60 completed, 12 terminated, 11 recruiting, 10 unknown. 56 Not applicable, 14 Phase 2, 12 Phase 3, 2 Phase 4, 1 Phase 1.
Follow Vulvodynia: new trials by email Literature Review of Vulvodynia trials Research Report on Vulvodynia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Pilot Study on the Efficacy of Oral Low Dose Naltrexone for Vulvodynia Low Dose Naltrexone - Vulvodynia | Phase 2 | Not yet recruiting | University of Florida | 20 | 2027-01-01 | 2026-10-09 |
| Transcutaneous Genital Nerves Stimulation for the Treatment of Refractory Chronic Pelvic and Genital Pain in Women. Transcutaneous Genital Nerves Stimulation - Refractory Visceral Pelvic Pain, Refractory Genital Pain | Not applicable | Not yet recruiting | Prof. Dr. med. Marc Possover | 50 | 2026-12-01 | 2026-10-20 |
| CPP Among Somali Women in Norway: SCED Multimodal physiotherapy - Chronic Pelvic Pain | Not applicable | Not yet recruiting | Kristiania University College | 30 | 2026-09-01 | 2026-09-15 |
| Efficacy of Dry Needling in Reducing Pain During Sexual Intercourse Real dry needling, Sham dry needling - Provoked Vestibulodynia | Not applicable | Recruiting | Université de Sherbrooke | 170 | 2026-05-11 | 2026-05-12 |
| Effectiveness of a Four-Session Focal Shock Wave Therapy Protocol in Women With Vulvodynia Low-Intensity Focal Extracorporeal Shock Wave Therapy - Vulvodynia | Recruiting | Nantes University Hospital | 50 | 2026-04-01 | 2026-06-24 | |
| Improving Postoperative Recovery: A Study of Multimodal Perineal Analgesia Protocol (MPAP) After Vaginal Surgery Perineal ice packs, medicated witch-hazel pads, and topical benzocaine spray - Perineal Injury, Pain Vulva | Phase 4 | Recruiting | University of Miami | 70 | 2026-02-18 | 2026-03-04 |
| Topical Ketotifen 0.25% for Secondary Vestibulodynia Ketotifen Fumarate 0.25% Cream, Placebo (Vehicle Cream) - Provoked Vestibulodynia, Secondary Provoked Vestibulodynia | Phase 2 | Recruiting | Center for Vulvovaginal Disorders | 54 | 2026-01-02 | 2026-03-18 |
| A Phase 2 Study to Evaluate the Efficacy and Safety of Pudafensine in Vulvodynia (Provoked Vestibulodynia) Pudafensine - Vulvodynia | Phase 2 | Recruiting | Initiator Pharma | 24 | 2025-12-17 | 2026-02-05 |
| Does a Virtual Program for Pelvic Pain Improve Pain and Sexual Outcomes in Individuals With Provoked Vestibulodynia? Virtual online pelvic health program - Vulvodynia (Chronic Vulvar Pain), Vulvar Vestibulitis | Not applicable | Recruiting | Queen's University | 250 | 2025-12-17 | 2026-02-12 |
| Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled Trial Estradiol 0.01% Vag Cream, testosterone 0.1% and estradiol 0.01% vaginal cream - Vulvodynia, Dyspareunia | Phase 2 / Phase 3 | Not yet recruiting | TriHealth Inc. | 44 | 2025-12-01 | 2025-12-03 |
| Light Emitting Diode in the Treatment of Vulvodynia Blue LED - Vulvodynia | Not applicable | Not yet recruiting | Centro de Atenção ao Assoalho Pélvico | 10 | 2025-08-16 | 2024-08-21 |
| Young Vulvodynia: Effect and Efficacy of Multimodal Treatment. Multimodal treatment - Vulvodynia | Not applicable | Active not recruiting | Region Örebro County | 15 | 2025-06-10 | 2026-08-12 |
| Biomodulation and Rehabilitation Interventions to tarGet Pelvic Health Photobiomodulation, Sham photobiomodulation, Multimodal physiotherapy - Vulvodynia, Provoked Vestibulodynia | Not applicable | Recruiting | University of Ottawa | 240 | 2025-03-17 | 2026-05-05 |
| Vulvodynia Intervention: the Effect of Multimodal Treatment for Provoked Vulvodynia Vulvodynia Intervention: a multimodal treatment for provoked vulvodynia - Vulvodynia (Chronic Vulvar Pain) | Not applicable | Active not recruiting | Karlstad University | 50 | 2025-03-11 | 2026-08-12 |
| VIBRating vs Traditional Therapy for Treatment of ENTry Dyspareunia Pelvic floor therapy - Genito-Pelvic Pain/Penetration Disorder, Dyspareunia | Not applicable | Recruiting | Medstar Health Research Institute | 60 | 2025-03-01 | 2025-05-21 |
