7 completed, 3 recruiting, 2 unknown. 12 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 12 | Completed 7, Recruiting 3, Unknown 2 |
Follow Chronobiology Disorders: new trials by email Literature Review of Chronobiology Disorders trials Research Report on Chronobiology Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Melatonin Agonist for Shift-time Workers. Ramelteon - Circadian Rhythm Disorders | Phase 4 | Completed | Tri-Service General Hospital (TSGH) | 61 | 2024-03-04 | 2026-02-03 |
| Lemborexant in Delayed Sleep Phase Syndrome Lemborexant, Placebo - Delayed Sleep Phase Syndrome | Phase 4 | Recruiting | University of California, San Francisco | 15 | 2023-03-13 | 2026-06-05 |
| Feasibility Study on the Use of Redormin®500 on Day-time Cognition Valerian-Hop Extract, Placebo - Sleep Disorders, Circadian Rhythm, Cognitive Dysfunction | Phase 4 | Completed | Max Zeller Soehne AG | 40 | 2023-03-01 | 2026-06-11 |
| The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional) Blue light exposure + Melatonin treatment, Melatonin treatment, Blue light exposure - Ischemic Stroke, Acute, Sleep Disorders, Circadian Rhythm | Phase 4 | Recruiting | Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health | 80 | 2022-03-01 | 2025-08-08 |
| Lemborexant in Delayed Sleep Phase Syndrome Lemborexant, Placebo - Delayed Sleep Phase Syndrome | Phase 4 | Recruiting | Stanford University | 86 | 2022-02-01 | 2026-10-26 |
| the Efficacy and Safety of Agomelatine in the Patients With Parkinson's Disease Agomelatine or PIacebo - Parkinson Disease, Depression | Phase 4 | Unknown | Second Affiliated Hospital of Soochow University | 240 | 2019-07-01 | 2019-06-06 |
| Are Patients Suffering From DSPS Show Compromising in Everyday Functions and Abilities Before Handling the Disorder? Melatonin and light therapy - Delayed Sleep Phase Syndrome | Phase 4 | Unknown | Lilach Kemer | 20 | 2016-11-01 | 2016-11-11 |
| Examination of the Effectiveness of Suvorexant in Improving Daytime Sleep in Shift Workers Suvorexant, Placebo - Sleep Disorder, Shift-Work | Phase 4 | Completed | VA Palo Alto Health Care System | 19 | 2016-02-01 | 2020-07-01 |
| Assessments in Stress and Quality of Sleep/Life in Night-shift Nurses and Doctors massage - Shift-Work Sleep Disorder | Phase 4 | Completed | Taichung Veterans General Hospital | 77 | 2014-06-01 | 2016-07-12 |
| Open Label Study to Assess the Absolute Bioavailability of Tasimelteon (HETLIOZ™) tasimelteon 20 mg capsule, tasimelteon 2 mg I.V. - Non-24-Hour-Sleep-Wake Disorder | Phase 4 | Completed | Vanda Pharmaceuticals | 14 | 2014-05-01 | 2016-08-22 |
| Randomized Controlled Trial on the Treatment Effects of Melatonin and Light Therapy on Delayed Sleep Phase Syndrome Melatonin, Bright light, Placebo red light - Delayed Sleep Phase Syndrome | Phase 4 | Completed | University of Bergen | 40 | 2008-10-01 | 2016-03-14 |
| Efficacy of Ramelteon on Insomnia Symptoms Associated With Jet Lag in Healthy Adult Volunteers Ramelteon, Placebo - Circadian Dysregulation | Phase 4 | Completed | Takeda | 110 | 2007-02-01 | 2012-02-28 |
Sleep Disorders, Circadian Rhythm (9) · Cognitive Dysfunction (1) · Depression (1) · Ischemic Stroke (1) · Jet Lag Syndrome (1) · Parkinson Disease (1) · Sleep Wake Disorders (1) · Syndrome (1)
Nervous System Diseases (12) · Mental Disorders (11) · Dyssomnias (10) · Sleep Wake Disorders (10) · Occupational Diseases (9) · Pathological Conditions, Signs and Symptoms (3) · Brain Diseases (2) · Central Nervous System Diseases (2) · Signs and Symptoms (2) · Basal Ganglia Diseases (1) · Behavior (1) · Behavioral Symptoms (1) · Cardiovascular Diseases (1) · Cerebrovascular Disorders (1)
Melatonin (2) · lemborexant (2) · ramelteon (2) · Hova (1) · Massage (1) · Phototherapy (1) · Pramipexole (1) · agomelatine (1) · suvorexant (1) · tasimelteon (1)
Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health (1) · Lilach Kemer (1) · Max Zeller Soehne AG (1) · Second Affiliated Hospital of Soochow University (1) · Stanford University (1) · Taichung Veterans General Hospital (1) · Takeda (1) · Tri-Service General Hospital (TSGH) (1) · University of Bergen (1) · University of California, San Francisco (1) · VA Palo Alto Health Care System (1) · Vanda Pharmaceuticals (1)
United States (4) · Taiwan (2) · Norway (1) · Russia (1) · Switzerland (1)
Andrew D Krystal, MD, MS (2) · Chin-Bin Yeh, M.D., Ph.D. (1) · Christiane Gerhards (1) · Chun-Feng Liu, MD (1) · Emmanuel Mignot, MD, PhD (1) · Lyudmila Korostovtseva (1) · Wayne HH Sheu, MD, PhD (1)
PMID 18052566, PMID 18583104, PMID 18673165, PMID 20483660, PMID 24132057, PMID 24144243, PMID 32484552, PMID 40462685