139 completed, 43 unknown, 39 recruiting, 15 active not recruiting. 118 Not applicable, 43 Phase 2, 18 Phase 1, 14 Phase 3, 10 Phase 4.
Follow Encephalomyelitis: new trials by email Literature Review of Encephalomyelitis trials Research Report on Encephalomyelitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CD19-B Cell Depletion in PAIS-ME/CFS Patients Inebilizumab, Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID 19 Condition (PCC or Long COVID) | Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 38 | 2026-12-01 | 2026-07-24 |
| Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard Care MS Boost, Standard of care - Multiple Sclerosis, Fatigue Syndrome, Chronic | Not applicable | Not yet recruiting | Ad scientiam | 208 | 2026-12-01 | 2025-10-03 |
| Low-Dose Naltrexone For ME/CFS: Dose-Finding Low-Dose Naltrexone, 1.5mg, Low-Dose Naltrexone, 3.0mg, Low-Dose Naltrexone, 4.5mg - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | Phase 2 | Not yet recruiting | University of Alabama at Birmingham | 75 | 2026-11-01 | 2026-10-08 |
| Whole-body Cryotherapy in Those With Chronic Fatigue: A Feasibility Study Cryotherapy - ME/CFS, Fibromyalgia (FM) | Not applicable | Not yet recruiting | Oxford Brookes University | 40 | 2026-10-01 | 2026-10-14 |
| Bao Yuan Tang Extract and Galactooligosaccharides for Sleep Regulation Combination product (Bao Yuan Tang full-component extract 2.0g and galactooligosaccharides 2.0g), Bao Yuan Tang full-component extract 2.0g plus a placebo consisting of maltodextrin 2.0g, Galactooligosaccharides 2.0g - Sleep Disturbance, Fatigue Syndrome, Chronic | Not applicable | Not yet recruiting | Hepatopancreatobiliary Surgery Institute of Gansu Province | 400 | 2026-09-30 | 2026-08-19 |
| Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Placebo condition, Molecular hydrogen produced by a metallic magnesium tablet, consumed 3x a day dissolved in water. Treatment duration is 16 weeks. - Chronic Fatigue Syndrome (CFS) | Not applicable | Recruiting | Fred Friedberg | 80 | 2026-08-15 | 2026-08-07 |
| Micro-choice-based Intervention for Multicausal Fatigue Micro-choice-based intervention - Multicausal Fatigue, Fatigue | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 24 | 2026-08-13 | 2026-08-18 |
| Hyperbaric Oxygen Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Hyperbaric oxygen therapy, SHAM treatment - Chronic Fatigue Syndrome, ME/CFS | Not applicable | Recruiting | Assaf-Harofeh Medical Center | 74 | 2026-07-19 | 2026-08-21 |
| ME/CFS Brain Fog: Cognitive Rehabilitation Trial Processing Speed Training, In-session Instrumental Activities of Daily Living Training, Transfer Package - ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis | Not applicable | Recruiting | University of Alabama at Birmingham | 30 | 2026-06-23 | 2026-10-29 |
| Photobiomodulation in Chronic Fatigue Syndrome Photobiomodulation (Low-Level Laser Therapy), sham Photobiomodulation (LLLT) - Chronic Fatigue Syndrome (CFS), Quality of Life | Not applicable | Recruiting | University of Lahore | 40 | 2026-06-15 | 2026-10-08 |
| Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) to Improve Fatigue, Pain, and Quality of Life by Targeting Mitochondrial Dysfunction and Autonomic Nervous System Impairment Intermittent hypoxia-hyperoxia treatment (IHHT), Placebo - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (ICD-10 G93.3) | Not applicable | Not yet recruiting | University of Aarhus | 104 | 2026-06-01 | 2026-05-22 |
| Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 Onset ME/CFS Versus Pre-Pandemic ME/CFS Patients Chronic Fatigue Syndrome | Enrolling by invitation | Johns Hopkins University | 200 | 2026-06-01 | 2026-06-11 | |
| Photobiomodulation for Chronic Pain and Fatigue in Hypermobile Ehlers-Danlos Syndrome (PBM-SEDh-01) Ehlers-Danlos Syndrome, Hypermobile, Chronic Pain | Recruiting | Centre Medical ISM (Integrative Systemic Medicine) | 25 | 2026-05-26 | 2026-06-15 | |
| A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS Voice Recording - Encephalomyelitis, Chronic Fatigue Syndrome | Recruiting | Mayo Clinic | 40 | 2026-05-26 | 2026-05-27 | |
| Fareon Open Label Device Clinical Trial Fareon device - Cognitive Dysfunction, Acquired Brain Injury | Not applicable | Enrolling by invitation | Icahn School of Medicine at Mount Sinai | 30 | 2026-05-11 | 2026-10-28 |
| The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Acupuncture, Sham acupuncture - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | Not applicable | Not yet recruiting | Xi Wu | 99 | 2026-05-01 | 2026-01-22 |
