16 recruiting. 16 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Recruiting 16 |
| Phase 2 | 2 | Recruiting 2 |
Follow Cardiovascular Abnormalities: new trials by email Literature Review of Cardiovascular Abnormalities trials Research Report on Cardiovascular Abnormalities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy Prasugrel 5mg, Transcatheter Closure of Patent Foramen Ovale - Migraine Disease, Patent Foramen Ovale | Phase 3 | Recruiting | Columbia University | 32 | 2026-10-15 | 2026-10-08 |
| A Trial to Assess the Efficacy and Safety of Engasertib in Participants With Moderate to Severe Hereditary Hemorrhagic Telangiectasia (HHT) Engasertib, Placebo - Hereditary Hemorrhagic Telangiectasia | Phase 3 | Recruiting | Vaderis Therapeutics AG | 240 | 2026-09-01 | 2026-09-17 |
| The Efficacy and Safety of Inpegsomatropin Injection in Children With Turner Syndrome (TS) and Short Stature Inpegsomatropin-Injection, Givopegsomatropin Solution Injection - Turner Syndrome | Phase 3 | Recruiting | Xiamen Amoytop Biotech Co., Ltd. | 84 | 2026-07-05 | 2026-07-22 |
| SGLT2 Inhibition With Empagliflozin in Fontan Circulatory Failure Empagliflozin 10 mg, Placebo - Congenital Heart Disease | Phase 3 | Recruiting | Subodh Verma | 410 | 2026-05-29 | 2026-09-02 |
| Evaluation of the Efficacy and Safety of THRV-1268 in Participants With Long QT Syndrome Type 2 (LQTS2) and Type 3 (LQTS3) baseline lead-in, THRV-1268 - Long QT Syndrome (LQTS) 2 | Phase 2 / Phase 3 | Recruiting | Thryv Therapeutics, Inc. | 84 | 2026-03-07 | 2026-09-21 |
| Efficacy and Safety of Anti-angiogenic Therapy With IV Bevacizumab in Patients With Symptomatic Cerebral Arteriovenous Malformations Bevacizumab, Placebo - Cerebral AV Malformation | Phase 2 / Phase 3 | Recruiting | Fondation Ophtalmologique Adolphe de Rothschild | 54 | 2026-01-16 | 2026-01-22 |
| Trial Investigating the Efficacy and Safety of Weekly Lonapegsomatropin Compared to Daily Somatropin in Children and Adolescents With Short Stature or Growth Failure Due to Growth Hormone Sufficient Disorders Lonapegsomatropin [SKYTROFA®], Somatropin Pen Injector - Turner Syndrome, Short Stature Homeobox Gene Mutation | Phase 3 | Recruiting | Ascendis Pharma A/S | 186 | 2025-12-12 | 2026-09-30 |
| Effect of Sacubitril-Valsartan on Cardiac Structure and Function Entresto Pill, Placebo - Congenital Heart Disease | Phase 3 | Recruiting | Mayo Clinic | 45 | 2025-02-03 | 2026-10-09 |
| A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections Mavorixafor, Placebo - Neutropenia | Phase 3 | Recruiting | X4 Pharmaceuticals | 176 | 2024-06-06 | 2026-08-06 |
| A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial) Losartan, Amlodipine, Placebo - Coarctation of Aorta, High Blood Pressure | Phase 3 | Recruiting | Mayo Clinic | 120 | 2024-04-01 | 2026-09-11 |
| Randomised Clinical Trial Comparing Drug-coated Balloon to Plain Balloon for All Peripheral AVF Stenosis Angioplasty of all peripheral AVF stenosis - Arteriovenous Fistula, Arteriovenous Fistula Stenosis | Phase 3 | Recruiting | Singapore General Hospital | 94 | 2024-01-04 | 2024-08-14 |
