4 completed, 4 not yet recruiting, 3 unknown, 2 terminated. 9 Not applicable, 2 Early Phase 1, 2 Phase 4, 1 Phase 2.
Follow Concussion Post Syndrome: new trials by email Literature Review of Concussion Post Syndrome trials Research Report on Concussion Post Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment Metoclopramide 10mg, Acetaminophen - Concussion Post Syndrome, Head Trauma Injury | Phase 4 | Not yet recruiting | Montefiore Medical Center | 200 | 2026-10-01 | 2026-10-01 |
| Effect of Vestibular Rehabilitation on Gait, Balance, and Coordination in Post Concussion Combat Athletes Vestibular Rehabilitation Program, Conventional Post-Concussion Rehabilitation - Concussion Post Syndrome, Concussion | Not applicable | Not yet recruiting | Riphah International University | 44 | 2026-07-01 | 2026-07-21 |
| Post-Concussion Sleep and Brain-heart Functions CBT-pI, Sleep Hygiene - Insomnia, Concussion Post Syndrome | Not applicable | Not yet recruiting | University of Ottawa | 70 | 2026-06-01 | 2026-06-11 |
| Female Concussion Head Cooling Brain Cooling - Concussion (Diagnosis), Concussion Post Syndrome | Not applicable | Not yet recruiting | Penn State University | 32 | 2026-01-15 | 2025-12-26 |
| Growth Hormone Deficiency in Mild Traumatic Brain Injury Growth Hormone, Placebo - Growth Hormone Treatment, Growth Hormone Deficiency | Early Phase 1 | Unknown | University of Calgary | 20 | 2023-02-01 | 2022-12-21 |
| Mindfulness Intervention in Young Adults With a Concussion History Mindfulness Exercises and Meditations - Concussion, Brain, Concussion Post Syndrome | Not applicable | Completed | University of North Carolina, Chapel Hill | 15 | 2022-07-25 | 2022-10-14 |
| Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms Hyperbaric oxygen at 1.5 ATA, Sham treatment - Persistent Post-concussive Syndrome, Concussion Post Syndrome | Phase 2 | Completed | Essentia Health | 20 | 2022-06-28 | 2026-10-15 |
| Auditory Slow Wave Enhancement After Concussion Auditory Stimulation - Concussion Post Syndrome | Not applicable | Recruiting | University Children's Hospital, Zurich | 120 | 2021-05-31 | 2024-12-09 |
| Pediatric Concussion Outcomes Nortriptyline, Placebo - Concussion Post Syndrome, Headaches Posttraumatic | Phase 4 | Terminated | Lancaster General Hospital | 8 | 2020-02-15 | 2025-09-10 |
| Impacting Children's Physical and Mental Health Through Kinesiology Support in Clinical Care Kinesiology Support - Congenital Heart Defect, Chronic Pain | Not applicable | Completed | Children's Hospital of Eastern Ontario | 111 | 2019-11-04 | 2023-08-29 |
| Blood Flow Restriction Concussion Blood Flow Restriction Training with Exercise - Concussion Post Syndrome | Not applicable | Terminated | Duke University | 4 | 2019-01-15 | 2024-11-22 |
| The Effect of Binasal Occlusion on Balance Following a Concussion Binasal occlusion, No binasal occlusion - Concussion Post Syndrome | Not applicable | Unknown | University of Ottawa | 40 | 2018-11-01 | 2018-10-31 |
| Treatment for Patients With Chronic Post-Concussion Symptoms Psychological Intervention - Mild Traumatic Brain Injury, Concussion Post Syndrome | Not applicable | Unknown | University of California, Los Angeles | 40 | 2018-06-01 | 2021-10-29 |
| A Cohort Study Evaluating the Efficacy of PO Magnesium in the Treatment of Acute Traumatic Brain Injury in Adolescents Magnesium Oxide, Acetaminophen, Zofran ODT 4 MG Disintegrating Oral Tablet - Concussion Post Syndrome | Early Phase 1 | Completed | Corewell Health South | 17 | 2017-09-01 | 2024-11-29 |
Post-Concussion Syndrome (14) · Brain Concussion (7) · Cerebral Palsy (1) · Charcot-Marie-Tooth disease, Type 1F (1) · Chronic Pain (1) · Craniocerebral Trauma (1) · Disease (1) · Dwarfism, Pituitary (1) · Headache (1) · Heart Defects, Congenital (1) · Motor Activity (1) · Neuroinflammatory Diseases (1) · Neuromuscular Diseases (1) · Post-Traumatic Headache (1) · Primary Dysautonomias (1)
Head Injuries, Closed (14) · Nervous System Diseases (14) · Trauma, Nervous System (14) · Wounds and Injuries (14) · Wounds, Nonpenetrating (14) · Craniocerebral Trauma (13) · Brain Diseases (8) · Central Nervous System Diseases (8) · Brain Concussion (7) · Brain Injuries (7) · Brain Injuries, Traumatic (7) · Pathological Conditions, Signs and Symptoms (3) · Behavior (2) · Neurologic Manifestations (2) · Pain (2)
Acetaminophen (2) · Acoustic Stimulation (1) · Blood Flow Restriction Therapy (1) · Exercise (1) · Growth Hormone (1) · Magnesium Oxide (1) · Meditation (1) · Metoclopramide (1) · Nortriptyline (1) · Ondansetron (1) · Psychosocial Intervention (1)
University of Ottawa (2) · Children's Hospital of Eastern Ontario (1) · Corewell Health South (1) · Duke University (1) · Essentia Health (1) · Lancaster General Hospital (1) · Montefiore Medical Center (1) · Penn State University (1) · Riphah International University (1) · University Children's Hospital, Zurich (1) · University of Calgary (1) · University of California, Los Angeles (1) · University of North Carolina, Chapel Hill (1)
United States (8) · Canada (1) · Pakistan (1) · Switzerland (1)
Benjamin W Friedman, MD,MS (1) · Chantel T Debert, MD, MSc (1) · Christine E Callahan, MS (1) · Christopher Trigger, MD, CAQSM (1) · Hana Alazem, MD (1) · Heidi Sveistrup, PhD (1) · Laura DiPaolo, MD (1) · Laura Pietrosimone (1) · Marc Basson, MD, PhD (1) · Marilyn Klug, PhD (1) · Olayinka D Ajayi, MD, MPH (1) · Patricia Longmuir, PhD (1) · Patrick Moreno, MD (1) · Paulina Kunecka, MD (1) · Rebecca Quinn, MSW, LMSW (1)
PMID 25723660, PMID 29734566, PMID 33879807, PMID 40756554
2025 (1)