7 completed, 2 recruiting, 2 withdrawn, 1 terminated. 12 Phase 2, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 7, Recruiting 2, Withdrawn 2, Terminated 1 |
| Phase 1 | 3 | Completed 2, Terminated 1 |
| Phase 3 | 2 | Completed 1, Withdrawn 1 |
Follow Chronic Rhinosinusitis (Diagnosis): new trials by email Literature Review of Chronic Rhinosinusitis (Diagnosis) trials Research Report on Chronic Rhinosinusitis (Diagnosis)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis Lactobacillus sakei proBio65, Isotonic Saline Solution - Chronic Rhinosinusitis (Diagnosis) | Phase 2 | Recruiting | University of Illinois at Chicago | 60 | 2025-02-05 | 2026-05-27 |
| The Effect of Intra-sinus Application of Betamethasone Dipropionate Nasal Cream on Patients with Chronic Rhinosinusitis Post Functional Endoscopic Sinus Surgery (FESS) Betamethasone Dipropionate Nasal Cream 0.0644%, Pre-filled syringe and applicator device - Chronic Rhinosinusitis (Diagnosis) | Phase 2 | Recruiting | Oticara Australia PTY LTD | 24 | 2023-08-17 | 2024-11-12 |
| Treatment of Eosinophilic Chronic Rhinosinusitis Utilizing Betamethasone Dipropionate Nasal Cream Betamethasone Dipropionate Nasal Cream 0.0644%, Pre-filled syringe and applicator device - Chronic Rhinosinusitis (Diagnosis) | Phase 1 / Phase 2 | Terminated | Oticara Australia PTY LTD | 2 | 2022-02-23 | 2024-05-02 |
| LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study) LYR-220 Design 1 (Part 1 only), LYR-220 Design 2 (Part 1 and Part 2), Bilateral sham procedure control (Part 2) - Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis) | Phase 2 | Completed | Lyra Therapeutics | 48 | 2021-11-23 | 2024-12-17 |
| Subcutaneously CM310/Placebo in Patients With Chronic Rhinosinusitis With Nasal Polyposis (CROWNS-1) CM310, Placebo - Chronic Rhinosinusitis (Diagnosis), Nasal Polyps | Phase 2 | Completed | Keymed Biosciences Co.Ltd | 56 | 2021-04-06 | 2022-06-29 |
| Hypertonic Versus Isotonic Saline Irrigations for Chronic Rhinosinusitis Isotonic saline, Hypertonic Nasal Wash, Fluticasone Propionate - Chronic Rhinosinusitis (Diagnosis) | Phase 2 / Phase 3 | Withdrawn | Stanford University | 2020-07-01 | 2021-03-18 | |
| Functional Endoscopic Sinus Surgery Study Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 1, Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 2 - Chronic Rhinosinusitis (Diagnosis) | Phase 1 / Phase 2 | Completed | University of Florida | 80 | 2019-09-25 | 2026-07-30 |
| Effect of Topical Sinonasal Antibiotics Oral versus topical antibioitics - Chronic Rhinosinusitis (Diagnosis), Antibiotic Side Effect | Phase 2 | Withdrawn | United States Naval Medical Center, San Diego | 2019-06-01 | 2025-08-03 | |
| LYR-210 Depot (LYR-210) for Adult Subjects With Chronic Sinusitis (LANTERN Study) LYR-210, Sham comparator - Chronic Sinusitis, Chronic Rhinosinusitis (Diagnosis) | Phase 2 | Completed | Lyra Therapeutics | 71 | 2019-05-09 | 2023-07-25 |
| Topical Antibiotics in Chronic Rhinosinusitis Mupirocin, Tobramycin, Levofloxacin - Chronic Rhinosinusitis (Diagnosis) | Phase 1 / Phase 2 | Completed | Mayo Clinic | 19 | 2018-09-26 | 2022-04-20 |
| Benralizumab Effect on Severe Chronic Rhinosinusitis With Eosinophilic Polyposis Benralizumab, Placebo - Chronic Rhinosinusitis (Diagnosis), Nasal Polyps | Phase 2 | Completed | Johns Hopkins University | 33 | 2017-07-01 | 2021-02-11 |
| Effect of Post-operative Ibuprofen After Surgery for Chronic Rhinosinusitis Ibuprofen 400 mg, Acetaminophen 650 mg, OxyCODONE 5 Mg Oral Tablet - Chronic Rhinosinusitis (Diagnosis) | Phase 2 / Phase 3 | Completed | University of Washington | 42 | 2017-04-01 | 2023-03-22 |
Disease (12) · Nasal Polyps (2) · Eosinophilia (1)
Pathologic Processes (12) · Pathological Conditions, Signs and Symptoms (12) · Nose Diseases (2) · Otorhinolaryngologic Diseases (2) · Pathological Conditions, Anatomical (2) · Polyps (2) · Respiratory Tract Diseases (2) · Hematologic Diseases (1) · Hemic and Lymphatic Diseases (1) · Leukocyte Disorders (1)
Acetaminophen (1) · Bupivacaine (1) · Epinephrine (1) · Fluticasone (1) · Ibuprofen (1) · Levofloxacin (1) · Mupirocin (1) · Oxycodone (1) · Ropivacaine (1) · Sodium Chloride (1) · Tablets (1) · Tobramycin (1) · Vancomycin (1) · benralizumab (1)
Lyra Therapeutics (2) · Oticara Australia PTY LTD (2) · Johns Hopkins University (1) · Keymed Biosciences Co.Ltd (1) · Mayo Clinic (1) · Stanford University (1) · United States Naval Medical Center, San Diego (1) · University of Florida (1) · University of Illinois at Chicago (1) · University of Washington (1)
United States (7) · Australia (4) · Austria (1) · China (1) · Czechia (1) · New Zealand (1) · Poland (1)
Cameron R Smith (1) · Craig Miller, MD (1) · Garret W Choby, MD (1) · Jody Tversky, MD (1) · Luo Zhang (1) · Neelaysh Vukkadala, MD (1) · Victoria Lee, MD (1)
PMID 33595845, PMID 34110505, PMID 37483544
2018 (1)