12 completed, 8 unknown, 5 recruiting, 4 not yet recruiting. 20 Not applicable, 4 Phase 3, 3 Phase 2, 3 Phase 4.
Follow Chronic Migraine, Headache: new trials by email Literature Review of Chronic Migraine, Headache trials Research Report on Chronic Migraine, Headache
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comprehensive Approach to Lifestyle Modification in Chronic Migraine Comprehensive Lifestyle Intervention - Chronic Migraine, Headache | Not applicable | Not yet recruiting | Hacettepe University | 30 | 2026-09-01 | 2026-09-03 |
| EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS) OF PRIMARY MOTOR CORTEX ON HEADACHE FREQUENCY IN PATIENTS WITH CHRONIC MIGRAINE Transcranial Direct Current stimulation - Chronic Migraine Headache, Chronic Migraine, Headache | Phase 3 | Not yet recruiting | Dr. Ram Manohar Lohia Hospital | 32 | 2026-08-01 | 2026-08-04 |
| Comparison Between Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine Greater occiptal nerve block, Pulsed radiofrequency - Chronic Migraine, Headache | Not applicable | Not yet recruiting | Sohag University | 70 | 2026-05-01 | 2026-04-06 |
| Ultrasound Guided Infratemporal Sphenopalatine Ganglion Supravoltage Versus Standard Voltage Pulsed Radiofrequency for Pain Alleviation in Chronic Refractory Migraine. Standarad PRF, Supravoltage PRF - Chronic Migraine, Headache | Not applicable | Recruiting | Minia University | 100 | 2026-03-31 | 2026-06-16 |
| Occipital Nerve Stimulation in Chronic Migraine Prodigy internal pulse generator occipital nerve stimulator - Chronic Migraine, Headache, Refractory Migraine | Not applicable | Not yet recruiting | University College, London | 40 | 2025-09-01 | 2025-07-28 |
| New Methods for Evaluating Preventive Migraine Treatment Active drug for chronic migraine treatment., Placebo Subcutaneous injection - Migraine, Migraine With or Without Aura | Not applicable | Recruiting | University of Aarhus | 60 | 2025-06-19 | 2026-05-19 |
| Chronic Migraines and Neurofdeeback Mindfulness Neurofeedback Mindfulness, Attention Task - Chronic Migraine, Headache | Not applicable | Unknown | University of Saskatchewan | 135 | 2024-12-01 | 2024-04-02 |
| Efficacy of Nerve Block Versus Botox in Chronic Migraine Management Nerve Block Injections, Botulinum Toxin A - Chronic Migraine, Chronic Migraine, Headache | Not applicable | Recruiting | Zagazig University | 64 | 2024-11-10 | 2024-11-12 |
| Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine CGRP antibody or gepant - Migraine, Episodic Migraine | Recruiting | Hospital Universitari Vall d'Hebron Research Institute | 700 | 2024-01-02 | 2025-09-08 | |
| Open Label, 6-month Study for High Frequency and Chronic Migraine, Daxibotulinumtonix A - Chronic Migraine, Headache | Unknown | Ki Health Partners. LLC | 20 | 2023-10-18 | 2024-08-27 | |
| Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia Psychological self-reported measures assesment (questionnaire) - Fibromyalgia, Chronic Migraine, Headache | Completed | University of Roma La Sapienza | 1006 | 2023-10-01 | 2024-12-04 | |
| The Efficacy Of Lidocaine Infusion IN Chronic Unilateral Migraine Headache Lidocaine IV - Chronic Migraine, Headache | Phase 2 | Unknown | Alexandria University | 80 | 2023-10-01 | 2023-10-31 |
| Pulse Radiofrequency and Occipital Nerve Block for Chronic Migraine Patients Greater occipital nerve block, Greater occipital nerve pulse radiofrequency - Chronic Migraine, Headache, Block | Not applicable | Unknown | Aydin Adnan Menderes University | 70 | 2023-09-26 | 2024-02-08 |
| Study Using the ShiraTronics Migraine Therapy System neurostimulator - Chronic Migraine, Headache | Not applicable | Unknown | ShiraTronics | 40 | 2023-05-05 | 2024-07-16 |
| COACT Study: CGRPmAbs + OnabotulinumtoxinA Assessment of Chronic Migraine Treatments Study Combination of Botox + CGRPmAb (Fremanezumab 225mg/1.5mL) - Chronic Migraine, Headache | Phase 4 | Unknown | Chicago Headache Center & Research Institute | 50 | 2023-01-26 | 2024-08-20 |
