32 completed, 11 unknown, 10 recruiting, 7 withdrawn. 26 Not applicable, 12 Phase 2, 6 Phase 1, 6 Phase 3, 4 Early Phase 1.
Follow Chronic Rhinosinusitis (Diagnosis): new trials by email Literature Review of Chronic Rhinosinusitis (Diagnosis) trials Research Report on Chronic Rhinosinusitis (Diagnosis)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis Lactobacillus sakei proBio65, Isotonic Saline Solution - Chronic Rhinosinusitis (Diagnosis) | Phase 2 | Recruiting | University of Illinois at Chicago | 60 | 2025-02-05 | 2026-05-27 |
| Effect of Photobiostimulation Versus Pulsed Electromagnetic Field on Quality of Life in Adults With Chronic Rhinosinusitis pulsed electromagnetic therapy, Photobiostimulation, Self-sinus massage technique - Photobiostimulation, Pulsed Electromagnetic Filed | Not applicable | Recruiting | Cairo University | 60 | 2025-02-01 | 2025-05-23 |
| The Sinonasal Microbiome Control Group, Chronic rhinosinusitis (CRS) with and without Nasal Polyposis - Sinonasal Disorder, Chronic Rhinosinusitis (Diagnosis) | Active not recruiting | University of Chicago | 285 | 2025-01-13 | 2026-02-02 | |
| Comparative Analysis of Silastic Stenting in Sinus Surgery Silastic Stenting - Chronic Rhinosinusitis (Diagnosis) | Not applicable | Unknown | University of British Columbia | 100 | 2024-09-02 | 2024-07-16 |
| The Role of IL5 in Epithelial Cell Integrity Mepolizumab - Chronic Rhinosinusitis With Nasal Polyps, Chronic Rhinosinusitis (Diagnosis) | Early Phase 1 | Completed | Johns Hopkins University | 17 | 2023-09-05 | 2026-07-06 |
| The Effect of Intra-sinus Application of Betamethasone Dipropionate Nasal Cream on Patients with Chronic Rhinosinusitis Post Functional Endoscopic Sinus Surgery (FESS) Betamethasone Dipropionate Nasal Cream 0.0644%, Pre-filled syringe and applicator device - Chronic Rhinosinusitis (Diagnosis) | Phase 2 | Recruiting | Oticara Australia PTY LTD | 24 | 2023-08-17 | 2024-11-12 |
| Propel Drug-Eluting Sinus Stent Family Open Cohort NA-Observational Registry - Chronic Rhinosinusitis (Diagnosis) | Completed | Medtronic | 215 | 2023-06-01 | 2026-01-20 | |
| Viral and Epigenetic Influences in CRSwNP Endoscopic sinus surgery (ESS) - Chronic Rhinosinusitis (Diagnosis) | Active not recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 60 | 2023-05-18 | 2026-03-20 | |
| Sinus Disease in Young Children With Cystic Fibrosis Ivacaftor or elexacaftor/tezacaftor/ivacaftor - Cystic Fibrosis in Children, Cystic Fibrosis | Recruiting | University of California, Los Angeles | 80 | 2023-04-12 | 2026-09-10 | |
| Pistacia Lentiscus Oil Nasal Drops for Preventing Recurrence of Chronic Rhinosinusitis Pistacia lentiscus Oil Nasal Drops (Bactorinol®), Isotonic Saline Nasal Wash - Chronic Rhinosinusitis Without Nasal Polyps, Chronic Rhinosinusitis (Diagnosis) | Completed | Liaquat University of Medical & Health Sciences | 100 | 2023-04-04 | 2026-05-14 | |
| A Prospective Single-center Cohort Study of Surgical Treatment of Chronic Rhinosinusitis Chronic Rhinosinusitis (Diagnosis), Cohort Study | Unknown | Beijing Tongren Hospital | 200 | 2023-01-01 | 2023-08-24 | |
| Role of Nanoemulsified Sesame Oil in Post-operative Care After Endoscopic Sinus Surgery application of different topical nasal solutions - Chronic Rhinosinusitis (Diagnosis) | Not applicable | Completed | Mansoura University | 60 | 2022-12-01 | 2025-09-12 |
| Xylitol vs Saline Nasal Irrigations in CF-CRS Nasal rinsing with saline 0.9%, Nasal rinsing with Xylitol - Chronic Rhinosinusitis (Diagnosis) | Not applicable | Enrolling by invitation | Universitaire Ziekenhuizen KU Leuven | 38 | 2022-12-01 | 2026-05-01 |
| Nasal Microbiota Transfer Therapy in Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) Microbiome Transplant, Placebo - Chronic Rhinosinusitis (Diagnosis) | Not applicable | Unknown | The University of Queensland | 60 | 2022-11-10 | 2023-12-07 |
| Adherence in Global Airways Controlgroup, Intervention - Chronic Rhinosinusitis Without Nasal Polyps, Asthma | Not applicable | Unknown | Christiane Haase | 90 | 2022-10-01 | 2023-04-20 |
