51 completed, 6 unknown, 5 terminated, 4 recruiting. 55 Not applicable, 11 Phase 2, 4 Phase 1, 2 Phase 3, 1 Early Phase 1.
Follow this drug Literature Review of Leucine trials Research Report on Leucine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Effect of a Seaweed Flour- and Leucine-Enriched Food on Metabolic and Inflammatory Status in Older Adults With Probable Sarcopenia or Sarcopenia Standard chocolate-flavored cake, Leucine-Enriched Chocolate Cake, Leucine Plus Seaweed Flour-Enriched Chocolate Cake - Sarcopenia in Elderly | Not applicable | Not yet recruiting | Finis Terrae University | 102 | 2026-08-01 | 2026-07-08 |
| How Animal and Plant Protein Shakes Change the Body's Nutrient and Health Responses Animal-Based Protein Smoothie, Plant-Based Protein Smoothie, Plant-Based Protein Smoothie with Leucine - Cardiometabolic Health | Not applicable | Recruiting | University of Pittsburgh | 20 | 2026-03-24 | 2026-10-06 |
| LEAN Mass Preservation With Resistance Exercise and Protein During Semaglutide/Tirzepatide Therapy Resistance exercise, Protein Intake - Obesity | Not applicable | Recruiting | Dasman Diabetes Institute | 232 | 2025-08-07 | 2026-04-21 |
| Leucine in Midlife Depression L-leucine, L-lysine - Major Depression | Phase 2 | Recruiting | Emory University | 75 | 2025-02-01 | 2026-09-11 |
| Leucine Supplementation Strategies to Enhance Muscle Anabolic Responses in Older Age Leucine - Muscle Protein Synthesis | Not applicable | Recruiting | University of Nottingham | 10 | 2024-08-05 | 2026-05-04 |
| Effects of Intragastric Quinine, Alone or Combined With L-leucine, on Postprandial Glycaemic Control Quinine, L-leucine, Combination of quinine and L-leucine - Healthy | Not applicable | Completed | University of Adelaide | 15 | 2023-02-02 | 2024-12-10 |
| Role of Leucine on Muscle Preservation During Weight Loss in Older Men Placebo, Protein, Leucine - Overweight and Obese Adults, BMI>=23 kg/m2 | Not applicable | Completed | Nanyang Technological University | 80 | 2022-11-14 | 2026-08-24 |
| Prandial Metabolic Phenotype in Adults Total Amino Acids, Essential Amino Acids, Essential Amino Acids + Hydroxy-methylbutyric acid (HMB) - Protein Metabolism | Not applicable | Active not recruiting | Texas A&M University | 38 | 2022-06-24 | 2026-10-05 |
| Leucine Requirement in Adult Men and Women Leucine - Healthy | Not applicable | Completed | The Hospital for Sick Children | 32 | 2022-04-29 | 2024-02-23 |
| Plasma Trimethylamine N-oxide Elevation Induced by L-carnitine Supplementation and Insulin Resistance L-carnitine, L-leucine, Change of the circadian cycle - Insulin Resistance | Not applicable | Completed | Poznan University of Physical Education | 40 | 2022-02-07 | 2026-08-17 |
| Low Calorie Diet or VLCKD Combined With Physical Training for Preserving Muscle Mass During Weight Loss in Sarcopenic Obesity meal replacements or supplementation with leucine - Sarcopenic Obesity | Not applicable | Completed | University of Roma La Sapienza | 50 | 2022-01-03 | 2022-03-18 |
| Study to Evaluate the Effect of Nicotinamide Mononucleotide (NMN) As an Adjuvant to Standard of Care (SOC) On Fatigue Associated With COVID-19 Infection Nicotinamide Mononucleotide, Nicotinamide Mononucleotide with L-Leucine, Placebo - COVID-19 Infection | Not applicable | Terminated | Vedic Lifesciences Pvt. Ltd. | 69 | 2021-12-27 | 2024-09-23 |
| Analysis of the Postprandial Effects of a Vegetable Protein Mixture Rich in Arginine, Cysteine and Leucine on Endothelial Dysfunction and Inflammation at Low Noise in Elderly People With Cardiometabolic Risk Vegetable proteins (VP) rich in leucine, cystein, arginine, Animal proteins (AP), No protein (T) - Metabolic Syndrome, Predisposition to Cardiovascular Disease | Not applicable | Completed | University Hospital, Clermont-Ferrand | 33 | 2021-11-09 | 2026-08-05 |
