15 completed, 6 unknown, 5 terminated, 3 not yet recruiting. 33 Phase 3, 10 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 33 | Completed 15, Unknown 6, Terminated 5, Not yet recruiting 3, Recruiting 3, Withdrawn 1 |
| Phase 2 | 10 | Unknown 5, Completed 2, Not yet recruiting 1, Terminated 1, Withdrawn 1 |
Follow Cerebral Infarction: new trials by email Literature Review of Cerebral Infarction trials Research Report on Cerebral Infarction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HR-MRI-Directed Tirofiban Therapy for Late-Window Acute Ischemic Stroke (TIAN) Tirofiban, dual antiplatelet therapy - Stroke, Acute, Stroke, Ischemic | Phase 3 | Recruiting | Weifang Medical University | 458 | 2026-06-22 | 2026-06-25 |
| Intravenous Thrombolysis With Tenecteplase Plus Thrombectomy Versus Thrombectomy Alone In Patients With A Large Ischemic Stroke: A Multicenter Randomized Controlled Trial (IVT-ALL-IN) Intravenous administration, MT alone - Stroke | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 486 | 2026-06-15 | 2026-05-22 |
| Safety and Efficacy of Baricitinib After Endovascular Treatment in Acute Anterior Circulation Large Vessel Occlusion: A Multicenter, Randomized Controlled Clinical Trial 2mg Baricitinib, 4mg Baricitinib, Placebo - Acute Ichemic Stroke, Anterior Cerebral Artery Stroke | Phase 2 / Phase 3 | Not yet recruiting | The First Affiliated Hospital of University of Science and Technology of China | 750 | 2026-03-17 | 2026-03-04 |
| Interleukin-6 Receptor Inhibition for Symptomatic Intracranial Atherosclerosis Tocilizumab, NaCl 0.9% 100ml - Brain Diseases, Ischemic Stroke | Phase 3 | Not yet recruiting | Zhujiang Hospital | 486 | 2025-10-30 | 2025-07-28 |
| Tirofiban for the Prevention of Early Neurological Deterioration After Intravenous Thrombolysis in Acute Ischemic Stroke Tirofiban Hydrochloride, Standard medical treatment (SMT) - Acute Stroke, Ischemic Stroke, Acute | Phase 2 / Phase 3 | Unknown | Capital Medical University | 302 | 2024-11-20 | 2024-10-29 |
| Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT) Aspirin, Placebo, Best medical management - Acute Ischemic Stroke, Cerebral Infarction | Phase 3 | Recruiting | Capital Medical University | 1184 | 2024-11-07 | 2026-09-24 |
| Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion Tenecteplase, direct EVT - Ischemic Stroke, Acute, Thrombolysis | Phase 3 | Completed | Beijing Tiantan Hospital | 391 | 2024-01-25 | 2025-11-26 |
| Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis Colchicine 0.5 MG, Ticagrelor 90mg, Aspirin 75-300mg - Stroke, Stroke, Ischemic | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 2800 | 2023-05-17 | 2025-09-08 |
| Efficacy of Sovateltide (PMZ-1620) in Patients of Acute Ischemic Stroke Normal Saline along with standard treatment, PMZ-1620 (sovateltide) along with standard treatment - Cerebral Ischemia, Cerebral Infarction | Phase 3 | Completed | Pharmazz, Inc. | 158 | 2019-11-10 | 2023-10-18 |
| DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval Direct endovascular clot retrieval, Bridging thrombolysis followed by ECR - Ischemic Stroke | Phase 3 | Completed | Neuroscience Trials Australia | 295 | 2018-04-27 | 2022-06-16 |
| Stroke Treatment Associate to Rehabilitation Therapy and Transcranial DC Stimulation Transcranial direct current stimulation, Constraint-Induced Movement Therapy, Placebo - Stroke, Cerebrovascular Disorders | Phase 2 / Phase 3 | Unknown | Federal University of Paraíba | 40 | 2016-02-01 | 2015-12-07 |
| Neurostimulation for Cognitive Rehabilitation in Stroke transcranial direct current stimulation - Stroke, Cognitive Impairment | Phase 2 / Phase 3 | Unknown | Federal University of Paraíba | 60 | 2015-12-01 | 2015-12-07 |
| Tenecteplase Versus Alteplase in Ischemic Stroke Management (TALISMAN) Tenecteplase, Alteplase - Ischemic Stroke | Phase 2 / Phase 3 | Withdrawn | Reza Behrouz, DO | 2015-01-01 | 2015-09-23 | |
| Edoxaban for TIA and Acute Minor Stroke Aspirin, edoxaban, placebo - Ischemia, Stroke | Phase 2 / Phase 3 | Unknown | Xijing Hospital | 3700 | 2013-12-01 | 2014-08-20 |
| The Carotid and Middle Cerebral Artery Occlusion Surgery Study bypass surgery, Aspirin, Clopidogrel - Carotid Artery Occlusion, Middle Cerebral Artery Occlusion | Phase 3 | Completed | Xuanwu Hospital, Beijing | 330 | 2013-06-06 | 2021-11-12 |
