324 completed, 12 unknown, 10 terminated, 2 active not recruiting. 93 Phase 2, 82 Not applicable, 71 Phase 3, 70 Phase 1, 33 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Research on the Psychological Status of Patients With HIV-1 Infection All kinds of INSTI medications, All kinds of conventional medications - HIV-1-infection, Anxiety Depression | Not yet recruiting | Shanxi Bethune Hospital | 500 | 2025-08-01 | 2025-07-23 | |
| Contribution of Dolutegravir to Obesity and Cardiovascular Disease Dolutegravir 50 MG, Antiretroviral/Anti HIV - HIV-1-infection, Antiviral Drug Adverse Reaction | Phase 4 | Completed | Augusta University | 10 | 2020-09-17 | 2023-07-27 |
| Nucleosides And Darunavir/Dolutegravir In Africa Darunavir, Ritonavir, Dolutegravir - Human Immunodeficiency Virus | Phase 3 | Unknown | Makerere University | 465 | 2019-07-30 | 2020-07-30 |
| RESIST-2: 2nd-line ART for HIV-2 Infection HIV-2 Genotypic Drug Resistance Testing using DBS, 2nd line ART ( Zidovudine 300mg BID + Lamivudine 150mg BID or Tenofovir DF 300mg QD + Lamividine 300mg QD or Emtricitabine 200mg QD + Lopinavir/Ritonavir 400/100mg BID), 2nd line ART (Tenofovir DF 300mg QD + Lamividine 300mg QD or Emtricitabine 200mg QD + Lopinavir/Ritonavir 400/100mg BID + Raltegravir 400mg BID ) - HIV-2 Infection | Not applicable | Terminated | University of Washington | 152 | 2018-07-04 | 2021-01-25 |
| Viral and Antiretroviral Dynamics in HIV-1 Mother-to-Child Transmission Fluids Tenofovir Disoproxil Fumarate (TDF) 300 mg + Lamivudine (3TC) 300 mg + Efavirenz (EFV) 600 mg, Abacavir (ABC) 600 mg + Lamivudine (3TC) 300 mg + Efavirenz (EFV) 600 mg, Zidovudine (AZT) 300 mg + Lamivudine (3TC) 150 mg twice daily + Efavirenz (EFV) 600 mg once daily - Human Immunodeficiency Virus Infection | Completed | Obafemi Awolowo University | 194 | 2017-12-22 | 2020-10-14 | |
| Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection "Raltegravir" and "Zidovudine" - HTLV-I Infections, Tropical Spastic Paraparesis | Early Phase 1 | Completed | Universidad Peruana Cayetano Heredia | 10 | 2017-07-01 | 2019-05-22 |
| Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma Belinostat, Zidovudine, Interferon-Alfa-2b - Adult T-cell Leukemia-Lymphoma, ATLL | Phase 2 | Completed | University of Miami | 15 | 2016-12-12 | 2026-03-10 |
| Study of HIV-Infected and Uninfected Pregnant Woman/Child Dyads in Gaborone, Botswana Zidovudine, Nevirapine - HIV, Insulin Sensitivity | Phase 4 | Completed | Ann & Robert H Lurie Children's Hospital of Chicago | 495 | 2016-08-22 | 2022-07-20 |
| Antiretroviral Regime for Viral Eradication in Newborns Zidovudine, Nevirapine, Lamivudine - HIV/AIDS and Infections | Phase 4 | Completed | National Center for Women and Children's Health, China CDC | 600 | 2016-04-01 | 2022-09-28 |
| First-Line Treatment for HIV-2 Tenofovir + Emtricitabine or Lamivudine + Zidovudine, Tenofovir + Emtricitabine or Lamivudine + Lopinavir/ritonavir, Tenofovir + Emtricitabine or Lamivudine + Raltegravir - HIV-2 Infection | Phase 2 / Phase 3 | Completed | ANRS, Emerging Infectious Diseases | 210 | 2016-01-26 | 2019-07-22 |
| IMPAACT P1092: Steady State PK in Malnourished HIV Infected Children ZDV+3TC+LPV/r - HIV Positive, Malnourished | Phase 4 | Completed | International Maternal Pediatric Adolescent AIDS Clinical Trials Group | 52 | 2015-10-26 | 2021-08-12 |
| Latency and Early Neonatal Provision of Antiretroviral Drugs Clinical Trial Nevirapine, Zidovudine, Lamivudine - HIV | Phase 4 | Completed | Columbia University | 73 | 2015-08-01 | 2020-08-04 |
| Early Infant HIV Treatment in Botswana Nevirapine, Kaletra, Lamivudine - HIV, Pediatric AIDS | Phase 2 / Phase 3 | Active not recruiting | Harvard School of Public Health (HSPH) | 67 | 2015-05-04 | 2026-02-23 |
