1 completed, 1 enrolling by invitation, 1 recruiting. 3 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 1, Enrolling by invitation 1, Recruiting 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow Contracture: new trials by email Literature Review of Contracture trials Research Report on Contracture
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Repurposing 5-Azacytidine for the Treatment of Muscle Contractures in Children With Cerebral Palsy Placebo for the AZA 10mg/m^2, Placebo for the AZA 20mg/m^2, Placebo for the AZA 35mg/m^2 - Cerebral Palsy, Contracture | Phase 1 | Enrolling by invitation | Shirley Ryan AbilityLab | 27 | 2025-07-01 | 2025-07-03 |
| Safety and Efficacy Study of Collagenase CNT201 Injection for Treatment of Dupuytren's Contracture [Step1] CNT201 First-dose, [Step1] CNT201 Low-dose, [Step1] CNT201 Intermediate-dose - Dupuytren Contracture, Dupuytren Disease of Finger | Phase 1 / Phase 2 | Recruiting | CONNEXT | 60 | 2024-07-23 | 2026-06-12 |
| A Pharmacokinetic Study of AA4500 (XIAFLEX™, Proposed Name) in Subjects With Dupuytren's Contracture collagenase clostridium histolyticum - Dupuytren's Contracture | Phase 1 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 16 | 2007-09-01 | 2017-10-05 |
Dupuytren Contracture (2) · Cerebral Palsy (1)
Muscular Diseases (3) · Musculoskeletal Diseases (3) · Connective Tissue Diseases (2) · Fibroma (2) · Neoplasms (2) · Neoplasms by Histologic Type (2) · Neoplasms, Connective Tissue (2) · Neoplasms, Connective and Soft Tissue (2) · Neoplasms, Fibrous Tissue (2) · Skin and Connective Tissue Diseases (2) · Brain Damage, Chronic (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Joint Diseases (1)
Azacitidine (1) · Microbial Collagenase (1)
CONNEXT (1) · Endo USA Inc., a Keenova Therapeutics Company (1) · Shirley Ryan AbilityLab (1)
United States (2) · Australia (1)
Andrea Domenighetti, PhD (1) · Patrick Curran, MD (1) · Richard L. Lieber, PhD (1) · Veronica Urdaneta, MD (1)