53 completed, 18 unknown, 11 recruiting, 5 terminated. 97 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 97 | Completed 53, Unknown 18, Recruiting 11, Terminated 5, Not yet recruiting 4, Withdrawn 4, Active not recruiting 1, Suspended 1 |
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Trial in Patients With Barth Syndrome- 4TAZPower Elamipretide, Placebo - Barth Syndrome | Phase 4 | Recruiting | Stealth BioTherapeutics Inc. | 48 | 2026-07-02 | 2026-09-17 |
| The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After Fontan Procedure Dapagliflozin (5-10 mg daily) - SGLT2 Inhibitor Therapy - Fontan, Heart Failure | Phase 4 | Recruiting | The University of Hong Kong | 30 | 2026-07-01 | 2026-07-28 |
| Perioperative Lidocaine for Lung Protection in Infants Undergoing Cardiac Surgery Lidocaine %2 ampoule, Normal Saline (0.9% NaCl) - Congenital Heart Disease, Postoperative Pulmonary Complications | Phase 4 | Not yet recruiting | The Children's Hospital of Zhejiang University School of Medicine | 320 | 2026-04-01 | 2026-03-30 |
| A Novel Echocardiography-Guided Strategy for Percutateous Closure of Atrial Septal Defect Assisted by PannaWire Ultrasound-guided intervention with assistance of specialized instruments, fluoroscopy-guided intervention - Atrial Septal Defect (ASD) | Phase 4 | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 666 | 2026-03-14 | 2026-03-17 |
| Effect of Tirzepatide on Cardiovascular and Metabolic Parameters in Obese Adult Patients With Congenital Heart Disease Treatment with tirzapatide, Treatment with placebo - Obesity & Overweight, Adult Congenital Heart Disease | Phase 4 | Not yet recruiting | University Medical Centre Ljubljana | 30 | 2026-01-20 | 2026-01-21 |
| A Multicenter Randomized Controlled Trial of Echocardiography-Guided Atrial Septal Defect Closure Performed in a Mobile Surgical Unit Mobile Surgical Vehicle Echocardiography-guided ASD closure Group, Conventional Operating Room Echocardiography-guided ASD closure Group - ASD - Atrial Septal Defect | Phase 4 | Not yet recruiting | China National Center for Cardiovascular Diseases | 300 | 2025-12-19 | 2025-12-09 |
| A Study of Sotatercept for Patients With Eisenmenger Syndrome or Unrepaired Shunt-Associated Pulmonary Arterial Hypertension Resistant to Vasodilator Therapy Sotatercept, vasodilator-based PAH therapy - Eisenmenger Syndrome, Pulmonary Arterial Hypertension of Congenital Heart Disease | Phase 4 | Recruiting | Kazuya Hosokawa | 36 | 2025-10-07 | 2026-01-21 |
| Long-Term Low-Intervention SafEty and Clinical Outcomes Clinical Study of LivmArli® in Patients With Alagille Syndrome or Progressive Familial Intrahepatic Cholestasis in the European Union (LEAP-EU) Livmarli Oral Product - Alagille Syndrome, Progressive Familial Intrahepatic Cholestasis | Phase 4 | Recruiting | Mirum Pharmaceuticals, Inc. | 230 | 2025-09-25 | 2026-06-23 |
| Intralesional Bleomycin Sclerotherapy for Low-Flow Vascular Malformations of the Head and Neck Bleomycin (Bleocel 15) - Vascular Malformations, Venous Malformation | Phase 4 | Completed | University Of Anbar | 20 | 2025-08-25 | 2026-07-27 |
| Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome Micronized progesterone 200 MG, Micronized Progesterone 100 MG - Turner Syndrome, Primary Ovarian Insufficiency (Poi) | Phase 4 | Recruiting | Children's Mercy Hospital Kansas City | 40 | 2025-07-31 | 2026-08-25 |
| Sodium-Glucose Cotransporter 2 Inhibitors for Repaired Tetralogy of Fallot Patients for Enhancement of Cardio-Pulmonary Status Trial SGLT2 inhibitor (Dapagliflozin 10mg) - Congenital Heart Disease, Repaired Tetralogy of Fallot (rTOF) | Phase 4 | Recruiting | The University of Hong Kong | 106 | 2025-05-12 | 2026-10-28 |
| Diltiazem in Jervell and Lange-Nielsen Syndrome diltiazem - Jervell and Lange Nielsen Syndrome | Phase 4 | Completed | Vanderbilt University Medical Center | 1 | 2024-10-16 | 2025-10-14 |
| Efficacy Of Sodium Glucose Transporter Inhibitor (SGLT2I) In Adult Patients With Congenital Heart Disease Empagliflozin 10 MG, Placebo - Adult Congenital Heart Disease, Heart Failure | Phase 4 | Active not recruiting | Anita Saraf | 40 | 2024-09-17 | 2026-09-17 |
| Effect of Dexmedetomidine Supplementation to General Anaesthesia in Paediatric Transcatheter Closure of Atrial Septal Defect Dexmedetomidine, Saline (NaCl 0,9 %) (placebo) - Atrial Septal Defect (ASD), Dexmedetomidine | Phase 4 | Recruiting | Alexandria University | 30 | 2024-04-03 | 2024-10-15 |
| Regional Anesthesia Following Pediatric Cardiac Surgery Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution - Atrial Septal Defect, Ventricular Septal Defect | Phase 4 | Completed | Duke University | 52 | 2023-03-29 | 2025-08-28 |
| DEX vs SEVO in Congenital Heart Surgery DEX group, Control group - Heart Defects, Congenital | Phase 4 | Unknown | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 150 | 2023-01-05 | 2022-09-23 |
| COMParison of the EffecT of dEvice Closure in Alleviating Migraine With PFO (COMPETE-2) PFO device closure, Aspirin - Migraine, Patent Foramen Ovale | Phase 4 | Unknown | Chinese Academy of Medical Sciences, Fuwai Hospital | 460 | 2022-10-01 | 2023-01-09 |
| Morphine Versus Fentanyl for Myocardial Protection in Acyanotic Children Undergoing Congenital Open-Heart Surgery Fentanyl (IV), morphine - Heart Defects, Congenital, Myocardial Reperfusion Injury | Phase 4 | Completed | Baskent University | 66 | 2022-09-02 | 2026-09-24 |
| Observation vs Progesterone Treatment for Management of Uterine Arteriovenous Malformation MedroxyPROGESTERone Injection [Depo-Provera], Other - Arteriovenous Malformations | Phase 4 | Unknown | HaEmek Medical Center, Israel | 28 | 2022-08-01 | 2022-08-08 |
| Atorvastatin Therapy on Xanthoma in Alagille Syndrome atorvastatin - Alagille Syndrome, Atorvastatin | Phase 4 | Completed | Children's Hospital of Fudan University | 15 | 2022-03-22 | 2026-03-27 |
Showing 20 of 97. Sign in to see all of them.
