49 completed, 21 recruiting, 18 unknown, 9 terminated. 31 Not applicable, 16 Phase 2, 13 Phase 3, 10 Phase 1, 5 Phase 4.
Follow Lyme Disease: new trials by email Literature Review of Lyme Disease trials Research Report on Lyme Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study. Hydroxychloroquin, Placebo, Doxycycline - Lyme Borreliosis, Nervous System | Phase 4 | Not yet recruiting | Radboud University Medical Center | 50 | 2027-03-01 | 2026-08-27 |
| The Precision Mito- Mito Map COMPASS Study Mito Map Energy Score and Home Functional Assessments - Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome | Not yet recruiting | AI Agent Vault, Inc. d/b/a Precision Mito | 400 | 2026-11-01 | 2026-10-02 | |
| Flow Cytometric Immune Monitoring of B. Afzelii-Specific T Lymphocytes Lyme Borreliosis, Lyme Disease | Not yet recruiting | University Hospital, Strasbourg, France | 20 | 2026-09-01 | 2026-07-14 | |
| Ceftriaxone for Post-Treatment Lyme Disease Ceftriaxone treatment, Placebo - Post-Treatment Lyme Disease Syndrome | Phase 1 / Phase 2 | Withdrawn | Hackensack Meridian Health | 2026-05-14 | 2026-05-18 | |
| A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1982 to Prevent Lyme Disease in Healthy Participants (18 to 70 Years of Age) mRNA-1982, Placebo - Lyme Disease | Phase 2 | Active not recruiting | ModernaTX, Inc. | 366 | 2026-04-29 | 2026-08-03 |
| A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine VLA15, Placebo - Lyme Disease | Phase 3 | Recruiting | Pfizer | 1712 | 2026-04-08 | 2026-05-06 |
| A Study to Evaluate Safety and Efficacy of TP-05 in Healthy Participants With Tick Exposure TP-05 (lotilaner) Low Dose, TP-05 (lotilaner) High Dose, Placebo - Lyme Disease | Phase 2 | Active not recruiting | Tarsus Pharmaceuticals, Inc. | 722 | 2026-03-09 | 2026-07-09 |
| Borrelia Arthritis - a Hidden Cause of Arthritis in Danish Patients? Synovial fluid Borrelia burgdorferi PCR - Lyme Arthritis | Not yet recruiting | Fredrikke Christie Knudtzen | 350 | 2026-01-01 | 2026-01-20 | |
| A Study to Learn About Different Dosing Schedules of a Lyme Disease Vaccine in Healthy Adults VLA15, Placebo - Lyme Borreliosis | Phase 3 | Active not recruiting | Pfizer | 207 | 2025-11-19 | 2026-05-06 |
| Safety and Effectiveness of the BlinkER System in Participants With Facial Nerve Palsy BlinkER device. - Bell's Palsy, Ramsay Hunt Syndrome | Not applicable | Not yet recruiting | Neurotrigger Ltd | 80 | 2025-10-01 | 2025-06-10 |
| A Multicenter Real-life Study of Disseminated Borreliosis Cases Occurring in Patients Receiving Anti-CD20 Treatment in France Borrelia Infections | Recruiting | University Hospital, Strasbourg, France | 100 | 2025-08-29 | 2026-01-15 | |
| Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis)) Amoxicillin + Saccharomyces boulardii CNCM I-745, Amoxicillin + Placebo, Stool samples - Erythema Migrans of Lyme Disease | Phase 4 | Recruiting | Biocodex | 120 | 2025-07-16 | 2025-08-27 |
| Transcranial Direct Current Stimulation for Post Treatment Lyme Disease Transcranial Direct Current Stimulation (tDCS), Cognitive training - Post-Treatment Lyme Disease | Not applicable | Recruiting | Columbia University | 110 | 2025-07-14 | 2026-05-06 |
| Anti-phospolipid Antibodies in Lyme Borreliosis Anti-phospholipid antibodies - Patients With Different Manifestations of Lyme Borreliosis, Persons With Nonspecific Symptoms and Positive Borrelia Antibodies in Serum | Not yet recruiting | University Medical Centre Ljubljana | 240 | 2025-05-15 | 2025-04-16 | |
| Experiences and Care Pathways Shared on Social Media Regarding 5 Conditions Causing Chronic Pain Lyme Borreliosis, Fibromyalgia | Completed | Central Hospital, Nancy, France | 501 | 2025-03-17 | 2026-10-13 | |
| Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases Peripheral venous blood sample - Leishmaniasis, Leptospirosis | Not applicable | Not yet recruiting | University Hospital, Montpellier | 183 | 2025-03-03 | 2025-03-05 |
