15 recruiting. 15 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Recruiting 15 |
| Phase 1 | 2 | Recruiting 2 |
| Phase 3 | 1 | Recruiting 1 |
Follow Bipolar Disorder: new trials by email Literature Review of Bipolar Disorder trials Research Report on Bipolar Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) - Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder | Phase 2 | Recruiting | Joshua Rosenblat | 120 | 2026-07-16 | 2026-07-29 |
| Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II Disorder psilocybin (25 mg), psilocybin 1mg micro-dose - Bipolar II Depression | Phase 2 | Recruiting | Lakshmi N Yatham | 90 | 2026-06-15 | 2026-09-15 |
| Melatonin Versus Placebo for Bipolar Disorder Melatonin, Placebo - Bipolar Affective Disorder | Phase 2 | Recruiting | Lars Vedel Kessing | 200 | 2026-05-08 | 2026-05-12 |
| A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder Icalcaprant, Placebo for Icalcaprant - Bipolar I Disorder, Bipolar II Disorder | Phase 2 | Recruiting | AbbVie | 195 | 2026-02-03 | 2026-08-14 |
| The PEDAL Intervention - Reducing Affective Lability in Bipolar Disorder Traditional group psychoeducation for bipolar disorder, Group psychoeducation with digital elements and focus on affective lability - Bipolar Disorder (BD) | Phase 2 | Recruiting | Oslo University Hospital | 120 | 2025-12-01 | 2026-09-04 |
| A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1) Brenipatide, Placebo - Bipolar Disorder | Phase 2 | Recruiting | Eli Lilly and Company | 400 | 2025-11-24 | 2026-10-07 |
| Adaptation and Validation of the Hypomanic Personality Scale (HPS-6) to Romanian Hypomanic Personality Scale - 6 - Bipolar Disorder (BD) | Phase 1 / Phase 2 | Recruiting | Babes-Bolyai University | 50 | 2025-09-22 | 2026-02-10 |
| Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality Psilocybin, Therapeutic Support - Bipolar II Disorder, Depression, Bipolar | Phase 2 | Recruiting | The University of Texas Health Science Center, Houston | 10 | 2025-07-07 | 2026-08-12 |
| Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder Melatonin, Placebo, Behavioral sleep intervention - Bipolar Disorder, Delayed Sleep-Wake Phase Disorder | Phase 2 | Recruiting | Leslie Swanson | 50 | 2024-08-13 | 2026-05-11 |
| Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy Sigma-Stim, RUL LAP-ST (Low-Amplitude Pulse Seizure Therapy - Right Unilateral) - Suicidal Ideation, Major Depressive Disorder | Phase 2 / Phase 3 | Recruiting | Michigan State University | 30 | 2024-07-03 | 2026-08-12 |
| Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression Exercise Session, Ibuprofen 800 mg, Rest - Bipolar Depression | Phase 1 / Phase 2 | Recruiting | Laureate Institute for Brain Research, Inc. | 20 | 2024-03-12 | 2025-05-23 |
| NMDA Receptor Modulation for the Treatment of Bipolar I Disorder NMDAE, Placebo Cap - Bipolar I Disorder | Phase 2 | Recruiting | China Medical University Hospital | 90 | 2023-10-04 | 2026-10-23 |
| Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder Cannabidiol - Bipolar Disorder | Phase 2 | Recruiting | Mclean Hospital | 25 | 2023-06-01 | 2026-03-30 |
| The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects Perampanel 6 MG, Ketamine, Placebo - Depressive Disorder, Major Depressive Disorder | Phase 2 | Recruiting | Yale University | 30 | 2023-04-03 | 2026-05-06 |
| OSU6162 in Bipolar Depression (OBID) OSU6162 - Bipolar Depression | Phase 2 | Recruiting | Göteborg University | 22 | 2021-10-25 | 2026-09-15 |
Suicidal Ideation (4) · Depressive Disorder, Major (3) · Depression (2) · Mood Disorders (2) · Suicide (2) · Bipolar and Related Disorders (1) · Borderline Personality Disorder (1) · Cyclothymic Disorder (1) · Depressive Disorder (1) · Depressive Disorder, Treatment-Resistant (1) · Emotional Regulation (1) · Mental Disorders (1) · Psychotic Disorders (1) · Sleep Disorders, Circadian Rhythm (1)
Bipolar and Related Disorders (14) · Mental Disorders (14) · Mood Disorders (13) · Behavior (6) · Behavioral Symptoms (5) · Self-Injurious Behavior (4) · Depressive Disorder (2) · Suicide (2) · Chronobiology Disorders (1) · Dyssomnias (1) · Nervous System Diseases (1) · Occupational Diseases (1) · Personality Disorders (1) · Schizophrenia Spectrum and Other Psychotic Disorders (1) · Self-Control (1)
Ketamine (2) · Melatonin (2) · Psilocybin (2) · Cannabidiol (1) · Ibuprofen (1) · MD1 (1) · Midazolam (1) · OSU 6162 (1) · RE1-silencing transcription factor (1) · Self-Help Groups (1) · perampanel (1)
AbbVie (1) · Babes-Bolyai University (1) · China Medical University Hospital (1) · Eli Lilly and Company (1) · Göteborg University (1) · Joshua Rosenblat (1) · Lakshmi N Yatham (1) · Lars Vedel Kessing (1) · Laureate Institute for Brain Research, Inc. (1) · Leslie Swanson (1) · Mclean Hospital (1) · Michigan State University (1) · Oslo University Hospital (1) · The University of Texas Health Science Center, Houston (1) · Yale University (1)
United States (8) · Canada (2) · Argentina (1) · Brazil (1) · China (1) · Denmark (1) · India (1) · Japan (1) · Mexico (1) · Norway (1) · Puerto Rico (1) · Romania (1) · Sweden (1) · Taiwan (1)
Dr. Lakshmi N Yatham (1) · Joshua D. Rosenblat, MD, MSc (1) · Lars Kessing (1) · Leslie Swanson, PhD (1) · Nagy A Youssef, MD, PhD (1) · Naomi Driesen, PhD (1) · Thomas Meyer, PhD (1)
R21MH132901 (1)