28 completed, 3 recruiting, 3 withdrawn, 2 not yet recruiting. 40 Phase 1, 15 Phase 2.
Follow Atrophy: new trials by email Literature Review of Atrophy trials Research Report on Atrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The FORCE Trial Pilot: Fish Oil-enriched Nutrition for Radiotherapy in Cancer of the hEad and Neck Nutrition counseling, Fresubin Supportan - Head &Amp;Amp; Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Anna Arthur, PhD | 15 | 2027-06-01 | 2026-08-07 |
| Evaluate the Efficacy and Safety of EN001 in Patients With Sarcopenia EN001, EN001 Placebo - Sarcopenia | Phase 1 / Phase 2 | Not yet recruiting | ENCell | 132 | 2027-03-01 | 2026-09-11 |
| CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy AAV9-Follistatin gene therapy, VEGF Plasmid - Age-related Muscle Decline | Phase 1 / Phase 2 | Recruiting | Unlimited Biotechnology LLC | 12 | 2026-06-01 | 2026-07-13 |
| Clinical Trial of CG-BM1 Allogeneic Human Bone Marrow Mesenchymal Stem Cell Injection in the Treatment of Sarcopenia CG-BM1- 5.0 × 10^7 cells, CG-BM1-1.0 × 10^8 cells - Sarcopenia | Phase 1 / Phase 2 | Recruiting | GuangZhou Cellgenes Biotechnology Co., Ltd. | 30 | 2026-04-30 | 2026-10-14 |
| AD-SVF Therapy for Refractory Endometrial Infertility AD-SVF - Endometrium; Atrophy, Intrauterine Synechiae | Phase 1 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 10 | 2025-11-01 | 2025-11-18 |
| PRF vs. Graftless Sinus Lift With Implant Placement Graftless Transcrestal Sinus Floor Elevation with Immediate Implant Placement, Platelet-Rich Fibrin (PRF)-Assisted Transcrestal Sinus Floor Elevation with Immediate Implant Placement - Maxillary Sinus Floor Augmentation, Alveolar Bone Loss | Phase 1 | Enrolling by invitation | Dar Al Uloom University | 8 | 2025-02-01 | 2025-07-29 |
| Mesenchymal Stem Cells for Age-Related Frailty Mesenchymal Stem Cells (MSCs) - Frailty | Phase 1 / Phase 2 | Withdrawn | VA Office of Research and Development | 2023-01-31 | 2023-02-06 | |
| Safety and Tolerability of IMM01-STEM in Patients With Muscle Atrophy Related to Knee Osteoarthritis. IMM01-STEM - Muscle Atrophy | Phase 1 / Phase 2 | Completed | Immunis, Inc. | 13 | 2022-09-13 | 2026-09-09 |
| Redefining Survivorship: POWER to Maximize Physical Function for Survivors of Critical Illness Power training - Critical Illness, Muscle Atrophy or Weakness | Phase 1 / Phase 2 | Withdrawn | Kirby Mayer | 2021-12-01 | 2020-10-28 | |
| Electrical Stimulation for Critically Ill Covid-19 Patients Electrical Stimulation, Electrical Stimulation - Sham - Covid19, Muscle Atrophy | Phase 1 | Completed | Baylor College of Medicine | 19 | 2020-12-22 | 2023-02-16 |
| Study to Assess the Safety and Tolerability of Repeated Doses of an Investigational New Drug in Patients With Cancer and Cachexia. PF-06946860 - Cachexia, Non-Small-Cell Lung Cancer | Phase 1 | Completed | Pfizer | 11 | 2020-11-17 | 2023-12-14 |
| Effect of a Ghrelin Receptor Agonist on Muscle and Bone Anamorelin Hydrochloride, Placebo - Sarcopenia, Osteopenia | Phase 1 | Completed | Tufts University | 32 | 2019-12-05 | 2024-03-27 |
| E-CEL UVEC Cells as an Adjunct Cell Therapy for the Arthroscopic Rotator Cuff Repair in Adults E-CEL UVEC - Rotator Cuff Tears, Muscle Atrophy or Weakness | Phase 1 | Active not recruiting | Hospital for Special Surgery, New York | 20 | 2019-11-20 | 2026-11-06 |
| Leucine Supplementation in Sarcopenic Older Individuals Leucine, Placebo - Frail Elderly Syndrome, Sarcopenia | Phase 1 | Completed | University of Valencia | 59 | 2019-02-01 | 2020-04-06 |
| Effects of Chicken Extract and Collagen on Mobility Collagen hydrolysate and chicken extract - Knee Osteoarthritis, Muscle Loss | Phase 1 | Completed | Shan May Yong | 160 | 2018-12-01 | 2020-07-29 |
| Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals Beet root juice - Aging, Sarcopenia | Phase 1 | Completed | Indiana University | 13 | 2018-09-01 | 2024-07-29 |
| The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity Oxytocin nasal spray, Placebo nasal spray - Obesity, Sarcopenic Obesity | Phase 1 / Phase 2 | Completed | Sara Espinoza | 23 | 2017-09-22 | 2021-10-22 |
| Buccal Fat Pad Derived Stem Cells With Cortical Tenting in Posterior Mandible Reconstruction BFPSC+FDBA+PRF, FDBA+PRF - Alveolar Bone Loss, Atrophy | Phase 1 | Unknown | Shahid Beheshti University of Medical Sciences | 20 | 2016-01-01 | 2016-10-17 |
| Nutritional Intervention for Age-related Muscular Function and Strength Losses-Study 2 Placebo, HMB plus Vitamin D, Non-Exercise - Sarcopenia | Phase 1 | Completed | Metabolic Technologies Inc. | 238 | 2014-08-01 | 2019-02-11 |
| Metformin and Muscle in Insulin-resistant Older Veterans metformin, placebo - Prediabetes | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 120 | 2014-04-08 | 2020-02-11 |
Showing 20 of 40. Sign in to see all of them.
