13 completed, 1 active not recruiting, 1 not yet recruiting, 1 withdrawn. 16 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Completed 13, Active not recruiting 1, Not yet recruiting 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
Follow Contracture: new trials by email Literature Review of Contracture trials Research Report on Contracture
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DEPART Study at Yale Radiation Therapy - Dupuytren's Contracture | Phase 3 | Not yet recruiting | Yale University | 158 | 2026-11-01 | 2026-10-13 |
| Study to Assess EN3835 in the Treatment of Plantar Fibromatosis (Also Known as Ledderhose Disease) EN3835, Placebo - Plantar Fibromatosis, Ledderhose Disease | Phase 3 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 436 | 2023-11-28 | 2026-10-14 |
| Long-Term Safety, Efficacy, and Durability of EN3835 in the Treatment and Retreatment of Plantar Fibromatosis EN3835 - Plantar Fibromatosis | Phase 3 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 145 | 2022-02-14 | 2025-03-21 |
| Effectiveness of Splinting After Collagenase Injection Collagenase Clostridium Histolyticum 0.9 MG [Xiaflex], Xiaflex + Hand-Based Custom Orthosis - Dupuytren Contracture, Dupuytren's Disease | Phase 3 | Completed | Foundation for Orthopaedic Research and Education | 80 | 2021-07-12 | 2025-02-26 |
| Ledderhose Disease: Radiotherapy or Not? Radiotherapy, Sham Radiotherapy - Ledderhose Disease | Phase 3 | Active not recruiting | University Medical Center Groningen | 84 | 2018-01-23 | 2024-02-28 |
| Evaluation of Xiaflex: Trial of Effectivenss iN Dupuytren's collagenase injection, limited palmar fasciectomy - Dupuytren's Disease | Phase 3 | Completed | McMaster University | 22 | 2017-07-08 | 2023-07-18 |
| Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease Collegenase injection, Needle aponeurotomy - Dupuytren Contracture | Phase 3 | Withdrawn | University of Alberta | 2013-05-01 | 2014-04-08 | |
| Safety and Efficacy of Two Concurrent Injections of AA4500 in Adult Subjects With Multiple Dupuytren's Contractures XIAFLEX / XIAPEX - Dupuytren's Contracture | Phase 3 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 715 | 2012-09-01 | 2017-10-05 |
| Collagenase Option for Reduction of Dupuytren's Contracture in Japan Collagenase Clostridium Histolyticum - Dupuytren's Contracture | Phase 3 | Completed | Asahi Kasei Therapeutics Corporation | 104 | 2012-05-01 | 2017-03-21 |
| Administration of Two Injections for Multiple Dupuytren's Contractures AA4500 collagenase clostridium histolyticum - Dupuytren's Contracture | Phase 3 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 60 | 2011-09-01 | 2017-10-05 |
| Treatment Of Dupuytren's Contracture With Collagenase Clostridium Histolyticum Injection (Xiapex) Xiapex - Dupuytren's Contracture | Phase 3 | Completed | Pfizer | 254 | 2010-12-01 | 2014-03-17 |
| Effects of Steroid Injection With Percutaneous Needle Aponeurotomy in Dupuytren's Contracture Triamcinolone Acetonide - Dupuytren's Contracture | Phase 3 | Completed | Sunnybrook Health Sciences Centre | 51 | 2007-11-01 | 2013-12-13 |
| Evaluation of the Efficiency of Autologous Platelet Gel (Platelet Rich Fibrin) Obtained From Own Patients' Blood Versus Vaselitulle in Dupuytren's Disease Postoperative Wound Healing Autologous platelets gel, Vaselitulle - Dupuytren's Contracture | Phase 2 / Phase 3 | Completed | Centre Hospitalier Universitaire de Nice | 80 | 2007-08-01 | 2012-03-20 |
| AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Dupuytren's Contracture collagenase clostridium histolyticum, Placebo - Dupuytren's Contracture | Phase 3 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 308 | 2007-08-01 | 2017-12-02 |
| Collagenase in the Treatment of Dupuytrens Disease collagenase clostridium histolyticum - Dupuytren's Disease | Phase 3 | Completed | Stony Brook University | 38 | 2003-06-01 | 2010-12-09 |
| Phase III Randomized Study of Collagenase in Patients With Residual Stage Dupuytren's Disease collagenase - Dupuytren's Contracture | Phase 3 | Completed | State University of New York | 72 | 2015-03-25 |
Dupuytren Contracture (13) · Fibromatosis, Plantar (3) · Arthritis (1) · Connective Tissue Diseases (1) · Pain (1) · Rare Diseases (1)
Fibroma (16) · Muscular Diseases (16) · Musculoskeletal Diseases (16) · Neoplasms (16) · Neoplasms by Histologic Type (16) · Neoplasms, Connective Tissue (16) · Neoplasms, Connective and Soft Tissue (16) · Neoplasms, Fibrous Tissue (16) · Skin and Connective Tissue Diseases (16) · Connective Tissue Diseases (15) · Foot Diseases (3) · Skin Diseases (3) · Joint Diseases (2) · Pathological Conditions, Signs and Symptoms (2)
Microbial Collagenase (7) · xiapex (4) · Collagenases (2) · Radiotherapy (2) · Enzymes (1) · Triamcinolone Acetonide (1)
Endo USA Inc., a Keenova Therapeutics Company (5) · Asahi Kasei Therapeutics Corporation (1) · Centre Hospitalier Universitaire de Nice (1) · Foundation for Orthopaedic Research and Education (1) · McMaster University (1) · Pfizer (1) · State University of New York (1) · Stony Brook University (1) · Sunnybrook Health Sciences Centre (1) · University Medical Center Groningen (1) · University of Alberta (1) · Yale University (1)
United States (8) · Canada (3) · France (2) · Australia (1) · Denmark (1) · Germany (1) · Hungary (1) · Italy (1) · Japan (1) · Netherlands (1) · Puerto Rico (1) · Spain (1) · Sweden (1) · United Kingdom (1)
Veronica Urdaneta, MD, MPPH (2) · Achilleas Thoma, MD MSc FRCSC (1) · Bruce McGibbon, MD (1) · Frank D Buono, PhD (1) · Jason Nydick, DO (1) · Lawrence C Hurst, MD (1) · Lawrence C. Hurst (1) · Louis Ortega (1) · Michael Morhart, MD MSc (1) · Nina Green (1) · Paul A. Binhammer, MD,MSc (1) · Veronica Urdaneta, MD (1)
PMID 19726771, PMID 21967070, PMID 23190833, PMID 24470559, PMID 27313184