6 completed, 2 not yet recruiting, 2 unknown, 1 active not recruiting. 13 Phase 2, 4 Phase 1, 3 Phase 3.
Follow Chronic Rhinosinusitis: new trials by email Literature Review of Chronic Rhinosinusitis trials Research Report on Chronic Rhinosinusitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy Ascorbic acid, Placebo - Chronic Rhinosinusitis, Intraoperative Bleeding | Phase 2 | Not yet recruiting | Assiut University | 78 | 2026-11-01 | 2026-10-08 |
| Nebulized Nasal Steroids nebulized budesonide via NasoNeb, budesonide lavage via NeilMed - Chronic Rhinosinusitis | Phase 1 / Phase 2 | Not yet recruiting | Washington University School of Medicine | 50 | 2025-12-01 | 2025-12-08 |
| Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal Endoscopic Surgery Esketamine, Magnesium sulfate, Saline - Chronic Rhinosinusitis, Enhanced Recovery After Surgery | Phase 1 / Phase 2 | Active not recruiting | The Second People's Hospital of Huai'an | 144 | 2025-03-01 | 2025-04-10 |
| Long-term Safety and Efficacy of TQH2722 Injection in the Treatment of Chronic Sinusitis With or Without Nasal Polyps 300mg/600mg of TQH2722 injection - Chronic Rhinosinusitis | Phase 2 | Completed | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 119 | 2024-07-16 | 2026-08-13 |
| Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery Esmolol Injection, Lidocaine IV - Chronic Rhinosinusitis, Enhanced Recovery After Surgery | Phase 1 / Phase 2 | Unknown | The Second People's Hospital of Huai'an | 60 | 2023-11-21 | 2024-06-13 |
| Adjunctive Treatment for Chronic Rhinosinusitis With Nasal Polyposis Triamcinolone-impregnated CMC foam, Propel Stent - Chronic Rhinosinusitis, Nasal Polyps | Phase 2 / Phase 3 | Unknown | Marina Boruk | 30 | 2023-07-24 | 2023-08-01 |
| Effect of Chinese Herbal Medicine Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis Chinese herbal medicine Powder, Salt Powder - Chronic Rhinosinusitis, Postoperative Care | Phase 2 | Recruiting | Taichung Veterans General Hospital | 80 | 2023-07-05 | 2026-01-14 |
| Etokimab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Etokimab, Placebo, Mometasone Furoate Nasal Spray - Chronic Rhinosinusitis | Phase 2 | Completed | AnaptysBio, Inc. | 105 | 2018-11-29 | 2022-01-24 |
| Xylitol for Chronic Sinusitis Xylitol, Saline - Chronic Rhinosinusitis, Rhinosinusitis | Phase 2 / Phase 3 | Completed | Ochsner Health System | 1 | 2018-03-01 | 2023-04-07 |
| Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps Itraconazole, Placebo - Chronic Rhinosinusitis | Phase 2 / Phase 3 | Terminated | The University of Texas Health Science Center, Houston | 58 | 2014-11-01 | 2020-10-28 |
| Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial placebo, doxycycline 100 mg - Chronic Rhinosinusitis, Nasal Polyps | Phase 2 | Completed | University Hospital, Ghent | 33 | 2011-11-22 | 2018-06-15 |
| Budesonide Application Via Mucosal Atomization Device as a Treatment for Chronic Rhinosinusitis When Utilized as a Topical Nasal Steroid Spray Mucosal Atomization Device (MAD), Budesonide via Nasal Syringe - Chronic Rhinosinusitis | Phase 1 / Phase 2 | Completed | St. Paul's Hospital, Canada | 20 | 2011-08-01 | 2014-03-10 |
| Subcutaneous Omalizumab for Treatment of Chronic Rhinosinusitis With Nasal Polyposis Xolair placebo, Xolair (omalizumab) - Chronic Rhinosinusitis, Nasal Polyps | Phase 2 | Completed | Massachusetts General Hospital | 27 | 2009-12-01 | 2017-06-14 |
Nasal Polyps (3) · Rhinosinusitis (2) · Blood Loss, Surgical (1) · Epistaxis (1) · Sinusitis (1)
Nose Diseases (5) · Otorhinolaryngologic Diseases (5) · Respiratory Tract Diseases (5) · Pathological Conditions, Signs and Symptoms (4) · Pathological Conditions, Anatomical (3) · Polyps (3) · Infections (2) · Paranasal Sinus Diseases (2) · Respiratory Tract Infections (2) · Rhinitis (2) · Hemorrhage (1) · Intraoperative Complications (1) · Pathologic Processes (1) · Signs and Symptoms (1) · Signs and Symptoms, Respiratory (1)
Sodium Chloride (2) · Ascorbic Acid (1) · Doxycycline (1) · Esketamine (1) · Itraconazole (1) · Magnesium Sulfate (1) · Omalizumab (1) · Triamcinolone (1) · Xylitol (1) · esmolol (1)
The Second People's Hospital of Huai'an (2) · AnaptysBio, Inc. (1) · Assiut University (1) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (1) · Marina Boruk (1) · Massachusetts General Hospital (1) · Ochsner Health System (1) · St. Paul's Hospital, Canada (1) · Taichung Veterans General Hospital (1) · The University of Texas Health Science Center, Houston (1) · University Hospital, Ghent (1) · Washington University School of Medicine (1)
United States (6) · China (3) · Belgium (1) · Canada (1) · Germany (1) · Taiwan (1)
Amber Luong, MD, PhD (1) · Amin R Javer, MD, FRCSC, FARS (1) · Claus Bachert, MD, PhD (1) · Ellen J Dutta, MD (1) · Marina Boruk, MD (1) · Nyssa Farrell, MD (1) · Rong-San Jiang, MD, PhD (1)
PMID 15023840, PMID 15316237, PMID 15510034, PMID 17405780, PMID 17882910, PMID 21994147, PMID 23378777, PMID 23785241, PMID 24449682, PMID 27394715, PMID 28390807, PMID 8281565, PMID 9755259