63 completed, 18 unknown, 16 recruiting, 8 not yet recruiting. 45 Not applicable, 16 Phase 3, 14 Phase 2, 11 Phase 4, 3 Early Phase 1.
Follow Contracture: new trials by email Literature Review of Contracture trials Research Report on Contracture
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DEPART Study at Yale Radiation Therapy - Dupuytren's Contracture | Phase 3 | Not yet recruiting | Yale University | 158 | 2026-11-01 | 2026-10-13 |
| Understanding Patient Preferences When Deciding on a Voluntary Musculoskeletal Test Diagnostic Advance Care Planning Discussion, Informational Statement Only - Non-traumatic Musculoskeletal Conditions, Carpal Tunnel Syndrome (CTS) | Not applicable | Not yet recruiting | University of Texas at Austin | 220 | 2026-10-25 | 2026-09-22 |
| NAC-REPAIR for Post-surgical Pain NAC, NAC 0mg/day (Placebo) - Carpal Tunnel Surgery, Trigger Finger Disorder | Phase 2 | Not yet recruiting | University of Arizona | 80 | 2026-10-15 | 2026-07-17 |
| Recurrence of Extremity Joint Contracture After Z-Plasty Versus Full-Thickness Skin Graft Z-Plasty, Full-Thickness Skin Graft - Joint Contracture, Contracture | Not yet recruiting | Universitas Sebelas Maret | 300 | 2026-10-13 | 2026-10-21 | |
| Kinesitherapy Plus Osteopathy After Surgery for Dupuytren Disease Physiotherapy, Sham Osteopathy - Dupuytren Disease | Not applicable | Not yet recruiting | Clinique Bizet | 50 | 2026-09-30 | 2026-10-30 |
| Collagenase Injection for Contracture Management Active XIAFLEX Collagenase injection - Contracture | Early Phase 1 | Not yet recruiting | The University of Texas Health Science Center, Houston | 15 | 2026-09-01 | 2026-07-09 |
| Effect of Transfer Energy Capacitive and Resistive Therapy on Palmar Fibromatosis Transfer Energy Capacitive and Resistive (TECAR) therapy, Traditional therapy - Palmar Fibromatosis | Not applicable | Not yet recruiting | Cairo University | 36 | 2026-03-02 | 2026-03-02 |
| Prognostic Profile of Dupuytren's Disease: a Cohort Study (PRODUCT) Questionnaires, Clinical examination - Dupuytren's Disease | Not applicable | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 305 | 2026-02-04 | 2026-01-20 |
| Repurposing 5-Azacytidine for the Treatment of Muscle Contractures in Children With Cerebral Palsy Placebo for the AZA 10mg/m^2, Placebo for the AZA 20mg/m^2, Placebo for the AZA 35mg/m^2 - Cerebral Palsy, Contracture | Phase 1 | Enrolling by invitation | Shirley Ryan AbilityLab | 27 | 2025-07-01 | 2025-07-03 |
| Ultrasound Features of Dupuytren's Disease Ultrasound assesment, ROM measurement - Dupuytren Disease | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 20 | 2025-04-24 | 2026-03-16 |
| Evaluating Ultrasound-Guided Needle Knife for Dupuytren's Contracture Ultrasound guided needle knife dissection - Dupuytren Contracture | Not applicable | Recruiting | Mohamed Maher Ismail Ahmed Elashmawy | 30 | 2025-01-19 | 2025-01-27 |
| Pilot Test of Caregiver Training Protocol for Brachial Plexus Birth Injury Pilot Training Protocol, Standard Training Protocol - Brachial Plexus Birth Palsy, Erbs Palsy | Not applicable | Recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 20 | 2025-01-01 | 2026-03-03 |
| Skin Involvement in Dupuytren Surgical Treatment Outcome Suction cutometry, Ultrasound measurement, Microbiopsy for histological analysis - Dupuytren Disease | Not applicable | Active not recruiting | Universitaire Ziekenhuizen KU Leuven | 50 | 2024-12-10 | 2026-07-10 |
| Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release Radiation therapy - Dupuytren Contracture | Not applicable | Recruiting | Dartmouth-Hitchcock Medical Center | 95 | 2024-09-16 | 2026-07-28 |
