412 completed, 95 unknown, 59 terminated, 45 recruiting. 685 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 685 | Completed 412, Unknown 95, Terminated 59, Recruiting 45, Withdrawn 28, Not yet recruiting 23, Active not recruiting 18, Enrolling by invitation 4, Suspended 1 |
Follow Bone Diseases: new trials by email Literature Review of Bone Diseases trials Research Report on Bone Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sequential Treatment With Romosozumab Followed by Denosumab vs. Zoledronic Acid for Gains in HIP BMD Romosozumab, Zoledronic Acid 5 MG in 5 ML Injection, Calcium 500 mg and Vitamin D3 800 IU - Osteoporosis in Post-menopausal Women | Phase 4 | Not yet recruiting | Sahlgrenska University Hospital | 216 | 2027-01-11 | 2026-08-19 |
| Romosozumab and Denosumab Combination Therapy for Osteoporosis Romosozumab, Romosozumab and Denosumab - Postmenopausal Osteoporosis | Phase 4 | Not yet recruiting | Massachusetts General Hospital | 100 | 2027-01-01 | 2026-11-03 |
| Remimazolam vs Propofol for Motor and Somatosensory Evoked Potentials in Spinal Tumor Surgery Remimazolam, Propofol - Spinal Cord Neoplasms, Spinal Neoplasms | Phase 4 | Not yet recruiting | Beijing Tsinghua Chang Gung Hospital | 190 | 2027-01-01 | 2026-10-28 |
| A Pragmatic Trial of Interleukin-17 Inhibition Versus Janus Kinase Inhibition After Tumor Necrosis Factor-alpha Inhibitor Failure in Axial Spondyloarthritis Secukinumab (IL-17i ), Upadacitinib (JAKi) - Axial Spondyloarthritis (AxSpA) | Phase 4 | Not yet recruiting | The University of Texas Health Science Center, Houston | 40 | 2026-11-01 | 2026-10-14 |
| Emerging Indications for Hyperbaric Oxygen Treatment Hyperbaric oxygen treatment (HBOT), 100% Oxygen - Post-COVID-19 Condition, Ulcerative Colitis | Phase 4 | Not yet recruiting | Jay C. Buckey Jr. | 100 | 2026-11-01 | 2026-09-09 |
| Ivarmacitinib With or Without Celecoxib for Ankylosing Spondylitis Ivarmacitinib with celecoxib, Ivarmacitinib Monotherapy - Ankylosing Spondylitis (AS) | Phase 4 | Not yet recruiting | Peking University Third Hospital | 138 | 2026-10-25 | 2026-10-27 |
| E-Type - Early Wear of Polyethylene Liners Used in DMC Total Hip Arthroplasty - Osteoarthritis, Osteonecrosis | Phase 4 | Recruiting | Uppsala University | 40 | 2026-10-08 | 2026-10-09 |
| Comparing Three Epidural Steroid Injection Approaches for Lumbar Radicular Pain High-Volume Parasagittal Interlaminar Epidural Steroid Injection, Low-Volume Parasagittal Interlaminar Epidural Steroid Injection, Transforaminal epidural steroid injection - Lumbar Disc Herniation, Lumbosacral Radiculopathy | Phase 4 | Not yet recruiting | Benha University | 99 | 2026-10-01 | 2026-09-14 |
| Romosozumab Versus Denosumab In Glucocorticoid-induced Osteoporosis: An Extended Observation Of a Clinical Trial at 6 Years Romosozumab, Denosumab - Glucocorticoid-Associated Osteopenia and Osteoporosis | Phase 4 | Not yet recruiting | Tuen Mun Hospital | 54 | 2026-09-01 | 2026-08-12 |
| A Clinical Trial of Antiplatelets in Psoriasis Aspirin, Clopidogrel, Placebo - Psoriasis (PsO), Psoriatic Arthritis (PsA) | Phase 4 | Not yet recruiting | NYU Langone Health | 60 | 2026-09-01 | 2026-08-05 |
| The Comparison of Ibandronate and Zoledronic Acid After Denosumab Discontinuation Ibandronate IV, Zoledronic acid IV - Postmenopausal Osteoporosis, Postmenopausal Osteopenia | Phase 4 | Recruiting | National Taiwan University Hospital | 52 | 2026-08-20 | 2026-08-25 |
| A Remotely Conducted Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are Receiving TREMFYA Therapeutically Breast Milk Sample Collection, Guselkumab - Psoriasis, Colitis, Ulcerative | Phase 4 | Recruiting | Janssen Research & Development, LLC | 10 | 2026-08-07 | 2026-11-03 |
| Influence of Lidocaine Infusion on Motor Evoked Potential Thresholds Lidocaine in Saline, Normal saline - Spinal Disease, Anesthesia | Phase 4 | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 44 | 2026-08-01 | 2025-11-24 |
| Extended Prophylactic Anticoagulation Following Spinal Surgery for Metastatic Disease Apixaban - Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT) | Phase 4 | Not yet recruiting | James Bayley | 50 | 2026-08-01 | 2026-07-20 |
| Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study) triamcinolone acetonide (Kenalog), Celestone Soluspan 6Mg/Ml Suspension for Injection, Depo-Medrol 40Mg/Ml Suspension for Injection - Back Pain Lower Back, Neck Pain | Phase 4 | Recruiting | Igor Wilderman. MD | 500 | 2026-07-30 | 2026-08-13 |
