9 completed, 2 terminated, 1 recruiting. 12 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 9, Terminated 2, Recruiting 1 |
| Phase 3 | 1 | Completed 1 |
Follow Chronobiology Disorders: new trials by email Literature Review of Chronobiology Disorders trials Research Report on Chronobiology Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder Melatonin, Placebo, Behavioral sleep intervention - Bipolar Disorder, Delayed Sleep-Wake Phase Disorder | Phase 2 | Recruiting | Leslie Swanson | 50 | 2024-08-13 | 2026-05-11 |
| The Effects of Lemborexant on the Ability to Sleep During Daytime Lemborexant 5 MG [Dayvigo], Matching Placebo - Shift-Work Sleep Disorder | Phase 2 | Terminated | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 5 | 2024-01-11 | 2026-05-28 |
| A Study to Assess the Wakefulness Promoting Effect, Safety, Tolerability, and Pharmacokinetics (PK) of LML134 in Shift Work Disorder LML134, Placebo - Circadian Rhythm Disorders | Phase 2 | Terminated | Novartis Pharmaceuticals | 24 | 2017-07-26 | 2021-01-05 |
| Setmelanotide Phase 2 Treatment Trial in Participants With Rare Genetic Disorders of Obesity Setmelanotide - Genetic Obesity, Obesity | Phase 2 | Completed | Rhythm Pharmaceuticals, Inc. | 213 | 2017-02-10 | 2023-08-18 |
| Melatonin as a Circadian Clock Regulator, Neuromodulator and Myelo-protector in Adjuvant Breast Cancer Chemotherapy Melatonin 20 MG Oral Capsule, Placebo oral capsule - Sleep Disorders, Circadian Rhythm, Depression | Phase 2 | Completed | Hospital de Clinicas de Porto Alegre | 36 | 2016-01-01 | 2017-07-02 |
| Evaluating the Effects of Tasimelteon vs Placebo on Sleep Disturbances in SMS tasimelteon, placebo - Smith-Magenis Syndrome, Circadian | Phase 2 / Phase 3 | Completed | Vanda Pharmaceuticals | 49 | 2015-09-01 | 2022-11-18 |
| Efficacy of Ramelteon on Speeding Up Sleep in Subjects With Delayed Sleep Phase Syndrome Ramelteon, Placebo - Sleep Disorders, Circadian Rhythm | Phase 2 | Completed | Takeda | 132 | 2007-10-01 | 2012-02-28 |
| Efficacy and Safety of Circadin for Non-24 Hour Sleep-Wake Disorder in Totally Blind Subjects melatonin (Circadin), placebo - Non-24 Hour Sleep-Wake Disorder, Blindness | Phase 2 | Completed | Neurim Pharmaceuticals Ltd. | 13 | 2006-02-01 | 2009-09-09 |
| Safety and Efficacy of Ramelteon in Healthy Subjects Ramelteon, Placebo - Sleep Disorder | Phase 2 | Completed | Takeda | 75 | 2005-03-01 | 2012-02-28 |
| Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag Hydrocortisone, Melatonin, Placebo - Jet Lag | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 57 | 2004-12-21 | 2026-11-12 |
| Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers VEC-162 - Circadian Rhythm Sleep Disorders | Phase 2 | Completed | Vanda Pharmaceuticals | 45 | 2004-07-01 | 2014-08-26 |
| Evaluation of the Effects of Pharmaton Tablets on Mental Performance and Physical Fatigue in Nurses Working Night Shift Pharmaton® Caplets, Placebo - Sleep Disorders, Circadian Rhythm | Phase 2 | Completed | Boehringer Ingelheim | 32 | 2000-06-01 | 2014-07-25 |
Sleep Disorders, Circadian Rhythm (8) · Smith-Magenis Syndrome (2) · Bipolar Disorder (1) · Blindness (1) · Breast Neoplasms (1) · Depression (1) · Jet Lag Syndrome (1) · Obesity (1) · Pain (1) · Sleep Wake Disorders (1)
Nervous System Diseases (12) · Dyssomnias (9) · Mental Disorders (9) · Occupational Diseases (8) · Sleep Wake Disorders (8) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Neurologic Manifestations (3) · Abnormalities, Multiple (2) · Chromosome Disorders (2) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Genetic Diseases, Inborn (2) · Behavior (1)
Melatonin (4) · ramelteon (2) · Hydrocortisone (1) · lemborexant (1) · setmelanotide (1) · tasimelteon (1)
Takeda (2) · Vanda Pharmaceuticals (2) · Boehringer Ingelheim (1) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (1) · Hospital de Clinicas de Porto Alegre (1) · Leslie Swanson (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Neurim Pharmaceuticals Ltd. (1) · Novartis Pharmaceuticals (1) · Rhythm Pharmaceuticals, Inc. (1)
United States (9) · Canada (2) · France (1) · Germany (1) · Greece (1) · Israel (1) · Netherlands (1) · Spain (1) · United Kingdom (1)
Alan Lankford, PhD (1) · David Meeker, MD (1) · Gary Zammit, PhD (1) · Leslie Swanson, PhD (1) · Lynnette K Nieman, M.D. (1) · Marlene Dressman, PhD (1) · Wolnei Caumo, PhD (1)
PMID 18853704, PMID 19054552, PMID 25678831, PMID 31824318, PMID 35112343, PMID 36961653
2017 (1), R21MH132901 (1)