11 completed, 5 recruiting, 4 active not recruiting, 3 unknown. 16 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 16 | Completed 6, Active not recruiting 3, Recruiting 3, Unknown 3, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow Aortic Insufficiency: new trials by email Literature Review of Aortic Insufficiency trials Research Report on Aortic Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| JOURNEY LVAD: JOURNEY Left Ventricular Assist Device J-Valve Transfemoral System - Aortic Valve Regurgitation, Aortic Valve Disease Mixed | Not applicable | Active not recruiting | JC Medical, Inc., an affiliate of Edwards Lifesciences LLC | 50 | 2026-09-22 | 2026-10-30 |
| ART Trial: Transcatheter J-VALVE Versus Surgery for Aortic Regurgitation Therapy J-VALVE Transfemoral Aortic Valve system, Commercially available surgical biological aortic valve replacement device - Aortic Regurgitation, Aortic Valve Insufficiency | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 1250 | 2026-03-05 | 2026-08-12 |
| Prospective, Long-term Evaluation of the SAPIEN 3 Ultra RESILIA Valve Transcatheter aortic valve (S3UR) replacement (TAVR) - Transcatheter Aortic Valve Replacement (TAVR), Aortic-Stenosis | Recruiting | Institut für Pharmakologie und Präventive Medizin | 500 | 2025-09-15 | 2026-07-30 | |
| ARTIST: Aortic Regurgitation Trial Investigating Surgery Versus Trilogy™ Transcatheter Aortic Valve Replacement (TAVR) using Trilogy THV System, SAVR - Aortic Regurgitation, Aortic Valve Insufficiency | Not applicable | Recruiting | JenaValve Technology, Inc. | 1016 | 2025-06-18 | 2026-10-29 |
| Impact of Anesthesia, Positive Pressure Ventilation and Modality of Imaging on the Echocardiographic Assessment of the Severity of Aortic Regurgitation Aortic Regurgitation Disease, Aortic Insufficiency | Recruiting | University of Liege | 100 | 2025-03-01 | 2025-04-10 | |
| The JenaValve ALIGN-AR LVAD Registry JenaValve Trilogy Heart Valve System - Aortic Regurgitation, Aortic Valve Insufficiency | Not applicable | Active not recruiting | JenaValve Technology, Inc. | 50 | 2024-12-09 | 2026-10-29 |
| Exploratory Study of the Diagnostic Potential of an Innovative Thoracic Vibration Analysis Technique SMC signal recording - Cardiac Disease, Pulmonary Disease, Healthy Volunteer | Not applicable | Completed | University Hospital, Caen | 270 | 2024-05-17 | 2026-07-29 |
| Influence of Lung Ultrasonography on the Prognosis and Postoperative Outcomes in Cardiac Surgical Patients Ultrasound examination of the lungs - Ischemic Heart Disease, Aortic Stenosis, Severe | Not applicable | Recruiting | Saint Petersburg State University, Russia | 186 | 2024-05-15 | 2024-12-09 |
| To Evaluate Safety and Effectiveness of Transcatheter Aortic Valve System in Patients With Severe Aortic Insufficiency Transcatheter Aortic Valve System - Aortic Insufficiency | Not applicable | Unknown | Chengdu Silara Meditech Inc. | 10 | 2022-08-01 | 2022-06-21 |
| Portico and Navitor India Clinical Trial Transcatheter Aortic Valve Replacement - Aortic Valve Stenosis, Aortic Valve Failure | Not applicable | Completed | Abbott Medical Devices | 30 | 2022-05-06 | 2026-04-15 |
| Portico Valve-in-Valve Retrospective Registry Transcatheter Aortic Valve Replacement - Aortic Valve Stenosis, Aortic Valve Failure | Completed | Abbott Medical Devices | 71 | 2021-10-21 | 2025-02-28 | |
| Conduction Disease After Transcatheter Aortic Valve Replacement Electrophysiology Study - Aortic Stenosis, Heart Block | Not applicable | Completed | Henry Ford Health System | 126 | 2020-07-16 | 2022-12-14 |
| The JenaValve ALIGN-AR Pivotal Trial JenaValve Trilogy Heart Valve System - Aortic Regurgitation, Aortic Valve Insufficiency | Not applicable | Active not recruiting | JenaValve Technology, Inc. | 180 | 2020-05-22 | 2022-09-13 |
