11 completed, 2 terminated, 2 unknown, 1 not yet recruiting. 16 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 11, Terminated 2, Unknown 2, Not yet recruiting 1 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
| Phase 3 | 1 | Terminated 1 |
Follow Bone Loss: new trials by email Literature Review of Bone Loss trials Research Report on Bone Loss
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Melatonin in Posterior Mandible Extraction Socket Melatonin group, Placebo group - Bone Loss | Phase 2 | Not yet recruiting | Cairo University | 40 | 2026-11-15 | 2026-11-06 |
| Bone in CKD Alkali Response (BICARb Pilot Trial) Potassium Citrate Extended Release Oral Tablet, Placebo, Potassium Citrate and Citric Acid Oral Solution - Chronic Kidney Diseases, Bone Loss | Phase 2 / Phase 3 | Terminated | Albert Einstein College of Medicine | 6 | 2024-08-15 | 2026-07-28 |
| Romosozumab in Women With Chronic SCI Romosozumab, Alendronate - Osteoporosis, Bone Loss | Phase 2 | Completed | Northwestern University | 12 | 2021-03-01 | 2025-09-24 |
| Zoledronic Acid for Prevention of Bone Loss After BAriatric Surgery (ZABAS) Zoledronic Acid, Placebo - Bone Loss, Muscle Atrophy | Phase 2 | Completed | Stinus Gadegaard Hansen | 59 | 2021-02-20 | 2026-06-01 |
| Healthy Body, Healthy Bones After Bariatric Surgery Trial Zoledronic Acid 5 mg/Bag 100 ml Inj, Placebos - Bariatric Surgery Candidate, Bone Loss | Phase 1 / Phase 2 | Completed | University of Nebraska | 10 | 2020-09-01 | 2024-09-24 |
| Evaluation, the Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) Wif Lovastatin in the Preservation of the Tooth Socket Lovastatin 40 MG, without drug with Bone graft - Bone Loss | Phase 2 | Unknown | Islamic Azad University, Sanandaj | 20 | 2018-02-22 | 2019-06-11 |
| The Effect of Chlorohexidine Gel on Tissue Healing Following Surgical Exposure of Dental Implants Corsodyl - Implant Infection, Bone Loss | Phase 1 / Phase 2 | Unknown | Rambam Health Care Campus | 40 | 2017-08-01 | 2017-06-22 |
| Prevention of Bone Loss After Acute SCI by Zoledronic Acid Zoledronic acid, Placebo - Spinal Cord Injury, Acute Spinal Cord Injury | Phase 2 | Completed | Northwestern University | 60 | 2015-02-01 | 2025-12-02 |
| Bone Mass and Strength After Kidney Transplantation Vitamin D3, Calcitriol, Placebo - End Stage Renal Disease, Kidney Transplantation | Phase 2 | Completed | Columbia University | 61 | 2014-08-18 | 2025-03-07 |
| Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide Alendronate, Calcium, Vitamin D - Spinal Cord Injury, Bone Loss | Phase 2 | Completed | Northwestern University | 17 | 2014-04-01 | 2023-03-30 |
| 12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI) Teriparatide, Vibration - Spinal Cord Injury, Bone Loss | Phase 2 | Completed | Northwestern University | 25 | 2013-01-01 | 2023-05-10 |
| Bone Loss and Immune Reconstitution in HIV/AIDS (BLIR-HIV) Zoledronic acid - HIV Infection, Bone Loss | Phase 2 | Completed | Emory University | 63 | 2011-01-01 | 2018-06-26 |
| Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury Teriparatide, vibration - Spinal Cord Injury, Bone Loss | Phase 2 | Completed | Thomas J. Schnitzer | 60 | 2010-10-01 | 2025-12-02 |
| Efficacy and Safety of Zoledronic Acid in Acute Spinal Cord Injury: Prevention of Bone Loss zoledronic acid, placebo - Bone Loss | Phase 2 | Terminated | Thomas J. Schnitzer | 17 | 2010-03-01 | 2017-06-14 |
| The Prevention Of Postmenopausal Osteoporosis With Lasofoxifene And Cytokine Evaluation Lasofoxifene, Placebo - Bone Loss | Phase 2 | Completed | Ligand Pharmaceuticals | 51 | 2004-09-01 | 2011-08-10 |
| Zoledronic Acid to Prevent Bone Loss During Androgen Deprivation Therapy for Prostate Cancer Zoledronic acid, Placebo - Bone Loss, Prostate Cancer | Phase 2 | Completed | Massachusetts General Hospital | 60 | 2003-09-01 | 2013-07-11 |
Bone Diseases, Metabolic (16) · Osteoporosis (8) · Spinal Cord Injuries (6) · Bone Diseases (4) · Spinal Cord Diseases (4) · Central Nervous System Diseases (3) · Fractures, Bone (3) · Musculoskeletal Diseases (3) · Nervous System Diseases (3) · Neurologic Manifestations (3) · Wounds and Injuries (3) · Acidosis (1) · Acquired Immunodeficiency Syndrome (1) · Bone Resorption (1) · HIV Infections (1)
Metabolic Diseases (16) · Nutritional and Metabolic Diseases (16) · Musculoskeletal Diseases (13) · Bone Diseases (12) · Pathological Conditions, Signs and Symptoms (6) · Trauma, Nervous System (6) · Wounds and Injuries (5) · Nervous System Diseases (4) · Signs and Symptoms (4) · Urogenital Diseases (4) · Central Nervous System Diseases (3) · Male Urogenital Diseases (3) · Chronic Disease (2) · Disease Attributes (2) · Female Urogenital Diseases (2)
Zoledronic Acid (6) · Alendronate (2) · Cholecalciferol (2) · Teriparatide (2) · Antacids (1) · Bone Transplantation (1) · Calcitriol (1) · Calcium (1) · Calcium Carbonate (1) · Chlorhexidine (1) · Citric Acid (1) · Diphosphonates (1) · Lasofoxifene (1) · Lovastatin (1) · Pharmaceutical Preparations (1)
Northwestern University (4) · Thomas J. Schnitzer (2) · Albert Einstein College of Medicine (1) · Cairo University (1) · Columbia University (1) · Emory University (1) · Islamic Azad University, Sanandaj (1) · Ligand Pharmaceuticals (1) · Massachusetts General Hospital (1) · Rambam Health Care Campus (1) · Stinus Gadegaard Hansen (1) · University of Nebraska (1)
United States (11) · Denmark (1) · Iran (1) · United Kingdom (1)
Thomas J Schnitzer, MD, PhD (5) · Hadar Zigdon, Dr. (1) · Igho Ofotokun, MD, MSc (1) · Kimberly Reidy, MD (1) · Laura D Bilek, PT, PhD (1) · Matthew Smith, MD (1) · Mervyn N Weitzmann, PhD (1) · Thomas J Schnizter, MD, PhD (1) · Thomas Nickolas, MD, MS (1)
PMID 30334093, PMID 26828618, PMID 27193748, PMID 31621838, PMID 34278611, PMID 34887285, PMID 36209245, PMID 39665575, PMID 41177144, PMID 42254059
2023 (1), R01DK131811 (1)