35 completed, 24 unknown, 8 recruiting, 4 withdrawn. 18 Phase 2, 15 Phase 4, 14 Phase 1, 12 Phase 3, 10 Not applicable.
Follow Drug Effect: new trials by email Literature Review of Drug Effect trials Research Report on Drug Effect
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke Tenecteplase, Alteplase - Stroke, Ischemic, Stroke, Acute | Phase 3 | Recruiting | Xuanwu Hospital, Beijing | 850 | 2025-12-25 | 2026-04-09 |
| GLP-1R Actions on Muscle and the Skeleton Tirzepatide, Lifestyle toolkit - Musculoskeletal Abnormalities, Obesity | Phase 4 | Recruiting | Pennington Biomedical Research Center | 50 | 2025-10-09 | 2026-08-27 |
| Randomized Comparison of Morning Versus Bedtime Administration of Statins: A Cardiovascular Circadian Chronotherapy (C3) Trial Statin in the evening (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin), Statin in the morning (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin) - Cardiovascular Diseases (CVD), Drug Effect | Phase 4 | Not yet recruiting | Tor Biering-Sørensen | 42000 | 2025-02-28 | 2025-03-04 |
| Early Application of Memantine and Pioglitazone to Protect Cognitive Function After Radiotherapy Memantine Oral Tablet, Pioglitazone 15mg, Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) - Radiation Disease, Cognitive Impairment | Phase 2 | Not yet recruiting | Affiliated Cancer Hospital & Institute of Guangzhou Medical University | 67 | 2024-09-10 | 2024-09-19 |
| A Single-Dose, Three-Way, Three-Sequence, Crossover BA Study of Azithromycin Oleogel Azithromycin Oleogel (Oral and Rectal) - Infectious Disease, Drug Effect | Phase 1 | Completed | Brigham and Women's Hospital | 18 | 2024-08-08 | 2026-02-04 |
| The Effect and Mechanism of Xiqing Regulating Intestinal Homeostasis on Drug Efficacy of Chronic Kidney Disease Xiqing, probiotics - CKD, Drug Effect | Phase 4 | Recruiting | Chujin Cao | 120 | 2024-06-07 | 2025-09-19 |
| Randomized Comparison of Morning Versus Bedtime Administration of Aspirin: A Cardiovascular Circadian Chronotherapy (C3) Trial Aspirin - Atherosclerosis, Cardiovascular Diseases | Phase 4 | Recruiting | Tor Biering-Sørensen | 32706 | 2024-01-15 | 2024-02-06 |
| Different Volumes of Articaine for Inferior Alveolar Nerve Block in Irreversible Pulpitis Articaine HCl 4 % / EPINEPHrine 1:100,000 in 1.8 mL Dental Cartridge - Drug Effect, Pulpitis - Irreversible | Phase 2 | Completed | Armed Forces Institute of Dentistry, Pakistan | 78 | 2023-12-01 | 2024-10-15 |
| Dose Finding Study for Remimazolam in Children Remimazolam besylate - Drug Effect | Phase 2 | Unknown | Seoul National University Hospital | 50 | 2023-11-16 | 2023-11-22 |
| Flurbiprofen Tablet vs Spray In Oral Soft Tissue Wounds Flurbiprofen - Oral Soft Tissue Conditions, Drug Effect | Phase 4 | Completed | Yuzuncu Yil University | 40 | 2023-10-26 | 2024-07-26 |
| Parathyroid Hormone Level and Growth in Pediatric Patients With ESRD on Regular Hemodialysis Cinacalcet - Drug Effect | Phase 4 | Completed | Tanta University | 35 | 2023-08-05 | 2024-01-24 |
| A Prospective, Randomized, Controlled Study of rhTPO in Combination With Herombopag + CsA vs Herombopag + CsA for the Treatment of Primary TD-NSAA Herombopag + CsA, rhTPO combined with Herombopag + CsA - Aplastic Anemia, Drug Effect | Phase 4 | Unknown | Peking Union Medical College Hospital | 90 | 2023-08-01 | 2023-08-22 |
| Study of Efficacy, Safety and Immunogenicity of GP40141 (GEROPHARM, Russia) in Patients With Immune Thrombocytopenia GP404141, Nplate - Drug Effect, Safety Issues | Phase 3 | Active not recruiting | Geropharm | 160 | 2023-04-04 | 2024-07-11 |
| Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in Children Remimazolam, Esketamine, Propofol - Drug Effect | Not applicable | Completed | Tongji Hospital | 106 | 2023-01-18 | 2023-08-21 |
| Mood and Cognitive Effects of Psilocybin in Healthy Participants Psilocybin, Inonotus Obliquus Whole Extract - Mood Disturbance, Mood Change | Early Phase 1 | Withdrawn | Optimi Health Corporation | 2023-01-01 | 2023-03-20 | |
| Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia ALL, Childhood, Pediatric Cancer | Recruiting | University of Geneva, Switzerland | 556 | 2022-12-01 | 2026-01-15 | |
| Pulpotomy Medications in Primary Teeth pulpotomy procedure and Histological evaluation, Immunohistochemistry Protocol for Fibronectin Antibody, Immunohistochemistry Protocol for Osteopontin Antibody - Drug Effect | Not applicable | Completed | Suez Canal University | 30 | 2022-10-02 | 2024-11-29 |
| ASSIST: A Surveillance Study of Illicit Substance Toxicity Surplus sample toxicology analysis - Overdose, Drug, Drug Use | Unknown | NHS Greater Glasgow and Clyde | 1000 | 2022-08-19 | 2022-09-19 | |
| Efficacy and Safety of Perioperative Use of Breztri Aerosphere to Relieve Cough After Lobectomy Breztri Aerosphere, Placebo - Lung Cancer, Nonsmall Cell, Perioperative | Not applicable | Unknown | Jianxing He | 128 | 2022-08-01 | 2022-07-25 |
| Acute Pharmacokinetic and Pharmacodynamic Effects of "Tobacco-Free" Oral Nicotine Pouches in Smokers Nicotine, Cigarette - Nicotine Withdrawal, Nicotine Addiction | Phase 1 | Completed | Johns Hopkins University | 71 | 2022-07-27 | 2026-07-23 |
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Drug-Related Side Effects and Adverse Reactions (14) · COVID-19 (5) · Psoriasis (5) · Anemia, Aplastic (4) · Obesity (4) · Pain (4) · Breast Neoplasms (2) · Cardiovascular Diseases (2) · Genetic Predisposition to Disease (2) · Opioid-Related Disorders (2) · Abnormalities, Radiation-Induced (1) · Acute Pain (1) · Agnosia (1) · Anxiety Disorders (1) · Arrhythmias, Cardiac (1)
Pathological Conditions, Signs and Symptoms (20) · Chemically-Induced Disorders (18) · Signs and Symptoms (13) · Pathologic Processes (9) · Infections (8) · Mental Disorders (8) · Respiratory Tract Diseases (8) · Cardiovascular Diseases (7) · Lung Diseases (7) · Skin Diseases (7) · Skin and Connective Tissue Diseases (7) · Behavior (6) · Hematologic Diseases (6) · Hemic and Lymphatic Diseases (6) · Nervous System Diseases (6)
Carticaine (2) · Dexmedetomidine (2) · Morphine (2) · Propofol (2) · remimazolam (2) · Acetaminophen (1) · Administration, Rectal (1) · Albuterol (1) · Analgesics (1) · Angioplasty (1) · Anti-Bacterial Agents (1) · Aspirin (1) · Atorvastatin (1) · Bupivacaine (1) · Buspirone (1)
Guangdong Provincial Hospital of Traditional Chinese Medicine (5) · Peking Union Medical College Hospital (4) · Boston Children's Hospital (3) · Johns Hopkins University (3) · Tabula Rasa HealthCare (3) · British University In Egypt (2) · Mansoura University (2) · Oslo University Hospital (2) · Peking University People's Hospital (2) · Suez Canal University (2) · Tor Biering-Sørensen (2) · University of Oslo (2) · Affiliated Cancer Hospital & Institute of Guangzhou Medical University (1) · Armed Forces Institute of Dentistry, Pakistan (1) · Brigham and Women's Hospital (1)
China (17) · United States (15) · Egypt (7) · Denmark (4) · Norway (4) · Turkey (Türkiye) (3) · Italy (2) · Pakistan (2) · Russia (2) · Switzerland (2) · Colombia (1) · India (1) · Iran (1) · Lebanon (1) · Mexico (1)
Chuanjian Lu, PhD (3) · Tory Spindle, PhD (2) · Veronique Michaud (2) · Absalon D Gutierrez, MD (1) · Bing Han, Master (1) · Bulat Bakirov, MD (1) · Cennet N Eroglu, DDS,PhD (1) · Chuanjian Lu (1) · Chunbo Chen, Ph. D. (1) · David J Lowe, MBChB BMSc FRCEM (1) · Dmitriy Romanov, MD (1) · Dmitry Kirtbaya (1)
PMID 10028738, PMID 10832257, PMID 12366885, PMID 15031728, PMID 15966499, PMID 16287208, PMID 17082283, PMID 18095221, PMID 18762633, PMID 19384201, PMID 20006669, PMID 20594297, PMID 21440486, PMID 21772732, PMID 22915899, PMID 23074314, PMID 23318279, PMID 24429437, PMID 24657044, PMID 25108173, PMID 25749200, PMID 26868800, PMID 26974879, PMID 27655029, PMID 29475179, PMID 29954243, PMID 30531947, PMID 30608563, PMID 31249952, PMID 31978945, PMID 32251768, PMID 32481505, PMID 33317729, PMID 33951024, PMID 34195402, PMID 34764932, PMID 34988162, PMID 35056370, PMID 37318085, PMID 38375038, PMID 40386713, PMID 40457274, PMID 40708707, PMID 40719187, PMID 40847743, PMID 9455502, PMID 9675443
2016 (1), 2019 (1), R01DA003889 (1), R01DA055962 (1), R21DK122234 (1)