34 terminated. 34 Phase 2, 5 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 34 | Terminated 34 |
| Phase 3 | 5 | Terminated 5 |
| Phase 1 | 1 | Terminated 1 |
Follow Craniocerebral Trauma: new trials by email Literature Review of Craniocerebral Trauma trials Research Report on Craniocerebral Trauma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Insulin-sensitizing NE3107 in Improving Sleep and Fatigue in Subjects With Traumatic Brain Injury NE3107 - Traumatic Brain Injury | Phase 2 | Terminated | Neurological Associates of West Los Angeles | 4 | 2023-12-21 | 2025-07-25 |
| Erenumab-aooe for the Management of Trigeminal Neuropathic Pain. Erenumab-Aooe, Placebo - Trigeminal Neuropathy | Phase 2 | Terminated | University of Maryland, Baltimore | 5 | 2022-05-31 | 2024-03-22 |
| Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity Phase 2; Low Dose MYOBLOC (10,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 2; Placebo - Spasticity, Cerebrovascular Accident | Phase 2 / Phase 3 | Terminated | Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC | 32 | 2021-11-02 | 2026-05-27 |
| Sphenopalatine Ganglion Block for Headache After Concussion Lidocaine in SphenoCath device, Saline Solution in SphenoCath device - Concussion, Headache | Phase 2 | Terminated | University of Michigan | 2 | 2021-03-18 | 2022-09-14 |
| Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity Phase 2; Low Dose MYOBLOC (15,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 2; Placebo - Spasticity | Phase 2 / Phase 3 | Terminated | Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC | 40 | 2019-12-17 | 2026-05-22 |
| A Study to Evaluate the Efficacy and Safety of BIIB093 in Participants With Brain Contusion BIIB093, Placebo - Brain Contusion | Phase 2 | Terminated | Remedy Pharmaceuticals, Inc. | 92 | 2019-10-06 | 2024-11-27 |
| Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military Sildenafil Citrate 50Mg Tab, functional Near-infrared Spectroscopy (fNIRS), Carbon Dioxide (CO2) 5% - Traumatic Brain Injury | Phase 2 | Terminated | Uniformed Services University of the Health Sciences | 1 | 2019-08-09 | 2024-02-28 |
| Pilot rTMS for AUD+mTBI repetitive transcranial magnetic stimulation - Alcohol Use Disorder, Mild Traumatic Brain Injury | Phase 2 | Terminated | VA Office of Research and Development | 2 | 2019-03-21 | 2026-10-30 |
| Sildenafil Treatment for Mild TBI Sildenafil Citrate, Placebo oral capsule - Vascular System Injuries, Concussion, Brain | Phase 2 | Terminated | University of Texas Southwestern Medical Center | 22 | 2018-07-25 | 2020-11-19 |
| Tocilizumab (RoActemra) and Tranexamic Acid (Cyklokapron) Used as Adjuncts to Chronic Subdural Hematoma Surgery Tranexamic acid and Tocilizumab - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Terminated | Oslo University Hospital | 382 | 2017-11-28 | 2021-10-13 |
| OPTIMA-TBI Pilot Study Omega-3 Polyunsaturated Fatty Acids (Fish Oil 1000 mg (contains 500 mg DHA & 100 mg EPA)) or placebo capsules., Placebo - Cap - Mild Traumatic Brain Injury | Phase 2 | Terminated | University of Michigan | 44 | 2017-09-12 | 2023-05-23 |
| fMRI-neuronavigated rTMS for the Treatment of Major Depression Associated With TBI Active, Sham - Major Depressive Disorder, Traumatic Brain Injury | Phase 2 | Terminated | Washington University School of Medicine | 15 | 2016-08-01 | 2018-03-29 |
| Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI methylphenidate, Placebo - Traumatic Brain Injury | Phase 2 | Terminated | Uniformed Services University of the Health Sciences | 11 | 2014-09-01 | 2018-10-04 |
| A Safety and Efficacy Study of NNZ-2566 in Patients With Mild Traumatic Brain Injury (mTBI) NNZ-2566, Placebo - Concussion | Phase 2 | Terminated | Neuren Pharmaceuticals Limited | 32 | 2014-09-01 | 2018-02-05 |
