52 completed, 7 unknown, 6 terminated, 5 not yet recruiting. 21 Not applicable, 13 Phase 2, 13 Phase 3, 7 Phase 4, 4 Phase 1.
Follow Chronic Rhinosinusitis: new trials by email Literature Review of Chronic Rhinosinusitis trials Research Report on Chronic Rhinosinusitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Firefighter's Longitudinal Airway and Respiratory Exposome/Multiome Study (FLARES) Anosmia, Chronic Obstructive Pulmonary Disease | Enrolling by invitation | National Institute of Allergy and Infectious Diseases (NIAID) | 350 | 2026-11-02 | 2026-10-28 | |
| Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy Ascorbic acid, Placebo - Chronic Rhinosinusitis, Intraoperative Bleeding | Phase 2 | Not yet recruiting | Assiut University | 78 | 2026-11-01 | 2026-10-08 |
| Bactorinol® Nasal Spray With Reduced-Dose Mometasone in Adults With Chronic Rhinosinusitis Bactorinol® (manufacturer: PharmExtracta S.p.A.), Mometasone Furoate Nasal Spray - Chronic Rhinosinusitis | Not applicable | Not yet recruiting | Liaquat University of Medical & Health Sciences | 78 | 2026-09-14 | 2026-09-02 |
| Nebulized Nasal Steroids nebulized budesonide via NasoNeb, budesonide lavage via NeilMed - Chronic Rhinosinusitis | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 50 | 2025-12-01 | 2025-12-08 |
| Efficacy Of Erythromycin Phonophoresis on Chronic Rhinosinusitis Erythromycin Phonophoresis, Ultrasound (US), Topical Erythromycin - Chronic Rhinosinusitis | Not applicable | Not yet recruiting | Cairo University | 90 | 2025-07-07 | 2025-07-14 |
| The Effect of Modified Olfactory Training on Postoperative Olfactory Dysfunction in Patients With CRS Conventional olfactory training device, Modified olfactory training device, Budesonide irrigation - Olfactory Dysfunction, Chronic Rhinosinusitis | Not applicable | Not yet recruiting | Peking University Third Hospital | 213 | 2025-03-14 | 2025-02-20 |
| Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal Endoscopic Surgery Esketamine, Magnesium sulfate, Saline - Chronic Rhinosinusitis, Enhanced Recovery After Surgery | Phase 1 / Phase 2 | Active not recruiting | The Second People's Hospital of Huai'an | 144 | 2025-03-01 | 2025-04-10 |
| Sleep Disturbance and Daytime Fatigue as Predictors of Cognitive Decline and Functional Decline in Chronic Rhinosinusitis Self-Reported Questionnaires for Sleep, Fatigue, and Quality of Life - Chronic Rhinosinusitis, Sleep Disorders | Completed | Sinai University | 134 | 2024-09-15 | 2025-11-21 | |
| Long-term Safety and Efficacy of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps 300mg/600mg of TQH2722 injection - Chronic Rhinosinusitis | Phase 2 | Completed | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 119 | 2024-07-16 | 2026-08-13 |
| Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery Esmolol Injection, Lidocaine IV - Chronic Rhinosinusitis, Enhanced Recovery After Surgery | Phase 1 / Phase 2 | Unknown | The Second People's Hospital of Huai'an | 60 | 2023-11-21 | 2024-06-13 |
| Adjunctive Treatment for Chronic Rhinosinusitis With Nasal Polyposis Triamcinolone-impregnated CMC foam, Propel Stent - Chronic Rhinosinusitis, Nasal Polyps | Phase 2 / Phase 3 | Unknown | Marina Boruk | 30 | 2023-07-24 | 2023-08-01 |
| Effect of Chinese Herbal Medicine Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis Chinese herbal medicine Powder, Salt Powder - Chronic Rhinosinusitis, Postoperative Care | Phase 2 | Recruiting | Taichung Veterans General Hospital | 80 | 2023-07-05 | 2026-01-14 |
| Paclitaxel-Coated Nasal Balloon for the Treatment of Recurrent Chronic Rhinosinusitis With or Without Nasal Polyps (FIH) Airiver Nasal Drug Coated Balloon (DCB) Catheter. - Chronic Rhinosinusitis | Early Phase 1 | Active not recruiting | Airiver Medical, Inc. | 45 | 2023-06-07 | 2025-12-15 |
| Nigella Sativa for Selected Outcomes in Chronic Rhinosinusitis Nigella sativa nasal oil drops, standard treatment - Chronic Rhinosinusitis | Not applicable | Completed | Cairo University | 102 | 2022-08-07 | 2024-04-17 |
| Microcurrent Device (TIVIC Health) Microcurrent TENS device, Sham Device - Chronic Rhinosinusitis | Not applicable | Completed | Icahn School of Medicine at Mount Sinai | 60 | 2022-03-30 | 2025-06-12 |
