25 completed, 15 recruiting, 8 unknown, 7 not yet recruiting. 27 Not applicable, 9 Phase 2, 8 Phase 4, 6 Phase 3, 5 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Network-based tDCS for Apathy transcranial direct current stimulation, sham stimulation - Apathy, Brain Stimulation | Not applicable | Not yet recruiting | Hebrew SeniorLife | 20 | 2026-11-10 | 2026-10-28 |
| Accelerated rTMS for Apathy in Parkinson's Disease Accelerated intermittent theta-burst stimulation (iTBS) rTMS to left dorsomedial prefrontal cortex (dmPFC) - Parkinson Disease, Apathy | Not applicable | Recruiting | Medical University of South Carolina | 30 | 2026-09-09 | 2026-11-05 |
| SENS'REM - SENSoriality and Multi-Sensory Emotional Reminiscences: a Pilot Study Multisensory Virtual Reality Reminiscence Intervention - Apathy, Apathy in Dementia | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Nice | 10 | 2026-09-01 | 2026-05-26 |
| Study of the Effects of Atomoxetine on Motivation Atomoxetine, Placebo - Apathy | Phase 4 | Not yet recruiting | University of Oxford | 40 | 2026-08-01 | 2026-08-18 |
| Robotic Technologies for APATHy in Dementia: a Randomised Controlled Trial (RAPHAel) telepresence robotic system, Pepper robot connected to a CAIR server, Occupational Therapy - Apathy, Apathy in Dementia | Not applicable | Recruiting | Giovanna Zamboni | 75 | 2026-04-28 | 2026-05-05 |
| Safety and Tolerability of IRL757 in Participants With Parkinson's Disease and Apathy IRL757, Placebo - PARKINSON DISEASE (Disorder), Apathy | Phase 1 / Phase 2 | Recruiting | Integrative Research Laboratories AB | 75 | 2026-02-18 | 2026-09-03 |
| Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia intermittent theta burst stimulation (iTBS), Methylphenidate (MPH) - Alzheimer s Disease, Alzheimer Dementia (AD) | Phase 2 | Recruiting | Sunnybrook Health Sciences Centre | 12 | 2026-01-01 | 2025-12-12 |
| Effects of Personalized Digital Reminiscence Therapy on Patients With Neurocognitive Disorders Neurocognitive Disorders, Mild, Cognitive Impairment, Mild | Recruiting | KompanionCare SAS | 80 | 2025-10-14 | 2026-03-09 | |
| Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics Targeted Cognitive Training Intervention, General Cognitive Training Intervention - Major Depressive Disorder, Apathy | Not applicable | Recruiting | AdventHealth | 84 | 2025-09-19 | 2026-11-06 |
| VC/VS for Apathy in PD Deep Brain Stimulation - Parkinson Disease, Deep Brain Stimulation | Not applicable | Not yet recruiting | Nora Vanegas | 5 | 2025-09-01 | 2025-05-31 |
| A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults Life Story Club - Apathy, Loneliness | Not applicable | Recruiting | Montefiore Medical Center | 50 | 2025-08-15 | 2026-09-25 |
| Accelerated rTMS vs. Sham for Stroke Apathy MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (Active), MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (Sham), Brainsight Neuronavigation System - Apathy, Stroke | Phase 1 / Phase 2 | Recruiting | Medical University of South Carolina | 40 | 2025-08-08 | 2026-07-08 |
| Respiratory-gated Transcutaneous Auricular Vagus Nerve Stimulation for Improving Apathy in Parkinson's Disease Active RAVANS, Sham RAVANS - Parkinson Disease, Apathy | Not applicable | Recruiting | Anhui Medical University | 60 | 2025-05-01 | 2025-11-19 |
| Effort and Antidepressant Study Test Escitalopram 10mg, Placebo 10 mg - Effort Based Decision Making, Prosocial Behavior | Phase 1 / Phase 2 | Not yet recruiting | University of Oxford | 50 | 2025-01-01 | 2024-11-20 |
| A Randomized Double-Blind Active-Controlled Crossover Trial of Respiratory-Gated Versus Non-Gated Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Motor and Non-Motor Symptoms in Parkinson's Disease Transcutaneous auricular vagus nerve stimulation - Parkinson Disease, Apathy | Not applicable | Enrolling by invitation | Anhui Medical University | 30 | 2024-10-01 | 2025-12-19 |
| Phase I Trial Evaluating the Pharmacokinetics of Single Ascending Oral Doses of IRL757 in Healthy Elderly Volunteers IRL757 - Not Applicable as This is a Mass Balance/Pharmacokinetic Study Performed in Healthy Subjects, Apathy | Phase 1 | Completed | Integrative Research Laboratories AB | 12 | 2024-09-23 | 2026-02-05 |
| Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept Actigraphy and MRI - Apathy, Bipolar Disorder | Recruiting | Hospital Center Guillaume Régnier | 30 | 2024-07-01 | 2025-04-06 | |
| Lumateperone for the Improvement of Apathy in Patients With Psychotic Symptoms. Lumateperone 42 mg, Risperidone 2 mg - Apathy, Schizophrenia | Phase 3 | Recruiting | Louisiana State University Health Sciences Center Shreveport | 80 | 2024-06-01 | 2024-07-01 |
| Stratifying Psychoses for Personalized REpetitive TMS in Persistent NEgative Symptoms Alleviation Personalized rTMS - Schizophrenia, Persistent Negative Symptoms | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 160 | 2024-03-01 | 2023-12-28 |
| Methylphenidate for Apathy in Veterans With Parkinson's Disease Psychosocial intervention, Methylphenidate - Parkinson Disease, Apathy | Phase 2 | Not yet recruiting | Ralph H. Johnson VA Medical Center | 60 | 2024-01-01 | 2022-12-30 |
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Lethargy (61) · Dementia (13) · Parkinson Disease (13) · Alzheimer Disease (11) · Schizophrenia (5) · Stroke (5) · Cognitive Dysfunction (4) · Depression (4) · Anhedonia (3) · Neurocognitive Disorders (3) · Anxiety Disorders (2) · Diabetes Mellitus (2) · Psychotic Disorders (2) · Altruism (1) · Alzheimer Disease 10 (1)
Neurobehavioral Manifestations (61) · Neurologic Manifestations (61) · Pathological Conditions, Signs and Symptoms (61) · Signs and Symptoms (61) · Nervous System Diseases (60) · Central Nervous System Diseases (38) · Brain Diseases (37) · Mental Disorders (31) · Neurodegenerative Diseases (27) · Neurocognitive Disorders (20) · Basal Ganglia Diseases (15) · Movement Disorders (15) · Parkinsonian Disorders (13) · Synucleinopathies (13) · Tauopathies (11)
Methylphenidate (9) · Transcranial Direct Current Stimulation (4) · Transcranial Magnetic Stimulation (3) · Bupropion (2) · Drug Delivery Systems (2) · Magnetic Resonance Spectroscopy (2) · Psychosocial Intervention (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Actigraphy (1) · Aripiprazole (1) · Atomoxetine Hydrochloride (1) · Cholinesterase Inhibitors (1) · Deep Brain Stimulation (1) · Demography (1) · Diet (1)
Institut National de la Santé Et de la Recherche Médicale, France (4) · Medical University of South Carolina (4) · Centre Hospitalier Universitaire de Nice (3) · Anhui Medical University (2) · Central Arkansas Veterans Healthcare System (2) · Integrative Research Laboratories AB (2) · Johns Hopkins Bloomberg School of Public Health (2) · University Hospital, Clermont-Ferrand (2) · University Hospital, Grenoble (2) · University Hospital, Strasbourg, France (2) · University of Oxford (2) · VA Office of Research and Development (2) · AdventHealth (1) · Brown University (1) · Changhai Hospital (1)
United States (23) · France (17) · Canada (4) · China (3) · Brazil (2) · Germany (2) · Italy (2) · Switzerland (2) · Bulgaria (1) · Poland (1) · Spain (1) · Sweden (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Cyrus DeSouza, MD (2) · Krista Lanctot, PhD (2) · Ahmed A Baig, M.D. (1) · Amit Anand, MD (1) · Andrew M Goldfine, MD (1) · Anna Castrioto, MD (1) · Anne-Julie Vaillant-Ciszewicz, PhD (1) · Birgit Kleim, Prof. Dr. (1) · Breno S Diniz, MD, PhD (1) · Candida J Rebello (1) · Catherine J Harmer, DPhil (1) · Catherine J Harmer, PhD (1) · Claudia K Suemoto, MD, PhD (1)
PMID 31551908, PMID 35751676, PMID 36155506, PMID 36658040, PMID 15817019, PMID 16614016, PMID 1754629, PMID 19008681, PMID 20220576, PMID 20540829, PMID 20734360, PMID 22687392, PMID 24021498, PMID 24218528, PMID 24262299, PMID 26030001, PMID 26931289, PMID 28578330, PMID 28945120, PMID 29331848, PMID 29347996, PMID 32925060, PMID 33851004, PMID 34570180, PMID 35608793, PMID 35653896, PMID 35700600, PMID 37066690, PMID 39345385, PMID 40751860, PMID 41521126, PMID 42282206
2008 (1), 2009 (1), 2018 (1), 2025 (1), F32MH075583 (1), K23MH129882 (1), R00AG065419 (1), R01AG033032 (1), R01AG046543 (1), UM1TR004400 (1)