Heart Defects, Congenital (26) · Turner Syndrome (13) · Arteriovenous Fistula (8) · Ductus Arteriosus, Patent (8) · Heart Septal Defects, Atrial (8) · Premature Birth (7) · Long QT Syndrome (5) · Arteriovenous Malformations (4) · Foramen Ovale, Patent (4) · Kidney Failure, Chronic (4) · Dwarfism, Pituitary (3) · Genetic Diseases, Inborn (3) · Hypogonadism (3) · Abnormalities, Drug-Induced (2) · Alagille Syndrome (2)
Congenital Abnormalities (97) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (97) · Cardiovascular Diseases (95) · Heart Diseases (77) · Heart Defects, Congenital (52) · Pathological Conditions, Signs and Symptoms (27) · Urogenital Diseases (25) · Female Urogenital Diseases and Pregnancy Complications (24) · Vascular Diseases (24) · Female Urogenital Diseases (17) · Male Urogenital Diseases (17) · Pathologic Processes (17) · Genetic Diseases, Inborn (16) · Chromosome Disorders (15)
Ibuprofen (7) · Human Growth Hormone (6) · Sodium Chloride (6) · Saline Solution (5) · Dexmedetomidine (4) · Estradiol (4) · Progesterone (4) · Acetaminophen (3) · Propofol (3) · ibutilide (3) · Aspirin (2) · Atorvastatin (2) · Bupivacaine (2) · Eplerenone (2) · Fentanyl (2)
Indiana University (3) · Merck KGaA, Darmstadt, Germany (3) · Novo Nordisk A/S (3) · Stanford University (3) · Aarhus University Hospital (2) · Baskent University (2) · Chinese Academy of Medical Sciences, Fuwai Hospital (2) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (2) · Duke University (2) · Emory University (2) · The Hospital for Sick Children (2) · The University of Hong Kong (2) · Zekai Tahir Burak Women's Health Research and Education Hospital (2) · Ain Shams University (1) · Alan Fujii (1)
United States (31) · Canada (8) · China (8) · France (7) · United Kingdom (7) · Belgium (5) · Denmark (4) · Germany (4) · Spain (4) · Turkey (Türkiye) (4) · Australia (3) · Italy (3) · South Korea (3) · Argentina (2) · Austria (2)
James E Tisdale, PharmD (3) · Claus H Gravholt, Professor (2) · Alan M Fujii, MD (1) · Alan Moody, MD (1) · Alexander Plotkin, PhD (1) · Amel HY Abelala, professor (1) · Andrew Lodge, MD (1) · Andrew M Atz, MD (1) · Anis Aribogan, Prof md (1) · Anita Saraf, MD, PhD (1) · Ben D Albert, MD (1) · Benjamin Chow, MD (1)
PMID 10518081, PMID 10599727, PMID 10599729, PMID 12045168, PMID 12466334, PMID 12629094, PMID 13678932, PMID 15232117, PMID 15900109, PMID 17564958, PMID 17572925, PMID 19047225, PMID 19380621, PMID 19902266, PMID 19956811, PMID 20336076, PMID 20336077, PMID 20368313, PMID 20970202, PMID 21356042, PMID 21388319, PMID 21398400, PMID 21403014, PMID 21760564, PMID 21880799, PMID 23514285, PMID 23567489, PMID 23678038, PMID 23737664, PMID 23824675, PMID 23842591, PMID 23972966, PMID 24359938, PMID 24445038, PMID 25691764, PMID 25770987, PMID 26066773, PMID 26114442, PMID 26340968, PMID 26409473, PMID 26551304, PMID 27470183, PMID 28151412, PMID 28185643, PMID 28395364, PMID 29222139, PMID 29292114, PMID 29424935, PMID 29526687, PMID 29544871
2009 (2), 2005 (1), R01HL153114 (1), R01NS032525 (1)