| Osteoporotic Fracture and Lidocaine Plaster 5% for Neuropathic Pain preventioN Lidocaine 5% medicated plaster - Osteoporotic Vertebral Fracture, Neuropathic Pain | Phase 4 | Not yet recruiting | University Hospital, Clermont-Ferrand | 30 | 2026-07-01 | 2026-07-08 |
| Return to Activity After Surgery for Lumbar Disc Herniation Postoperative therapy - Lumbar Disc Herniation Surgery, Disc Herniation | Phase 4 | Not yet recruiting | Intrinsic Therapeutics | 120 | 2026-06-30 | 2026-06-25 |
| Deucravacitinib-TNFi Combination Therapy for Difficult-to-Control Psoriatic Disease Deucravacitinib, Placebo - Psoriatic Arthritis (PsA) | Phase 4 | Recruiting | University of Texas Southwestern Medical Center | 128 | 2026-06-16 | 2026-09-01 |
| Impact Of Upadacitinib On The Frequency Of Acute Recurrent Anterior Uveitis In Patients With Axial Spondyloarthritis Upadacitinib 15 MG [Rinvoq] - Axial Spondylarthritis (axSpA) | Phase 4 | Not yet recruiting | CARE ARTHRITIS LTD. | 200 | 2026-05-01 | 2026-02-06 |
| Impact of Glucagon-like Peptide-1 (GLP-1) Analogs on Disease Outcomes in Psoriatic Arthritis: A Pragmatic Randomized Controlled Trial GLP-1 agonists, Nutrition Counseling - Psoriatic Arthritis (PsA) | Phase 4 | Recruiting | Medical College of Wisconsin | 22 | 2026-05-01 | 2026-11-05 |
Showing 20 of 685. Sign in to see all of them.
Osteoporosis (166) · Bone Diseases, Metabolic (72) · Osteoporosis, Postmenopausal (72) · Spondylitis, Ankylosing (59) · Arthritis, Psoriatic (48) · Spinal Stenosis (37) · Arthritis, Rheumatoid (32) · Intervertebral Disc Displacement (32) · Dwarfism, Pituitary (30) · Osteonecrosis (28) · Acromegaly (25) · Osteoarthritis (25) · Scoliosis (22) · Spondylarthritis (22) · Spinal Diseases (19)
Musculoskeletal Diseases (684) · Nutritional and Metabolic Diseases (283) · Metabolic Diseases (281) · Spinal Diseases (228) · Bone Diseases, Metabolic (201) · Joint Diseases (172) · Arthritis (166) · Pathological Conditions, Signs and Symptoms (164) · Spondylitis (133) · Spondylarthritis (111) · Spondylarthropathies (111) · Pathologic Processes (102) · Skin and Connective Tissue Diseases (99) · Nervous System Diseases (92)
Denosumab (41) · Zoledronic Acid (40) · Teriparatide (35) · Alendronate (32) · Etanercept (32) · Risedronic Acid (28) · Vitamin D (25) · Ibandronic Acid (24) · Adalimumab (23) · Sodium Chloride (22) · Calcium (18) · Cholecalciferol (16) · Infliximab (16) · Saline Solution (16) · Human Growth Hormone (14)
Eli Lilly and Company (19) · Hoffmann-La Roche (17) · Novartis Pharmaceuticals (17) · DePuy International (15) · Pfizer (13) · Massachusetts General Hospital (12) · Columbia University (9) · National Taiwan University Hospital (9) · Sanofi (9) · Sun Yat-sen University (9) · Wyeth is now a wholly owned subsidiary of Pfizer (9) · Amgen (8) · Tuen Mun Hospital (8) · Charite University, Berlin, Germany (7) · Merck Sharp & Dohme LLC (7)
United States (211) · China (60) · Germany (56) · France (46) · Canada (44) · Spain (44) · Denmark (41) · United Kingdom (41) · Italy (35) · Poland (34) · South Korea (29) · Netherlands (26) · Sweden (23) · Australia (22) · Brazil (22)
Benjamin Leder, MD (4) · Anne Kenny, MD (3) · Chi Chiu Mok, MD, FRCP (3) · Hannu T Aro, MD, PhD (3) · James N. Weinstein, DO, MS (3) · Jieruo Gu, Prof (3)
PMID 22048651, PMID 34231877, PMID 11138687, PMID 15613435, PMID 15827109, PMID 16018754, PMID 33813753, PMID 35478046, PMID 36088628, PMID 38488976, PMID 38979716, PMID 39527056, PMID 10469005, PMID 10690849, PMID 10999798, PMID 11063900, PMID 11181474, PMID 11397887, PMID 11514795, PMID 11788630, PMID 11840097, PMID 12177541, PMID 12843148, PMID 12925248, PMID 1421796, PMID 14742657, PMID 14764779, PMID 15070920, PMID 15080776, PMID 15080778, PMID 15099442, PMID 15362960, PMID 15886238, PMID 15886256, PMID 15915040, PMID 15995108, PMID 16306743, PMID 16373932, PMID 16449332, PMID 16487447, PMID 16490909, PMID 16537687, PMID 16757774, PMID 16918950, PMID 17119140, PMID 17119141, PMID 17182297, PMID 17202417, PMID 17259801, PMID 17355365
2015 (9), 2005 (6), 2016 (5), 2018 (4), 2023 (4), 2014 (3), 2025 (3), U01AR045444 (3), 2008 (2), 2017 (2), 2009 (1), K23DA020681 (1), K23HL152013 (1), P30AG024827 (1), R01AG018887 (1)