30 completed, 27 unknown, 15 recruiting, 13 not yet recruiting. 113 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 113 | Completed 30, Unknown 27, Recruiting 15, Not yet recruiting 13, Terminated 11, Withdrawn 7, Active not recruiting 6, Enrolling by invitation 2, Suspended 2 |
Follow Colonic Diseases: new trials by email Literature Review of Colonic Diseases trials Research Report on Colonic Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Aeromonas sp. MTB Phage Therapy for Pouchitis in Patients With Ulcerative Colitis (UC) MTB-targeted phage therapy - Pouchitis, UC - Ulcerative Colitis | Early Phase 1 | Not yet recruiting | Jinling Hospital, China | 12 | 2027-01-01 | 2026-10-22 |
| GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer GLP1-RA (semaglutide) - Pancreatic Cancer, Colorectal Cancer | Early Phase 1 | Recruiting | University of Arizona | 30 | 2026-10-10 | 2026-09-18 |
| Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer [64Cu]CM500, [68Ga]CM500, PET/MR - Bladder Cancer, Glioma | Early Phase 1 | Not yet recruiting | Lumina Pharmaceuticals Inc | 40 | 2026-09-01 | 2026-08-28 |
| VIBRANT-IBD: Brain Effects of Non-Invasive Vagus Nerve Stimulation in IBD Remission Non-invasive vagus nerve stimulation (nVNS) - Inflammatory Bowel Diseases (IBD), Remission of IBD | Early Phase 1 | Enrolling by invitation | University of Gdansk | 15 | 2026-08-07 | 2026-08-11 |
| Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS) Psilocybin 25 mg, Psychotherapy Treatment Session, Niacin 100 mg - IBS - Irritable Bowel Syndrome | Early Phase 1 | Not yet recruiting | NYU Langone Health | 10 | 2026-08-01 | 2026-03-05 |
| ND-12 Combined With H-6 for Adult Chronic Inflammatory Diarrhea mesalazine, ND-12, ND-12/H-6 - Diarrhea Chronic, UC - Ulcerative Colitis | Early Phase 1 | Recruiting | The Second Hospital of Nanjing Medical University | 36 | 2026-07-20 | 2026-08-17 |
| Botensilimab, Balstilimab, and SBRT in Colorectal Cancer Stereotactic Body Radiation Therapy (SBRT), Botensilimab, Balstilimab - Non-MSI-H or pMMR Colorectal Cancer With Liver Metastasis | Early Phase 1 | Recruiting | Massachusetts General Hospital | 15 | 2026-05-12 | 2026-05-13 |
| A Preliminary Efficacy of SNA028 in Patients With Advanced Colorectal Cancer Positive for GPA33 GPA33-CC；177Lu-SmartD2 - Colorectal Cancer | Early Phase 1 | Not yet recruiting | SmartNuclide Biopharma | 20 | 2026-05-01 | 2026-05-15 |
| ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer SOC (Standard of care), Bevacizumab, Cetuximab - Dynamic Tumor Resistance, Metastatic Colorectal Cancer | Early Phase 1 | Recruiting | M.D. Anderson Cancer Center | 100 | 2026-04-22 | 2026-10-14 |
| An Open-label, Single-arm Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Profile, and Preliminary Efficacy of KT032 Cell Injection in Patients With Mesothelin-positive Advanced Solid Tumors. KT032(anti-MSLN chimeric antigen receptor autologous T cell injection) - Ovarian Cancer, Mesothelioma | Early Phase 1 | Not yet recruiting | Weijia Fang, MD | 24 | 2026-03-15 | 2026-02-19 |
| COLONYVAQ™, a Quantum-Classical Guided Personalized Neoantigen Vaccine for MSS Stage III Colorectal Cancer Experimental: COLONYVAQ-CRC + mFOLFOX6 or CAPOX + Nivolumab - Colorectal Cancer Metastatic, Colorectal Cancer Stage III | Early Phase 1 | Recruiting | Biogenea Pharmaceuticals Ltd. | 12 | 2026-02-02 | 2026-01-09 |
| A Study of Cizutamig for Patients With Ulcerative Colitis cizutamig - Ulcerative Colitis (UC) | Early Phase 1 | Not yet recruiting | Ruijin Hospital | 15 | 2026-01-01 | 2026-01-20 |
| Use of A Complex Gut Bacterial Consortium (MITI 001) for the Treatment of Irritable Bowel Syndrome With Diarrhea MITI-001 administration - IBS (Irritable Bowel Syndrome), Diarrhea | Early Phase 1 | Not yet recruiting | Stanford University | 13 | 2025-12-01 | 2025-11-20 |
| Efficacy and Safety Study of DC-CIK Cell Therapy Combined With Epaloliposide, Vortexil, and Regorafenib as Third-line Treatment for Advanced Colorectal Cancer. DC-CIK combined with regorafenib ,Iparomlimab and Tuvonralimab Injection - DC-CIK Treatment, Regorafenib | Early Phase 1 | Recruiting | JIANG LONGWEI | 14 | 2025-11-19 | 2026-01-15 |
| Phase IIT Trial of SNA009 68Ga-NODAGA-SNA009 - Colorectal Cancer, GPA33 | Early Phase 1 | Completed | SmartNuclide Biopharma | 12 | 2025-10-30 | 2026-05-19 |
| Safety and Efficacy of NK510 to Treat Gastric Cancer and Colorectal Cancer NK510 - Gastric Cancer (GC), Colorectal Cancer | Early Phase 1 | Recruiting | Base Therapeutics (Shanghai) Co., Ltd. | 15 | 2025-10-16 | 2026-10-01 |
