44 completed, 7 not yet recruiting, 6 recruiting, 2 withdrawn. 25 Not applicable, 16 Phase 2, 8 Phase 4, 5 Phase 3, 2 Phase 1.
Follow Dental Pain: new trials by email Literature Review of Dental Pain trials Research Report on Dental Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Compare the Intensity of Pain Felt by Children During the Local Anesthesia Procedure to That Perceived by the Accompanying Parent. Dental Pain, Dental Anxiety | Recruiting | University Hospital, Clermont-Ferrand | 100 | 2026-10-08 | 2026-10-13 | |
| A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar Extraction CYT-1010, Placebo - Acute Postoperative Pain, Dental Pain | Phase 1 / Phase 2 | Recruiting | Cytogel Pharma, LLC | 32 | 2026-09-25 | 2026-10-29 |
| Comparing Obturation Using Bioceramic Nano-coated Gutta-percha With Bioceramic Sealer Versus Traditional Gutta-percha With Resin Sealer for Reducing Postoperative Pain and Swelling After Root Canal Treatment in Necrotic Single-rooted Teeth. Resin sealer with conventional gutta percha., Bioceramic sealer with bioceramic gutta-percha. - Dental Pain, Facial Swelling | Not applicable | Not yet recruiting | Cairo University | 30 | 2026-09-01 | 2026-05-20 |
| Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis Saline (0.9%, sterile, for infusion), Dexamethasone - Symptomatic Irreversible Pulpitis (SIP), Dental Pain | Not applicable | Recruiting | Marmara University | 84 | 2026-06-15 | 2026-06-29 |
| Kaleidoscope Compared to Tell-Show-Do for Reducing Children Pain and Anxiety During Pulp Therapy behavior management using Kaleidoscope glasses (SOL, country of origin: China)., behavior management using the Tell-Show-Do technique and Kaleidoscope glasses (SOL, country of origin: China)., behavior management using the Tell-Show-Do technique. - Dental Anxiety in Children, Dental Pain | Not applicable | Not yet recruiting | Cairo University | 39 | 2026-06-01 | 2026-06-08 |
| Identification of Possible Trigeminal Neuralgia Completion of the IDTN Questionnaire - Trigeminal Neuralgia (TN), Orofacial Pain | Not yet recruiting | University College, London | 250 | 2026-04-01 | 2026-03-23 | |
| Effect of Play Dough, Slime, and Plush Toys on Dental Anxiety and Pain in Children During Dental Treatment Play Dough Distraction, Slime Distraction, Plush Toy Distraction - Dental Anxiety, Dental Pain | Not applicable | Not yet recruiting | Afyonkarahisar Health Sciences University | 90 | 2026-02-17 | 2026-03-03 |
| Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry lidocaine + epinephrine 1:100,000, Articaine 4% with epinephrine 1:100,000 - Dental Pain | Phase 4 | Not yet recruiting | Universidad Austral de Chile | 100 | 2025-12-20 | 2025-11-17 |
| Patient Education and AI-Assisted Complaint Summaries in Endodontic Patients Standardized Verbal Education, Leaflet-Based Education, Video-Based Education - Toothache, Dental Pain | Not applicable | Completed | Cukurova University | 120 | 2025-12-15 | 2026-07-13 |
| Evaluation of the Sedative Effect of Contextualized Music Listening on Patient Pain and Anxiety in a Dental Care Setting Baseline Assessment (T0), Control Condition - Silence (Pre-Music Phase), Music Listening Condition (Intervention Phase) - Dental Pain, Dental Anxiety | Not applicable | Completed | Rawane El Dimachki | 30 | 2025-10-01 | 2026-04-21 |
| A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours. Trinase, placebo capsule - Symptomatic Irreversible Pulpitis (SIP), Postoperative Pain After Endodontic Treatment | Not applicable | Completed | Fayoum University | 400 | 2025-08-01 | 2026-09-30 |
| A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults ibuprofen 400 mg in combination with Curcumin covered with liquorice root 100 mg, ibuprofen 200 mg in combination with Curcumin covered with liquorice root 100 mg, The combination of ibuprofen 400 mg and placebo in patients after 2-4 molars procedure - Dental Pain | Not applicable | Not yet recruiting | S.LAB (SOLOWAYS) | 264 | 2025-07-28 | 2025-06-08 |
| Photobiomodulation and Tooth Analgesia Photobiomodulation, Topical Benzocaine, Local Anesthesia - Dental Anaesthesia, Dental Pain | Not applicable | Recruiting | University of Maryland, Baltimore | 200 | 2025-07-07 | 2026-08-12 |
| Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial Intraligamentary Injection, Inferior Alveolar Nerve Block - Symptomatic Irreversible Pulpitis (SIP), Dental Pain | Not applicable | Recruiting | Aula Dental Avanzada | 52 | 2025-06-20 | 2026-11-03 |