| Transcranial Stimulation and Motor Training in Stroke Rehabilitation Anodal tDCS, Motor Training - Stroke, Cerebral Infarction | Phase 2 / Phase 3 | Unknown | University of Oxford | 80 | 2011-01-01 | 2012-06-20 |
| The Effects of Very Early Use of Rosuvastatin in Preventing Recurrence of Ischemic Stroke Rosuvastatin, Placebo tablet - Stroke | Phase 3 | Terminated | Severance Hospital | 318 | 2010-08-01 | 2014-11-20 |
| The Intravascular Cooling in the Treatment of Stroke 2/3 Trial hypothermia and anti-shivering treatment, Group1: IV t-PA and normothermia - Stroke, Acute | Phase 2 / Phase 3 | Terminated | University of California, San Diego | 120 | 2010-06-01 | 2017-04-05 |
| Action of Amantadine on Post-Stroke Aphasic Patients Amantadin, Placebo - Cerebral Infarction | Phase 2 / Phase 3 | Completed | Centre Hospitalier Universitaire de Nice | 50 | 2009-03-01 | 2014-04-21 |
| Melodic-Intonation-Therapy and Speech-Repetition-Therapy for Patients With Non-fluent Aphasia Melodic Intonation Therapy, Speech-Repetition-Therapy - Aphasia, Stroke | Phase 3 | Completed | Beth Israel Deaconess Medical Center | 30 | 2008-02-01 | 2020-09-21 |
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Stroke (24) · Ischemic Stroke (10) · Cerebrovascular Disorders (7) · Brain Ischemia (6) · Brain Diseases (4) · Brain Infarction (4) · Infarction, Middle Cerebral Artery (4) · Ischemia (4) · Vascular Diseases (3) · Atherosclerosis (2) · Cardiovascular Diseases (2) · Central Nervous System Diseases (2) · Ischemic Attack, Transient (2) · Myocardial Infarction (2)
Infarction (33) · Necrosis (33) · Pathological Conditions, Signs and Symptoms (33) · Pathologic Processes (32) · Cardiovascular Diseases (31) · Central Nervous System Diseases (31) · Nervous System Diseases (31) · Vascular Diseases (30) · Brain Diseases (29) · Brain Infarction (29) · Ischemia (29) · Brain Ischemia (27) · Cerebrovascular Disorders (26) · Stroke (9) · Intracranial Arterial Diseases (6)
Aspirin (8) · Transcranial Direct Current Stimulation (3) · Cilostazol (2) · Clopidogrel (2) · Tenecteplase (2) · Tirofiban (2) · Tissue Plasminogen Activator (2) · sarpogrelate (2) · Administration, Intravenous (1) · Amantadine (1) · Cerebral Revascularization (1) · Colchicine (1) · Constraint Induced Movement Therapy (1) · Cool-Down Exercise (1) · Coronary Artery Bypass (1)
Tanabe Pharma Corporation (3) · Assistance Publique - Hôpitaux de Paris (2) · Capital Medical University (2) · Federal University of Paraíba (2) · National Institute of Neurological Disorders and Stroke (NINDS) (2) · Beijing Tiantan Hospital (1) · Beth Israel Deaconess Medical Center (1) · Bispebjerg Hospital (1) · CHIMES Society (1) · Centre Hospitalier Universitaire de Nice (1) · Ferrer Internacional S.A. (1) · Max-Planck-Institute of Experimental Medicine (1) · Neuroscience Trials Australia (1) · Otsuka Beijing Research Institute (1) · Otsuka Pharmaceutical Co., Ltd. (1)
China (9) · United States (6) · France (3) · Brazil (2) · Germany (2) · Japan (2) · Singapore (2) · Switzerland (2) · Australia (1) · Austria (1) · Denmark (1) · Hong Kong (1) · India (1) · Malaysia (1) · Philippines (1)
Andrea Norton, BM (1) · Anil Gulati, MD, PhD (1) · Bernard Yan, MD (1) · Christopher Chen, MBBS (1) · Feng Ling, MD (1) · Fengyuan Che, MD (1) · Gang Zhao, M.D. (1) · Gottfried Schlaug, MD, PhD (1) · Gudrun Boysen, MD (1) · James C. Grotta, MD (1) · James F. Toole, M.D. (1) · Ji Hoe Heo, MD., Ph. D (1)
PMID 22068990, PMID 16763187, PMID 17494672, PMID 17622759, PMID 18029233, PMID 18388340, PMID 18456558, PMID 19673813, PMID 19834012, PMID 19900934, PMID 21197418, PMID 21737309, PMID 21852153, PMID 21960571, PMID 22668888, PMID 22691567, PMID 22949472, PMID 23101451, PMID 23780952, PMID 24135924, PMID 26387127, PMID 26420269, PMID 26628386, PMID 26822418, PMID 27834742, PMID 27852286, PMID 31570084, PMID 33175411, PMID 33428177, PMID 35135060, PMID 35810757, PMID 37256974, PMID 37606672, PMID 38648030, PMID 38934799, PMID 39334395, PMID 39542995, PMID 39727027, PMID 40534574, PMID 41717940, PMID 42099212, PMID 9757852
P50NS044148 (1), P50NS044227 (1), R01DC008796 (1)