| A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine TNX-1900, Placebo Nasal Spray - Chronic Migraine, Chronic Migraine, Headache | Phase 2 | Completed | Tonix Pharmaceuticals, Inc. | 88 | 2022-12-06 | 2025-02-25 |
| Molecular Phenotyping of Migraine Patients According to Sex and Age Through CGRP Quantification Saliva test - Headache (Migraine), Migraine | Recruiting | Hospital Universitari Vall d'Hebron Research Institute | 440 | 2022-11-29 | 2024-11-13 | |
| Cannabidiol 133mg + Cannabigerol 66mg + Tetrahydrocannabinol 4mg Vs Placebo As Adjuvant Treatment in Chronic Migraine - Placebo oral drops, Cannabidiol + Cannabigerol + Tetrahydrocannabinol 133/66/4mg - Chronic Migraine, Headache, Overuse Headache Medication | Phase 2 / Phase 3 | Terminated | Hospital Israelita Albert Einstein | 110 | 2022-10-18 | 2025-02-24 |
| Osteopathic Manipulative Techniques for the Treatment of Chronic Migraine Headaches Osteopathic manipulative therapy - Chronic Migraine, Headache | Not applicable | Terminated | Milton S. Hershey Medical Center | 11 | 2022-09-08 | 2023-08-14 |
| Effect of Auricular Vagus Nerve Stimulation in Women With Migraine Disease Auricular Vagus Nerve Stimulation - Chronic Migraine, Headache | Not applicable | Completed | Bahçeşehir University | 60 | 2022-06-06 | 2023-02-28 |
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Headache (35) · Migraine Disorders (9) · Pain (4) · Headache Disorders (3) · Fibromyalgia (2) · Headache Disorders, Secondary (2) · Migraine with Aura (2) · Agnosia (1) · Bites and Stings (1) · Chronic Pain (1) · Migraine without Aura (1) · Motor Activity (1) · Neuroinflammatory Diseases (1) · Temporomandibular Joint Disorders (1) · Vulvodynia (1)
Neurologic Manifestations (35) · Pathological Conditions, Signs and Symptoms (35) · Signs and Symptoms (35) · Pain (31) · Nervous System Diseases (16) · Brain Diseases (13) · Central Nervous System Diseases (13) · Headache Disorders (10) · Headache Disorders, Primary (9) · Muscular Diseases (3) · Musculoskeletal Diseases (3) · Neuromuscular Diseases (2) · Rheumatic Diseases (2) · Behavior (1) · Chemically-Induced Disorders (1)
Botulinum Toxins, Type A (2) · Lidocaine (2) · Quality of Life (2) · Saline Solution (2) · Sleep (2) · Sodium Chloride (2) · Calcitonin Gene-Related Peptide Receptor Antagonists (1) · Cannabidiol (1) · Central Nervous System Sensitization (1) · Diet, Ketogenic (1) · Dronabinol (1) · Functional Status (1) · Hematologic Tests (1) · Implantable Neurostimulators (1) · Manipulation, Osteopathic (1)
Hospital Universitari Vall d'Hebron Research Institute (2) · Istanbul University - Cerrahpasa (2) · Alexandria University (1) · Allergan (1) · Assiut University (1) · Ataturk University (1) · Aydin Adnan Menderes University (1) · Bahçeşehir University (1) · Barts & The London NHS Trust (1) · ChairsideSplint.com (1) · Chicago Headache Center & Research Institute (1) · Children's Hospital of Philadelphia (1) · Dr. Ram Manohar Lohia Hospital (1) · Eskisehir Osmangazi University (1) · Hacettepe University (1)
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Ahmed Bessar, MD, PhD (1) · Alexandre O Kaup, MD, PhD (1) · Anish Bahra (1) · Ashish K Duggal, DM Neurology (1) · Christina L. Szperka, MD, MSCE (1) · Cristina Tassorelli, Prof (1) · Donald B Penzien, PhD (1) · Elif Ozyigit, MD (1) · Esra Ertilav (1) · Federica M Galli, AP (1) · Gregory Sullivan, MD (1) · Lene Vase, MSc, PhD, DMSc (1) · Ozlem Ulger (1)
PMID 10772585, PMID 11554951, PMID 15613213, PMID 15957691, PMID 16389388, PMID 22083262, PMID 25156013, PMID 25205974, PMID 30674285, PMID 31870279, PMID 32915024, PMID 33527209, PMID 34145431, PMID 34873540, PMID 34956071, PMID 35246048, PMID 35295486, PMID 35609890, PMID 39256847
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