10 completed, 7 recruiting, 4 not yet recruiting, 3 unknown. 27 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 27 | Completed 10, Recruiting 7, Not yet recruiting 4, Unknown 3, Active not recruiting 1, Enrolling by invitation 1, Terminated 1 |
Follow Apathy: new trials by email Literature Review of Apathy trials Research Report on Apathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Network-based tDCS for Apathy transcranial direct current stimulation, sham stimulation - Apathy, Brain Stimulation | Not applicable | Not yet recruiting | Hebrew SeniorLife | 20 | 2026-11-10 | 2026-10-28 |
| Accelerated rTMS for Apathy in Parkinson's Disease Accelerated intermittent theta-burst stimulation (iTBS) rTMS to left dorsomedial prefrontal cortex (dmPFC) - Parkinson Disease, Apathy | Not applicable | Recruiting | Medical University of South Carolina | 30 | 2026-09-09 | 2026-11-05 |
| SENS'REM - SENSoriality and Multi-Sensory Emotional Reminiscences: a Pilot Study Multisensory Virtual Reality Reminiscence Intervention - Apathy, Apathy in Dementia | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Nice | 10 | 2026-09-01 | 2026-05-26 |
| Robotic Technologies for APATHy in Dementia: a Randomised Controlled Trial (RAPHAel) telepresence robotic system, Pepper robot connected to a CAIR server, Occupational Therapy - Apathy, Apathy in Dementia | Not applicable | Recruiting | Giovanna Zamboni | 75 | 2026-04-28 | 2026-05-05 |
| Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics Targeted Cognitive Training Intervention, General Cognitive Training Intervention - Major Depressive Disorder, Apathy | Not applicable | Recruiting | AdventHealth | 84 | 2025-09-19 | 2026-11-06 |
| VC/VS for Apathy in PD Deep Brain Stimulation - Parkinson Disease, Deep Brain Stimulation | Not applicable | Not yet recruiting | Nora Vanegas | 5 | 2025-09-01 | 2025-05-31 |
| A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults Life Story Club - Apathy, Loneliness | Not applicable | Recruiting | Montefiore Medical Center | 50 | 2025-08-15 | 2026-09-25 |
| Respiratory-gated Transcutaneous Auricular Vagus Nerve Stimulation for Improving Apathy in Parkinson's Disease Active RAVANS, Sham RAVANS - Parkinson Disease, Apathy | Not applicable | Recruiting | Anhui Medical University | 60 | 2025-05-01 | 2025-11-19 |
| A Randomized Double-Blind Active-Controlled Crossover Trial of Respiratory-Gated Versus Non-Gated Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Motor and Non-Motor Symptoms in Parkinson's Disease Transcutaneous auricular vagus nerve stimulation - Parkinson Disease, Apathy | Not applicable | Enrolling by invitation | Anhui Medical University | 30 | 2024-10-01 | 2025-12-19 |
| Stratifying Psychoses for Personalized REpetitive TMS in Persistent NEgative Symptoms Alleviation Personalized rTMS - Schizophrenia, Persistent Negative Symptoms | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 160 | 2024-03-01 | 2023-12-28 |
| Cognitive Stimulation Therapy Cognitive Stimulation Therapy - Alzheimer Disease 10, Dementia | Not applicable | Completed | Hasan Kalyoncu University | 56 | 2023-05-01 | 2024-03-15 |
| Lifestyle Intervention for Improving Insulin Resistance and Concern for Health Diet without soy, Diet with soy - Insulin Sensitivity, Apathy | Not applicable | Completed | Pennington Biomedical Research Center | 40 | 2023-02-13 | 2026-09-09 |
| Effects of t-DCS and Cognitive Training on Apathy in Elderly With Minor Neurocognitive Impairment SHAM tDCS, tDCS - Apathy, Neurocognitive Disorders | Not applicable | Active not recruiting | Centre Hospitalier Universitaire de Nice | 27 | 2022-04-05 | 2025-11-26 |
