21 completed, 13 recruiting, 8 unknown, 3 not yet recruiting. 21 Not applicable, 2 Phase 1, 1 Early Phase 1, 1 Phase 2, 1 Phase 3.
Follow Disorders of Consciousness: new trials by email Literature Review of Disorders of Consciousness trials Research Report on Disorders of Consciousness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy - Disorders of Consciousness, Vegetative State | Not applicable | Not yet recruiting | Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. | 200 | 2026-12-01 | 2026-10-02 |
| Walking With Overground Robotic Exoskeleton Device to Increase Behavioral Responsiveness in Patients With Disorders of Consciousness (WALK DOC) Overground Robotic Exoskeleton (ORE) - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness | Not yet recruiting | Spaulding Rehabilitation Hospital | 18 | 2026-11-01 | 2026-09-21 | |
| Transcutaneous Auricular Vagus Nerve Stimulation for Recovery of Consciousness After Surgery for Spontaneous Intracerebral Hemorrhage Active Transcutaneous Auricular Vagus Nerve Stimulation, Sham Transcutaneous Auricular Vagus Nerve Stimulation - Disorders of Consciousness, Spontaneous Intracerebral Hemorrhage | Not applicable | Recruiting | Beijing Tiantan Hospital | 160 | 2026-08-01 | 2026-08-12 |
| fNIRS for Disorders of Consciousness Functional Near-Infrared Spectroscopy Monitoring - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness | Recruiting | University of California, Los Angeles | 55 | 2026-05-01 | 2026-06-08 | |
| Effectiveness of tTIs for Improving Consciousness in Patients With DoC Theta-burst Patterned Temporal Interference Stimulation (tTIs), Sham Temporal Interference Stimulation - Disorders of Consciousness, Vegetative State | Not applicable | Recruiting | Zhujiang Hospital | 136 | 2026-03-08 | 2026-04-20 |
| REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study Deep brain stimulation (DBS) electrode implantation - Disorders of Consciousness | Early Phase 1 | Recruiting | Samuel Snider, MD | 2 | 2025-11-01 | 2026-06-23 |
| Investigation of Mnesic Capacities in Patients With a Disorder of Consciousness Physiological recordings, Semi-structured interviews, Psychological scales - Disorders of Consciousness | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 175 | 2025-09-30 | 2026-04-13 |
| Advancing Assessment for Disorders of Consciousness Disorders of Consciousness | Not yet recruiting | Xuanwu Hospital, Beijing | 200 | 2025-09-25 | 2025-09-18 | |
| Assessment of Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Disorders of Consciousness Next Generation Dome Helmet (NGDH) - Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 10 | 2025-09-10 | 2026-07-09 |
| Tactile Stimulation in Disorders of Consciousness (DoC) Tactile stimulation, Neurophysiological Monitoring with SedLine - Disorders of Consciousness | Completed | Anna Estraneo | 8 | 2025-06-19 | 2026-09-11 | |
| Spontaneous Eye Blinking in Disorders of Consciousness Disorders of Consciousness | Recruiting | Fondazione Don Carlo Gnocchi ETS | 70 | 2025-05-08 | 2026-07-13 | |
| What is the Perceived Role of Risk in DOC Healthcare. Observation - Disorders of Consciousness | Recruiting | University of Nottingham | 40 | 2025-05-01 | 2025-07-10 | |
| Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness tTIS - Disorders of Consciousness, Severe Brain Injury | Not applicable | Recruiting | Xijing Hospital | 10 | 2025-04-07 | 2025-04-09 |
| The Temporally Interfering in Patients With Disorders of Consciousness sham TI, real TI - Disorders of Consciousness | Not applicable | Completed | Zhejiang Provincial People's Hospital | 28 | 2025-01-20 | 2026-07-22 |