| PFO Closure, Oral Anticoagulants or Antiplatelet Therapy After PFO-associated Stroke in Patients Aged 60 to 80 Years Transcatheter PFO closure, Oral Anticoagulant, Direct-Acting, Antiplatelet therapy - Cryptogenic Ischemic Stroke, Patent Foramen Ovale | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 792 | 2023-07-07 | 2026-03-24 |
| NO During CPB in Neonates to Reduce Risk of AKI Nitric Oxide, Oxygen - AKI, CHD - Congenital Heart Disease | Phase 3 | Recruiting | Children's Hospital Medical Center, Cincinnati | 40 | 2023-01-10 | 2026-08-05 |
| Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass Allopurinol, Mannitol - Congenital Heart Disease in Children, Neuroprotection | Phase 3 | Recruiting | dr. M.J.N.L. Benders | 236 | 2020-02-14 | 2024-05-16 |
| Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial) Autologous cardiac stem cells (JRM-001) - Hypoplastic Left Heart Syndrome, Single Ventricle | Phase 3 | Recruiting | Metcela Inc. | 40 | 2016-06-01 | 2026-10-19 |
| Efficacy and Safety of Sirolimus in Vascular Anomalies That Are Refractory to Standard Care Sirolimus - Vascular Malformations | Phase 3 | Recruiting | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | 250 | 2016-01-25 | 2023-02-24 |
Heart Defects, Congenital (5) · Foramen Ovale, Patent (2) · Turner Syndrome (2) · Aortic Coarctation (1) · Arteriovenous Fistula (1) · Autoimmune Diseases (1) · Barth Syndrome (1) · Brain Injuries (1) · Chromosome Disorders (1) · Cohen syndrome (1) · Dwarfism (1) · Endocrine System Diseases (1) · Failure to Thrive (1) · Hypertension (1) · Hypoplastic Left Heart Syndrome (1)
Cardiovascular Diseases (16) · Congenital Abnormalities (16) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (16) · Heart Diseases (12) · Heart Defects, Congenital (7) · Vascular Diseases (6) · Brain Diseases (4) · Central Nervous System Diseases (4) · Nervous System Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Cerebrovascular Disorders (3) · Genetic Diseases, Inborn (3) · Vascular Malformations (3) · Arteriovenous Malformations (2)
Allopurinol (1) · Amlodipine (1) · Bevacizumab (1) · Factor Xa Inhibitors (1) · Losartan (1) · Mannitol (1) · Nitric Oxide (1) · Oxygen (1) · Prasugrel Hydrochloride (1) · Sirolimus (1) · empagliflozin (1) · lonapegsomatropin (1) · mavorixafor (1) · sacubitril and valsartan sodium hydrate drug combination (1)
Mayo Clinic (2) · Ascendis Pharma A/S (1) · Assistance Publique - Hôpitaux de Paris (1) · Children's Hospital Medical Center, Cincinnati (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Columbia University (1) · Fondation Ophtalmologique Adolphe de Rothschild (1) · Metcela Inc. (1) · Singapore General Hospital (1) · Subodh Verma (1) · Thryv Therapeutics, Inc. (1) · Vaderis Therapeutics AG (1) · X4 Pharmaceuticals (1) · Xiamen Amoytop Biotech Co., Ltd. (1) · dr. M.J.N.L. Benders (1)
United States (8) · France (5) · Germany (3) · Belgium (2) · Canada (2) · Italy (2) · Romania (2) · Spain (2) · Argentina (1) · Australia (1) · China (1) · Colombia (1) · Czechia (1) · Georgia (1) · Greece (1)
Alexander Egbe (1) · Alexander Egbe, MBBS, MPH (1) · Gilles Chatellier, MD (1) · Jean-Louis Mas, MD (1) · Jessica Ailani, MD (1) · Laurence M Boon, MD, PhD (1) · Raymond Stegeman, MD (1) · Robert J Sommer, MD (1) · Xiaoping Luo (1)
PMID 37937645, PMID 39147988, PMID 41281754, PMID 41366677
R01HL162830 (2), 2017 (1), 2023 (1), 2025 (1)