| Post-operative Pain Control With Acetaminophen and Ibuprofen After Functional Endoscopic Sinus Surgery Comparison of medication administration for pain control - Chronic Rhinosinusitis (Diagnosis) | Not applicable | Terminated | University of Illinois at Chicago | 60 | 2022-07-29 | 2025-05-20 |
| Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2) LYR-210, Sham procedure control, Background therapy - Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis) | Phase 3 | Completed | Lyra Therapeutics | 182 | 2022-05-13 | 2026-02-19 |
| Treatment of Eosinophilic Chronic Rhinosinusitis Utilizing Betamethasone Dipropionate Nasal Cream Betamethasone Dipropionate Nasal Cream 0.0644%, Pre-filled syringe and applicator device - Chronic Rhinosinusitis (Diagnosis) | Phase 1 / Phase 2 | Terminated | Oticara Australia PTY LTD | 2 | 2022-02-23 | 2024-05-02 |
| Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults LYR-210, Sham procedure control, Background Therapy - Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis) | Phase 3 | Completed | Lyra Therapeutics | 196 | 2022-01-27 | 2025-05-02 |
| Impact of Chronic Rhinosinusitis on the Index of Ciliary Beat Efficiency Using Fluorescent Nanosticks: (R-IMPAC) nasal brushing and bacteriological sample - Chronic Rhinosinusitis (Diagnosis) | Not applicable | Withdrawn | Centre Hospitalier Intercommunal Creteil | 2022-01-01 | 2026-02-12 |
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Disease (67) · Nasal Polyps (8) · Asthma (7) · Cystic Fibrosis (4) · Eosinophilia (2) · Rhinosinusitis (2) · Agnosia (1) · Anosmia (1) · Blood Loss, Surgical (1) · Bronchiectasis (1) · COVID-19 (1) · Confusion (1) · Hidradenitis Suppurativa (1) · Infections (1) · Laryngopharyngeal Reflux (1)
Pathologic Processes (67) · Pathological Conditions, Signs and Symptoms (67) · Respiratory Tract Diseases (21) · Lung Diseases (12) · Otorhinolaryngologic Diseases (11) · Nose Diseases (10) · Bronchial Diseases (8) · Hypersensitivity (8) · Hypersensitivity, Immediate (8) · Immune System Diseases (8) · Pathological Conditions, Anatomical (8) · Polyps (8) · Respiratory Hypersensitivity (8) · Lung Diseases, Obstructive (7) · Nervous System Diseases (6)
Budesonide (2) · Fecal Microbiota Transplantation (2) · Fluticasone (2) · Levofloxacin (2) · Mupirocin (2) · Povidone-Iodine (2) · Sodium Chloride (2) · Surveys and Questionnaires (2) · Tablets (2) · Vancomycin (2) · ivacaftor (2) · Acetaminophen (1) · Analgesia (1) · Anti-Infective Agents (1) · Biopsy (1)
St. Paul's Hospital, Canada (5) · Lyra Therapeutics (4) · Beijing Tongren Hospital (3) · Universitaire Ziekenhuizen KU Leuven (3) · University of British Columbia (3) · Intersect ENT (2) · Johns Hopkins University (2) · Oticara Australia PTY LTD (2) · University of California, Los Angeles (2) · University of Florida (2) · University of Illinois at Chicago (2) · University of Rochester (2) · Washington University School of Medicine (2) · Benha University (1) · Cairo University (1)
United States (24) · Belgium (6) · Australia (5) · Canada (5) · Austria (4) · Denmark (4) · China (3) · Czechia (3) · Egypt (3) · Finland (3) · Germany (3) · Poland (3) · France (2) · Italy (2) · Spain (2)
Andrew Thamboo, MD (2) · Daniel M Beswick, MD (2) · Li-Xing Man, MSc, MD, MPA (2) · Abdelrahman A Abdelalim, MD (1) · Amin JAver, MD (1) · Amin Javer, M.D. (1) · Amin Javer, MD (1) · Anders Cervin, MD,FRACS (1) · Aya L Hassan, Resident (1) · Bobby Tajudeen, MD (1) · Bradford Woodworth, MD (1) · Cameron R Smith (1) · Claus Bachert, MD, PhD (1) · Craig Miller, MD (1)
PMID 18702902, PMID 19128645, PMID 21271600, PMID 22311838, PMID 22980682, PMID 23255493, PMID 23776108, PMID 24119597, PMID 25137523, PMID 25832968, PMID 26363164, PMID 26452438, PMID 27440128, PMID 27466854, PMID 27556896, PMID 28124652, PMID 28922579, PMID 29024410, PMID 33595845, PMID 34110505, PMID 35390177, PMID 37483544, PMID 38145393, PMID 38967583, PMID 39325787, PMID 39811548, PMID 40156369, PMID 40463360
2017 (1), 2018 (1), P01HL107202 (1), R01HL133006 (1)