| Comparison of Chitodex Gel Vs NexFoam on Post-operative Outcomes in the Treatment of Chronic Rhinosinusitis Chitogel, Nexfoam - Chronic Rhinosinusitis | Terminated | St. Louis University | 7 | 2021-12-27 | 2024-09-19 | |
| Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis Severe Uncontrolled Chronic Rhinosinusitis patients (CRS) - Chronic Rhinosinusitis | Recruiting | Italian Academy of Rhinology | 5000 | 2021-11-01 | 2024-07-19 | |
| Povidone-Iodine Nasal Irrigation After Surgery for Chronic Rhinosinusitis Normal Saline Nasal Irrigation, Acetylcysteine (Mucomyst) Nasal Irrigation, Povidone-Iodine Nasal Irrigation - Chronic Rhinosinusitis | Not applicable | Completed | Pusan National University Hospital | 48 | 2021-10-13 | 2026-03-13 |
| Self-assessment of Olfactory Disorders for French Speaking Patients Self-assessment of olfactory disorders through two questionnaires. - Post-viral Anosmia, Post-traumatic Anosmia | Completed | University Hospital, Strasbourg, France | 135 | 2021-01-22 | 2023-04-18 | |
| Validity of the French Version of the Child's Chronic Rhinosinusitis Questionnaire Sinus and nasal quality of life survey questionnaire (SN-5) - Chronic Rhinosinusitis | Completed | Assistance Publique - Hôpitaux de Paris | 89 | 2020-04-06 | 2026-03-11 |
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Sinusitis (8) · Nasal Polyps (6) · Bronchiolitis Obliterans Syndrome (4) · Rhinosinusitis (4) · Asthma (3) · Cystic Fibrosis (2) · Disease (2) · Fistula (2) · Paranasal Sinus Diseases (2) · Anosmia (1) · Blood Loss, Surgical (1) · Cognitive Dysfunction (1) · Epistaxis (1) · Fatigue (1) · Nose Diseases (1)
Respiratory Tract Diseases (22) · Pathological Conditions, Signs and Symptoms (17) · Nose Diseases (16) · Otorhinolaryngologic Diseases (16) · Infections (12) · Respiratory Tract Infections (11) · Lung Diseases (9) · Paranasal Sinus Diseases (9) · Pathological Conditions, Anatomical (9) · Bronchial Diseases (7) · Immune System Diseases (7) · Lung Diseases, Obstructive (7) · Pathologic Processes (6) · Polyps (6) · Signs and Symptoms (5)
Omalizumab (4) · Sodium Chloride (3) · Biopsy (2) · Fluticasone (2) · Prednisone (2) · Acetylcysteine (1) · Ascorbic Acid (1) · Azithromycin (1) · Catheters (1) · Clarithromycin (1) · Debridement (1) · Dexamethasone (1) · Doxycycline (1) · Erythromycin (1) · Esketamine (1)
Oregon Health and Science University (6) · Hoffmann-La Roche (3) · The University of Texas Health Science Center, Houston (3) · Cairo University (2) · Centre hospitalier de l'Université de Montréal (CHUM) (2) · Icahn School of Medicine at Mount Sinai (2) · Integra LifeSciences Corporation (2) · Massachusetts General Hospital (2) · Odense University Hospital (2) · Optinose US Inc. (2) · Taichung Veterans General Hospital (2) · The Second People's Hospital of Huai'an (2) · University of California, San Francisco (2) · University of Michigan (2) · Airiver Medical, Inc. (1)
United States (33) · Canada (12) · Poland (6) · China (5) · France (5) · Germany (5) · Russia (4) · United Kingdom (4) · Belgium (3) · Czechia (3) · Egypt (3) · Mexico (3) · Spain (3) · Ukraine (3) · Bulgaria (2)
Jennifer Carothers (2) · John Messina (2) · Rong-San Jiang, MD, PhD (2) · Adel El-Antably, Doctorate (1) · Alfred-Marc Iloreta, MD (1) · Amber Luong, MD, PhD (1) · Amin R Javer, MD, FRCSC, FARS (1) · Aya Gamal Fawzy Elsayed, PhD (1) · Bassamat O. Ahmed, Doctorate (1) · Bibi Lange, MD (1) · Claus Bachert, MD, PhD (1) · Constanza J Valdes, MD (1)
PMID 37951571, PMID 38197558, PMID 24753507, PMID 26806047, PMID 28776718, PMID 29756211, PMID 33548517, PMID 33710614, PMID 34382434, PMID 37214171, PMID 40417805, PMID 42647052, PMID 42692406, PMID 15023840, PMID 15316237, PMID 15510034, PMID 16369166, PMID 16826060, PMID 17283567, PMID 17405780, PMID 17424882, PMID 17473677, PMID 17882910, PMID 17891047, PMID 18025315, PMID 18043488, PMID 18588763, PMID 18588769, PMID 18702910, PMID 18702911, PMID 20096224, PMID 20096225, PMID 20232413, PMID 20403849, PMID 20537292, PMID 20819467, PMID 21271599, PMID 21299922, PMID 21731825, PMID 21994147, PMID 22028948, PMID 22034223, PMID 22034233, PMID 22253199, PMID 22287332, PMID 22287426, PMID 22487286, PMID 22736422, PMID 22764607, PMID 22887970
2017 (3), 2015 (1), R01DC005805 (1)