434 completed, 169 unknown, 141 recruiting, 51 not yet recruiting. 513 Not applicable, 68 Phase 2, 27 Phase 3, 27 Phase 4, 21 Phase 1.
Follow Cognitive Impairment: new trials by email Literature Review of Cognitive Impairment trials Research Report on Cognitive Impairment
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fall Prevention in Mild Cognitive Impairment Virtual Neurophysiological Rehabilitation - Cognitive Impairment, High Fall Risk | Not applicable | Not yet recruiting | VA Office of Research and Development | 28 | 2027-06-01 | 2026-04-09 |
| Dyadic Cognitive Intervention for Older Adults With Cognitive Impairment and Their Spouses Dyadic Cognitive Intervention Program for Older Couples, Standard Community Health Education on Cognitive Impairment - Cognitive Impairment | Not applicable | Not yet recruiting | Gansu University of Chinese Medicine | 136 | 2027-06-01 | 2026-10-13 |
| Auditory-Cognitive Optimization Care Program for Older Adults With Hearing Loss and Cognitive Impairment Auditory-Cognitive Optimization Care Program (A-COP), Hearing Management and Newspaper-Reading Activities - Hearing Loss, Cognitive Impairment | Not applicable | Not yet recruiting | Taipei Medical University | 76 | 2027-02-01 | 2026-10-13 |
| A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia Xanomeline/trospium - Schizophrenia; Psychosis, Cognitive Impairment | Phase 3 | Not yet recruiting | European Group for Research In Schizophrenia | 171 | 2027-01-01 | 2026-05-13 |
| Synbiotic LA-5 and Agave Inulin for Mild Cognitive Impairment Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin) Intervention Type: - Cognitive Impairment | Not applicable | Recruiting | Anahuac University | 20 | 2026-12-31 | 2026-09-14 |
| International Study of Comparative Health Effectiveness With Medical and Invasive Approaches-Left Ventricular Dysfunction Trial Guideline-directed medical therapy (GDMT), Coronary artery bypass grafting (CABG), Percutaneous coronary intervention (PCI). - Coronary Artery Disease, Cognitive Impairment | Phase 3 | Suspended | NYU Langone Health | 1200 | 2026-12-01 | 2026-06-05 |
| Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance Cannabis - Cannabis Use, Impaired Driving | Phase 1 | Not yet recruiting | Johns Hopkins University | 40 | 2026-12-01 | 2026-10-16 |
| Minocycline In Neurocognitive Outcomes - Sickle Cell Disease Minocycline, Placebo - Sickle Cell Disease, Cognitive Impairment | Phase 1 | Not yet recruiting | University of Cincinnati | 30 | 2026-12-01 | 2026-05-14 |
| NEURO-COGS: Neurometabolic Mechanisms of Cognitive Training in Schizophrenia Perceptual Discrimination Training, Cognitive Control Training - Schizophrenia, Schizoaffective Disorder | Not applicable | Not yet recruiting | University of Minnesota | 168 | 2026-11-02 | 2026-10-02 |
| Negotiation Training for Family Caregivers of People With Alzheimer's Disease NegotiAge, PlanYourLifespan - Alzheimer's Disease (AD), Dementia | Not applicable | Not yet recruiting | Northwestern University | 200 | 2026-11-01 | 2026-10-05 |
| Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description - Dementia (Diagnosis), Alzheimer Dementia (AD) | Not yet recruiting | Zealand University Hospital | 440 | 2026-11-01 | 2026-09-02 | |
| Cognitive Assessment And Post-Operative Complications After Surgery: Linking Anaesthesia And Risk Montreal Cognitive Assessment, biomarkers - Cognitive Impairment, Cognitive Impairment, Mild | Not yet recruiting | University of Edinburgh | 40 | 2026-11-01 | 2026-09-24 | |
| Robot-Assisted Meditation for Older Adults With Cognitive Concerns Robot-Guided Meditation, Audio-Only Robot - Cognitive Impairment, Perceived Stress | Not applicable | Not yet recruiting | Johns Hopkins University | 100 | 2026-11-01 | 2026-08-31 |
| The Care for America's Aging Study Enhanced home health aide training in dementia and dementia-related behaviors - Cognitive Impairment, Dementia With Behavioral Disturbance | Not applicable | Not yet recruiting | Massachusetts General Hospital | 120 | 2026-10-01 | 2026-07-06 |
| Beta-1 Band Functional Connectivity Mediates the Effects of Acute Exercise on Cognitive Flexibility in Older Adults With Cognitive Impairment: A Randomized Controlled Trial Baduanjin, Brisk walking, Resistance band - Cognitive Impairment, Cognitive Flexibility | Not applicable | Not yet recruiting | Shanghai University of Sport | 60 | 2026-10-01 | 2026-10-02 |
| Cognitive Impairment in Older Adults With Hematologic Malignancies Cognitive Impairment, Hematologic Malignancies | Not yet recruiting | Assiut University | 120 | 2026-09-26 | 2026-09-28 | |
| Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter Trial Rosuvastatin, Ezetimibe, Recaticimab - Intracranial Arteriosclerosis, Cognitive Impairment | Phase 4 | Not yet recruiting | Peking Union Medical College Hospital | 440 | 2026-09-17 | 2026-09-15 |
| Immersive Virtual Reality for Older Adults in Long-Term Care Settings Adapted Virtual Reality Mindfulness Meditation Program, Usual Care - Cognitive Impairment, Long-term Care Centres for Old Adults Users | Not applicable | Recruiting | Laval University | 24 | 2026-09-14 | 2026-09-10 |
| Endovascular Treatment for Symptomatic Non-acute Carotid Occlusion Guideline-Based Best Medical Treatment, Endovascular Recanalization With Proximal Balloon Protection, Endovascular Recanalization Without Proximal Protection - Non-acute Carotid Artery Occlusion, Cognitive Impairment | Not applicable | Not yet recruiting | Dapeng Mo | 180 | 2026-09-01 | 2026-09-03 |
| PICS-p Longitudinal Cohort Study Physical Functional Impairment, Cognitive Impairment | Not yet recruiting | Children's Hospital of Fudan University | 200 | 2026-09-01 | 2026-10-15 |
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PMID 18686756, PMID 25459243, PMID 28601132, PMID 32905623, PMID 33189147, PMID 35349186, PMID 36398903, PMID 37290122, PMID 37819663, PMID 38775299, PMID 10404935, PMID 10406981, PMID 10990547, PMID 11328886, PMID 11861697, PMID 1202204, PMID 12558716, PMID 12823087, PMID 15006652, PMID 15324367, PMID 15999258, PMID 16045502, PMID 16300724, PMID 16322379, PMID 16879891, PMID 16981607, PMID 17027061, PMID 17030755, PMID 17086909, PMID 17088170, PMID 17329432, PMID 1734182, PMID 17364516, PMID 17452283, PMID 17552026, PMID 17577852, PMID 17956625, PMID 18212180, PMID 18296124, PMID 18443554, PMID 18779287, PMID 18845654, PMID 18929686, PMID 18940639, PMID 19117659, PMID 19170163, PMID 19515734, PMID 19584889, PMID 19617584, PMID 19809365
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