29 completed, 12 recruiting, 8 unknown, 5 not yet recruiting. 38 Not applicable, 4 Phase 2, 3 Early Phase 1, 2 Phase 1, 1 Phase 4.
Follow Cognitive Impairment, Mild: new trials by email Literature Review of Cognitive Impairment, Mild trials Research Report on Cognitive Impairment, Mild
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cholinergic Enhancement of Theta COBENFY KarXT (50/20 mg), Control - Epilepsy, Seizures | Early Phase 1 | Not yet recruiting | University of Texas Southwestern Medical Center | 50 | 2026-12-01 | 2026-09-29 |
| Cognitive Assessment And Post-Operative Complications After Surgery: Linking Anaesthesia And Risk Montreal Cognitive Assessment, biomarkers - Cognitive Impairment, Cognitive Impairment, Mild | Not yet recruiting | University of Edinburgh | 40 | 2026-11-01 | 2026-09-24 | |
| [11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection Fraction [11C]PS13: [carbon-11]PS13; COX-1 PET radioligand, Sacubitril-Valsartan - Heart Failure With Reduced Ejection Fraction, Cognitive Impairment, Mild | Phase 1 | Not yet recruiting | Stony Brook University | 18 | 2026-10-01 | 2026-10-02 |
| Comparative Evaluation of Immediate vs Progressive Standing Dual Task Training in Elderly With Mild and Moderate Cognitive Impairment Immediate standing dual task training, progressive standing dual task training - Cognitive Impairment, Cognitive Impairment, Mild | Not applicable | Recruiting | Shifa Tameer-e-Millat University | 96 | 2026-06-25 | 2026-09-01 |
| Cognitive Care Bundle for Ischaemic Stroke : A Pilot Randomised Controlled Trial Cognitive care bundle, Standard Medical Care (SMC) - Ischaemic Stroke, Cognitive Impairment, Mild | Not applicable | Not yet recruiting | National University of Malaysia | 50 | 2026-06-01 | 2026-07-13 |
| How Video Game Therapy Affects Thinking and Emotions in Older Adults With Cognitive Impairment Videogames masterclass, Therapy with videogames - Older Adults (65 Years and Older), Cognitive Impairment, Mild | Not applicable | Completed | Golden Gamers Go SL | 60 | 2026-04-13 | 2026-09-14 |
| Low-intensity Hippocampal Transcranial Ultrasound Stimulation for Managing Cognitive and Sleep Dysfunction in Preclinical Alzheimer's Disease Low-intensity transcranial ultrasound stimulation, Sham low-intensity transcranial ultrasound stimulation - Sleep Disturbances, Aging | Not applicable | Enrolling by invitation | Chinese University of Hong Kong | 20 | 2026-04-01 | 2025-12-23 |
| Depressive Symptoms, Cognitive Impairment, and Outcomes in Hospitalized Chronic Heart Failure Patients Congestive Heart Failure Chronic, Cognitive Impairment, Mild | Recruiting | Lithuanian University of Health Sciences | 300 | 2025-12-02 | 2025-12-16 | |
| Tau PET Outcomes With Anti-amyloid Immunotherapies 18F-AV-1451 - Cognitive Impairment, Mild, Dementia, Mild | Phase 2 | Enrolling by invitation | Mayo Clinic | 135 | 2025-11-04 | 2025-11-18 |
| Dance Intervention to Improve Executive Function and Physical Performance in Older Adults With Cognitive Impairment Music-based dance, Control - Older Adults, Cognitive Impairment, Mild | Not applicable | Recruiting | Taipei Medical University Shuang Ho Hospital | 50 | 2025-11-01 | 2026-04-28 |
| Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive Disorders Neurocognitive Disorders, Mild, Cognitive Impairment, Mild | Recruiting | KompanionCare SAS | 80 | 2025-10-14 | 2026-03-09 | |
| Repurposing Siponimod for Alzheimer's Disease Siponimod, Placebo - Alzheimer Disease, Mild Alzheimer Disease | Phase 2 | Recruiting | St. Joseph's Hospital and Medical Center, Phoenix | 105 | 2025-08-26 | 2026-03-04 |
| Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease Coronary Heart Disease, Cognitive Impairment, Mild | Recruiting | Beijing Anzhen Hospital | 2352 | 2025-06-30 | 2026-07-15 | |
| ENACT Program on Auditory Perception and Function, Cognitive Function and Health-related Quality of Life Empowerment Network for Auditory-Cognitive Training (ENACT) Program, Usual Care - Hearing Loss, Cognitive Impairment, Mild | Not applicable | Recruiting | The University of Hong Kong | 62 | 2025-06-04 | 2025-12-03 |
| MCLENA-2: A Phase II Clinical Trial for the Assessment of Lenalidomide in Patients With Mild Cognitive Impairment Lenalidomide 10 mg - Cognitive Impairment, Mild, Cognitive Dysfunction | Phase 2 | Not yet recruiting | St. Joseph's Hospital and Medical Center, Phoenix | 45 | 2025-06-01 | 2025-05-18 |
| Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment Phase-locked auditory stimulation (PLAS), Sham Phase-Locked Auditory Stimulation - Cognitive Decline, Alzheimer Disease | Not applicable | Recruiting | University of Bern | 60 | 2025-02-21 | 2026-04-03 |
| Buddy-Up Dyadic Physical Activity Program for Persons With Dementia and Family Caregivers Buddy-Up Dyadic Physical Activity (BUDPA) program, Usual care with waitlist control - Cognitive Impairment, Mild, Dementia, Mild | Not applicable | Recruiting | The University of Hong Kong | 236 | 2024-10-01 | 2026-04-06 |
| Anticipating Decline and Providing Therapy Usual Care post-Intensive Care Unit (ICU), Anticipating Decline and Providing Therapy (ADAPT) - Cognitive Impairment, Dementia | Not applicable | Active not recruiting | Wake Forest University Health Sciences | 109 | 2024-03-08 | 2026-08-05 |
| Repeated Transcranial Magnetic Stimulation in the Elderly With Cognitive Impairment High-frequency repetitive transcranial magnetic stimulation (40Hz), Moderately high-frequency repetitive transcranial magnetic stimulation (10Hz) - Dementia, Cognitive Impairment, Mild | Not applicable | Completed | Taipei Hospital, Ministry of Health and Welfare | 18 | 2023-07-26 | 2024-11-21 |
| Effects of Training Dose on Computerized Cognitive Training in Patients With Cognitive Impairment Computerized cognitive training with different training doses - Cognitive Impairment, Mild, Dementia | Completed | Xuanwu Hospital, Beijing | 21845 | 2023-07-01 | 2024-05-21 |
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Cognitive Dysfunction (60) · Dementia (17) · Alzheimer Disease (13) · Lymphoma, Follicular (10) · Memory Disorders (4) · Cognition Disorders (3) · Encephalitis (3) · Heart Failure (3) · Epilepsy (2) · Hearing Loss (2) · Neurobehavioral Manifestations (2) · Neurocognitive Disorders (2) · Parasomnias (2) · Plaque, Amyloid (2) · Seizures (2)
Mental Disorders (59) · Neurocognitive Disorders (58) · Cognition Disorders (57) · Nervous System Diseases (34) · Brain Diseases (28) · Central Nervous System Diseases (28) · Neurodegenerative Diseases (15) · Pathological Conditions, Signs and Symptoms (14) · Tauopathies (13) · Neoplasms (11) · Hemic and Lymphatic Diseases (10) · Immune System Diseases (10) · Immunoproliferative Disorders (10) · Lymphatic Diseases (10) · Lymphoma (10)
Exercise (2) · Lenalidomide (2) · 11C-PS13 (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Acoustic Stimulation (1) · Andrographis paniculata extract (1) · Atorvastatin (1) · Cognitive Training (1) · Dosage Forms (1) · Electric Countershock (1) · Environmental Biomarkers (1) · Low-Level Light Therapy (1) · Mental Status and Dementia Tests (1) · Methods (1) · Paper (1)
St. Joseph's Hospital and Medical Center, Phoenix (3) · Chinese University of Hong Kong (2) · Cognito Therapeutics, Inc. (2) · The University of Hong Kong (2) · University of Texas Southwestern Medical Center (2) · Andreas Monsch (1) · Baycrest (1) · Baylor College of Medicine (1) · Baylor University (1) · Beijing Anzhen Hospital (1) · Brain In Game scientific-technical service (1) · Bright Cloud International Corp (1) · Cairo University (1) · David Brunk, PA-C, MMS (1) · Duke University (1)
United States (26) · Hong Kong (5) · China (3) · Spain (3) · Taiwan (3) · Denmark (2) · France (2) · Sweden (2) · Switzerland (2) · United Kingdom (2) · Belgium (1) · Canada (1) · Czechia (1) · Egypt (1) · Germany (1)
Boris Decourt, PhD (2) · Bradley C Lega, MD (2) · Alessandra Thomann, MSc (1) · Andreas Monsch, PhD (1) · Anja Maier, Ph.D. (1) · Brian Levine, PhD (1) · Bulent Elbasan, Proffessor (1) · David R Brunk, PA-C, MMS (1) · Deborah Barnes, PhD (1) · Ebtesam Nabil, doctoral (1)
PMID 20719820, PMID 22169081, PMID 27455923, PMID 28481814, PMID 28840742, PMID 30684403, PMID 31228177, PMID 31868666, PMID 32442136, PMID 33469351, PMID 33589714, PMID 34491113, PMID 34583593, PMID 34630050, PMID 34630733, PMID 35065656, PMID 35264340, PMID 35351783, PMID 35524188, PMID 36413436, PMID 36530084, PMID 36642072, PMID 37082807, PMID 37243355, PMID 37540692, PMID 37875856, PMID 38515445, PMID 39804128, PMID 39805990, PMID 39824702, PMID 40082316, PMID 40394335, PMID 42172614, PMID 42497412
2016 (1), K01AG047279 (1), K23AG073529 (1), K23DC016656 (1), KL2TR002370 (1), P30AG064103 (1), R01AG059008 (1), R01AG073212 (1), R01HD059205 (1), R01NS125250 (1), R21AG053161 (1), R21AG102953 (1), R43CA232936 (1), R44AG074727 (1), T32CA102618 (1)