| Influence of a Home-based Nutrition and Exercise Program on Quality of Life of Palliative Cancer Outpatients Whey protein supplement high in leucine and β-hydroxy-β-methylbutyrate (HMB), Standardized nutritional program, Standardized exercise program - Cancer, Gastrointestinal, Cancer, Lung | Not applicable | Completed | Kantonsspital Winterthur KSW | 72 | 2021-06-07 | 2024-11-08 |
| Dileucine and Resistance Training Adaptations Placebo, Leucine, Dileucine - Hypertrophy, Strength Training Adaptations | Not applicable | Completed | Lindenwood University | 34 | 2021-05-07 | 2023-11-08 |
| Dose Response of Leucine on Muscle Maintenance During Weight Loss leucine - Overweight and Obese Adults, BMI >= 23 | Not applicable | Completed | Nanyang Technological University | 92 | 2020-08-18 | 2026-08-18 |
| Kinetic Study of Lp(a) and PCSK9 in Humans infusion of tracer [5,5,5-2H3] -L-leucine - Cholesterol; Metabolic Disorder, Lipoproteinemia | Not applicable | Completed | Nantes University Hospital | 21 | 2020-07-31 | 2022-02-23 |
| Skeletal Muscle Protein Synthetic Response to Amino Acid and Peptides Resistance Exercise, No Resistance Exercise, Leucine - Protein Metabolism | Not applicable | Completed | University of Illinois at Urbana-Champaign | 10 | 2019-05-03 | 2020-09-28 |
| Leucine Supplementation in Sarcopenic Older Individuals Leucine, Placebo - Frail Elderly Syndrome, Sarcopenia | Phase 1 | Completed | University of Valencia | 59 | 2019-02-01 | 2020-04-06 |
| Impact of Whey and Leucine on Glycaemia in Adults Without Diabetes Whey Protein Isolate, Wheat Protein, Wheat Protein with Leucine - Pre Diabetes | Not applicable | Unknown | University of Reading | 40 | 2018-12-01 | 2018-12-24 |
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Muscular Atrophy (6) · Sarcopenia (6) · Obesity (5) · Diabetes Mellitus, Type 2 (4) · Diabetes Mellitus (3) · Endocrine System Diseases (3) · Inflammation (3) · Motor Activity (3) · Overweight (3) · Pulmonary Disease, Chronic Obstructive (3) · Anemia, Diamond-Blackfan (2) · Atherosclerosis (2) · Atrophy (2) · Cystic Fibrosis (2) · Depression (2)
Texas A&M University (5) · Maastricht University Medical Center (4) · University of Sao Paulo (4) · University of Florida (3) · McMaster University (2) · Nanyang Technological University (2) · National Center for Research Resources (NCRR) (2) · NuSirt Biopharma (2) · Poznan University of Physical Education (2) · The Hospital for Sick Children (2) · The University of Texas Medical Branch, Galveston (2) · University Hospital, Basel, Switzerland (2) · University of Illinois at Urbana-Champaign (2) · University of Nottingham (2) · University of Oregon (2)
United States (30) · Canada (6) · United Kingdom (5) · Brazil (4) · Netherlands (4) · France (3) · Switzerland (3) · Poland (2) · Singapore (2) · Spain (2) · Australia (1) · Chile (1) · Germany (1) · India (1) · Italy (1)
Christoph Beglinger, Prof. (2) · Marielle PK Engelen, PhD (2) · Robert Olek, PhD (2) · Stuart M Phillips, PhD (2) · A. de Lange (1) · Adrianna Vlachos, MD (1) · Agneta L. Sunehag (1) · Andreu Farran, PhD (1) · Babak Razani, MD-PhD (1) · Chad M Kerksick, PhD (1) · Christian Britschgi, PD Dr. med. Dr. phil (1) · Christine Feinle-Bisset, PhD (1) · Cynthia Neill Epperson, M.D. (1) · Dana S. Hardin (1) · Doug Paddon-Jones, Ph.D. (1)
PMID 25527663, PMID 26765812, PMID 37542951, PMID 12449285, PMID 17364057, PMID 18029478, PMID 18317237, PMID 18383112, PMID 19158217, PMID 19321567, PMID 19515736, PMID 19647838, PMID 20539253, PMID 21430249, PMID 21525248, PMID 22204954, PMID 22222548, PMID 22337229, PMID 22451437, PMID 22526637, PMID 23166334, PMID 23886411, PMID 24135139, PMID 24401239, PMID 24423745, PMID 24657120, PMID 24871971, PMID 25712598, PMID 26201817, PMID 26694707, PMID 26718415, PMID 26733251, PMID 26781817, PMID 26829246, PMID 26962179, PMID 27146652, PMID 27875537, PMID 27935521, PMID 30100106, PMID 30150004, PMID 30280129, PMID 31149709, PMID 31343947, PMID 31965179, PMID 32230954, PMID 32910813, PMID 33006765, PMID 33025707, PMID 33330915, PMID 33553232
2009 (2), K01HD057332 (1), P50MH099910 (1), R01AG046401 (1), R01ES014617 (1), R01HL082747 (1), R01MH132059 (1), R21MH113915 (1), U54DK083908 (1)