| Effects of Maraviroc vs. Efavirenz on CD4/CD8 Ratio Maraviroc (UK-427,857) QD + Zidovudine/Lamivudine BID, Efavirenz QD + Zidovudine/Lamivudine BID, Maraviroc (UK-427,857) BID + Zidovudine/Lamivudine QD - HIV/AIDS | Phase 3 | Completed | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 721 | 2014-10-15 | 2023-09-13 |
| Early cART and cART in Combination With Autologous HIV-1 Specific Cytotoxic T Lymphocyte (CTL) Infusion in The Treatment of Acute HIV-1 Infected Adults cART(TDF/AZT+3TC+LPV/r), CTL infusion - Acute HIV Infection | Phase 3 | Unknown | Yongtao Sun, MD, PhD | 65 | 2014-08-01 | 2018-04-26 |
| A Trial to Confirm a Sustained Virological Suppression Defined as HIV-RNA <50 Copies/ml of 3 Different Doses of Fozivudine in Context to a Standard Zidovudine Based Antiretroviral Therapy Regimen FZD, 3TC, EFV - HIV-1 Infection | Phase 2 | Completed | Michael Hoelscher | 120 | 2012-12-01 | 2018-03-07 |
| Economic, Clinical and Quality of Life Assessment in Patients on Antiretroviral Therapy Tenofovir, Zidovudine - HIV | Phase 4 | Completed | Tufts University | 68 | 2012-11-01 | 2014-11-24 |
| The Mochudi Prevention Project ART Protocol highly active antiretroviral therapy: Lopinavir/Ritonavir, Lamivudine, Zidovudine, Efavirenz, Tenofovir Disoproxil Fumarate, Emtricitabine - HIV Infections | Not applicable | Terminated | Harvard School of Public Health (HSPH) | 11 | 2012-09-01 | 2015-03-19 |
| MARCH Central Nervous System Substudy Arm 1 TNucleotide Analogue Reverse Transcriptase Inhibitors and Boosted Protease Inhibitors, Arm 2 Maraviroc and Protease Inhibitors, Arm 3 Maraviroc and Nucleotide Analogue Reverse Transcriptase Inhibitors - HIV-1 Infection | Completed | Kirby Institute | 28 | 2012-06-01 | 2016-01-20 | |
| MARCH Renal Substudy arm 1 nucleotide analogue reverse transcriptase inhibitors and boosted protease inhibitors, Arm 2 boosted protease inhibitors and maraviroc, Arm 3 nucleotide analogue reverse transcriptase inhibitors and maraviroc - Proteinuria, HIV | Phase 4 | Completed | Kirby Institute | 76 | 2012-06-01 | 2016-01-20 |
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National Institute of Allergy and Infectious Diseases (NIAID) (167) · Glaxo Wellcome (28) · Hoffmann-La Roche (10) · Boehringer Ingelheim (9) · Merck Sharp & Dohme LLC (7) · Bristol-Myers Squibb (6) · Kirby Institute (6) · National Cancer Institute (NCI) (6) · Pharmacia and Upjohn (6) · Gilead Sciences (5) · University of Miami (4) · Centers for Disease Control and Prevention (3) · Harvard School of Public Health (HSPH) (3) · Institut de Recherche pour le Developpement (3) · International Maternal Pediatric Adolescent AIDS Clinical Trials Group (3)
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Fischl MA (5) · Richman D (5) · Corey L (4) · M Fischl (4) · Collier AC (3) · D Richman (3) · Fischl M (3) · Friedland G (3) · Havlir D (3) · Hirsch M (3) · Johnson V (3) · Marc Lallemant, MD (3) · Merigan TC (3) · Pollard R (3)
PMID 33901188, PMID 16148846, PMID 24326304, PMID 24979445, PMID 32829410, PMID 38160309, PMID 38941593, PMID 10485720, PMID 10659875, PMID 11509999, PMID 11600822, PMID 11840078, PMID 11980557, PMID 12439209, PMID 12522449, PMID 13678973, PMID 14668455, PMID 14668456, PMID 14669723, PMID 14722443, PMID 15115831, PMID 15187476, PMID 15213559, PMID 15242535, PMID 15472843, PMID 15687448, PMID 15736019, PMID 15892437, PMID 16048984, PMID 16103764, PMID 16123677, PMID 16220994, PMID 16267764, PMID 16284468, PMID 16287792, PMID 16511414, PMID 16547789, PMID 16640817, PMID 16782488, PMID 16810109, PMID 16816555, PMID 16905783, PMID 17109339, PMID 17280617, PMID 17310819, PMID 17357053, PMID 17376384, PMID 17392561, PMID 17527093, PMID 17662759
U01AI068632 (3), 2008 (2), R01HD052461 (2), R01HD056953 (2), U01AI068636 (2), 5UM1AI068634 (1), K23AI077355 (1), K24AI051966 (1), P01CA128115 (1), P01HD059454 (1), P30CA016672 (1), R01AI051219 (1), R01AI062512 (1), R01AI064029 (1), R01AI083036 (1)