44 completed, 5 recruiting, 4 unknown, 3 active not recruiting. 31 Phase 1, 23 Phase 2, 5 Phase 3, 2 Not applicable, 1 Phase 4.
Follow Dysentery, Bacillary: new trials by email Literature Review of Dysentery, Bacillary trials Research Report on Dysentery, Bacillary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Immunogenicity Study of IP-QSV Vaccine in Healthy Adults/Adolescents, Children and Infants 30μg IP-QSV, Placebo, 10μg IP-QSV - Shigella Infection | Phase 1 / Phase 2 | Not yet recruiting | International Vaccine Institute | 370 | 2026-07-01 | 2026-06-24 |
| The Impact of Shigellosis and Recommended Treatment in Children Azithromycin, Placebo - Diarrhea Infectious, Shigella | Phase 2 | Recruiting | Johns Hopkins Bloomberg School of Public Health | 700 | 2026-03-18 | 2026-03-30 |
| First in Human Dose Escalation Study Evaluating the Safety and Immunogenicity of IVT's Shigella-04 Vaccine in Healthy Young Adults IVT Shigella-04, Placebo (0.9% saline) - Shigella, Diarrhea | Phase 1 | Recruiting | Inventprise Inc. | 60 | 2025-10-09 | 2025-11-19 |
| Safety, and Efficacy Study of ShigETEC, a Live, Attenuated, Oral Combination Vaccine to Prevent Shigella and ETEC Disease Delivered to Healthy Adults Ages 18 to 50 Years Old ShigETEC vaccine, Placebo, Challenge: Shigella flexneri 2457T at a dose of 1.5x10^3 CFU - Shigella | Phase 2 | Recruiting | Eveliqure Biotechnologies GmbH | 72 | 2025-06-30 | 2025-07-08 |
| Clinical Trial of the S. Flexneri-S. Sonnei Bivalent Conjugate Vaccine S. Flexneri-S. Sonnei bivalent conjugate vaccine, Placebo - Dysentery, Dysentery, Shigella | Phase 3 | Active not recruiting | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 8000 | 2025-05-12 | 2026-04-01 |
| Study to Expand Safety and Immunogenicity Data With Shigella Bioconjugate Vaccine (Shigella4V2) in 9-month-old Infants. Shigella4V2, MenACWY - Shigellosis | Phase 2 | Completed | LimmaTech Biologics AG | 110 | 2025-04-07 | 2026-08-07 |
| Shigella Sonnei 53G Human Infection Study in Kenyan Adults Shigella sonnei 53G, Ciprofloxacin 500 mg - Shigellosis | Phase 1 | Recruiting | University of Oxford | 70 | 2025-01-21 | 2025-03-13 |
| A Study on the Immune Response and Safety of a Multicomponent Shigella Vaccine in Preventing Shigellosis in Infants altSonflex1-2-3 Dose A, altSonflex1-2-3 Dose B, altSonflex1-2-3 Dose C - Diarrhoea | Phase 2 | Completed | GlaxoSmithKline | 200 | 2024-11-13 | 2026-10-26 |
| A Human Challenge Study to Assess Protection of a Shigella Tetravalent Bioconjugate Vaccine Shigella4V2, Placebo - Shigellosis | Phase 2 | Completed | LimmaTech Biologics AG | 97 | 2024-11-12 | 2026-10-01 |
| InvaplexAR-Detox and DmLT Adjuvant in the Netherlands and Zambia 2.5 μg InvaplexAR-Detox, 10 μg InvaplexAR-Detox, 0.1 μg of dmLT - Shigellosis, Bacillary Dysentery | Phase 1 | Recruiting | Leiden University Medical Center | 85 | 2024-10-10 | 2024-11-07 |
| ShigETEC Vaccine Study in Bangladesh ShigETEC live, attenuated, oral vaccine, Placebo - Healthy Volunteers | Phase 1 | Completed | Eveliqure Biotechnologies GmbH | 196 | 2023-11-26 | 2026-01-23 |
| Safety and Efficacy of the Bacteriophage Preparation, ShigActive™, in a Human Experimental Model of Shigellosis bacteriophage, Placebo - Shigellosis | Phase 1 / Phase 2 | Active not recruiting | Intralytix, Inc. | 52 | 2023-02-23 | 2025-06-15 |
| Phase 2 Shigella Vaccine and Challenge Placebo, Shigella sonnei strain 53G, WRSs2 - Immunisation, Shigella Infection | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 69 | 2022-10-12 | 2026-08-10 |
| Shigella CVD 31000: Study of Responses With Shigella-ETEC Vaccine Strain CVD 1208S-122 strain CVD 1208S-122, Placebo - Shigella Infection, Enterotoxigenic Escherichia Coli Infection | Phase 1 | Completed | University of Maryland, Baltimore | 53 | 2022-09-29 | 2026-02-02 |
| Enterics for Global Health (EFGH) Shigella, Child | Active not recruiting | University of Washington | 9800 | 2022-08-25 | 2025-01-14 | |
| Tebipenem Trial in Children With Shigellosis Tebipenem Pivoxil, Azithromycin, Ceftriaxon - Shigellosis | Phase 2 | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 132 | 2022-08-18 | 2026-09-01 |
| Controlled Human Infection Model Challenge/Rechallenge Shigella sonnei 53G, Shigella flexneri 2a 2457T - Shigellosis | Phase 1 | Completed | PATH | 46 | 2022-04-26 | 2025-01-31 |
| Efficacy, Immunogenicity and Safety of S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine in Volunteers Aged From 6 Months to 5 Years S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine, Placebo - Dysentery, Shigellosis | Phase 3 | Unknown | Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd | 21000 | 2021-12-11 | 2022-01-11 |
| A Study on the Safety and Immune Responses to the GVGH altSonflex1-2-3 Vaccine Against Shigellosis in Adults, Children, and Infants AltSonflex1-2-3 High Dose, AltSonflex1-2-3 Medium Dose, AltSonflex1-2-3 Low Dose - Diarrhoea | Phase 1 / Phase 2 | Completed | GlaxoSmithKline | 551 | 2021-10-06 | 2026-06-22 |
| Egg Intervention During Pregnancy in Indonesia Egg intervention - Weight Gain, Anemia, Iron Deficiency | Not applicable | Unknown | SEAMEO Regional Centre for Food and Nutrition | 702 | 2021-02-12 | 2024-07-03 |
Showing 20 of 61. Sign in to see all of them.
