16 completed, 5 unknown, 2 terminated. 23 Phase 2, 4 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 23 | Completed 16, Unknown 5, Terminated 2 |
| Phase 1 | 4 | Completed 3, Unknown 1 |
| Phase 3 | 3 | Completed 2, Unknown 1 |
Follow Critically Ill: new trials by email Literature Review of Critically Ill trials Research Report on Critically Ill
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Rapid Pathogen Detection in ICU Patients With Suspected Pneumonia on Antimicrobial Therapy FA Pneumonia Panel - Pneumonia, Critically Ill | Phase 2 | Completed | Chinese University of Hong Kong | 40 | 2024-06-26 | 2026-03-06 |
| Early Goal Nutrition Therapy Guided by Indirect Calorimetry and Nitrogen Balance Among Critically Ill Patients With Acute Kidney Injury (ENGINE Study) indirect calorimetry and nitrogen balance, Indirect calorimetry (Standard care nutrition arm) - Critically Ill, Nutrition Disorders | Phase 1 / Phase 2 | Unknown | Wankawee Jeerangsapasuk | 80 | 2023-03-07 | 2024-02-02 |
| Efficacy and Safety of Remimazolam Besylate Versus Propofol for Sedation in Critically Ill Patients With Deep Sedation Remimazolam Besylate, Propofol - Critically Ill, Deep Sedation | Phase 2 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 60 | 2022-09-05 | 2022-09-26 |
| Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS Fludrocortisone Acetate, Standard Therapy - Critically Ill, Septic Shock | Phase 2 | Completed | The George Institute | 155 | 2021-02-11 | 2024-01-18 |
| Comparison of Biphozyl® and Phoxilium® as a Replacement Fluid During CVVH for AKI in Adults and Their Effects on pH-, Bicarbonate-levels and Respiratory Situation CVVH with Phoxilium® in the first 48h after randomization, CVVH with Biphozyl® in the first 48h after randomization, CVVH with Phoxilium® in the second 48h after randomization (after previous 48h with Biphozyl®) - Critically Ill, Acute Kidney Injury | Phase 2 | Completed | Medical University Innsbruck | 88 | 2020-08-01 | 2024-03-13 |
| Coated Devices to Decrease Infection in the Intensive Care Unit Coated devices, Control - Critically Ill | Phase 1 / Phase 2 | Completed | Hospital do Coracao | 103 | 2019-04-06 | 2020-03-09 |
| Intensive Nutrition in Critically Ill Adults Supplemental parenteral nutrition - Critical Illness, Critically Ill | Phase 2 | Completed | Australian and New Zealand Intensive Care Research Centre | 240 | 2018-10-15 | 2024-05-24 |
| The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial Vitamin C, Thiamine, Hydrocortisone, - Shock, Septic, Critically Ill | Phase 2 | Completed | Australian and New Zealand Intensive Care Research Centre | 216 | 2018-05-02 | 2019-10-10 |
| Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury Calcifediol, Calcitriol, Placebos - Critically Ill, Acute Kidney Injury | Phase 2 | Completed | David Leaf | 150 | 2017-04-03 | 2025-09-29 |
| Promotion of Oesophageal Motility to Prevent Regurgitation and Enhance Nutrition Intake in ICU Patients. E-Motion System, Sham E-Motion System - Critically Ill, Malnutrition | Phase 2 | Completed | E-Motion Medical Ltd. | 158 | 2016-02-01 | 2019-07-10 |
| Spironolactone Administration to Prevent Ischemic Kidney Injury in Critically Ill Cancer Patients Spironolactone, Placebo - Critically Ill, Cancer | Phase 2 / Phase 3 | Unknown | Instituto Nacional de Cancerologia de Mexico | 24 | 2015-10-01 | 2017-01-04 |
| Screening Elderly Patients for Weaning Once daily screening, At least twice daily screening - Critically Ill | Phase 2 | Completed | Unity Health Toronto | 102 | 2015-01-01 | 2017-10-20 |
| Prevention of Nosocomial Infections in Critically Ill Patients With Lactoferrin: The PREVAIL Study Lactoferrin, Placebo - Critically Ill | Phase 2 | Completed | Queen's University | 214 | 2013-11-01 | 2017-02-20 |
| The Effect of Thiamine vs. Placebo on VO2 in Critical Illness Thiamine - Critically Ill, Respiratory Failure | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 66 | 2013-10-01 | 2017-10-02 |