Sarcopenia (21) · Muscular Atrophy (15) · Frailty (3) · Alveolar Bone Loss (2) · Asthenia (2) · Insulin Resistance (2) · Motor Activity (2) · Muscle Weakness (2) · Anorexia (1) · Bone Diseases, Metabolic (1) · COVID-19 (1) · Cachexia (1) · Carcinoma, Non-Small-Cell Lung (1) · Colorectal Neoplasms (1)
Pathological Conditions, Anatomical (40) · Pathological Conditions, Signs and Symptoms (40) · Neurologic Manifestations (36) · Signs and Symptoms (36) · Nervous System Diseases (35) · Neuromuscular Manifestations (35) · Muscular Atrophy (20) · Musculoskeletal Diseases (7) · Nutritional and Metabolic Diseases (5) · Pathologic Processes (5) · Bone Diseases (4) · Metabolic Diseases (4) · Behavior (3) · Mouth Diseases (3)
ACVR2B protein, human (2) · Cholecalciferol (2) · Exercise (2) · Leucine (2) · Nitroprusside (2) · SRT2104 (2) · Vitamin D (2) · Amino Acids (1) · Amino Acids, Essential (1) · Electric Stimulation (1) · Fatty Acids, Omega-3 (1) · Insulin (1) · Magnetic Resonance Spectroscopy (1) · Metformin (1) · Mometasone Furoate (1)
GlaxoSmithKline (3) · The University of Texas Medical Branch, Galveston (3) · Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA (2) · Maastricht University Medical Center (2) · Metabolic Technologies Inc. (2) · VA Office of Research and Development (2) · Anna Arthur, PhD (1) · Baylor College of Medicine (1) · Dar Al Uloom University (1) · ENCell (1) · GuangZhou Cellgenes Biotechnology Co., Ltd. (1) · High Point Pharmaceuticals, LLC. (1) · Hospital for Special Surgery, New York (1) · Immunis, Inc. (1) · Indiana University (1)
United States (19) · Canada (3) · Netherlands (3) · China (2) · Iran (2) · United Kingdom (2) · France (1) · Germany (1) · Honduras (1) · Saudi Arabia (1) · South Korea (1) · Spain (1) · Taiwan (1)
Luc JC van Loon, PhD (2) · Andrew R Coggan, PhD (1) · Arash Khojasteh, DMD, OMFS (1) · Bess Dawson-Hughes, MD (1) · Blake Rasmussen, PhD (1) · Dennis T Villareal, MD (1) · Elena Volpi, MD, PhD (1) · Elena Volpi, MD,PhD (1) · Hsin-Nung Shih, MD (1) · Huiyan Wang (1) · Ian R Lanza, PhD (1) · Johannes Gassmueller, M.D. (1) · John A Rathmacher, PhD (1) · John A. Rathmacher, Ph.D. (1)
PMID 16030064, PMID 16614412, PMID 16896165, PMID 17351147, PMID 18323467, PMID 18342407, PMID 18713956, PMID 18787087, PMID 20876843, PMID 22338078, PMID 15798081, PMID 16365098, PMID 16464955, PMID 16705054, PMID 16868746, PMID 16873412, PMID 17478528, PMID 17569770, PMID 17885021, PMID 18056791, PMID 18090658, PMID 18236467, PMID 18317375, PMID 18347658, PMID 18403916, PMID 18535123, PMID 18827171, PMID 18845784, PMID 19057193, PMID 19106243, PMID 19150856, PMID 19188252, PMID 19321567, PMID 19588121, PMID 19828686, PMID 20070283, PMID 20150565, PMID 20304764, PMID 20484484, PMID 20519362, PMID 20724580, PMID 20739716, PMID 20844186, PMID 21076294, PMID 21389329, PMID 21430254, PMID 21527663, PMID 21529326, PMID 21606874, PMID 21798089
R01AG018311 (1), R01AG030070 (1), R01AR049877 (1), R21AR074138 (1)