Diarrhea (15) · Dysentery (12) · Escherichia coli Infections (3) · Gastrointestinal Diseases (3) · Bacterial Infections (2) · Digestive System Diseases (2) · Enterobacteriaceae Infections (2) · Gastroenteritis (2) · Gram-Negative Bacterial Infections (2) · Intestinal Diseases (2) · Abdominal Pain (1) · Amebiasis (1) · Anemia, Iron-Deficiency (1) · Arthritis, Reactive (1)
Bacterial Infections and Mycoses (61) · Infections (61) · Bacterial Infections (59) · Digestive System Diseases (59) · Enterobacteriaceae Infections (59) · Gastroenteritis (59) · Gram-Negative Bacterial Infections (59) · Intestinal Diseases (59) · Gastrointestinal Diseases (58) · Dysentery (49) · Pathological Conditions, Signs and Symptoms (18) · Signs and Symptoms (17) · Signs and Symptoms, Digestive (16) · Anemia (1) · Anemia, Hypochromic (1)
Vaccines (6) · Azithromycin (3) · Adjuvants, Pharmaceutic (2) · Ciprofloxacin (2) · MenACWY (2) · Shigella Vaccines (2) · Sodium Chloride (2) · Tetanus Toxoid (2) · diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine (2) · Aluminum Hydroxide (1) · Boostrix (1) · Butyric Acid (1) · Ceftriaxone (1) · Hepatitis B Vaccines (1) · HibTITER protein, Haemophilus influenzae (1)
PATH (7) · LimmaTech Biologics AG (5) · University of Maryland, Baltimore (5) · Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd (4) · GlaxoSmithKline (4) · U.S. Army Medical Research and Development Command (4) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (3) · Eveliqure Biotechnologies GmbH (3) · Institut Pasteur (3) · International Centre for Diarrhoeal Disease Research, Bangladesh (3) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · GSK Vaccines Institute For Global Health S.r.l. (2) · Bausch Health Americas, Inc. (1) · Centre for Infectious Disease Research in Zambia (1) · China Academy of Chinese Medical Sciences (1)
United States (23) · Bangladesh (9) · Kenya (7) · China (3) · France (3) · Israel (3) · Indonesia (2) · Mali (2) · United Kingdom (2) · Zambia (2) · Belgium (1) · Burkina Faso (1) · Côte d’Ivoire (1) · Hungary (1) · Malawi (1)
Karen L Kotloff, M.D. (2) · Kawsar R Talaat, MD (2) · Lin Du (2) · Wilbur Chen, MD, MS (2) · Alexander Sulakvelidze, PhD (1) · Armelle Phalipon, PhD (1) · Carl Mason, MD (1) · Christiane Gerke, PhD (1) · Christoph Hatz, Prof. Dr. (1) · Christopher Duplessis, MD, MPH, MS (1) · Clayton D Harro, MD, ScM (1) · David JM Lewis, MD (1)
PMID 27490698, PMID 28735965, PMID 34017343, PMID 17554249, PMID 20056180, PMID 20412178, PMID 20619378, PMID 22574737, PMID 26162850, PMID 26282537, PMID 26865592, PMID 27146000, PMID 27581434, PMID 29534721, PMID 30074085, PMID 32239137, PMID 33186516, PMID 33207794, PMID 33862589, PMID 34374425, PMID 34793505, PMID 35062694, PMID 37666695, PMID 38853614, PMID 39852827, PMID 39893179, PMID 40000088, PMID 40152601, PMID 41286621, PMID 41746130, PMID 41999631, PMID 42379208, PMID 42617627
2016 (1), U01AI179562 (1)