18 completed, 1 recruiting, 1 terminated, 1 unknown. 16 Not applicable, 4 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 16 | Completed 14, Terminated 1, Unknown 1 |
| Phase 1 | 4 | Completed 4 |
| Phase 2 | 1 | Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Influence of β-hydroxy β-methyl Butyrate (HMB)Supplementation on Post-operative Muscle Mass and Function in Female Athletes CaHMB (Dietary supplement, not Drug), CaLa - Atrophy | Phase 2 | Recruiting | University of Kansas Medical Center | 30 | 2023-05-29 | 2026-03-02 |
| Independent and Combined Effects of Resistance Exercise Training and β-hydroxy β-methylbutyrate Plus Vitamin D Non-Exercise Control, Resistance Exercise Training, Placebo - Aging, Skeletal Muscle | Not applicable | Unknown | University of Illinois at Urbana-Champaign | 48 | 2019-04-01 | 2019-07-17 |
| 2-HOBA: Multiple Dosing Study in Older Adults 2-HOBA, Placebo - Older Adults | Not applicable | Completed | Metabolic Technologies Inc. | 18 | 2018-05-23 | 2021-12-14 |
| 2-HOBA: Multiple Dosing Study in Healthy Humans 2-HOBA, Placebo - Healthy Volunteers | Not applicable | Completed | Metabolic Technologies Inc. | 18 | 2018-05-23 | 2019-08-13 |
| Brain Penetrance of 2-HOBA in Humans 2-HOBA - Healthy Adults | Not applicable | Completed | Metabolic Technologies Inc. | 3 | 2018-05-23 | 2019-02-20 |
| Time-Restricted Feeding Plus Resistance Training in Active Females Beta-hydroxy beta-methylbutyrate, Resistance Training, Protein Supplementation - Healthy Active Females | Not applicable | Completed | Texas Tech University | 40 | 2018-01-17 | 2018-09-12 |
| 2-HOBA: Initial Evaluation in Humans 2-HOBA - Healthy Volunteers | Not applicable | Completed | Metabolic Technologies Inc. | 18 | 2017-08-02 | 2018-06-04 |
| The Effects of Probiotic and HMB Supplementation on Immune and Digestive Function in Special Operations Soldiers Placebo, HMB, BC30 - Military Training | Not applicable | Completed | Metabolic Technologies Inc. | 26 | 2016-04-01 | 2017-01-30 |
| The Effect of HMB Supplementation on Adipose Tissue Inflammation and Metabolism Placebo, HMB - Obesity | Not applicable | Terminated | Metabolic Technologies Inc. | 10 | 2016-03-01 | 2017-03-03 |
| Effects of HMB Supplementation on Recovery Following ACL Surgery HMB, Placebo - ACL Injury | Not applicable | Completed | Metabolic Technologies Inc. | 4 | 2015-11-01 | 2019-03-13 |
| Effects of 14-days of HMB-free Acid on Changes in Muscle During 4-days of Survival Training Placebo, HMB-FA - Survival Training | Not applicable | Completed | Metabolic Technologies Inc. | 27 | 2015-07-01 | 2015-11-25 |
| Nutritional Intervention for Age-related Muscular Function and Strength Losses-Study 2 Placebo, HMB plus Vitamin D, Non-Exercise - Sarcopenia | Phase 1 | Completed | Metabolic Technologies Inc. | 238 | 2014-08-01 | 2019-02-11 |
| The Effects of β-Hydroxy-β-methylbutyrate Free Acid and High-Intensity Interval Training Placebo, HMB-FA, High Intensity Interval Training - Exercise | Not applicable | Completed | Metabolic Technologies Inc. | 40 | 2013-09-01 | 2014-03-17 |
| Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout Placebo, ATP - Muscle Fatigue Caused by Repetitive Muscle Exercise | Not applicable | Completed | Metabolic Technologies Inc. | 42 | 2013-07-01 | 2015-09-28 |
| Alternate Dosing Strategies for Beta-hydroxy-beta-methylbutyrate (HMB) Supplementation: Effect on Plasma HMB Responses CaHMB capsule, HMB free acid gelcap, HMB free acid mixed in water - Focus of the Study is to Examine Plasma HMB Levels After Oral HMB Supplementation | Not applicable | Completed | Metabolic Technologies Inc. | 11 | 2013-05-01 | 2014-09-16 |
| Comparison of Pre-exercise Beta-hydroxy-beta-methylbutyrate Free Acid (HMB-FA) and Cold Water Therapy for the Attenuation of Muscle Damage and Soreness cold water immersion, beta-hydroxy-beta-methylbutyrate free acid (HMB-FA), Placebo - Muscle Damage | Not applicable | Completed | Metabolic Technologies Inc. | 40 | 2012-12-01 | 2013-08-01 |
| Effect of Whey and Albumin Protein on Plasma Levels of Amino Acids Whey Milk Protein, Bovine Albumin Concentrate - Healthy Men and Women | Not applicable | Completed | Metabolic Technologies Inc. | 8 | 2012-07-01 | 2013-02-15 |
| The Effects of HMB, ATP, and HMB Plus ATP on Muscle Mass, Strength, and Power in Resistance Trained Athletes Placebo, HMB, Peak ATP and HMB - Healthy Experienced Weight Training Males | Not applicable | Completed | Metabolic Technologies Inc. | 44 | 2012-01-01 | 2017-08-01 |
| Efficacy of a New Delivery System for Beta-hydroxy-beta-methylbutyrate CaHMB, HMB Free Acid Gel, Placebo - Healthy | Phase 1 | Completed | Metabolic Technologies Inc. | 41 | 2010-10-01 | 2012-07-18 |
| Effect of Oral Adenosine-triphosphate (ATP) on Human Muscle Performance PeakATP 250, Placebo, PeakATP 400 - Healthy Subjects | Phase 1 | Completed | Metabolic Technologies Inc. | 16 | 2010-06-01 | 2012-01-10 |
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Sarcopenia (2) · Anterior Cruciate Ligament Injuries (1) · Atrophy (1) · Motor Activity (1) · Myositis, Inclusion Body (1) · Obesity (1) · Platelet Glycoprotein IV Deficiency (1)
2-(aminomethyl)phenol (4) · beta-hydroxyisovaleric acid (4) · Adenosine Triphosphate (2) · Cholecalciferol (2) · Resistance Training (2) · Vitamin D (2) · Dietary Supplements (1) · Exercise (1) · High-Intensity Interval Training (1) · Water (1) · calcium lactate (1)
United States (19) · Israel (2)
John A Rathmacher, PhD (11) · Adam Konopka, PhD (1) · Grant Tinsley, Ph.D. (1) · Ishay Osterfeld, MD (1) · Jay R Hoffman, PhD (1) · Jeffery Stout, PhD (1) · John A. Rathmacher, Ph.D. (1) · Rick Sharp, PhD (1) · Rudy Valentine, PhD (1)
PMID 31907026, PMID 24330670, PMID 24782684, PMID 30611293, PMID 31268131, PMID 33512717
R44AG055184 (4)