| Dexamethasone Versus Burr Hole Craniostomy for Symptomatic Chronic Subdural Hematoma Dexamethasone, Burr Hole Craniostomy - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Terminated | University of Virginia | 10 | 2014-03-01 | 2018-12-11 |
| Effects of Huperzine A in Treatment of Moderate to Severe TBI Huperzine A, Placebo - Traumatic Brain Injury | Phase 2 | Terminated | Spaulding Rehabilitation Hospital | 14 | 2013-12-01 | 2019-11-05 |
| EVPOME Versus AlloDerm in Subjects Reconstructed With Large Defect Mandibular Resection AlloDerm, EVPOME - Mandibular Injuries | Phase 2 | Terminated | Stephen E. Feinberg | 1 | 2013-09-01 | 2017-11-22 |
| Mild Hypothermia and Supplemental Magnesium Sulfate Infusion in Severe Traumatic Brain Injury (TBI) Subjects Arctic Sun, Magnesium Sulfate - Traumatic Brain Injury | Phase 2 | Terminated | United States Department of Defense | 6 | 2011-12-01 | 2015-10-28 |
| Sevoflurane Sedation on Intra Cranial Pressure in Traumatic Brain Injury Patients 1: Sevoflurane - Brain Injury | Phase 2 | Terminated | Assistance Publique - Hôpitaux de Paris | 10 | 2011-12-01 | 2015-03-27 |
| Cognitive REmediation After Trauma Exposure Trial = CREATE Trial Methylphenidate Hydrochloride 20 mg, Placebo Capsule, Galantamine 12 mg - Posttraumatic Stress Disorder, Traumatic Brain Injury | Phase 2 | Terminated | INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium | 32 | 2011-08-01 | 2013-04-26 |
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Brain Injuries, Traumatic (19) · Brain Concussion (6) · Brain Injuries (6) · Post-Concussion Syndrome (3) · Stress Disorders, Post-Traumatic (3) · Depression (2) · Hematoma, Subdural, Chronic (2) · Hemiplegia (2) · Muscle Spasticity (2) · Stroke (2) · Alcoholism (1) · Attention Deficit Disorder with Hyperactivity (1) · Autonomic Nervous System Diseases (1) · Brain Contusion (1) · Caregiver Burden (1)
Nervous System Diseases (34) · Trauma, Nervous System (34) · Wounds and Injuries (33) · Brain Diseases (30) · Central Nervous System Diseases (30) · Brain Injuries (22) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (8) · Wounds, Nonpenetrating (8) · Head Injuries, Closed (7) · Neurologic Manifestations (7) · Brain Injuries, Traumatic (6) · Cardiovascular Diseases (6) · Vascular Diseases (6)
Clinical Trials, Phase II as Topic (2) · Clinical Trials, Phase III as Topic (2) · Methylphenidate (2) · Saline Solution (2) · Sildenafil Citrate (2) · perfluoro(t-butylcyclohexane) (2) · rimabotulinumtoxinB (2) · Alloderm (1) · Atorvastatin (1) · Baclofen (1) · Carbon Dioxide (1) · Dexamethasone (1) · Docosahexaenoic Acids (1) · Duloxetine Hydrochloride (1) · Erythropoietin (1)
Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC (2) · Tenax Therapeutics, Inc. (2) · Uniformed Services University of the Health Sciences (2) · University of Michigan (2) · Abbott Products (1) · Assistance Publique - Hôpitaux de Paris (1) · Atlantic Health System (1) · Baylor College of Medicine (1) · Cedars-Sinai Medical Center (1) · INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium (1) · Icahn School of Medicine at Mount Sinai (1) · Institut d'Anesthesiologie des Alpes Maritimes (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1) · Manhattan Eye, Ear & Throat Hospital (1) · Neuren Pharmaceuticals Limited (1)
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Joseph T Hull, PhD (2) · Alex Hishaw, MD (1) · Alex P Chapman, Ph.D. (1) · Allen E Thornton, Ph.D. (1) · Amy A Herrold, PhD BA (1) · Brian O'Neil, MD (1) · Claudia S Robertson, MD (1) · David Cox, Ph.D. (1) · Emmanuel Cuny, Professor (1) · Eric Wassermann, MD (1) · Eveline Frischknecht, lic. phil. (1) · Frederick Korley, M.D., Ph.D. (1) · Greg Zorman, MD (1) · Hansjoerg Znoj, Prof. Dr. phil. (1)
PMID 12411660, PMID 17143244, PMID 17188664, PMID 18234750, PMID 18418368, PMID 20571524, PMID 21468088, PMID 26314998, PMID 28006970, PMID 29065769, PMID 33165153, PMID 42423601
2008 (1), 2017 (1), 2018 (1), IK2RX000949 (1)