| Safety and Efficacy Study of Collagenase CNT201 Injection for Treatment of Dupuytren's Contracture [Step1] CNT201 First-dose, [Step1] CNT201 Low-dose, [Step1] CNT201 Intermediate-dose - Dupuytren Contracture, Dupuytren Disease of Finger | Phase 1 / Phase 2 | Recruiting | CONNEXT | 60 | 2024-07-23 | 2026-06-12 |
| Effect of Stretching Exercises on Plantar Fascia Stretching with/without device - Stretch, Plantar Fascia; Contracture | Not applicable | Unknown | Okan University | 10 | 2024-04-01 | 2024-04-17 |
| Effectiveness of Rehabilitation Protocol in Patients With Shortened Posterior Leg Muscles Specific protocol of rehabilitation exercise, Short gastrocnemius surgery. - Equinus Deformity of Foot, Gastrocnemius Equinus | Not applicable | Unknown | Fundación Universidad Católica de Valencia San Vicente Mártir | 40 | 2024-03-10 | 2025-05-11 |
| Effect Of Extracorporeal Shock Wave Therapy On Ultrasonography Changes In Patients With Palmar Fibromatosis: A Randomized Controlled Trial Extracorporeal Shock Wave Therapy, traditional treatment - Palmar Fibromatosis | Not applicable | Completed | Cairo University | 60 | 2024-03-04 | 2026-07-14 |
| Palmaris Longus Muscle and Dupuytren Non-invasive tests to determine the presence or absence of the palmaris longus tendon in both hands., Ultrasound - Dupuytren's Disease | Not applicable | Completed | Universitaire Ziekenhuizen KU Leuven | 243 | 2024-02-16 | 2026-03-09 |
| Nodular Shrinking in Dupuytren Disease Vitamin E-creme (Remederm®) vs Vaseline (Placebo), Ultrasound measurement - Dupuytren's Disease | Phase 2 | Recruiting | Universitaire Ziekenhuizen KU Leuven | 80 | 2024-02-15 | 2026-05-11 |
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Dupuytren Contracture (76) · Pain (6) · Trigger Finger Disorder (6) · Arthritis (5) · Carpal Tunnel Syndrome (5) · Cerebral Palsy (5) · Connective Tissue Diseases (5) · Fibromatosis, Plantar (5) · Osteoarthritis (5) · Cicatrix (4) · Muscle Spasticity (4) · Wrist Fractures (4) · Burns (3) · Ganglion Cysts (3)
Muscular Diseases (116) · Musculoskeletal Diseases (114) · Skin and Connective Tissue Diseases (84) · Fibroma (80) · Neoplasms (80) · Neoplasms by Histologic Type (80) · Neoplasms, Connective Tissue (80) · Neoplasms, Connective and Soft Tissue (80) · Neoplasms, Fibrous Tissue (80) · Connective Tissue Diseases (79) · Joint Diseases (45) · Pathological Conditions, Signs and Symptoms (25) · Nervous System Diseases (18) · Signs and Symptoms (16)
Microbial Collagenase (16) · xiapex (12) · Collagenases (4) · Radiotherapy (4) · Surgical Procedures, Operative (3) · Extracorporeal Shockwave Therapy (2) · Sodium Chloride (2) · Acetaminophen (1) · Adalimumab (1) · Adrenal Cortex Hormones (1) · Arthroplasty (1) · Arthroplasty, Replacement, Elbow (1) · Arthroplasty, Replacement, Knee (1) · Arthroplasty, Replacement, Shoulder (1) · Azacitidine (1)
Endo USA Inc., a Keenova Therapeutics Company (13) · Universitaire Ziekenhuizen KU Leuven (6) · University Medical Center Groningen (4) · Cairo University (2) · Eva Ponten (2) · GCS Ramsay Santé pour l'Enseignement et la Recherche (2) · Indiana Hand to Shoulder Center (2) · Istanbul University (2) · Ottawa Hospital Research Institute (2) · Riphah International University (2) · State University of New York (2) · Sunnybrook Health Sciences Centre (2) · University of Calgary (2) · University of Oxford (2) · University of Texas at Austin (2)
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PMID 19726771, PMID 21267044, PMID 21967070, PMID 23190833, PMID 23385985, PMID 24470559, PMID 24569424, PMID 27313184, PMID 28854973, PMID 29983350, PMID 30722822, PMID 30786996, PMID 31455312, PMID 32639394, PMID 33040610, PMID 33381769, PMID 33410485, PMID 33483776, PMID 34230015, PMID 34233971, PMID 34397515, PMID 35544581, PMID 35938625, PMID 35949922, PMID 36325678, PMID 36378072, PMID 36758713, PMID 38332642, PMID 38346307, PMID 39223657, PMID 39749555, PMID 41334972
2015 (1)