6 recruiting, 4 completed, 3 not yet recruiting, 3 unknown. 18 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 18 | Recruiting 6, Completed 4, Not yet recruiting 3, Unknown 2, Enrolling by invitation 1, Terminated 1, Withdrawn 1 |
Follow Locked-In Syndrome: new trials by email Literature Review of Locked-In Syndrome trials Research Report on Locked-In Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS) Chronic speech BCI - Locked in Syndrome, ALS (Amyotrophic Lateral Sclerosis) | Not applicable | Not yet recruiting | University Hospital, Grenoble | 3 | 2026-10-10 | 2026-07-13 |
| iBCI Optimization for Veterans With Paralysis Mobile neural decoding platform (mobile iBCI) - Spinal Cord Injury, Amyotrophic Lateral Sclerosis | Not applicable | Not yet recruiting | VA Office of Research and Development | 2 | 2026-10-02 | 2026-07-27 |
| Chinese-Specific Speech Imagery Coding Using High-Density ECoG Intraoperative high-density ECoG recording, Permanent high-density ECoG implantation - Aphasia, Dysarthria | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 50 | 2026-03-15 | 2026-03-10 |
| TDCS-RTMS Intervention for Motor Function Repetitive transcranial magnetic stimulation, Transcranial direct current stimulation - Locked in Syndrome | Not applicable | Not yet recruiting | Zhujiang Hospital | 72 | 2025-11-30 | 2025-12-10 |
| mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness mindBEAGLE daily device use - Disorders of Consciousness | Not applicable | Enrolling by invitation | Amy Wagner | 40 | 2024-10-01 | 2026-06-04 |
| Investigation on the Cortical Communication System ECoG (electrocorticography) sensing - Locked-in Syndrome, Neuromuscular Diseases | Not applicable | Recruiting | UMC Utrecht | 2 | 2023-12-15 | 2025-10-03 |
| Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia BrainGate Neural Interface System - Anarthria, Dysarthria | Not applicable | Recruiting | Leigh R. Hochberg, MD, PhD. | 3 | 2023-10-18 | 2026-06-02 |
| Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02) BrainGate Neural Interface System - Anarthria, Dysarthria | Not applicable | Recruiting | Leigh R. Hochberg, MD, PhD. | 2 | 2023-10-16 | 2025-12-01 |
| Brain-Computer Interface Implant for Severe Communication Disability Summit System - Locked-in Syndrome | Not applicable | Withdrawn | Johns Hopkins University | 2022-10-01 | 2022-11-07 | |
| Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying - Amyotrophic Lateral Sclerosis, Brainstem Stroke | Not applicable | Completed | Oregon Health and Science University | 55 | 2022-07-15 | 2025-05-16 |
| Investigation on the Cortical Communication (CortiCom) System Surgical implantation of CortiCom system - Tetraplegia, Locked-in Syndrome | Not applicable | Recruiting | Johns Hopkins University | 3 | 2021-12-14 | 2026-08-21 |
| Telehealth Implementation of Brain-Computer Interface Use of BCI - Amyotrophic Lateral Sclerosis, Stroke | Not applicable | Unknown | Shirley Ryan AbilityLab | 7 | 2021-09-30 | 2023-07-19 |
| [BrainConnexion] - Neurodevice Phase I Trial BrainConnexion - Tetraplegia, Tetraplegia/Tetraparesis | Not applicable | Unknown | National Neuroscience Institute | 5 | 2017-11-21 | 2023-05-06 |
| Stable and Independent Communication Brain-computer Interfaces Stable and Independent Brain-computer Interfaces for Communication - Healthy, Tetraplegia | Not applicable | Terminated | Tomislav Milekovic | 10 | 2017-07-11 | 2020-03-30 |
| CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG Acute Brain Injuries, Consciousness Disorders | Unknown | Copenhagen University Hospital, Rigshospitalet | 100 | 2017-04-12 | 2023-11-15 | |
