68 completed, 9 recruiting, 8 unknown, 5 terminated. 32 Phase 1, 29 Phase 2, 19 Not applicable, 9 Phase 3, 3 Phase 4.
Follow Dysentery: new trials by email Literature Review of Dysentery trials Research Report on Dysentery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Immunogenicity Study of IP-QSV Vaccine in Healthy Adults/Adolescents, Children and Infants 30μg IP-QSV, Placebo, 10μg IP-QSV - Shigella Infection | Phase 1 / Phase 2 | Not yet recruiting | International Vaccine Institute | 370 | 2026-07-01 | 2026-06-24 |
| The Utility and Feasibility of Accessible Diarrhea Etiology Prediction Tool (ADEPT) in an Informal Healthcare Setting Diagnostic test: Accessible Diarrhea Etiology Prediction Tool (ADEPT) - Diarrhea Infectious, Algorithms | Not applicable | Completed | Daniel Leung | 30 | 2026-04-12 | 2026-10-08 |
| The Impact of Shigellosis and Recommended Treatment in Children Azithromycin, Placebo - Diarrhea Infectious, Shigella | Phase 2 | Recruiting | Johns Hopkins Bloomberg School of Public Health | 700 | 2026-03-18 | 2026-03-30 |
| Pilot Trial of a Clinical Decision-Support App for Managing Emergencies Among Clinicians in a Rural Ugandan Hospital OASES App - Diarrhea Infectious, Seizures | Not applicable | Completed | University of Milano Bicocca | 15 | 2026-02-06 | 2026-02-24 |
| First in Human Dose Escalation Study Evaluating the Safety and Immunogenicity of IVT's Shigella-04 Vaccine in Healthy Young Adults IVT Shigella-04, Placebo (0.9% saline) - Shigella, Diarrhea | Phase 1 | Recruiting | Inventprise Inc. | 60 | 2025-10-09 | 2025-11-19 |
| Safety, and Efficacy Study of ShigETEC, a Live, Attenuated, Oral Combination Vaccine to Prevent Shigella and ETEC Disease Delivered to Healthy Adults Ages 18 to 50 Years Old ShigETEC vaccine, Placebo, Challenge: Shigella flexneri 2457T at a dose of 1.5x10^3 CFU - Shigella | Phase 2 | Recruiting | Eveliqure Biotechnologies GmbH | 72 | 2025-06-30 | 2025-07-08 |
| Clinical Trial of the S. Flexneri-S. Sonnei Bivalent Conjugate Vaccine S. Flexneri-S. Sonnei bivalent conjugate vaccine, Placebo - Dysentery, Dysentery, Shigella | Phase 3 | Active not recruiting | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 8000 | 2025-05-12 | 2026-04-01 |
| Study to Expand Safety and Immunogenicity Data With Shigella Bioconjugate Vaccine (Shigella4V2) in 9-month-old Infants. Shigella4V2, MenACWY - Shigellosis | Phase 2 | Completed | LimmaTech Biologics AG | 110 | 2025-04-07 | 2026-08-07 |
| Study in Healthy Adults Challenged With Enterotoxigenic E. Coli, of the Safety, Tolerability and Anti-Diarrheal Activity of VENBETA6890, an Orally Administered, Human Monoclonal IgA VENBETA6890, Placebo - Diarrhea Infectious | Phase 1 | Completed | Mark Klempner | 36 | 2025-02-11 | 2025-07-22 |
| Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure - Malnutrition Pregnancy, Malnutrition in Children | Recruiting | University of Zimbabwe | 368 | 2025-01-27 | 2025-09-26 | |
| Shigella Sonnei 53G Human Infection Study in Kenyan Adults Shigella sonnei 53G, Ciprofloxacin 500 mg - Shigellosis | Phase 1 | Recruiting | University of Oxford | 70 | 2025-01-21 | 2025-03-13 |
| A Study on the Immune Response and Safety of a Multicomponent Shigella Vaccine in Preventing Shigellosis in Infants altSonflex1-2-3 Dose A, altSonflex1-2-3 Dose B, altSonflex1-2-3 Dose C - Diarrhoea | Phase 2 | Completed | GlaxoSmithKline | 200 | 2024-11-13 | 2026-10-26 |
| A Human Challenge Study to Assess Protection of a Shigella Tetravalent Bioconjugate Vaccine Shigella4V2, Placebo - Shigellosis | Phase 2 | Completed | LimmaTech Biologics AG | 97 | 2024-11-12 | 2026-10-01 |
| InvaplexAR-Detox and DmLT Adjuvant in the Netherlands and Zambia 2.5 μg InvaplexAR-Detox, 10 μg InvaplexAR-Detox, 0.1 μg of dmLT - Shigellosis, Bacillary Dysentery | Phase 1 | Recruiting | Leiden University Medical Center | 85 | 2024-10-10 | 2024-11-07 |
| Testing a Scalable Model of the Cholera Hospital-Based Intervention for 7 Days (CHoBI7) Standard Recommendation, CHoBI7 Scale-Up Program - Diarrhea Infectious, Cholera | Not applicable | Recruiting | Johns Hopkins Bloomberg School of Public Health | 1600 | 2024-08-19 | 2026-04-15 |