| Neuroprotective Potential of Cannabidiol (CBD) in Preventing Oxaliplatin (Ox)-Induced Neuropathy Cannabidiol (CBD), oxaliplatin-based chemotherapy - Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients, Metastatic Colorectal Cancer (CRC) | Early Phase 1 | Recruiting | Fox Chase Cancer Center | 30 | 2025-10-14 | 2026-10-29 |
| A Dose-Expansion Trial of Intravenous HNF4α srRNA for Unresectable or Metastatic Colorectal Cancer CD-GA-102 - Colorectal Cancer Metastatic, Colorectal Cancer Recurrent | Early Phase 1 | Recruiting | Shanghai Changzheng Hospital | 20 | 2025-06-10 | 2025-07-03 |
| hucMSCs Exosomes for the Treatment of Active Ulcerative Colitis exosomes derived from human umbilical cord mesenchymal stem cells, saline +5% albumin - Ulcerative Colitis (UC) | Early Phase 1 | Not yet recruiting | Shanghai East Hospital | 40 | 2025-05-30 | 2025-04-27 |
| Autologous CAR-T Cells (WD-01) for Metastatic Colorectal Cancer An armored GCC targeting WD-01 CAR-T to treat cancer patients Other Name: - CRC (Colorectal Cancer), Metastatic Colorectal Cancer | Early Phase 1 | Suspended | Wondercel Biotech (ShenZhen) | 30 | 2025-05-18 | 2026-05-07 |
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Colorectal Neoplasms (56) · Colonic Neoplasms (26) · Colitis, Ulcerative (19) · Breast Neoplasms (16) · Pancreatic Neoplasms (13) · Lung Neoplasms (11) · Ovarian Neoplasms (9) · Stomach Neoplasms (9) · Rectal Neoplasms (7) · Sarcoma (7) · Inflammatory Bowel Diseases (6) · Prostatic Neoplasms (6) · Carcinoma, Non-Small-Cell Lung (5) · Irritable Bowel Syndrome (5) · Neoplasms (5)
Digestive System Diseases (113) · Gastrointestinal Diseases (113) · Intestinal Diseases (113) · Intestinal Neoplasms (83) · Neoplasms by Site (83) · Digestive System Neoplasms (82) · Gastrointestinal Neoplasms (80) · Neoplasms (78) · Rectal Diseases (63) · Colorectal Neoplasms (27) · Gastroenteritis (23) · Colitis (20) · Endocrine Gland Neoplasms (18) · Endocrine System Diseases (18)
Magnetic Resonance Spectroscopy (4) · Blood Specimen Collection (3) · Cetuximab (3) · Fecal Microbiota Transplantation (3) · Fluorouracil (3) · Glycopyrrolate (3) · Aspirin (2) · Bevacizumab (2) · Biopsy (2) · Cannabidiol (2) · Cholecalciferol (2) · Folfox protocol (2) · Iontophoresis (2) · Leucovorin (2) · Mesalamine (2)
Mayo Clinic (5) · James J. Peters Veterans Affairs Medical Center (3) · National Cancer Institute (NCI) (3) · Tanta University (3) · Fox Chase Cancer Center (2) · Massachusetts General Hospital (2) · McMaster University (2) · National Institute of Medical Sciences and Nutrition, Salvador Zubiran (2) · Peking Union Medical College Hospital (2) · Roswell Park Cancer Institute (2) · Ruijin Hospital (2) · Second Affiliated Hospital of Wenzhou Medical University (2) · Shanghai Changzheng Hospital (2) · Shanghai Yunying Medical Technology (2) · SmartNuclide Biopharma (2)
United States (48) · China (28) · France (4) · United Kingdom (3) · Canada (2) · Egypt (2) · Mexico (2) · Netherlands (2) · Poland (2) · Greece (1) · Iraq (1) · Ireland (1) · Italy (1) · Jamaica (1) · Romania (1)
Christopher P Cardozo, MD (2) · Zhaohui Zhu (2) · Aaron J Scott, MD (1) · Adam H Buchanan, MS, MPH, CGC (1) · Alexandru Alexa, Assist Prof (1) · Andrew T Chan, MD, MPH (1) · Anupama Chawla, MD (1) · Anuradha Krishnamurthy, MBBS (1) · Aparna R. Parikh, MD (1) · Ari Grinspan, MD (1) · Arjun Gupta, MD (1) · Ashish Patel, MD (1) · Benjamin Phillips, MD (1) · Brian E Lacy, MD (1) · Charles M. Friel, MD (1)
PMID 10786614, PMID 11773501, PMID 12167685, PMID 12220494, PMID 12677098, PMID 12739326, PMID 12851164, PMID 15958805, PMID 17197840, PMID 17255260, PMID 17262812, PMID 17416034, PMID 17499606, PMID 18338782, PMID 19057395, PMID 20016696, PMID 20423763, PMID 20518581, PMID 21047794, PMID 21618351, PMID 21654383, PMID 22941427, PMID 25209657, PMID 25633465, PMID 27139220, PMID 27496381, PMID 28275113, PMID 28615929, PMID 28626380, PMID 29385143, PMID 30243583, PMID 30342719, PMID 30498390, PMID 3117625, PMID 31579027, PMID 32414353, PMID 32801008, PMID 34115764, PMID 34238227, PMID 35303929, PMID 36512649, PMID 36748942, PMID 37244790, PMID 37302449, PMID 37344887, PMID 38582094, PMID 38926162, PMID 38970713, PMID 39708822, PMID 40135850
P30CA068485 (2), 2025 (1), K01DK120742 (1), P30CA006973 (1), P30CA014089 (1), P30CA033572 (1), P30CA093373 (1), P50CA127003 (1), R01CA154982 (1), R01CA243454 (1), R01CA257523 (1), R01HG009671 (1), R21CA260447 (1), R21CA292276 (1), R35CA253185 (1)