10 completed, 2 unknown, 1 terminated. 13 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 10, Unknown 2, Terminated 1 |
| Phase 2 | 3 | Completed 1, Terminated 1, Unknown 1 |
Follow Chronic Rhinosinusitis: new trials by email Literature Review of Chronic Rhinosinusitis trials Research Report on Chronic Rhinosinusitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adjunctive Treatment for Chronic Rhinosinusitis With Nasal Polyposis Triamcinolone-impregnated CMC foam, Propel Stent - Chronic Rhinosinusitis, Nasal Polyps | Phase 2 / Phase 3 | Unknown | Marina Boruk | 30 | 2023-07-24 | 2023-08-01 |
| Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis Without the Presence of Nasal Polyps OPN-375 - Chronic Rhinosinusitis | Phase 3 | Completed | Optinose US Inc. | 223 | 2019-06-06 | 2023-12-21 |
| Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps OPN-375 - Chronic Rhinosinusitis | Phase 3 | Completed | Optinose US Inc. | 332 | 2018-11-27 | 2024-05-29 |
| An Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps Omalizumab, Placebo - Nasal Polyps, Chronic Rhinosinusitis | Phase 3 | Completed | Hoffmann-La Roche | 249 | 2018-05-09 | 2022-04-04 |
| Xylitol for Chronic Sinusitis Xylitol, Saline - Chronic Rhinosinusitis, Rhinosinusitis | Phase 2 / Phase 3 | Completed | Ochsner Health System | 1 | 2018-03-01 | 2023-04-07 |
| A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps Omalizumab, Placebo - Nasal Polyps, Chronic Rhinosinusitis | Phase 3 | Completed | Hoffmann-La Roche | 127 | 2017-11-21 | 2020-03-23 |
| A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps Omalizumab, Placebo - Nasal Polyps, Chronic Rhinosinusitis | Phase 3 | Completed | Hoffmann-La Roche | 138 | 2017-11-15 | 2020-03-23 |
| Sinupret Extract Coated Tablets in Chronic Rhinosinusitis Sinupret extract coated tablets, Placebo coated tablets - Chronic Rhinosinusitis | Phase 3 | Completed | Bionorica SE | 572 | 2016-04-28 | 2018-02-28 |
| Prednisone in Chronic Rhinosinusitis Without Nasal Polyps Prednisone, Placebo - Sinusitis, Chronic Rhinosinusitis | Phase 3 | Unknown | University of Chile | 90 | 2015-06-01 | 2015-06-04 |
| Mitomicin C for Prevention Postoperative Endoscopic Sinus Surgery Synechia and QOL in Chronic Rhinosinusitis Mitomicin C, Identical placebo solution - Chronic Rhinosinusitis, Postoperative Nasal Synerchia | Phase 3 | Completed | Mahidol University | 224 | 2015-03-01 | 2018-05-23 |
| Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps Itraconazole, Placebo - Chronic Rhinosinusitis | Phase 2 / Phase 3 | Terminated | The University of Texas Health Science Center, Houston | 58 | 2014-11-01 | 2020-10-28 |
| Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations oral levofloxacin, nebulized levofloxacin - Chronic Rhinosinusitis | Phase 3 | Completed | University of Rochester | 33 | 2013-10-01 | 2021-03-24 |
| Nasal Inhalation of Dornase Alfa (Pulmozyme) in Patients With Cystic Fibrosis and Chronic Rhinosinusitis Pulmozyme - Cystic Fibrosis, Chronic Rhinosinusitis | Phase 3 | Completed | University of Jena | 5 | 2005-12-01 | 2014-12-04 |
Nasal Polyps (4) · Sinusitis (2) · Cystic Fibrosis (1) · Rhinosinusitis (1)
Respiratory Tract Diseases (7) · Nose Diseases (6) · Otorhinolaryngologic Diseases (6) · Pathological Conditions, Anatomical (4) · Pathological Conditions, Signs and Symptoms (4) · Polyps (4) · Infections (2) · Paranasal Sinus Diseases (2) · Respiratory Tract Infections (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Digestive System Diseases (1) · Genetic Diseases, Inborn (1) · Infant, Newborn, Diseases (1) · Lung Diseases (1) · Pancreatic Diseases (1)
Omalizumab (3) · Itraconazole (1) · Levofloxacin (1) · Mitomycin (1) · Prednisone (1) · Sinupret (1) · Sodium Chloride (1) · Triamcinolone (1) · Xylitol (1) · dornase alfa (1)
Hoffmann-La Roche (3) · Optinose US Inc. (2) · Bionorica SE (1) · Mahidol University (1) · Marina Boruk (1) · Ochsner Health System (1) · The University of Texas Health Science Center, Houston (1) · University of Chile (1) · University of Jena (1) · University of Rochester (1)
United States (9) · Poland (6) · Germany (4) · Russia (4) · United Kingdom (4) · Canada (3) · Czechia (3) · Mexico (3) · Spain (3) · Ukraine (3) · Belgium (2) · Bulgaria (2) · France (2) · Georgia (2) · Hungary (2)
Jennifer Carothers (2) · John Messina (2) · Amber Luong, MD, PhD (1) · Constanza J Valdes, MD (1) · Jochen G. Mainz, M.D. (1) · Li-Xing Man, MD, MPA, Msc (1) · Marcela A Veloz, MD (1) · Marina Boruk, MD (1) · Pawin Numthavaj, M.D. (1)
PMID 37951571, PMID 38197558, PMID 33548517, PMID 33710614, PMID 34382434, PMID 37214171, PMID 42647052, PMID 42692406, PMID 15023840, PMID 15316237, PMID 15510034, PMID 17405780, PMID 17882910, PMID 21994147, PMID 22287332, PMID 22764607, PMID 22887970, PMID 23378777, PMID 23785241, PMID 24610673, PMID 24753507, PMID 24889751, PMID 27394715, PMID 28390807, PMID 8281565, PMID 9755259
2017 (3), 2015 (1)