28 completed, 11 recruiting, 9 unknown, 4 active not recruiting. 33 Not applicable, 2 Phase 2, 2 Phase 3, 2 Phase 4.
Follow Medically Unexplained Symptoms: new trials by email Literature Review of Medically Unexplained Symptoms trials Research Report on Medically Unexplained Symptoms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms Stress Management and Resiliency Training with Qigong/Tai Chi, Healthy Living Program - Depression / Major Depressive Disorder, Mental Health (Depression) | Not applicable | Recruiting | Massachusetts General Hospital | 70 | 2026-09-01 | 2026-10-07 |
| Exposure Therapy for Reactivity to Symptoms Planned, systematic, exposure exercises, Response prevention - Psychological Factors Affecting Other Medical Conditions, Somatic Symptom and Related Disorders | Not applicable | Not yet recruiting | Region Stockholm | 360 | 2026-09-01 | 2026-08-11 |
| Interoceptive Awareness and Dream Themes Adult Women | Active not recruiting | Recep Tayyip Erdogan University | 307 | 2026-07-01 | 2026-07-21 | |
| Mapping the Healthcare Pathway to Multidisciplinary Assessment of 12-25 Year Olds With Somatic Symptom Disorder Face-to-face interviews assisted by a biographical grid - Somatic Symptoms, Medically Unexplained Symptoms | Recruiting | Assistance Publique - Hôpitaux de Paris | 36 | 2026-06-10 | 2026-07-20 | |
| Grow With Grit: A School Nurse-Led SBIRT Pilot for Early Anxiety Detection Grow with Grit - Anxiety | Not applicable | Recruiting | McLaughlin Research Institute for Biomedical Sciences, Inc. | 60 | 2026-02-09 | 2026-08-17 |
| Impact of Humor Prescription on the Emotional Well-being of Patients With Medically Unexplained Symptoms: A Quasi-experimental Study Humor therapy - Medically Unexplained Symptoms | Not applicable | Active not recruiting | Consorci Sanitari de l'Alt Penedès i Garraf | 28 | 2025-09-01 | 2025-12-05 |
| An Ecological Momentary Intervention for the Reduction of Impairment in Somatic Symptom Disorder Music listening, Cognitive reappraisal, No intervention - Somatic Symptom Disorder (DSM-5), Impairment | Not applicable | Recruiting | University of Vienna | 40 | 2025-06-26 | 2026-06-12 |
| ISTDP for Patients With Treatment Resistance PPS Individual intensive short term psychodynamic therapy - Somatic Symptom Disorder, Persistent Physical Symptoms | Not applicable | Completed | Daniel Maroti | 25 | 2025-02-01 | 2026-07-27 |
| Telehealth Group-based Emotional Awareness and Expression Therapy for Patients With Persistent Physical Symptoms: A Pilot Study Emotional Awareness and Expression Therapy - Somatic Symptom and Related Disorders, Somatic Symptom Disorder | Not applicable | Withdrawn | Daniel Maroti | 2025-01-01 | 2026-07-27 | |
| Mindfulness Meditation: Alleviating Symptoms and Inflammation in Nurses Mindfulness meditation - Inflammation, Somatization | Not applicable | Active not recruiting | Jordan University of Science and Technology | 102 | 2024-08-01 | 2024-10-10 |
| Online Therapy Youth, Equivalent to Treatment As Usual? EMDR, ACT - Depression, Trauma | Not applicable | Unknown | GGZ Noord-Holland-Noord | 172 | 2024-07-01 | 2024-09-27 |
| Stress and Musculoskeletal Health in Employees Diaphragmatic breathing (DF), Progressive Muscle Relaxation (PMR) - Musculoskeletal Diseases or Conditions, Musculoskeletal Pain | Not applicable | Recruiting | University of Thessaly | 57 | 2024-06-01 | 2024-07-05 |
| Acceptance and Commitment Therapy Based Group Psychoeducation for Nursing Students Acceptance and commitment therapy based group psychoeducation - Psychological Flexibility, Somatic Symptom | Not applicable | Completed | Tugba Yildirim | 54 | 2024-04-18 | 2024-10-23 |
| Non-Medication Methods to Relieve Adolescents with Somatoform Disorders Tai Chi and Relaxation Intervention - Chronic Somatoform Disorders in Adolescents | Recruiting | Assistance Publique - Hôpitaux de Paris | 50 | 2024-03-06 | 2025-03-10 | |
| Effectiveness of a Cognitive and Behavioral Treatment Program in People With Idiopathic Environmental Intolerance (IEI) Cognitive Behavioral Therapy - Idiopathic Environmental Intolerance | Not applicable | Recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 82 | 2024-02-20 | 2025-08-13 |
| Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic Disorder Patient Education, Duloxetine, Benztropine Mesylate 0.5 MG and passive placebo RAP - Functional Disorder | Phase 4 | Recruiting | Aarhus University Hospital | 424 | 2024-01-01 | 2024-01-30 |
| Feasibility of Virtual Tai Chi Easy for Registered Nurses Virtual Tai Chi Easy - Transition Shock, Nurses' Intention to Quit | Not applicable | Unknown | University of Arizona | 40 | 2023-12-22 | 2024-05-21 |
| Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation BOLD-fMRI, Regular treatment of functional constipation, fluoxetine - Constipation - Functional, Refractory Constipation | Recruiting | Xijing Hospital of Digestive Diseases | 150 | 2023-11-01 | 2025-07-24 | |
| Development of Online EMDR Therapy System and Its Comparative Testing With Face-to-Face EMDR Therapy for Treatment of Anxiety and Depressive Disorders in Pakistan Online EMDR Therapy System, Face to Face Eye Movement Desensitization & Reprocessing Therapy - Generalized Anxiety Disorder, Major Depressive Disorder | Not applicable | Unknown | Khushal Khan Khattak Univeristy, Karak, Pakistan | 30 | 2023-07-01 | 2023-03-27 |
| Efficacy and Safety of Toluedesvenlafaxine Hydrochloride Extended-release Tablets in Somatic Symptoms of Depression toludesvenlafaxine hydrochloride sustained-release tablets - Somatic Symptom | Phase 4 | Completed | Shanghai Mental Health Center | 60 | 2023-05-12 | 2025-05-31 |
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Somatoform Disorders (14) · Depression (8) · Anxiety Disorders (7) · Fibromyalgia (5) · Irritable Bowel Syndrome (5) · Fatigue Syndrome, Chronic (4) · Affective Symptoms (2) · Depressive Disorder, Major (2) · Neurasthenia (2) · Psychological Well-Being (2) · Sleep Initiation and Maintenance Disorders (2) · Wounds and Injuries (2) · Airway Obstruction (1) · Airway Remodeling (1)
Pathological Conditions, Signs and Symptoms (54) · Signs and Symptoms (54) · Mental Disorders (26) · Behavior (15) · Behavioral Symptoms (13) · Nervous System Diseases (7) · Muscular Diseases (6) · Colonic Diseases (5) · Colonic Diseases, Functional (5) · Digestive System Diseases (5) · Gastrointestinal Diseases (5) · Intestinal Diseases (5) · Musculoskeletal Diseases (5) · Neuromuscular Diseases (5) · Pathologic Processes (5)
Cognitive Behavioral Therapy (5) · Acceptance and Commitment Therapy (2) · ARHGAP32 protein, human (1) · Autogenic Training (1) · Benztropine (1) · Biofeedback, Psychology (1) · Duloxetine Hydrochloride (1) · Eye Movement Desensitization Reprocessing (1) · Fluoxetine (1) · Mindfulness (1) · Mindfulness-Based Cognitive Therapy (1) · Patient Education as Topic (1) · Psychosocial Intervention (1) · Serotonin and Noradrenaline Reuptake Inhibitors (1) · Tai Ji (1)
University of Aarhus (7) · Assistance Publique - Hôpitaux de Paris (2) · Daniel Maroti (2) · National Taiwan University Hospital (2) · Philipps University Marburg (2) · Region Stockholm (2) · RenJi Hospital (2) · Wayne State University (2) · Aarhus University Hospital (1) · Basque Health Service (1) · Consorci Sanitari de l'Alt Penedès i Garraf (1) · Endeavor Health (1) · Finnish Institute of Occupational Health (1) · Fondation Santé des Étudiants de France (1) · GGZ Noord-Holland-Noord (1)
United States (9) · Denmark (6) · Sweden (5) · China (4) · France (4) · Austria (2) · Finland (2) · Germany (2) · Greece (2) · Netherlands (2) · Taiwan (2) · Turkey (Türkiye) (2) · United Kingdom (2) · Canada (1) · Italy (1)
Per Fink, DMSc (3) · Erland Axelsson, PhD (2) · Afton L Hassett, Psy.D. (1) · Auddie Sweis, MD (1) · Carlie M Felion (1) · Cedric Lemogne, PR, MD (1) · Charles Taft, associate professor (1) · Charlotte U Rask, MD, PhD (1) · Christoph Janka, DI (1) · Eleni Zigkiri, PhD (c) (1) · Helena Liira, MD, PhD (1) · Hossam Alhawatmeh, Doctoral degree (1) · Japhia-Maria Gottschalk, M.Sc. (1) · Jian Hou (1) · Joel M Town, DClinPsy (1)
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R34AT012922 (1)