| The Aim of the Present Study is to Determine Outcome Predictors in Children Who Were Diagnosed as Acute Disseminated Encephalomyelitis (ADEM). Acute Disseminated Encephalomyelitis, Encephalomyelitis | Not yet recruiting | Assiut University | 25 | 2026-03-29 | 2026-04-20 | |
| Clinical Laboratory Evaluation, Assessment of Symptoms and Recovery in Patients With Post-COVID-19-Vaccination Syndrome Blood sampling and analysis, The continuous Reactive Hyperemia Index (InRHI) measured by EndoPAT - Post-Acute COVID-19 Vaccination Syndrome, Postviral Fatigue | Recruiting | University of Bern | 200 | 2026-03-22 | 2026-05-05 | |
| Multicomponent Care for Aromatase Inhibitor-Related Musculoskeletal Symptoms Multicomponent Care for Aromatase Inhibitor-Related Musculoskeletal Symptoms (AIMSS-CARE) - Breast Neoplasms, Musculoskeletal Pain | Not applicable | Not yet recruiting | Addis Ababa University | 88 | 2026-03-15 | 2026-02-13 |
| Observational Study on Immunoadsorption (IA) in Patients With Autoantibody-Positive Post-Infectious ME/CFS IA with TheraSorb ® column (Miltenyi) - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), ME/CFS Following COVID-19 | Recruiting | Charite University, Berlin, Germany | 50 | 2026-03-11 | 2026-04-14 |
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Fatigue Syndrome, Chronic (260) · Fatigue (58) · Fibromyalgia (47) · Post-Acute COVID-19 Syndrome (38) · Pain (19) · Irritable Bowel Syndrome (18) · Depression (15) · Chronic Pain (13) · COVID-19 (12) · Anxiety Disorders (10) · Multiple Sclerosis (10) · Encephalomyelitis, Venezuelan Equine (8) · Mental Fatigue (8) · Motor Activity (8) · Sleep Initiation and Maintenance Disorders (8)
Neuroinflammatory Diseases (274) · Nervous System Diseases (272) · Disease Attributes (261) · Pathologic Processes (261) · Pathological Conditions, Signs and Symptoms (261) · Chronic Disease (260) · Neuromuscular Diseases (260) · Muscular Diseases (259) · Musculoskeletal Diseases (258) · Signs and Symptoms (90) · Infections (76) · Virus Diseases (65) · RNA Virus Infections (60) · Respiratory Tract Diseases (53)
Sodium Chloride (5) · Acupuncture Therapy (4) · Exercise Test (4) · Naltrexone (4) · Rituximab (4) · coenzyme Q10 (4) · Cognitive Behavioral Therapy (3) · Desiccation (3) · Exercise (3) · Sodium Oxybate (3) · Water (3) · Acceptance and Commitment Therapy (2) · Actigraphy (2) · Ascorbic Acid (2) · Clonidine (2)
Haukeland University Hospital (7) · Stony Brook University (7) · Charite University, Berlin, Germany (6) · U.S. Army Medical Research and Development Command (6) · Icahn School of Medicine at Mount Sinai (5) · Norwegian University of Science and Technology (5) · University of Aarhus (5) · University of Alabama at Birmingham (5) · Centre Hospitalier Universitaire de Saint Etienne (4) · Hospital Universitari Vall d'Hebron Research Institute (4) · Oslo University Hospital (4) · Technical University of Munich (4) · Aarhus University Hospital (3) · Duke University (3) · Radboud University Medical Center (3)
United States (98) · Norway (24) · Spain (18) · Germany (17) · United Kingdom (11) · China (8) · Turkey (Türkiye) (8) · Canada (7) · Netherlands (7) · Sweden (7) · France (6) · Denmark (5) · Poland (5) · Belgium (4) · Finland (4)
Fred Friedberg, PhD (5) · Benjamin Natelson, MD (3) · Per Fink, DMSc (3) · Anthony Cardile, DO (2) · Carmen Scheibenbogen, Prof. Dr. (2) · David Systrom, MD (2) · Jarred Younger, PhD (2) · Judith Bellmann-Strobl, MD (2) · Lucinda Bateman, MD (2) · Olav Mella, MD, PhD (2) · Olav Mella, PhD, MD (2) · Robert Rivard, MD (2)
PMID 25386668, PMID 26212172, PMID 22871021, PMID 23600892, PMID 26132314, PMID 10529146, PMID 11088089, PMID 11093451, PMID 11516765, PMID 12358329, PMID 15941694, PMID 17350488, PMID 17350675, PMID 18247252, PMID 1865419, PMID 18768089, PMID 19004564, PMID 19843509, PMID 19962493, PMID 20095909, PMID 20336547, PMID 20447621, PMID 20617920, PMID 20703820, PMID 20717848, PMID 21112746, PMID 21333021, PMID 21375763, PMID 21682669, PMID 21906029, PMID 22039471, PMID 22385563, PMID 22431963, PMID 22588748, PMID 22790224, PMID 22985998, PMID 23261007, PMID 23514202, PMID 23813081, PMID 23898301, PMID 23922399, PMID 23959519, PMID 24493300, PMID 24528544, PMID 24634898, PMID 24755065, PMID 25084634, PMID 25274261, PMID 25287104, PMID 25421363
2014 (2), 2025 (2), 1UG3NS141843-01A1 (1), 2015 (1), P20NR016575 (1), R01ES015382 (1), R01HD096331 (1), R01NS072599 (1), R01NS109529 (1), R01NS116887 (1), R01NS117638 (1), R21AR053963 (1), R21AT004537 (1), R21NR010539 (1), R21NS094644 (1)