| First in Human Feasibility Study With ADAPT 3D - ALR for Aortic Leaflet Repair Implantation of ADAPT 3D ALR - Aortic Stenosis, Aortic Insufficiency | Not applicable | Unknown | Anteris Technologies Ltd. | 15 | 2020-03-26 | 2022-02-16 |
| Automated Phonocardiography Analysis in Adults Automated Heart Murmur Detection AI - Aortic Insufficiency, Aortic Stenosis | Completed | CSD Labs GmbH | 90 | 2015-12-10 | 2018-07-26 | |
| CardioCel Tri-leaflet Repair Study CardioCel - Aortic Stenosis, Aortic Insufficiency | Not applicable | Completed | Anteris Technologies Ltd. | 28 | 2015-09-01 | 2019-01-29 |
| The CardioPAT Project: A Randomized Trial cardioPAT cell saver - Coronary Artery Disease, Aortic Stenosis | Not applicable | Terminated | Copenhagen University Hospital, Rigshospitalet | 68 | 2013-12-01 | 2018-04-18 |
| HAART 200 Aortic Valve Annuloplasty Trial HAART 200 Aortic Valve Annuloplasty Device - Aortic Insufficiency | Not applicable | Completed | Biostable Science & Engineering | 20 | 2013-09-01 | 2017-04-17 |
| The HAART 300 Annuloplasty Ring Trial Extended Safety and Performance HAART 300 Annuloplasty Device - Aortic Insufficiency | Not applicable | Completed | Biostable Science & Engineering | 68 | 2012-12-01 | 2017-03-10 |
| JUPITER Study: Transapical Aortic Valve Implantation for Aortic Regurgitation Transcatheter aortic valve replacement - Aortic Stenosis, Aortic Insufficiency | Completed | JenaValve Technology, Inc. | 210 | 2012-05-30 | 2020-11-24 |
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Aortic Valve Insufficiency (24) · Aortic Valve Stenosis (12) · Mitral Valve Insufficiency (4) · Aortic Valve Disease (2) · Heart Valve Diseases (2) · Tricuspid Valve Insufficiency (2) · Aneurysm, Ascending Aorta (1) · Aortic Aneurysm (1) · Aortic Diseases (1) · Coronary Artery Disease (1) · Heart Block (1) · Heart Diseases (1) · Lung Diseases (1) · Mitral Valve Stenosis (1) · Myocardial Ischemia (1)
Cardiovascular Diseases (24) · Heart Diseases (23) · Aortic Valve Disease (22) · Heart Valve Diseases (22) · Ventricular Outflow Obstruction (12) · Vascular Diseases (3) · Aneurysm (2) · Aortic Diseases (2) · Aortic Aneurysm (1) · Aortic Aneurysm, Thoracic (1) · Arrhythmias, Cardiac (1) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Cardiac Conduction System Disease (1) · Coronary Disease (1)
Transcatheter Aortic Valve Replacement (4) · Magnetic Resonance Spectroscopy (1) · Replantation (1)
JenaValve Technology, Inc. (4) · Abbott Medical Devices (2) · Anteris Technologies Ltd. (2) · Biostable Science & Engineering (2) · CSD Labs GmbH (1) · Chengdu Silara Meditech Inc. (1) · Copenhagen University Hospital, Rigshospitalet (1) · Henry Ford Health System (1) · Institut für Pharmakologie und Präventive Medizin (1) · JC Medical, Inc., an affiliate of Edwards Lifesciences LLC (1) · Lille Catholic University (1) · Meshalkin Research Institute of Pathology of Circulation (1) · Saint Petersburg State University, Russia (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Sorin Group USA, Inc. (1)
United States (6) · Germany (5) · Belgium (3) · Denmark (2) · Russia (2) · United Kingdom (2) · Australia (1) · Austria (1) · Canada (1) · China (1) · Czechia (1) · France (1) · India (1) · Netherlands (1) · Switzerland (1)
Barathi Sethuraman (2) · Dominico Mazzitelli, MD (2) · Vinod Thourani, MD (2) · Alex Zapolanski, MD (1) · Alexandre Altes, MD (1) · Ali Khoynezhad, MD (1) · Andrew Maitland, MD (1) · Andrew Morse, MD (1) · Bart Meuris, Prof. Dr. (1) · David Heimansohn, MD (1) · Dominico Mazzitelli, M.D. (1) · Eric Roselli, M.D. (1) · Erika Nodin, MD (1) · Gabriel Sayer, MD (1) · Hendrik Treede, MD (1)
PMID 25865762, PMID 27242354, PMID 29171730, PMID 34191132, PMID 34556282, PMID 38552656, PMID 41260228, PMID 41928824, PMID 42417958