| TEAM: A Trial of Early Activity and Mobility in ICU Early mobilisation - Critically Ill | Phase 1 / Phase 2 | Completed | Australian and New Zealand Intensive Care Research Centre | 50 | 2013-08-01 | 2018-08-22 |
| The Use of Methadone in Newborn Infants Methadone - Premature Birth of Newborn, Critically Ill | Phase 1 / Phase 2 | Completed | John van den Anker | 60 | 2010-12-01 | 2018-07-26 |
| Collaborative H1N1 Adjuvant Treatment Pilot Trial Rosuvastatin, Placebo - Critically Ill, H1N1/Influenza Infection | Phase 2 | Terminated | Canadian Critical Care Trials Group | 8 | 2010-01-01 | 2013-02-21 |
| The Efficacy of Glucagon Like Peptide (GLP) - 1(7-36) Amide for Glycemic Control in Critically Ill Patients Glucagon-Like Peptide-1, Saline - Critically Ill, Hypoglycemia | Phase 2 | Terminated | Johns Hopkins University | 19 | 2008-12-01 | 2017-07-02 |
| Improving Blood Glucose Control With a Computerized Decision Support Tool: Phase 2 glucose control with computer generated recommendations - Critically Ill, Hyperglycemia | Phase 2 | Unknown | Intermountain Health Care, Inc. | 200 | 2007-09-01 | 2015-02-26 |
| Improving Blood Glucose Control With a Computerized Decision Support Tool: Phase 1 glucose control with computer generated recommendations - Critically Ill, Hyperglycemia | Phase 2 | Unknown | Intermountain Health Care, Inc. | 200 | 2006-02-01 | 2015-02-26 |
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Critical Illness (23) · Acute Kidney Injury (4) · Hyperglycemia (2) · Insulin Resistance (2) · Sepsis (2) · Shock, Septic (2) · Hyperphagia (1) · Hypoglycemia (1) · Infections (1) · Malnutrition (1) · Neoplasms (1) · Nutrition Disorders (1) · Pneumonia (1) · Pneumonia, Ventilator-Associated (1) · Premature Birth (1)
Disease Attributes (23) · Pathologic Processes (23) · Pathological Conditions, Signs and Symptoms (23) · Female Urogenital Diseases and Pregnancy Complications (5) · Nutritional and Metabolic Diseases (5) · Urogenital Diseases (5) · Female Urogenital Diseases (4) · Kidney Diseases (4) · Male Urogenital Diseases (4) · Renal Insufficiency (4) · Respiratory Tract Diseases (4) · Urologic Diseases (4) · Glucose Metabolism Disorders (3) · Infections (3) · Inflammation (3)
Thiamine (2) · Acetylcysteine (1) · Ascorbic Acid (1) · Calcifediol (1) · Calcitriol (1) · Calorimetry, Indirect (1) · Filgrastim (1) · Glucagon-Like Peptide 1 (1) · Hydrocortisone (1) · Inulin (1) · Lactoferrin (1) · Methadone (1) · Propofol (1) · Rehabilitation (1) · Rosuvastatin Calcium (1)
Australian and New Zealand Intensive Care Research Centre (3) · Intermountain Health Care, Inc. (2) · Unity Health Toronto (2) · Beth Israel Deaconess Medical Center (1) · Canadian Critical Care Trials Group (1) · Chinese University of Hong Kong (1) · David Leaf (1) · E-Motion Medical Ltd. (1) · Helsinki University Central Hospital (1) · Hospital do Coracao (1) · Instituto Nacional de Cancerologia de Mexico (1) · John van den Anker (1) · Johns Hopkins University (1) · Medical University Innsbruck (1) · Queen's University (1)
United States (7) · Canada (5) · Australia (4) · New Zealand (3) · Brazil (2) · Austria (1) · China (1) · Finland (1) · Hong Kong (1) · Mexico (1) · Thailand (1)
Alan H Morris, MD (2) · Alexandre Biasi, MD/PhD (1) · Bertha M Cordova-Sanchez, MD (1) · Carol L Hodgson, PhD (1) · Claudio M Martin, MD, FRCPC, MSc (1) · Daren K Heyland, MD (1) · Dariush Elahi, PhD (1) · David E Leaf, MD, MMSc (1) · Emma Ridley, PhD (1) · James Walsham, MB ChB, MRCP, FCICM. (1) · John C Marshall, MD, FRCPS (1) · John G Muscedere, MD (1) · Karen E. A. Burns, MD, FRCPC (1) · Karen EA Burns, MD,FRCPC,MSc (1) · Karin T Kirchhoff (1)
PMID 11098963, PMID 15883741, PMID 23363492, PMID 29924393, PMID 30805946, PMID 30920411, PMID 31142242, PMID 31950979, PMID 32526149, PMID 33315720, PMID 35260448, PMID 39235623, PMID 39762887, PMID 40759107, PMID 40924491, PMID 41247497
K23DK106448 (1)