| Spontaneous Eye Blinking Evaluation for Cognitive Assessment of Individuals With Severe Acquired Brain Injury EEG-EOG recording at rest and during an auditory oddball paradigm - Disorders of Consciousness, Acquired Brain Injury | Completed | Alfonso Magliacano | 44 | 2025-01-13 | 2026-07-10 | |
| Diagnosis Value of Interoceptive EEG Indicators by Rectal Stimulation in DoC Rectal Stimulation - Disorders of Consciousness | Recruiting | YiLin Zhao | 45 | 2024-12-01 | 2025-10-06 | |
| The Effects of Psilocybin on Shared Experience in Film Processing Psilocybin, Placebo - Disorders of Consciousness, Psychedelic Experiences | Not applicable | Unknown | Western University, Canada | 30 | 2024-11-01 | 2024-09-27 |
| mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness mindBEAGLE daily device use - Disorders of Consciousness | Not applicable | Enrolling by invitation | Amy Wagner | 40 | 2024-10-01 | 2026-06-04 |
| Robot-assisted Training After Acquired Brain Injury and Disorders of Consciousness GAIT-assisted training, STEP-assisted training - Acquired Brain Injury, Disorders of Consciousness | Not applicable | Completed | Christina Kruuse | 10 | 2024-08-12 | 2026-03-11 |
| Validation of a Clinical Complications Scale (CCS) in Patients With Disorders of Consciousness No intervention, study is observational - Disorders of Consciousness | Completed | Fondazione Don Carlo Gnocchi ETS | 42 | 2024-05-15 | 2025-02-06 |
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Consciousness Disorders (49) · Persistent Vegetative State (13) · Brain Injuries (11) · Brain Injuries, Traumatic (5) · Coma (4) · Disease (3) · Caregiver Burden (1) · Communication Disorders (1) · Deglutition Disorders (1) · Encephalitis (1) · Heart Arrest (1) · Hemorrhagic Stroke (1) · Ischemic Attack, Transient (1) · Ischemic Stroke (1) · Locked-In Syndrome (1)
Mental Disorders (49) · Nervous System Diseases (49) · Neurobehavioral Manifestations (49) · Neurocognitive Disorders (49) · Neurologic Manifestations (49) · Pathological Conditions, Signs and Symptoms (49) · Signs and Symptoms (49) · Brain Diseases (24) · Central Nervous System Diseases (24) · Unconsciousness (14) · Brain Damage, Chronic (13) · Craniocerebral Trauma (13) · Trauma, Nervous System (13) · Wounds and Injuries (13) · Cardiovascular Diseases (3)
Transcranial Direct Current Stimulation (4) · Neurophysiological Monitoring (2) · Surveys and Questionnaires (2) · Anesthetics, General (1) · Conservative Treatment (1) · Deep Brain Stimulation (1) · Diagnosis (1) · Diagnostic Imaging (1) · Magnetic Resonance Spectroscopy (1) · Melatonin (1) · Methods (1) · Observation (1) · Odorants (1) · Psilocybin (1) · Sound (1)
University of Liege (6) · Beijing Tiantan Hospital (3) · Anna Estraneo (2) · Centre Hospitalier Universitaire de Besancon (2) · First Affiliated Hospital of Zhejiang University (2) · Fondazione Don Carlo Gnocchi ETS (2) · Hangzhou Normal University (2) · Xijing Hospital (2) · Zhujiang Hospital (2) · Alfonso Magliacano (1) · Amy Wagner (1) · Anhui Medical University (1) · Assistance Publique - Hôpitaux de Paris (1) · Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd. (1) · Christina Kruuse (1)
China (16) · Belgium (8) · Italy (8) · United States (8) · France (5) · Germany (3) · Denmark (2) · Canada (1) · Israel (1) · Spain (1) · United Kingdom (1)
Anna Estraneo, MD (3) · Olivia Gosseries, PhD, Professor (2) · Amy Wagner, M.D. (1) · Andreas Bender, Prof.Dr. (1) · Benjamin Rohaut, MD PhD (1) · Benyuan Luo (1) · Chad Swank, PhD (1) · Christina Kruuse, Professor (1) · Claude Hemphill, MD, MAS (1) · Hao YA Wang (1) · Jeffrey Ware, MD (1) · Kai Wang, PhD (1) · Katherine Hill, Ph.D. (1) · Maria Grazia Maggio (1) · Nicholas Schiff, MD (1)
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