| VE303 for Prevention of Recurrent Clostridioides Difficile Infection VE303, Placebo - Clostridium Difficile, Clostridium Difficile Infections | Phase 3 | Recruiting | Vedanta Biosciences, Inc. | 852 | 2024-05-20 | 2026-09-29 |
| Lactobacillus Acidophilus and Limosilactobacillus Reuteri for Acute Diarrhea in Children Probiotic, Standard therapy - Infectious Diarrhea, Acute Gastroenteritis | Not applicable | Completed | Eskisehir Osmangazi University | 145 | 2024-05-01 | 2026-01-16 |
| ShigETEC Vaccine Study in Bangladesh ShigETEC live, attenuated, oral vaccine, Placebo - Healthy Volunteers | Phase 1 | Completed | Eveliqure Biotechnologies GmbH | 196 | 2023-11-26 | 2026-01-23 |
| Clinical Study to Assess the Efficacy of Once-daily IMM-124E (Travelan®) in a Controlled Human Infection Model. Travelan, Placebo - Diarrhea, Travelers Diarrhea | Phase 2 | Completed | Immuron Ltd. | 63 | 2023-05-29 | 2026-06-12 |
| Probiotics Administration Via Colonoscopic Spray and Oral Administration in CDAD Patients Probiotics administration - Diarrhea Infectious | Not applicable | Unknown | National Cheng-Kung University Hospital | 60 | 2023-04-21 | 2024-05-16 |
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Dysentery, Bacillary (61) · Diarrhea (29) · Dysentery, Amebic (4) · Escherichia coli Infections (4) · Gastrointestinal Diseases (4) · Amebiasis (3) · Bacterial Infections (3) · Enterocolitis, Pseudomembranous (3) · Gastroenteritis (3) · Campylobacter Infections (2) · Cholera (2) · Clostridium Infections (2) · Digestive System Diseases (2) · Enterobacteriaceae Infections (2)
Digestive System Diseases (94) · Intestinal Diseases (94) · Gastroenteritis (93) · Gastrointestinal Diseases (92) · Infections (75) · Bacterial Infections and Mycoses (70) · Bacterial Infections (67) · Gram-Negative Bacterial Infections (63) · Enterobacteriaceae Infections (60) · Pathological Conditions, Signs and Symptoms (36) · Signs and Symptoms (33) · Signs and Symptoms, Digestive (31) · Parasitic Diseases (6) · Protozoan Infections (6)
Vaccines (6) · Azithromycin (4) · Adjuvants, Pharmaceutic (2) · Ciprofloxacin (2) · MenACWY (2) · Probiotics (2) · Rifaximin (2) · Shigella Vaccines (2) · Sodium Chloride (2) · Tetanus Toxoid (2) · diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine (2) · Aluminum Hydroxide (1) · Auranofin (1) · Boostrix (1) · Butyric Acid (1)
PATH (7) · LimmaTech Biologics AG (5) · University of Maryland, Baltimore (5) · Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd (4) · GlaxoSmithKline (4) · Johns Hopkins Bloomberg School of Public Health (4) · National Institute of Allergy and Infectious Diseases (NIAID) (4) · U.S. Army Medical Research and Development Command (4) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (3) · Eveliqure Biotechnologies GmbH (3) · Genzyme, a Sanofi Company (3) · Institut Pasteur (3) · International Centre for Diarrhoeal Disease Research, Bangladesh (3) · Assistance Publique - Hôpitaux de Paris (2) · Centre for Infectious Disease Research in Zambia (2)
United States (32) · Bangladesh (13) · Kenya (9) · France (5) · Israel (5) · United Kingdom (4) · Canada (3) · China (3) · Mali (3) · Netherlands (3) · Zambia (3) · Belgium (2) · Hungary (2) · Indonesia (2) · Mexico (2)
Christine Marie George, PhD (2) · Karen L Kotloff, M.D. (2) · Kawsar R Talaat, MD (2) · Kevin G McGuigan, PhD (2) · Lin Du (2) · Wilbur Chen, MD, MS (2) · Abhijit Banerjee, PhD (1) · Alexander Sulakvelidze, PhD (1) · Andrew Meltzer, MD, MS (1) · Armelle Phalipon, PhD (1) · Arthur Ouwehand, PhD (1)
PMID 20412178, PMID 27490698, PMID 28735965, PMID 34017343, PMID 11692292, PMID 12809830, PMID 15017618, PMID 15933002, PMID 16595054, PMID 17382603, PMID 17554249, PMID 18199029, PMID 18254055, PMID 18809665, PMID 18971494, PMID 19753922, PMID 19842970, PMID 20056180, PMID 20086085, PMID 20619378, PMID 20977257, PMID 21050319, PMID 21198703, PMID 21502971, PMID 21896097, PMID 21936492, PMID 22570464, PMID 22574737, PMID 22864805, PMID 23320049, PMID 23323867, PMID 23840001, PMID 23930950, PMID 25626036, PMID 25952354, PMID 26019620, PMID 26162850, PMID 26282537, PMID 26865592, PMID 27146000, PMID 27404502, PMID 27581434, PMID 28764983, PMID 29029033, PMID 29145631, PMID 29208562, PMID 29462280, PMID 29534721, PMID 30074085, PMID 30154172
2016 (1), R33HD109819 (1), U01AI179562 (1)