| Clinical Outcomes of Mandibular Primary Molar Extraction Using Physics Forceps in Children ARM 1 Physics forceps (40 Participant), ARM 2 conventional forceps (40 Participant) - Dental Anxiety, Dental Pain | Not applicable | Completed | Damascus University | 80 | 2025-05-21 | 2026-03-19 |
| Immersive Virtual Reality for Pain and Dental Anxiety During Pediatric Restorative Treatment Immersive Virtual Reality - Dental Anxiety in Children, Dental Pain | Not applicable | Completed | University of Gaziantep | 70 | 2025-05-20 | 2026-08-24 |
| Meloxicam Versus Ibuprofen for Pain Control After Third Molar Exodontia in Adult Patients meloxicam 7,5mg - Dental Pain, Sensation Disorders | Phase 4 | Not yet recruiting | Universidad Austral de Chile | 68 | 2024-12-15 | 2024-11-25 |
| Evaluation of Pulpal and Salivary Neuropeptides in Dental Pain Dental Pain, Pulpitis | Completed | Kahramanmaras Sutcu Imam University | 72 | 2024-11-01 | 2026-01-09 | |
| The Effect of Rubber Dam on Objective and Subjective Parameters of Stress During Dental Treatment in Children Evaluation of objective and subjective stress parameters caused by local anesthesia during treatments, Evaluation of objective and subjective stress parameters caused by topical anesthesia during treatments, Evaluation of objective and subjective stress parameters caused by the application of rubber dam during treatments in the patient and dentist - Dental Anxiety, Dental Fear | Not applicable | Completed | Izmir Katip Celebi University | 100 | 2024-07-01 | 2025-07-11 |
| XP-Endo Finisher on Postoperative Pain in Retreatment Cases Using Mtwo R Files Mtwo R files with Xp-Endo finisher file, Mtwo R files - Dental Pain, Endodontically Treated Teeth | Not applicable | Completed | Hams Hamed Abdelrahman | 50 | 2023-09-12 | 2024-10-03 |
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Toothache (61) · Pain, Postoperative (7) · Agnosia (4) · Anxiety Disorders (3) · Pain (3) · Dental Caries (2) · Acute Pain (1) · Anosmia (1) · Bites and Stings (1) · Dental Pulp Diseases (1) · Dentin Sensitivity (1) · Depression (1) · Facial Pain (1) · Fractures, Stress (1) · Hypersensitivity (1)
Neurologic Manifestations (61) · Pathological Conditions, Signs and Symptoms (61) · Signs and Symptoms (61) · Stomatognathic Diseases (61) · Tooth Diseases (61) · Facial Pain (60) · Pain (58) · Pathologic Processes (8) · Nervous System Diseases (7) · Postoperative Complications (7) · Neurobehavioral Manifestations (4) · Perceptual Disorders (4) · Mental Disorders (3) · Behavior (2) · Dental Pulp Diseases (2)
Ibuprofen (6) · Acetaminophen (4) · Celecoxib (3) · ARRY-371797 (2) · Benzocaine (2) · Buprenorphine (2) · Carticaine (2) · Lidocaine (2) · Anesthesia, Dental (1) · Anesthesia, Local (1) · Aromatherapy (1) · Cyclooxygenase 2 Inhibitors (1) · Dental Atraumatic Restorative Treatment (1) · Dentists (1) · Dexamethasone (1)
GlaxoSmithKline (3) · Iroko Pharmaceuticals, LLC (3) · AFT Pharmaceuticals, Ltd. (2) · Cairo University (2) · Hypnalgesics, LLC (2) · IBSA Institut Biochimique SA (2) · Nevakar, Inc. (2) · Pfizer (2) · Universidad Austral de Chile (2) · University Hospital, Clermont-Ferrand (2) · Abdulkadir Tiftik,DDS (1) · Afyonkarahisar Health Sciences University (1) · Alexandria University (1) · Alkermes, Inc. (1) · Ana Flavia Granville-Garcia (1)
United States (26) · Turkey (Türkiye) (9) · Egypt (5) · France (3) · United Kingdom (3) · Brazil (1) · Chile (1) · Denmark (1) · Ireland (1) · Lebanon (1) · New Zealand (1) · Poland (1) · Russia (1) · Saudi Arabia (1) · Spain (1)
Steven Christensen, DDS (2) · Abdulkadir Tiftik, DDS, DDS (1) · Alaa ElBaz, Professor (1) · Amina M. Abdelrahman, PhD (1) · Ana Flavia Granville-Garcia, Professor (1) · Arthur H Jeske, DDS, PhD (1) · Brian Chinnock, MD (1) · Carla Santana, PhD (1) · Darius Sagheri (1) · David Blum, MD (1) · Elvira V Lang, MD, PhD (1) · Eric Lang, MD (1)
PMID 16320034, PMID 24127200, PMID 25015020, PMID 25597878, PMID 29329493, PMID 29742264, PMID 30245281, PMID 30737315, PMID 32801526, PMID 33602209, PMID 34909472, PMID 35122442, PMID 35699807, PMID 36110718, PMID 37252611, PMID 3785962, PMID 39420491, PMID 39984891, PMID 40448060, PMID 40932429, PMID 42458416, PMID 42564486, PMID 7267140, PMID 8008411