| Ceftriaxone Pulse Dose for Post-Treatment Lyme Disease Ceftriaxone (Rocephin®), Dextrose 5% (D5W) - Post-Treatment Lyme Disease | Early Phase 1 | Recruiting | State University of New York - Upstate Medical University | 44 | 2025-02-03 | 2026-03-19 |
| Clinicaly Manifested Reinfections with Borrelia Burgdorferi Sensu Lato Lyme Borreliosis | Active not recruiting | University Medical Centre Ljubljana | 15000 | 2024-12-31 | 2025-02-21 | |
| Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Lumbrokinase - Long Covid, Post-treatment Lyme Disease Syndrome | Phase 1 / Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 120 | 2024-10-09 | 2026-03-13 |
| Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain Sana Pain Reliever, Sham SPR - Post-treatment Lyme Disease Syndrome, Chronic Pain | Not applicable | Recruiting | Icahn School of Medicine at Mount Sinai | 20 | 2024-10-04 | 2026-05-18 |
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Post-Lyme Disease Syndrome (22) · Lyme Neuroborreliosis (19) · Glossitis, Benign Migratory (15) · Borrelia Infections (9) · Tick-Borne Diseases (8) · Erythema Chronicum Migrans (6) · Fatigue Syndrome, Chronic (5) · Arthritis, Rheumatoid (4) · Fatigue (4) · Fibromyalgia (4) · Inflammation (4) · Anxiety Disorders (3) · Arthritis (3) · Chronic Pain (3)
Bacterial Infections (114) · Bacterial Infections and Mycoses (114) · Gram-Negative Bacterial Infections (114) · Spirochaetales Infections (114) · Vector Borne Diseases (113) · Infections (112) · Tick-Borne Diseases (107) · Borrelia Infections (106) · Pathological Conditions, Signs and Symptoms (37) · Pathologic Processes (33) · Nervous System Diseases (32) · Disease Attributes (28) · Central Nervous System Diseases (27) · Chronic Disease (26) · Post-Infectious Disorders (23)
Doxycycline (16) · Ceftriaxone (10) · Blood Specimen Collection (3) · Amoxicillin (2) · Anti-Bacterial Agents (2) · Hydroxychloroquine (2) · Meditation (2) · Sodium Chloride (2) · lotilaner (2) · Acetaminophen (1) · Acyclovir (1) · Arthrocentesis (1) · BID protein, human (1) · Clarithromycin (1) · Cognitive Training (1)
University Medical Centre Ljubljana (19) · National Institute of Allergy and Infectious Diseases (NIAID) (12) · Pfizer (8) · University Hospital, Strasbourg, France (7) · Research Foundation for Mental Hygiene, Inc. (3) · Brigham and Women's Hospital (2) · Children's National Research Institute (2) · Columbia University (2) · Icahn School of Medicine at Mount Sinai (2) · Johns Hopkins University (2) · ModernaTX, Inc. (2) · National Institute of Neurological Disorders and Stroke (NINDS) (2) · Optimal Health Research (2) · ProgenaBiome (2) · Radboud University Medical Center (2)
United States (62) · Slovenia (18) · France (14) · Canada (3) · Denmark (3) · Germany (3) · Switzerland (3) · Belgium (2) · Finland (2) · Netherlands (2) · Norway (2) · Poland (2) · Australia (1) · Austria (1) · Czechia (1)
Adriana R Marques, M.D. (8) · Brian A Fallon, MD (4) · Franc Strle, MD, PhD (4) · Franc Strle, MD (3) · Dasa Stupica, MD, PhD (2) · Franc Strle, MD PhD (2) · Fredrikke C Knudtzen, MD (2) · Sabine Hazan, MD (2) · Albert Garcia-Romeu, PhD (1) · Alison Rand, MD (1) · Andrew Friedl, MS, MBA (1) · Anne Marit Solheim, M.D (1)
PMID 30075748, PMID 38830375, PMID 39248571, PMID 18567539, PMID 22523260, PMID 24523212, PMID 27028911, PMID 27248436, PMID 28878005, PMID 29048514, PMID 29385444, PMID 29505880, PMID 30796143, PMID 31590634, PMID 31710647, PMID 32133487, PMID 34031759, PMID 35289310, PMID 35323885, PMID 35483736, PMID 35816681, PMID 36209759, PMID 37419129, PMID 38262807, PMID 39029481, PMID 40265182, PMID 40294611, PMID 41213278, PMID 41563326, PMID 41703273, PMID 41741501, PMID 42086599, PMID 42680745, PMID 42766572
2023 (3), 2025 (2), 2009 (1), 2015 (1), P60AR036308 (1), R01AI031561 (1)