53 completed, 9 unknown, 4 recruiting, 3 active not recruiting. 19 Phase 2, 15 Phase 4, 12 Phase 1, 10 Phase 3, 8 Not applicable.
Follow Typhoid Fever: new trials by email Literature Review of Typhoid Fever trials Research Report on Typhoid Fever
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Curcumin Extract Added to Ciprofloxacin for Typhoid Carriers Among Food Handlers of the Free Nutritious Meal Program Curcumin extract, Ciprofloxacin, Placebo - Typhoid Carrier, Typhoid Fever | Phase 2 | Not yet recruiting | Universitas Sebelas Maret | 100 | 2026-11-02 | 2026-10-30 |
| COMPARISON OF SINGLE VERSUS COMBINATION DRUG THERAPY IN EXTENSIVELY DRUG RESISTANT SALMONELLA TYPHI IN TERMS OF TIME TO DEFERVESCENCE meropenem, Meropenem and azithromycin combination - Typhoid Fever | Not applicable | Not yet recruiting | Iqra Asghar Ali | 94 | 2026-07-01 | 2026-06-11 |
| A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella Disease and Typhoid Fever in Infants Low dose of iNTS-TCV, Full dose of iNTS-TCV, TYPHIBEV - Salmonella Infections | Phase 2 | Recruiting | GlaxoSmithKline | 537 | 2026-04-01 | 2026-04-20 |
| This Randomized Controlled Trial Evaluates the Comparative Efficacy of Intravenous Meropenem Alone Versus Intravenous Meropenem Combined With Oral Azithromycin in Children Aged 6 Months to Under 5 Years Diagnosed With Blood Culture-confirmed Extensively Drug-resistant Uncomplicated Typhoid Fever Meropenem, Azithromycin + Metronidazole - Extensively Drug-Resistant Typhoid Fever, Typhoid Fever | Phase 4 | Completed | Sheikh Zayed Medical College | 90 | 2025-05-14 | 2026-03-03 |
| Meropenem vs Azithromycin Efficacy in Case XDR Enteric Fever Azithromycin, Meropenem Injection - Enteric Fever | Phase 4 | Recruiting | Indus Hospital and Health Network | 40 | 2025-04-22 | 2026-05-08 |
| ZyVac-TCV Bangladesh Study Purified Vi capsular polysaccharide of Salmonella typhi conjugated to tetanus toxoid as carrier protein (Typhoid Vi Conjugate Vaccine I.P.). Trade name: ZyVac® TCV - Typhoid Vaccination, Typhoid | Phase 3 | Not yet recruiting | International Centre for Diarrhoeal Disease Research, Bangladesh | 4000 | 2025-04-01 | 2025-02-07 |
| Efficacy of Levofloxacin Versus Ciprofloxacin in the Treatment of Childhood Typhoid Fever Levofloxacin, ciprofloxacin - Typhoid, Fever | Phase 2 | Completed | Avicenna Medical College Lahore | 360 | 2025-02-07 | 2025-09-02 |
| Immunogenicity and Tolerability of Booster Typhoid Conjugate Vaccine (TCV) 5-6 Years After Initial Dose in Children in Burkina Faso Vi capsular polysaccharide-CRM197 conjugate vaccine (Vi-CRM), 0.5 mL IM - Typhoid | Phase 2 | Completed | Kathleen Neuzil | 147 | 2024-08-17 | 2026-06-03 |
| Immune Response Elicited by Concomitant Administration of Oral Typhoid Fever (Vivotif®) and Cholera (Dukoral®) Vaccines Oral typhoid fever vaccine, Oral cholera vaccine - Vaccine-Preventable Diseases, Typhoid Fever | Phase 4 | Completed | Helsinki University Central Hospital | 65 | 2023-10-25 | 2024-12-05 |
| Co-administration Study of OCV, TCV and MR Oral Cholera Vaccine (OCV), Typhoid Conjugate Vaccine (TCV), Measles and Rubella (MR) - Typhoid, Cholera | Phase 3 | Unknown | International Centre for Diarrhoeal Disease Research, Bangladesh | 2117 | 2023-10-14 | 2023-10-13 |
| Challenge Non-Typhoidal Salmonella (CHANTS) Study Salmonella Typhimurium - Salmonella Infections, Salmonella Typhimurium | Not applicable | Active not recruiting | Imperial College Healthcare NHS Trust | 80 | 2023-08-31 | 2025-05-02 |
| Diagnosis and Staging of Typhoid Fever Using Surface-enhanced Raman Spectroscopy Liquid Biopsy Surface-enhanced Raman Spectroscopy - Typhoid Fever | Not applicable | Completed | University Hospital, Aachen | 30 | 2023-07-15 | 2025-03-05 |
| Vellore Typhoid Vaccine Impact Trial Typhoid conjugate Vaccine - Typhoid Fever | Phase 4 | Completed | Christian Medical College, Vellore, India | 72400 | 2023-05-01 | 2026-03-17 |
| Safety and Immunogenicity of a Novel Conjugate Vaccine Against Salmonella Typhi and Salmonella Paratyphi A in Healthy Adults TYP04A Low Dose without Alum investigational vaccine, TYP04B Full Dose without Alum investigational vaccine, TYP03A Low Dose with Alum investigational vaccine - Typhoid Fever | Phase 1 | Completed | GlaxoSmithKline | 97 | 2022-11-28 | 2025-01-24 |
| WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study Inulin, Maltodextrin, Ty21a Typhoid Fever Vaccine - Inflammation, Vaccine | Early Phase 1 | Completed | USDA, Western Human Nutrition Research Center | 60 | 2022-09-27 | 2025-12-17 |
| Evaluation Study of DPP® Typhoid Assay Typhoid DPP assay - Typhoid Fever | Completed | Foundation for Innovative New Diagnostics, Switzerland | 387 | 2022-09-15 | 2023-11-21 | |
| Non-inferiority Trial of Locally Manufactured Typhoid Conjugate Vaccine 'Typhocon' in Bangladesh Typhoid Vi polysaccharide-diphtheria toxoid conjugate vaccine (Vi-DT) - Typhoid | Phase 1 / Phase 2 | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 630 | 2022-07-01 | 2024-12-24 |
| Transcriptomic Responses for the Identification of Pathogens 5-gene transcription signature - Enteric Fever, Acute Febrile Illness | Recruiting | University of Sheffield | 2000 | 2022-05-02 | 2025-03-03 | |
| Effectiveness of a Typhoid Conjugate Vaccine in DRC Vi-TT - Typhoid Fever | Phase 4 | Unknown | International Vaccine Institute | 48000 | 2022-02-11 | 2023-04-18 |
| Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana Vi-TT, MCV-A vaccine - Typhoid Fever | Phase 4 | Unknown | International Vaccine Institute | 23000 | 2021-08-24 | 2024-03-08 |
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Paratyphoid Fever (9) · Salmonella Infections (5) · Cholera (3) · Bacterial Infections (2) · Fever (2) · Hepatitis A (2) · Inflammation (2) · Malaria (2) · Yellow Fever (2) · Brucellosis (1) · Chikungunya Fever (1) · Communicable Diseases (1) · Dengue (1) · Encephalitis, Japanese (1)
Bacterial Infections and Mycoses (72) · Enterobacteriaceae Infections (72) · Infections (72) · Gram-Negative Bacterial Infections (71) · Bacterial Infections (70) · Salmonella Infections (67) · Digestive System Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · RNA Virus Infections (5) · Virus Diseases (5) · Liver Diseases (3) · Mononegavirales Infections (3) · Mosquito-Borne Diseases (3) · Pathologic Processes (3) · Vector Borne Diseases (3)
Vi polysaccharide vaccine, typhoid (12) · Azithromycin (5) · Ty21a typhoid vaccine (5) · Hepatitis A Vaccines (4) · Meropenem (4) · Vaccines (4) · 13-valent pneumococcal vaccine (3) · Polysaccharides (3) · Cefixime (2) · Ceftriaxone (2) · Cholera Vaccines (2) · Ciprofloxacin (2) · Pneumococcal Vaccines (2) · Adjuvants, Vaccine (1) · Albendazole (1)
International Vaccine Institute (11) · Novartis (6) · University of Oxford (6) · International Centre for Diarrhoeal Disease Research, Bangladesh (4) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (3) · GlaxoSmithKline (3) · Oxford University Clinical Research Unit, Vietnam (3) · University of Maryland, Baltimore (3) · EuBiologics Co.,Ltd (2) · Foundation for Innovative New Diagnostics, Switzerland (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Stanford University (2) · USDA, Western Human Nutrition Research Center (2) · Avant Immunotherapeutics (1) · Avicenna Medical College Lahore (1)
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Andrew J Pollard (2) · Andrew J Pollard, FRCPCH, PhD (2) · Danielle Lemay, PhD (2) · Florian Marks, PhD (2) · Maria Rosario Capeding, MD (2) · Andrew Pollard, FRCPCH, PhD (1) · Andrew Pollard, MBBS (1) · Anu Kantele, MD, PhD (1) · Bess Caswell, PhD (1) · Buddha Basnyat, MBBS,MSc,MD (1) · Buddha Basnyat, MBBS,Msc,MD (1) · Buddha Basnyat, MD (1) · Canh G Do, MD (1) · Clark McKeever, MD (1)
PMID 21980445, PMID 24290843, PMID 31877141, PMID 10348767, PMID 17145784, PMID 18493312, PMID 19625715, PMID 20188175, PMID 20205702, PMID 22718054, PMID 23505506, PMID 24218407, PMID 24265775, PMID 24657719, PMID 24873986, PMID 24995178, PMID 25308927, PMID 25778504, PMID 26082464, PMID 26094960, PMID 26809813, PMID 27533046, PMID 27812090, PMID 28158395, PMID 28515903, PMID 28545155, PMID 28965718, PMID 28969659, PMID 29343684, PMID 29684022, PMID 29776750, PMID 30767000, PMID 30845320, PMID 30845330, PMID 31585725, PMID 31722678, PMID 31749999, PMID 31905228, PMID 31967084, PMID 32991678, PMID 33150320, PMID 3331577, PMID 33807097, PMID 33849723, PMID 34525285, PMID 34942090, PMID 35097222, PMID 35491421, PMID 35664443, PMID 35961356
R01AI130398 (1)