| Study of the Effectiveness of Mental Contrasting and Implementation Intention in the Management of Apathy in Schizophrenia CM-II, Psychoeducation - Schizophrenia, Apathy | Not applicable | Unknown | University Hospital, Montpellier | 68 | 2022-02-22 | 2022-03-31 |
| Targeting Apathy With Music in Parkinson's Disease Music listening, Podcast listening - Parkinson Disease, Apathy | Not applicable | Recruiting | University of British Columbia | 50 | 2022-02-09 | 2026-03-23 |
| Multidimensional Apathy in Psychiatric Pathologies. Cognitive tasks with EEG recording - Apathy | Not applicable | Recruiting | University Hospital, Strasbourg, France | 144 | 2022-01-05 | 2026-08-19 |
| The Effects of Apathy on Different Forms of Fatigue Follow up and Assessment - Apathy, Fatigue | Not applicable | Completed | Centre Hospitalier Universitaire de Nice | 57 | 2021-01-14 | 2026-03-24 |
| Motive-specific Intervention for Negative Symptoms in Schizophrenia Motive-specific intervention, Supportive conversations - Negative Type; Schizophrenic, Anhedonia | Not applicable | Unknown | University of Zurich | 100 | 2021-01-01 | 2021-03-11 |
| Move to Improve Physical Activity in Parkinson's Disease Gameficiation - Parkinson Disease, Apathy | Not applicable | Completed | University of Pennsylvania | 84 | 2019-08-26 | 2024-01-19 |
| Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment Transcranial Magnetic Stimulation - Apathy, Mild Cognitive Impairment | Not applicable | Completed | VA Office of Research and Development | 103 | 2018-11-01 | 2026-05-22 |
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Lethargy (27) · Parkinson Disease (7) · Dementia (6) · Schizophrenia (3) · Anhedonia (2) · Neurocognitive Disorders (2) · Alzheimer Disease (1) · Alzheimer Disease 10 (1) · Anxiety Disorders (1) · Behavior (1) · Brain Diseases (1) · Cerebrovascular Disorders (1) · Cognitive Dysfunction (1) · Depression (1) · Depressive Disorder, Major (1)
Neurobehavioral Manifestations (27) · Neurologic Manifestations (27) · Pathological Conditions, Signs and Symptoms (27) · Signs and Symptoms (27) · Nervous System Diseases (26) · Central Nervous System Diseases (15) · Brain Diseases (14) · Mental Disorders (14) · Neurodegenerative Diseases (9) · Basal Ganglia Diseases (7) · Movement Disorders (7) · Neurocognitive Disorders (7) · Parkinsonian Disorders (7) · Synucleinopathies (7) · Nutritional and Metabolic Diseases (4)
Transcranial Direct Current Stimulation (3) · Deep Brain Stimulation (1) · Diet (1) · Diffusion Tensor Imaging (1) · Heart Rate (1) · Methylphenidate (1) · Occupational Therapy (1) · Restraint, Physical (1) · Standard of Care (1) · Transcranial Magnetic Stimulation (1)
Centre Hospitalier Universitaire de Nice (3) · Anhui Medical University (2) · Institut National de la Santé Et de la Recherche Médicale, France (2) · University Hospital, Strasbourg, France (2) · AdventHealth (1) · Giovanna Zamboni (1) · Hasan Kalyoncu University (1) · Hebrew SeniorLife (1) · Medical University of South Carolina (1) · Montefiore Medical Center (1) · Nora Vanegas (1) · Pennington Biomedical Research Center (1) · Stony Brook University (1) · US Department of Veterans Affairs (1) · University Hospital, Clermont-Ferrand (1)
United States (10) · France (8) · China (2) · Switzerland (2) · Canada (1) · Italy (1) · Turkey (Türkiye) (1)
Cyrus DeSouza, MD (2) · Andrew M Goldfine, MD (1) · Anne-Julie Vaillant-Ciszewicz, PhD (1) · Birgit Kleim, Prof. Dr. (1) · Candida J Rebello (1) · Daniel Lench (1) · Heidrun Becker, Prof.DR. (1) · Kai Wang, Ph.D. (1) · Lauren Oberlin, PhD (1) · Mirnova Ceide, MD (1) · Nabila Dahodwala, MD (1) · Nora Vanegas-Arroyave, MD (1)
PMID 31551908, PMID 35751676, PMID 36155506, PMID 36658040, PMID 33851004, PMID 35608793, PMID 35653896, PMID 35700600, PMID 39345385
2018 (1), 2025 (1), K23MH129882 (1), R00AG065419 (1), UM1TR004400 (1)