| Feasibility of mindBEAGLE in Disorders of Consciousness or Locked-In Syndrome mindBEAGLE EEG-based brain-computer interface - Consciousness Disorders, Locked-In Syndrome | Not applicable | Completed | Massachusetts General Hospital | 20 | 2016-03-01 | 2021-06-03 |
| First Study With a Brain Implant to Help Locked-in Patients Communicate at Home ECoG (electrocorticography) sensing - Locked-In Syndrome | Not applicable | Completed | UMC Utrecht | 6 | 2015-09-09 | 2025-12-03 |
| Mindfulness Meditation for Subjects With Severe Speech and Physical Impairments Mindfulness Meditation Training, Audio Group - Physical Impairments, Cerebral Palsy | Not applicable | Completed | Oregon Health and Science University | 8 | 2013-01-01 | 2017-04-13 |
| BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Placement of the BrainGate2 sensor(s) into the motor-related cortex - Tetraplegia, Spinal Cord Injuries | Not applicable | Recruiting | Leigh R. Hochberg, MD, PhD. | 27 | 2009-05-01 | 2026-06-01 |
Amyotrophic Lateral Sclerosis (10) · Brain Stem Infarctions (7) · Muscular Dystrophies (6) · Quadriplegia (6) · Spinal Cord Injuries (6) · Stroke (4) · Consciousness Disorders (3) · Dysarthria (3) · Brain Injuries, Traumatic (2) · Persistent Vegetative State (2) · Aphasia (1) · Brain Injuries (1) · Cerebral Palsy (1) · Coma (1)
Nervous System Diseases (19) · Neurologic Manifestations (19) · Paralysis (19) · Pathological Conditions, Signs and Symptoms (19) · Signs and Symptoms (19) · Neuromuscular Diseases (18) · Central Nervous System Diseases (14) · Quadriplegia (13) · Brain Diseases (12) · Cardiovascular Diseases (10) · Cerebrovascular Disorders (10) · Metabolic Diseases (10) · Nutritional and Metabolic Diseases (10) · Proteostasis Deficiencies (10) · Spinal Cord Diseases (10)
Electrocorticography (2) · Brain-Computer Interfaces (1) · Neural Prostheses (1) · Transcranial Direct Current Stimulation (1) · Transcranial Magnetic Stimulation (1)
Leigh R. Hochberg, MD, PhD. (3) · Johns Hopkins University (2) · Oregon Health and Science University (2) · UMC Utrecht (2) · Amy Wagner (1) · Copenhagen University Hospital, Rigshospitalet (1) · Massachusetts General Hospital (1) · National Neuroscience Institute (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Shirley Ryan AbilityLab (1) · Tomislav Milekovic (1) · University Hospital, Grenoble (1) · VA Office of Research and Development (1) · Zhujiang Hospital (1)
United States (11) · Netherlands (2) · China (1) · Denmark (1) · France (1) · Singapore (1) · Switzerland (1)
Nick F Ramsey, PhD (2) · Amy Wagner, M.D. (1) · Barry Oken, MD (1) · Brian L. Edlow, M.D. (1) · Colin Franz, MD (1) · Daniel Kondziella, MD PhD FEBN (1) · Feng Yan (1) · Jaimie Henderson, MD (1) · John D Simeral, PhD (1) · Katherine Hill, Ph.D. (1) · Leigh R Hochberg, M.D., Ph.D. (1) · Melanie Fried-Oken, PhD (1) · Nathan Crone, MD (1) · Nathan E Crone, MD (1) · Sergey Stavisky, Ph.D. (1)
PMID 21436513, PMID 22596161, PMID 23838067, PMID 25385765, PMID 26413781, PMID 27900953, PMID 27959736, PMID 28220753, PMID 28278476, PMID 28363483, PMID 28639486, PMID 29363625, PMID 30542319, PMID 31401488, PMID 31680806, PMID 32963279, PMID 36097353, PMID 36639237, PMID 37425721, PMID 37657190, PMID 37697124, PMID 37841873, PMID 38579696, PMID 38671062, PMID 38925110, PMID 39141853, PMID 39141854, PMID 39371161, PMID 39433597, PMID 39484239, PMID 39793200, PMID 40280150, PMID 40506548, PMID 40972658, PMID 41256173, PMID 41928799
1DP2DC021055 (1), 2017 (1), I01RX003803 (1), R01DC009899 (1), R01DC014034 (1), U01DC016686 (1), U01DC017844 (1), U01DC019430 (1), U01NS123101 (1), UH2NS095548 (1), UH3NS114439 (1)