| Application of Cheek Acupuncture in Vaginal Tightening Surgery acupuncture treatment - Pain Vulva | Not applicable | Unknown | The Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College | 60 | 2024-09-01 | 2024-09-19 |
| Vestibulodynia At High Resolution: Omics Approach to Improve Diagnosis vulvar biopsy and blood semples - Vestibulodynia (VBD), Vulvodynia | Recruiting | Fondazione IRCCS Policlinico San Matteo di Pavia | 400 | 2024-06-25 | 2025-03-10 | |
| Vaginal Ecosystem and Network in the United States Study Vaginal Swab Collection - Bacterial Vaginosis, Candidiasis | Enrolling by invitation | Vaginal Biome Science | 3250 | 2024-05-16 | 2025-07-01 | |
| Treatment and Mapping of Impostor Phenomenon Impostor tasks - Dermatoses, Vestibulodynia | Not applicable | Unknown | Umeå University | 20 | 2024-05-15 | 2024-05-10 |
| Analysis of the Understanding of the French Version of the Vulvar Pain Assessment Questionnaire Questionnaire - Vulvodynia | Not applicable | Completed | Hopital Foch | 30 | 2024-05-06 | 2025-03-07 |
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Dyspareunia (17) · Vulvar Vestibulitis (14) · Pain (11) · Cystitis, Interstitial (9) · Chronic Pain (7) · Pelvic Pain (7) · Fibromyalgia (5) · Vulvar Diseases (5) · Irritable Bowel Syndrome (4) · Lichen Sclerosus et Atrophicus (4) · Sexual Dysfunction, Physiological (4) · Endometriosis (3) · Lichen Planus (3) · Vulvar Lichen Sclerosus (3)
Female Urogenital Diseases (107) · Female Urogenital Diseases and Pregnancy Complications (107) · Genital Diseases (107) · Genital Diseases, Female (107) · Urogenital Diseases (107) · Vulvar Diseases (102) · Pathological Conditions, Signs and Symptoms (29) · Signs and Symptoms (29) · Neurologic Manifestations (27) · Male Urogenital Diseases (26) · Mental Disorders (20) · Genital Diseases, Male (17) · Sexual Dysfunctions, Psychological (16) · Pain (14) · Sexual Dysfunction, Physiological (14)
Lidocaine (6) · Acupuncture Therapy (5) · Botulinum Toxins, Type A (4) · Physical Therapy Modalities (3) · Cognitive Behavioral Therapy (2) · Gabapentin (2) · Low-Level Light Therapy (2) · Naltrexone (2) · Sodium Chloride (2) · Surveys and Questionnaires (2) · Therapeutics (2) · salicylhydroxamic acid (2) · Acceptance and Commitment Therapy (1) · Administration, Intravesical (1) · Amitriptyline (1)
Université de Sherbrooke (7) · Western Galilee Hospital-Nahariya (7) · Corewell Health East (5) · University of British Columbia (4) · Centre Hospitalier Universitaire de Besancon (3) · Oregon Health and Science University (3) · University of California, Los Angeles (3) · Uppsala University (3) · Ipsen (2) · Karolinska Institutet (2) · Medical University of Graz (2) · Medstar Health Research Institute (2) · TriHealth Inc. (2) · University of Illinois at Chicago (2) · University of Ottawa (2)
United States (46) · Canada (19) · Sweden (8) · Israel (7) · France (5) · Italy (3) · Norway (3) · Austria (2) · Brazil (2) · Belgium (1) · China (1) · Croatia (1) · Ireland (1) · Poland (1) · Spain (1)
Catherine Leclair, MD (3) · Fabien Pelletier, MD (3) · Jacob Bornstein, MD (3) · Lori A Brotto, PhD (3) · Cheryl Iglesia, MD (2) · Donna Carrico, NP (2) · Judith M. Schlaeger, PhD (2) · Monica Buhrman, PhD (2) · Nina Bohm-Starke, MD (2) · Sophie Bergeron, PhD (2) · Abimbola Babajide, Dr (1) · Ahinoam LevSagie, MD (1) · Alkistis Skalkidou, MD, PhD (1)
PMID 32734597, PMID 17012991, PMID 18981976, PMID 19305326, PMID 20059663, PMID 20733439, PMID 22914465, PMID 24080300, PMID 24807329, PMID 25540035, PMID 25603224, PMID 26215946, PMID 27045258, PMID 27150263, PMID 29686883, PMID 29742655, PMID 30341023, PMID 31592976, PMID 32434709, PMID 32769643, PMID 32818475, PMID 32843320, PMID 32915024, PMID 33957642, PMID 33996511, PMID 35943448, PMID 35972459, PMID 36130137, PMID 36269028, PMID 36307361, PMID 36387991, PMID 36862472, PMID 36951987, PMID 39940084, PMID 39953376, PMID 40590401, PMID 42857927
2016 (1), 2023 (1), R01HD040123 (1), R01HD058608 (1), R01HD096331 (1), UL1TR001412 (1)