PCR-based Algorithm for Carbapenemase-producing Enterobacterales (CPE) and Infection Control Bundle in a Tertiary Hospital Rapid PCR-based algorithm for CPE detection - Carbapenemase-Producing Enterobacterales (CPE) Colonization | Not applicable | Not yet recruiting | Hospital Italiano de Buenos Aires | 800 | 2026-03-01 | 2026-02-09 |
| Safety of Combined Intravenous Antibiotic and Bacteriophage Therapy in Adults With Cystic Fibrosis and Antibiotic-Resistant Lung Infections Intravenous Bacteriophage Cocktail plus Standard IV Antibiotics - CF - Cystic Fibrosis, Klebsiella Pneumoniae Infection | Phase 1 | Not yet recruiting | University of California, San Diego | 30 | 2025-12-31 | 2025-12-12 |
| Pivmecillinam as Oral Step-Down Treatment for Escherichia Coli Febrile Urinary Tract Infection Versus Standard of Care Pivmecillinam, Standard of Care (Investigator Choice) - Febrile Urinary Tract Infection | Phase 4 | Recruiting | Uppsala University | 560 | 2025-12-01 | 2025-12-17 |
| First in Human Dose Escalation Study Evaluating the Safety and Immunogenicity of IVT's Shigella-04 Vaccine in Healthy Young Adults IVT Shigella-04, Placebo (0.9% saline) - Shigella, Diarrhea | Phase 1 | Recruiting | Inventprise Inc. | 60 | 2025-10-09 | 2025-11-19 |
| Predictive Value of a Rectal Swab With Detection of Enterobacteria (ESBL-E), Carbapenemases, and High-level Cephalosporinase (HLC) on the Risk of Infections With C3G-resistant Enterobacteria Infections, Enterobacteriaceae | Recruiting | University Hospital, Strasbourg, France | 1000 | 2025-10-06 | 2026-01-16 | |
| Extended Tricyle Project Indonesia for Extended-spectrum Beta-lactamase Positive Klebsiella Pneumoniae and Escherichia Coli Community pregnant women: rectal and throat swab - Carriage of ESBL-positive Escherichia Coli, Carriage of ESBL-positive Klebsiella Pneumoniae | Not yet recruiting | Erasmus Medical Center | 100 | 2025-08-11 | 2025-08-06 | |
| Safety, and Efficacy Study of ShigETEC, a Live, Attenuated, Oral Combination Vaccine to Prevent Shigella and ETEC Disease Delivered to Healthy Adults Ages 18 to 50 Years Old ShigETEC vaccine, Placebo, Challenge: Shigella flexneri 2457T at a dose of 1.5x10^3 CFU - Shigella | Phase 2 | Recruiting | Eveliqure Biotechnologies GmbH | 72 | 2025-06-30 | 2025-07-08 |
| This Randomized Controlled Trial Evaluates the Comparative Efficacy of Intravenous Meropenem Alone Versus Intravenous Meropenem Combined With Oral Azithromycin in Children Aged 6 Months to Under 5 Years Diagnosed With Blood Culture-confirmed Extensively Drug-resistant Uncomplicated Typhoid Fever Meropenem, Azithromycin + Metronidazole - Extensively Drug-Resistant Typhoid Fever, Typhoid Fever | Phase 4 | Completed | Sheikh Zayed Medical College | 90 | 2025-05-14 | 2026-03-03 |
Showing 20 of 296. Sign in to see all of them.
Escherichia coli Infections (96) · Typhoid Fever (72) · Dysentery, Bacillary (61) · Diarrhea (30) · Urinary Tract Infections (25) · Bacterial Infections (13) · Dysentery (13) · Salmonella Infections (13) · Plague (12) · Klebsiella Infections (11) · Infections (10) · Bacteremia (9) · Paratyphoid Fever (9) · Gastroenteritis (8)
Bacterial Infections and Mycoses (296) · Gram-Negative Bacterial Infections (293) · Infections (286) · Bacterial Infections (283) · Digestive System Diseases (78) · Gastrointestinal Diseases (70) · Salmonella Infections (67) · Intestinal Diseases (66) · Pathological Conditions, Signs and Symptoms (65) · Gastroenteritis (63) · Dysentery (49) · Signs and Symptoms (36) · Male Urogenital Diseases (32) · Urogenital Diseases (32)
Vi polysaccharide vaccine, typhoid (14) · Vaccines (13) · Ciprofloxacin (10) · Meropenem (9) · Azithromycin (8) · Ertapenem (5) · Piperacillin, Tazobactam Drug Combination (5) · Trimethoprim, Sulfamethoxazole Drug Combination (5) · Ty21a typhoid vaccine (5) · Ceftriaxone (4) · Hepatitis A Vaccines (4) · Meningococcal Vaccines (4) · Sodium Chloride (4) · 13-valent pneumococcal vaccine (3) · Adjuvants, Pharmaceutic (3)
GlaxoSmithKline (12) · International Vaccine Institute (12) · National Institute of Allergy and Infectious Diseases (NIAID) (11) · PATH (9) · University of Maryland, Baltimore (8) · University of Oxford (8) · University of Pittsburgh (8) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (7) · International Centre for Diarrhoeal Disease Research, Bangladesh (7) · U.S. Army Medical Research and Development Command (7) · Novartis (6) · Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd (5) · LimmaTech Biologics AG (5) · NIZO Food Research (5) · Assistance Publique - Hôpitaux de Paris (4)
United States (87) · France (28) · Bangladesh (16) · United Kingdom (13) · China (11) · Kenya (10) · Pakistan (10) · Switzerland (9) · Belgium (8) · Spain (8) · Democratic Republic of the Congo (7) · Nepal (7) · Netherlands (7) · Israel (6) · Canada (5)
Yohei Doi, MD (4) · Kawsar R Talaat, MD (3) · Lin Du (3) · Andrew J Pollard (2) · Andrew J Pollard, FRCPCH, PhD (2) · Barbara Trautner, MD (2) · Danielle Lemay, PhD (2) · David van Duin, MD, PhD (2) · Florian Marks, PhD (2) · Karen L Kotloff, M.D. (2) · Kawsar Talaat, MD (2) · Maria Rosario Capeding, MD (2)
PMID 40277027, PMID 21980445, PMID 24290843, PMID 27490698, PMID 28735965, PMID 31877141, PMID 34017343, PMID 34219224, PMID 37068952, PMID 37947276, PMID 10334980, PMID 10348767, PMID 10471979, PMID 10798549, PMID 11448564, PMID 12966125, PMID 14557966, PMID 15269195, PMID 15561858, PMID 17121631, PMID 17145784, PMID 17192170, PMID 17554249, PMID 18199038, PMID 18444865, PMID 18493312, PMID 18554712, PMID 18625681, PMID 19146007, PMID 1928194, PMID 19374579, PMID 19625715, PMID 19684008, PMID 20056180, PMID 20175247, PMID 20188175, PMID 20205702, PMID 20412178, PMID 20619378, PMID 20929476, PMID 21410904, PMID 21453653, PMID 21683991, PMID 21793988, PMID 21813209, PMID 22252816, PMID 2246576, PMID 22574737, PMID 22718054, PMID 22752516
2019 (3), 2016 (1), 2023 (1), R01AI116993 (1), R01AI130398 (1), R01AI143910 (1), R01AI165327 (1), R01DK052147 (1), U01AI179562 (1), UM1AI104681 (1)