9 completed, 2 recruiting, 1 not yet recruiting, 1 terminated. 14 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Completed 9, Recruiting 2, Not yet recruiting 1, Terminated 1, Unknown 1 |
| Phase 1 | 1 | Recruiting 1 |
| Phase 3 | 1 | Completed 1 |
Follow Contracture: new trials by email Literature Review of Contracture trials Research Report on Contracture
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NAC-REPAIR for Post-surgical Pain NAC, NAC 0mg/day (Placebo) - Carpal Tunnel Surgery, Trigger Finger Disorder | Phase 2 | Not yet recruiting | University of Arizona | 80 | 2026-10-15 | 2026-07-17 |
| Safety and Efficacy Study of Collagenase CNT201 Injection for Treatment of Dupuytren's Contracture [Step1] CNT201 First-dose, [Step1] CNT201 Low-dose, [Step1] CNT201 Intermediate-dose - Dupuytren Contracture, Dupuytren Disease of Finger | Phase 1 / Phase 2 | Recruiting | CONNEXT | 60 | 2024-07-23 | 2026-06-12 |
| Nodular Shrinking in Dupuytren Disease Vitamin E-creme (Remederm®) vs Vaseline (Placebo), Ultrasound measurement - Dupuytren's Disease | Phase 2 | Recruiting | Universitaire Ziekenhuizen KU Leuven | 80 | 2024-02-15 | 2026-05-11 |
| Efficacy, Safety, and Tolerability, of EN3835 vs Placebo in the Treatment of Plantar Fibromatosis EN3835, Placebo - Plantar Fibromatosis | Phase 2 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 176 | 2021-11-29 | 2026-03-27 |
| Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery Oxycodone Hcl 5Mg, Ibuprofen 400 mg, Acetaminophen 650 mg - Carpal Tunnel Syndrome, Dupuytren Contracture | Phase 2 | Completed | University of Southern California | 40 | 2017-04-24 | 2019-09-26 |
| Long Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of Consciousness Real soft splint (6 cm), Placebo soft splint (1 cm) - Brain Injuries, Disorder of Consciousness | Phase 2 | Completed | Géraldine Martens | 12 | 2017-01-01 | 2019-09-25 |
| Repurposing Anti-TNF for Treating Dupuytren's Disease Adalimumab, Saline - Dupuytren's Disease | Phase 2 | Completed | University of Oxford | 140 | 2016-03-02 | 2024-06-28 |
| Phase 2a Dose-Ranging Study to Evaluate Safety and Effectiveness of AA4500 in Treatment of Dupuytren's Disease Nodules Collagenase clostridium histolyticum, Placebo - Dupuytren's Disease | Phase 2 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 76 | 2014-07-01 | 2017-10-05 |
| Investigations of Mechanisms and Treatment in Post-traumatic Joint Contractures Ketotifen, Placebo - Joint Contractures | Phase 2 | Completed | University of Calgary | 152 | 2013-06-01 | 2018-03-27 |
| Pilot Study of Azficel-T for the Treatment of Restrictive Burn Scars Autologous fibroblasts, placebo sterile saline - Restrictive Burn Scars | Phase 2 | Terminated | Castle Creek Biosciences, LLC. | 5 | 2013-05-01 | 2021-10-13 |
| Early Use of Botulinum Toxin in Spasticity Post Stroke. onabotulinumtoxinA, Placebo - Stroke, Muscle Spasticity | Phase 2 | Completed | Sandwell & West Birmingham Hospitals NHS Trust | 120 | 2012-01-01 | 2014-11-18 |
| Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Intervention - ESWT Storz Duolith high energy, CONTROL SHAM-ESWT Storz Duolith [0.01mJ/mm2] - Dupuytren Contracture | Phase 2 | Unknown | Hannover Medical School | 60 | 2011-11-01 | 2011-12-02 |
| Evaluation of the Efficiency of Autologous Platelet Gel (Platelet Rich Fibrin) Obtained From Own Patients' Blood Versus Vaselitulle in Dupuytren's Disease Postoperative Wound Healing Autologous platelets gel, Vaselitulle - Dupuytren's Contracture | Phase 2 / Phase 3 | Completed | Centre Hospitalier Universitaire de Nice | 80 | 2007-08-01 | 2012-03-20 |
| Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren's Disease collagenase - Dupuytren's Contracture | Phase 2 | Completed | State University of New York | 36 | 1995-08-01 | 2015-03-25 |
Dupuytren Contracture (9) · Stroke (2) · Trigger Finger Disorder (2) · Arthritis (1) · Brain Injuries (1) · Carpal Tunnel Syndrome (1) · Central Nervous System Diseases (1) · Connective Tissue Diseases (1) · Consciousness Disorders (1) · Craniocerebral Trauma (1) · De Quervain Disease (1) · Fibromatosis, Plantar (1) · Fractures, Bone (1) · Ganglion Cysts (1)
Muscular Diseases (14) · Musculoskeletal Diseases (14) · Fibroma (10) · Neoplasms (10) · Neoplasms by Histologic Type (10) · Neoplasms, Connective Tissue (10) · Neoplasms, Connective and Soft Tissue (10) · Neoplasms, Fibrous Tissue (10) · Skin and Connective Tissue Diseases (10) · Connective Tissue Diseases (9) · Joint Diseases (6) · Pathological Conditions, Signs and Symptoms (5) · Nervous System Diseases (4) · Neurologic Manifestations (4)
Acetaminophen (1) · Adalimumab (1) · Botulinum Toxins, Type A (1) · Collagenases (1) · Ibuprofen (1) · Ketotifen (1) · Microbial Collagenase (1) · Oxycodone (1) · Sodium Chloride (1) · xiapex (1)
Endo USA Inc., a Keenova Therapeutics Company (2) · CONNEXT (1) · Castle Creek Biosciences, LLC. (1) · Centre Hospitalier Universitaire de Nice (1) · Géraldine Martens (1) · Hannover Medical School (1) · Sandwell & West Birmingham Hospitals NHS Trust (1) · State University of New York (1) · Universitaire Ziekenhuizen KU Leuven (1) · University of Arizona (1) · University of Calgary (1) · University of Oxford (1) · University of Southern California (1)
United States (6) · Australia (2) · Belgium (2) · United Kingdom (2) · Canada (1) · France (1) · Germany (1) · Netherlands (1)
Alidad Ghiassi, MD (1) · Anand D Pandyan, PhD (1) · Daniel D Lozano, MD (1) · Ilse Degreef, Prof. Dr. (1) · Jagdeep Nanchahal, PhD FRCS (1) · Karsten Knobloch, MD (1) · Kevin Hildebrand, MD (1) · Lawrence C. Hurst (1) · Luis Ortega, MD (1) · Nicolas Lejeune (1) · Peter M Vogt, MD, PhD (1) · Stephen G Sturman, MB ChB (1) · Veronica Urdaneta, MD MPH (1)
PMID 23190833, PMID 28854973, PMID 29983350, PMID 32639394, PMID 33040610, PMID 33483776, PMID 35949922, PMID 36325678, PMID 36378072
2015 (1)