75 completed, 25 unknown, 10 recruiting, 8 terminated. 56 Not applicable, 21 Phase 2, 11 Phase 1, 8 Phase 4, 6 Phase 3.
Follow Chronic Fatigue Syndrome: new trials by email Literature Review of Chronic Fatigue Syndrome trials Research Report on Chronic Fatigue Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hyperbaric Oxygen Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Hyperbaric oxygen therapy, SHAM treatment - Chronic Fatigue Syndrome, ME/CFS | Not applicable | Recruiting | Assaf-Harofeh Medical Center | 74 | 2026-07-19 | 2026-08-21 |
| Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 Onset ME/CFS Versus Pre-Pandemic ME/CFS Patients Chronic Fatigue Syndrome | Enrolling by invitation | Johns Hopkins University | 200 | 2026-06-01 | 2026-06-11 | |
| A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS Voice Recording - Encephalomyelitis, Chronic Fatigue Syndrome | Recruiting | Mayo Clinic | 40 | 2026-05-26 | 2026-05-27 | |
| Hydrogen Water Intervention With Heart Rate Variability as an Outcome Biomarker in ME/CFS Hydrogen water which is prepared from an OTC supplement. - Chronic Fatigue Syndrome | Not applicable | Recruiting | Stony Brook University | 50 | 2025-06-09 | 2025-06-08 |
| tVNS in Long COVID-19 Transcutaneous vagus nerve stimulator - Long COVID, Chronic Fatigue Syndrome | Not applicable | Active not recruiting | Icahn School of Medicine at Mount Sinai | 50 | 2024-11-01 | 2026-08-03 |
| Psychoneuromentalism Disorder: A Medical Condition That Affects People With Psychological Impairments From Health Issues Decompartmentalization Framework, Liquid Herbal TInctures, Mental Imagery - Schizoaffective Disorder, Bipolar Type, Bipolar Disorder | Early Phase 1 | Unknown | The Essence of Integrative Health and Medicine Practice | 30 | 2024-10-10 | 2024-08-12 |
| Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Lumbrokinase - Long Covid, Post-treatment Lyme Disease Syndrome | Phase 1 / Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 120 | 2024-10-09 | 2026-03-13 |
| Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue APA program, Active transcutaneous VNS, Sham transcutaneous VNS - Chronic Fatigue Syndrome | Not applicable | Recruiting | Centre Hospitalier Universitaire de Saint Etienne | 60 | 2024-10-03 | 2026-05-06 |
| Discovering Trends in Chronic Fatigue Syndrome Patients' Clinical Study Experiences Chronic Fatigue Syndrome | Unknown | Power Life Sciences Inc. | 500 | 2024-08-01 | 2023-08-01 | |
| A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis Photobiomodulation therapy - Myalgic Encephalomyelitis, Chronic Fatigue Syndrome | Not applicable | Unknown | Quadram Institute Bioscience | 10 | 2024-04-24 | 2024-04-29 |
| Compound Ciwujia Granules Treat Chronic Fatigue Syndrome Compound Ciwujia Granules, Guipi Granules - Chronic Fatigue Syndrome | Phase 4 | Completed | Heilongjiang Quanle Pharmaceutical Co., Ltd. | 235 | 2024-03-19 | 2025-09-23 |
| Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function Questionnaires, blood test, Maximal effort test - Chronic Fatigue Syndrome, Intensive Care Unit | Not applicable | Withdrawn | Centre Hospitalier Universitaire de Saint Etienne | 2023-12-01 | 2023-04-26 | |
| The Long COVID-19 Wearable Device Study Wearable device - Long COVID, Postural Orthostatic Tachycardia Syndrome | Not applicable | Recruiting | Scripps Translational Science Institute | 100500 | 2023-11-16 | 2025-05-11 |
| Investigation of Treating Chronic Fatigue Syndrome After COVID With Pharmacotherapy (Pregabalin) or Complex Rehabilitation Pregabalin, Independent walking training, Placebo - Chronic Fatigue Syndrome, COVID-19, Long Haul | Phase 2 | Terminated | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | 23 | 2023-10-24 | 2026-06-17 |
| A Multicenter, Adaptive, Randomized, doublE-blinded, Placebo-controlled Study in Participants With Long COVID-19: The REVIVE Trial Fluvoxamine Maleate 100 MG, Placebo, Metformin Extended Release Oral Tablet - Long COVID-19 Syndrome, Chronic Fatigue Syndrome | Phase 3 | Completed | Cardresearch | 399 | 2023-10-18 | 2026-04-13 |
| Exploring Worry in CFS/ME No intervention - Chronic Fatigue Syndrome | Unknown | King's College London | 15 | 2023-10-01 | 2023-08-25 | |
| Effect of Stellate Ganglion Block on ME/CFS Bupivacaine Injection - Encephalomyelitis, Myalgic, Chronic Fatigue Syndrome | Phase 1 | Completed | Neuroversion, Inc. | 10 | 2023-03-15 | 2024-12-06 |
| Melatonin and Zinc Administration on Cardinal Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome melatonin plus zinc, isomaltose and magnesium stearate - Chronic Fatigue Syndrome, Myalgic Encephalomyelitis | Not applicable | Unknown | Laboratorios Viñas, S.A. | 106 | 2022-09-05 | 2022-07-12 |
| Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders "One step at a time", "Get started" - Bodily Distress Disorder Moderate, Bodily Distress Disorder Severe | Not applicable | Recruiting | University of Aarhus | 166 | 2022-08-24 | 2025-06-27 |
| Monitoring of Chronic Conditions in Breast Cancer Breast Cancer, Chronic Fatigue Syndrome | Recruiting | Helse Stavanger HF | 150 | 2022-06-15 | 2022-10-20 |
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Fatigue Syndrome, Chronic (134) · Fibromyalgia (30) · Fatigue (25) · Irritable Bowel Syndrome (13) · Post-Acute COVID-19 Syndrome (9) · Depression (8) · Pain (7) · Anxiety Disorders (5) · Somatoform Disorders (5) · Chronic Pain (4) · Medically Unexplained Symptoms (4) · Motor Activity (4) · Orthostatic Intolerance (4) · Postural Orthostatic Tachycardia Syndrome (4) · Stress Disorders, Post-Traumatic (4)
Chronic Disease (134) · Disease Attributes (134) · Muscular Diseases (134) · Musculoskeletal Diseases (134) · Nervous System Diseases (134) · Neuroinflammatory Diseases (134) · Neuromuscular Diseases (134) · Pathologic Processes (134) · Pathological Conditions, Signs and Symptoms (134) · Encephalomyelitis (132) · Signs and Symptoms (36) · Rheumatic Diseases (31) · Mental Disorders (18) · Behavior (17) · Infections (17)
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Fred Friedberg, PhD (4) · Benjamin Natelson, MD (3) · Per Fink, DMSc (3) · Olav Mella, PhD, MD (2) · Sergej M Ostojic, MD, PhD (2) · Vegard Bruun Wyller, MD, PhD (2) · Afton L Hassett, Psy.D. (1) · Alba Azola, MD (1) · Alfred E Slonim, MD (1) · Alfred Slonim, MD (1) · An Mariman, MD (1) · Anders Luts, MD, PhD (1) · Andrea Nackley, PhD (1) · Andrew Krystal, M.D. (1)
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R01ES015382 (1), R01HD096331 (1), R01NS072599 (1), R01NS109529 (1), R01NS116887 (1), R01NS117638 (1), R21AT004537 (1), R21NR010539 (1), R21NS094644 (1), U54NS105541 (1)