9 completed, 2 unknown, 1 not yet recruiting. 6 Phase 2, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 5, Unknown 1 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 2 |
Follow Plague: new trials by email Literature Review of Plague trials Research Report on Plague
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing of a New Rapid Antigen Test for Plague in Ituri, Democratic Republic of the Congo. Plague, Bubonic; Plague, Skin | Not yet recruiting | Institute of Tropical Medicine, Belgium | 300 | 2026-12-01 | 2026-09-29 | |
| Trial of the Immunogenicity, Safety, and Tolerability of rF1V Vaccine With CpG 1018® Adjuvant Compared With rF1V Vaccine in Adults 18 to 55 Years of Age rF1V-1018, rF1V vaccine - Plague, Pneumonic, Plague | Phase 2 | Completed | Dynavax Technologies Corporation | 200 | 2022-08-09 | 2025-07-29 |
| Yersinia Pestis Lateral Flow Immunoassay for Blood Samples Lateral Flow Assay for Pathogens of the Plague - Plague, Plague, Bubonic | Unknown | Brimrose Technology Corporation | 500 | 2020-10-19 | 2022-12-14 | |
| Immunogenicity and Safety of Subunit Vaccine of Plague Vaccine With Two Immunization Regimens plague vaccine(F1+rV) - Plague | Phase 2 | Unknown | Jiangsu Province Centers for Disease Control and Prevention | 720 | 2020-05-08 | 2022-04-15 |
| Ciprofloxacin Versus an Aminoglycoside Followed by Ciprofloxacin for Bubonic Plague Ciprofloxacin, Streptomycin, Gentamicin - Plague, Bubonic, Plague, Pneumonic | Phase 3 | Completed | University of Oxford | 222 | 2020-02-15 | 2025-03-06 |
| Immunogenicity and Safety of Subunit Plague Vaccine Plague vaccine - Plague | Phase 2 | Completed | Jiangsu Province Centers for Disease Control and Prevention | 240 | 2014-10-01 | 2015-11-04 |
| Dose Escalation Trial of a Plague Vaccine, Flagellin/F1/V, in Healthy Adult Volunteers Flagellin/F1/V, Placebo - Plague | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 48 | 2012-02-01 | 2016-01-29 |
| A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans ciprofloxacin, doxyxcycline - Plague | Phase 2 | Completed | Centers for Disease Control and Prevention | 5 | 2010-12-01 | 2026-06-03 |
| Randomized Single-Blinded Study to Evaluate Safety and Immunogenicity of Recombinant Plague Vaccine With and Without Adjuvant rF1V vaccine (with Adjuvant), rF1V vaccine (without Adjuvant) - Plague Vaccine | Phase 2 | Completed | DynPort Vaccine Company LLC, A GDIT Company | 402 | 2010-07-01 | 2020-07-30 |
| One Year Study to Evaluate Three Different Adjuvanted Doses of the Recombinant Plague Vaccine (rF1 and rV Antigens) Alhydrogel, rF1 and rV protein antigens - Plague | Phase 1 | Completed | PharmAthene UK Limited | 123 | 2005-10-01 | 2008-09-15 |
| Safety, Tolerability & Immunogenicity of the Recombinant Plague Vaccine rF1V rF1V vaccine - Pneumonic Plague, Preventive Therapy | Phase 1 | Completed | DynPort Vaccine Company LLC, A GDIT Company | 40 | 2004-11-01 | 2011-06-30 |
| Treatment and Diagnosis of Plague gentamicin, streptomycin - Plague | Phase 2 / Phase 3 | Completed | Centers for Disease Control and Prevention | 114 | 2004-08-01 | 2009-02-26 |
Vaccine-Preventable Diseases (1)
Bacterial Infections (12) · Bacterial Infections and Mycoses (12) · Enterobacteriaceae Infections (12) · Gram-Negative Bacterial Infections (12) · Infections (12) · Vector Borne Diseases (12) · Yersinia Infections (12)
Ciprofloxacin (2) · Gentamicins (2) · Streptomycin (2) · Adjuvants, Pharmaceutic (1) · Aluminum Hydroxide (1) · Plague Vaccine (1)
Centers for Disease Control and Prevention (2) · DynPort Vaccine Company LLC, A GDIT Company (2) · Jiangsu Province Centers for Disease Control and Prevention (2) · Brimrose Technology Corporation (1) · Dynavax Technologies Corporation (1) · Institute of Tropical Medicine, Belgium (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · PharmAthene UK Limited (1) · University of Oxford (1)
United States (6) · Madagascar (3) · China (2) · Democratic Republic of the Congo (1) · Uganda (1) · United Kingdom (1)
Caroline Balagout (1) · Chris Myers, Ph.D. (1) · David M Wagner, Ph.D. (1) · David P Trudil (1) · Dawn J Birdsell, Ph.D. (1) · Edward Mbidde, MD (1) · Eric Sheldon, MD (1) · Fengcai Zhu, Master (1) · George Saviolakis, MD (1) · Issa Makumbi, MD (1) · Kevin Griffith, MD, MPH (1) · Kevin S. Griffith, MD, MPH (1) · Laurens Liesenborghs (1) · Martin Schriefer, PhD (1) · Minoarisoa Rajerison, Ph.D. (1)